Go Pro
→ Someone just dumped the biggest gold fund. (From Behind the Markets) (Ad)tc pixel Free KPTI Stock Alerts

Karyopharm Therapeutics (KPTI) Institutional Ownership

Karyopharm Therapeutics logo
$1.96 0.00 (0.00%)
As of 08/21/2026 04:00 PM Eastern
Compare

Institutional Ownership Changes (13F Filings) for Karyopharm Therapeutics (NASDAQ:KPTI)

Current
Institutional Ownership
Percentage
66.44%
Number of
Institutional Buyers
(last 12 months)
23
Total
Institutional Inflows
(last 12 months)
$28.93M
Number of
Institutional Sellers
(last 12 months)
11
Total
Institutional Outflows
(last 12 months)
$515.12M
Get KPTI Insider Trade Alerts

Want to know when executives and insiders are buying or selling Karyopharm Therapeutics stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily.

Subscribe Now
SMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy.
Skip Chart & View Institutional Buying and Selling Data

KPTI Institutional Buying and Selling by Quarter

Karyopharm Therapeutics Major Shareholders & Ownership History

Export
Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
8/20/2026 Headlands Technologies LLC12,113$118K0.0%N/A0.053%
8/6/2026 Bank of New York Mellon Corp57,262$559K0.0%N/A0.253%
5/28/2026 Avidity Partners Management LP463,741$2.58M0.5%+244.6%2.047%
5/19/2026 Bank of America Corp DE19,472$108K0.0%-59.5%0.086%
5/18/2026 Royal Bank of Canada60,399$336K0.0%+4.1%0.267%
5/15/2026 Commodore Capital LP1,950,000$10.86M0.6%N/A8.647%
5/15/2026 OMERS ADMINISTRATION Corp19,400$108K0.0%N/A0.086%
5/15/2026 Affinity Asset Advisors LLC500,000$2.79M0.1%-43.8%2.217%
5/14/2026 Renaissance Technologies LLC105,414$587K0.0%+75.9%0.467%
4/30/2026 Hsbc Holdings PLC11,495$66K0.0%N/A0.051%
3/9/2026 Corient Private Wealth LLC10,039$74K0.0%N/A0.055%
2/19/2026 T. Rowe Price Investment Management Inc.1,491,409$10.98M0.0%+112.8%8.132%
2/19/2026 Corient Private Wealth LLC10,039$74K0.0%N/A0.055%
2/18/2026 XTX Topco Ltd11,904$88K0.0%-17.3%0.065%
2/18/2026 Ikarian Capital LLC544,554$4.01M0.3%+1,897.9%2.974%
2/18/2026 Tudor Investment Corp ET AL12,922$95K0.0%N/A0.071%
2/18/2026 Quadrature Capital Ltd59,708$439K0.0%N/A0.326%
2/18/2026 Opaleye Management Inc.930,000$6.85M0.9%-84.5%5.079%
2/18/2026 Bridgeway Capital Management LLC65,873$485K0.0%+88.9%0.360%
2/18/2026 Boothbay Fund Management LLC144,628$1.06M0.0%N/A0.790%
2/17/2026 ADAR1 Capital Management LLC50,000$368K0.0%+100.0%0.273%
2/17/2026 Braidwell LP303,370$2.23M0.1%-99.4%1.657%
2/17/2026 Trexquant Investment LP41,733$307K0.0%N/A0.228%
2/17/2026 Jump Financial LLC53,816$396K0.0%N/A0.294%
2/17/2026 T. Rowe Price Investment Management Inc.585,908$4.31M0.0%-16.4%3.200%
2/17/2026 Royal Bank of Canada58,000$427K0.0%+761.3%0.317%
2/17/2026 Persistent Asset Partners Ltd18,316$135K0.1%N/A0.100%
2/16/2026 Context Capital Management LLC62,995$464K0.0%N/A0.344%
2/13/2026 Walleye Capital LLC95,672$704K0.0%N/A0.523%
2/13/2026 Affinity Asset Advisors LLC889,575$6.55M0.4%-94.2%4.858%
2/13/2026 Exome Asset Management LLC295,541$2.18M1.0%-84.9%1.614%
2/13/2026 State Street Corp58,942$434K0.0%+27.2%0.322%
2/12/2026 Renaissance Technologies LLC59,914$441K0.0%-7.4%0.327%
2/9/2026 Geode Capital Management LLC187,734$1.38M0.0%+101.2%1.025%
11/14/2025 ADAR1 Capital Management LLC25,000$164K0.0%N/A0.147%
11/14/2025 Bridgeway Capital Management LLC34,873$228K0.0%-7.8%0.205%
11/14/2025 Silverback Asset Management LLC40,000$262K0.0%-42.9%0.235%
11/7/2025Vanguard Group Inc.408,222$2.67M0.0%-21.2%4.708%
8/15/2025 Bridgeway Capital Management LLC37,836$163K0.0%N/A0.436%
8/15/2025 Bank of America Corp DE168,534$726K0.0%+26.8%1.944%
It’s not about Greenland (Ad)

The petrodollar arrangement that anchored the US dollar for 50 years quietly expired in June 2024. Since then, China has cut its Treasury holdings by 45% from their peak, and BRICS nations offloaded $47 billion of American debt in a single month. The Trump administration has responded with a $12 billion critical minerals stockpile called Project Vault, equity stakes in miners like MP Materials and Lithium Americas, and a push to secure resources from Greenland to Ukraine. Porter Stansberry lays out the full story in a new documentary, including five companies positioned at the chokepoints of what he calls Trump's New Dollar.tc pixel

Watch the full documentary before December's economic summit in Miami
8/13/2025 Baird Financial Group Inc.10,532$45K0.0%N/A0.122%
8/13/2025 Silverback Asset Management LLC70,000$302K0.0%+40.0%0.810%
8/12/2025 XTX Topco Ltd13,056$56K0.0%N/A0.151%
8/8/2025 Geode Capital Management LLC91,841$396K0.0%-7.8%1.063%
6/27/2025 Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.989%
5/19/2025Jane Street Group LLC11,420$43K0.0%-98.5%0.132%
5/16/2025Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.997%
5/16/2025Adage Capital Partners GP L.L.C.421,322$1.58M0.0%-93.3%4.916%
5/15/2025Birchview Capital LP27,985$105K0.1%-93.3%0.327%
5/15/2025Palo Alto Investors LP324,032$1.21M0.2%-93.4%3.781%
5/14/2025T. Rowe Price Investment Management Inc.139,646$523K0.0%N/A1.629%
5/13/2025Altium Capital Management LLC49,333$185K0.4%-93.3%0.576%
5/5/2025C WorldWide Group Holding A S100,000$374K0.0%-93.3%1.167%
4/29/2025Bank of New York Mellon Corp11,086$41K0.0%-93.3%0.129%
2/17/2025Velan Capital Investment Management LP40,000$27K0.0%N/A0.032%
2/17/2025Two Sigma Advisers LP76,600$52K0.0%+145.5%0.061%
2/17/2025Two Sigma Investments LP137,786$93K0.0%+60.3%0.109%
2/17/2025Shay Capital LLC172,153$116K0.0%N/A0.136%
2/17/2025Millennium Management LLC1,154,414$781K0.0%-8.0%0.915%
2/17/2025Focus Partners Wealth45,818$31K0.0%N/A0.036%
2/17/2025D. E. Shaw & Co. Inc.229,685$155K0.0%-78.1%0.182%
2/17/2025Cubist Systematic Strategies LLC328,807$222K0.0%-33.7%0.261%
2/17/2025Bank of America Corp DE161,708$109K0.0%-29.4%0.128%
2/17/2025BNP Paribas Financial Markets1,313,893$889K0.0%-33.7%1.041%
2/14/2025Jane Street Group LLC748,306$506K0.0%+265.5%0.593%
2/14/2025Northern Trust Corp283,729$192K0.0%+23.5%0.225%
2/14/2025Birchview Capital LP419,832$284K0.2%-10.6%0.333%
2/14/2025Opti Capital Management LP125,000$85K0.0%N/A0.099%
2/14/2025Adage Capital Partners GP L.L.C.6,319,842$4.27M0.0%+46.3%5.008%
2/14/2025Price T Rowe Associates Inc. MD64,300$44K0.0%-52.3%0.051%
2/14/2025Silverarc Capital Management LLC595,990$403K0.1%+6.7%0.472%
2/14/2025Eversept Partners LP2,088,757$1.41M0.1%-62.4%1.655%
2/14/2025TD Waterhouse Canada Inc.48,049$32K0.0%N/A0.038%
2/13/2025Marshall Wace LLP2,401,413$1.63M0.0%+15.3%1.903%
2/13/2025Renaissance Technologies LLC1,202,590$813K0.0%-3.1%0.953%
2/12/2025Geode Capital Management LLC1,392,314$942K0.0%+2.7%1.103%
11/19/2024Barclays PLC95,767$79K0.0%-89.0%0.076%
11/16/2024Geode Capital Management LLC1,355,392$1.13M0.0%+3.3%1.082%
11/15/2024Barclays PLC95,767$79K0.0%-89.0%0.076%
11/15/2024Jane Street Group LLC204,750$170K0.0%-86.8%0.163%
11/15/2024State Street Corp409,510$340K0.0%-9.8%0.327%
11/15/2024Point72 Asia Singapore Pte. Ltd.82,446$68K0.0%-50.1%0.066%
11/13/2024BNP Paribas Financial Markets1,982,354$1.65M0.0%-12.8%1.582%
11/13/2024FMR LLC369,723$307K0.0%+26.1%0.295%
11/5/2024GSA Capital Partners LLP1,775,700$1.47M0.1%+80.6%1.424%
10/10/2024Exchange Traded Concepts LLC218,791$182K0.0%+34.9%0.176%
9/16/2024Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
9/16/2024Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.456%
9/16/2024Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/15/2024AQR Capital Management LLC748,020$649K0.0%+494.5%0.600%
Someone just dumped the biggest gold fund. (Ad)

Investors pulled 2.9 billion dollars from the world's largest gold fund in a single day this March, pushing total outflows to 14 billion. At the same time, the World Gold Council recorded the highest quarterly central bank gold buying on record, with buyers taking physical delivery instead of paper shares.tc pixel

Discover the company on the buying side before the September 30th delivery date.
8/15/2024Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/14/2024Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.457%
8/14/2024Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
8/14/2024Marshall Wace LLP2,580,863$2.25M0.0%-0.6%2.071%
8/12/2024XTX Topco Ltd140,576$122K0.0%-42.1%0.113%
8/9/2024Renaissance Technologies LLC756,227$656K0.0%-16.6%0.607%
8/6/2024Acadian Asset Management LLC194,168$167K0.0%N/A0.156%
8/6/2024Los Angeles Capital Management LLC354,020$307K0.0%-8.6%0.284%
7/26/2024Bank of New York Mellon Corp166,315$144K0.0%-65.9%0.133%
5/17/2024Ikarian Capital LLC409,355$618K0.1%+2.3%0.348%


KPTI Institutional Ownership - Frequently Asked Questions

During the previous two years, 61 institutional investors and hedge funds held shares of Karyopharm Therapeutics. The most heavily invested institutionals were T. Rowe Price Investment Management Inc. ($10.98M), Commodore Capital LP ($10.86M), Opaleye Management Inc. ($6.85M), Ikarian Capital LLC ($4.01M), Affinity Asset Advisors LLC ($2.79M), Vanguard Group Inc. ($2.67M), and Avidity Partners Management LP ($2.58M).Learn more on Karyopharm Therapeutics' institutional investors.

66.44% of Karyopharm Therapeutics' stock is owned by institutional investors. Learn more on KPTI's institutional investor holdings.

Of the 45 institutional investors that purchased Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Adage Capital Partners GP L.L.C. ($2M), Commodore Capital LP ($1.95M), T. Rowe Price Investment Management Inc. ($930.06K), GSA Capital Partners LLP ($792.28K), Cubist Systematic Strategies LLC ($568.98K), Jane Street Group LLC ($543.56K), and Ikarian Capital LLC ($517.30K).

Institutional investors have bought a total of 4,484,237 shares in the last 24 months. This purchase volume represents approximately $28.93M in transactions.

Of the 11 institutional investors that sold Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Braidwell LP ($48.18M), Affinity Asset Advisors LLC ($14.91M), Opaleye Management Inc. ($5.07M), Exome Asset Management LLC ($1.66M), T. Rowe Price Investment Management Inc. ($115.08K), Vanguard Group Inc. ($110.05K), and Silverback Asset Management LLC ($30K).

Institutional investors have sold a total of 70,106,597 shares in the last 24 months. This volume of shares sold represents approximately $515.12M in transactions.


Related Companies

Institutional ownership data for NASDAQ:KPTI is compiled from quarterly 13F filings submitted to the U.S. Securities and Exchange Commission (SEC), with the most recent received on 8/20/2026. New 13F filings are added each quarter as they're published.
From Our Partners
A Simple Guide to Options Trading While It's Still Free
A free copy of Options Trading Made Simple is available now but wont stay that way for long. Chris Rowe cal...
True Market Insiders | Sponsoredtc pixel
The retirement stock I'd buy before Nvidia today
In 2014, Marc Chaikin pointed readers toward Nvidia. Now the 60-year Wall Street veteran and creator of the Ch...
Chaikin Analytics | Sponsoredtc pixel
Someone just dumped the biggest gold fund.
Investors pulled 2.9 billion dollars from the world's largest gold fund in a single day this March, pushing to...
Behind the Markets | Sponsoredtc pixel
They didn't warn anyone in 1971. This time someone is warning you.
On August 15, 1971, Nixon interrupted prime-time television and ended the gold standard in 15 minutes - no deb...
Reagan Gold Group | Sponsoredtc pixel
A $382 trillion migration and the position no one is talking about
Trump just signed a law requiring America's entire $382 trillion financial system to migrate to a new money ne...
Awesomely | Sponsoredtc pixel
These gold assets are priced for $1,800 gold [it's over $4,000]
Gold's major miners are generating record free cash flow, with margins as high as 75 percent even after gold's...
Golden Portfolio | Sponsoredtc pixel
A New Gold Era Is Coming - Here's How to Help Protect Your Retirement Now
Washington insiders are quietly talking about a coordinated move to revalue gold—and with the national debt ap...
Preserve Gold | Sponsoredtc pixel
The cat is out the bag
Almost 80,000 tech jobs vanished in the first three months of 2026. Meta cut 14,000 roles, Microsoft offered s...
Porter & Company | Sponsoredtc pixel