Esperion Therapeutics (ESPR) Stock Price, News & Analysis

Company Overview

Esperion Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of oral, low–density lipoprotein cholesterol (LDL-C)–lowering therapies. The company’s research and development efforts center on small-molecule compounds designed to address atherosclerotic cardiovascular disease by targeting cholesterol biosynthesis pathways. Esperion seeks to provide novel treatment options for patients who require additional LDL-C reduction beyond what is achieved with statins or who are statin-intolerant.

The company’s lead products include NEXLETOL (bempedoic acid), an oral adenosine triphosphate–citrate lyase (ACL) inhibitor approved by the U.S. Food and Drug Administration, and NILEMDO (bempedoic acid/ezetimibe), an oral fixed-dose combination therapy. Both products are indicated as adjuncts to diet and maximally tolerated statin therapy for adult patients with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease. Esperion continues to explore additional formulations and indications for its ACL inhibition platform, with clinical programs aimed at expanding patient access and optimizing long-term cardiovascular outcomes.

Headquartered in Ann Arbor, Michigan, Esperion was re-established in 2013 following the acquisition of specific cardiovascular assets from a global pharmaceutical company. The company completed its initial public offering on the NASDAQ Global Market under the ticker symbol “ESPR” and maintains research, development and commercial operations in the United States. Esperion has also pursued regulatory approvals and market launches in Europe, working to broaden its geographic footprint and engage with healthcare providers and payers worldwide.

Esperion’s leadership team is led by President and Chief Executive Officer Timothy M. Mayleben, who brings extensive experience in commercial strategy and product launches within the cardiovascular therapeutic area. Under this leadership, the company aims to further develop its pipeline, enhance patient outreach and drive adoption of oral LDL-C–lowering treatments to address the significant unmet needs in cardiovascular health management.

Key Stats

• Today's Range: $3.13 to $3.15
• 50-Day Range: $1.91 to $3.36
• 52-Week Range: $0.69 to $4.18
• Volume: 13.95 million shs
• Average Volume: 8.57 million shs
• Market Capitalization: $809.52 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $5.54
• Consensus Rating: Hold

Esperion Therapeutics Stock Analysis - MarketRank™

Esperion Therapeutics scored higher than 78% of companies evaluated by MarketBeat, and ranked 142nd out of 857 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 4.0 / 5
• Analyst Rating: Hold

Consensus Rating

Esperion Therapeutics has received a consensus rating of Hold. The company's average rating score is 2.00, and is based on no strong buy ratings, 1 buy rating, 6 hold ratings, and 1 sell rating.

Upside Potential

Esperion Therapeutics has a consensus price target of $5.54, representing about 76.7% upside from its current price of $3.14.

Amount of Analyst Coverage

Esperion Therapeutics has been the subject of 7 research reports in the past 90 days, demonstrating strong analyst interest in this stock.

Earnings and Valuation

• Score: 1.9 / 5
• Proj. Earnings Growth: 340.00%

Earnings Growth

Earnings for Esperion Therapeutics are expected to grow by 340.00% in the coming year, from $0.05 to $0.22 per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Esperion Therapeutics is -18.44, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Esperion Therapeutics is -18.44, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Growth Ratio

Esperion Therapeutics has a PEG Ratio of 2.53. PEG Ratios above 1 indicate that a company could be overvalued.

Short Interest

• Score: 3.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

12.58% of the float of Esperion Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Esperion Therapeutics has a short interest ratio ("days to cover") of 3.73, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Esperion Therapeutics has recently decreased by 3.92%, indicating that investor sentiment is improving.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Esperion Therapeutics does not currently pay a dividend.

Dividend Growth

Esperion Therapeutics does not have a long track record of dividend growth.

News and Social Media

• Score: 2.6 / 5
• News Sentiment: 0.23

News Sentiment

Esperion Therapeutics has a news sentiment score of 0.23. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.51 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 29 news articles for Esperion Therapeutics this week, compared to 4 articles on an average week.

Search Interest

Only 9 people have searched for ESPR on MarketBeat in the last 30 days. This is a decrease of -53% compared to the previous 30 days.

MarketBeat Follows

3 people have added Esperion Therapeutics to their MarketBeat watchlist in the last 30 days. This is an increase of 200% compared to the previous 30 days.

Company Ownership

• Score: 1.3 / 5
• Insider Trading: Selling Shares

Insider Buying vs. Insider Selling

In the past three months, Esperion Therapeutics insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $32,821.00 in company stock.

Percentage Held by Insiders

1.70% of the stock of Esperion Therapeutics is held by insiders.

Percentage Held by Institutions

47.39% of the stock of Esperion Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

ESPR Stock Analysis - Frequently Asked Questions

How have ESPR shares performed this year?

Esperion Therapeutics' stock was trading at $3.70 at the start of the year. Since then, ESPR shares have decreased by 15.3% and is now trading at $3.1350.

How were Esperion Therapeutics' earnings last quarter?

Esperion Therapeutics, Inc. (NASDAQ:ESPR) posted its quarterly earnings data on Tuesday, March, 10th. The biopharmaceutical company reported $0.22 earnings per share for the quarter, missing analysts' consensus estimates of $0.23 by $0.01. The biopharmaceutical company earned $168.45 million during the quarter, compared to analyst estimates of $165.12 million.
Read the conference call transcript.

When did Esperion Therapeutics IPO?

Esperion Therapeutics (ESPR) raised $70 million in an initial public offering on Wednesday, June 26th 2013. The company issued 5,000,000 shares at a price of $13.00-$15.00 per share.

Who are Esperion Therapeutics' major shareholders?

Esperion Therapeutics' top institutional investors include Wasatch Advisors LP (6.13%), AIGH Capital Management LLC (1.71%), Bank of New York Mellon Corp (0.22%) and Principal Financial Group Inc. (0.16%). Insiders that own company stock include Benjamin Halladay, Benjamin Looker, Sheldon L Koenig, Eric Warren and J Martin Carroll.
View institutional ownership trends.

How do I buy shares of Esperion Therapeutics?

Shares of ESPR stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Esperion Therapeutics own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Esperion Therapeutics investors own include Humana (HUM), Voyager Therapeutics (VYGR), American Water Works (AWK), Waste Connections (WCN), The RMR Group (RMR), AUO (AUOTY).

Company Calendar

• Last Earnings: 3/10/2026
• Today: 5/07/2026
• Next Earnings (Estimated): 5/07/2026
• Fiscal Year End: 12/31/2026

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - DRUGS
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:ESPR
• CIK: 1434868
• Web: www.esperion.com
• Phone: (734) 887-3903
• Fax: N/A
• Employees: 200
• Year Founded: 2008

Price Target and Rating

• Average Price Target for Esperion Therapeutics: $5.54
• High Price Target: $9.00
• Low Price Target: $3.16
• Potential Upside/Downside: +76.2%
• Consensus Rating: Hold
• Rating Score (0-4): 2.00
• Research Coverage: 8 Analysts

Profitability

• EPS (Trailing Twelve Months): ($0.17)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: 62.90
• P/E Growth: 2.53
• Net Income: -$22.68 million
• Net Margins: -3.66%
• Pretax Margin: -5.17%
• Return on Equity: N/A
• Return on Assets: -3.93%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 1.54
• Quick Ratio: 1.19

Sales & Book Value

• Annual Sales: $403.14 million
• Price / Sales: 2.01
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: ($1.26) per share
• Price / Book: -2.50

Miscellaneous

• Outstanding Shares: 257,400,000
• Free Float: 253,029,000
• Market Cap: $809.52 million
• Optionable: Optionable
• Beta: 0.91