Top 5 Stocks to Buy Now
→ Louis Navellier: My #1 AI stock for 2026 (name & ticker inside) (From InvestorPlace) (Ad)tc pixel Free KPTI Stock Alerts

Karyopharm Therapeutics (KPTI) Institutional Ownership

Karyopharm Therapeutics logo
$9.02 -0.38 (-4.04%)
Closing price 06/18/2026 04:00 PM Eastern
Extended Trading
$9.10 +0.08 (+0.93%)
As of 06/18/2026 07:03 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.
Compare

Institutional Ownership Changes (13F Filings) for Karyopharm Therapeutics (NASDAQ:KPTI)

Current
Institutional Ownership
Percentage
66.44%
Number of
Institutional Buyers
(last 12 months)
25
Total
Institutional Inflows
(last 12 months)
$28.76M
Number of
Institutional Sellers
(last 12 months)
13
Total
Institutional Outflows
(last 12 months)
$519.83M
Get KPTI Insider Trade Alerts

Want to know when executives and insiders are buying or selling Karyopharm Therapeutics stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily.

Subscribe Now
SMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy.
Skip Chart & View Institutional Buying and Selling Data

KPTI Institutional Buying and Selling by Quarter

Karyopharm Therapeutics Major Shareholders & Ownership History

Export
Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
5/28/2026 Avidity Partners Management LP463,741$2.58M0.5%+244.6%2.047%
5/19/2026 Bank of America Corp DE19,472$108K0.0%-59.5%0.086%
5/18/2026 Royal Bank of Canada60,399$336K0.0%+4.1%0.267%
5/15/2026 Commodore Capital LP1,950,000$10.86M0.6%N/A8.647%
5/15/2026 OMERS ADMINISTRATION Corp19,400$108K0.0%N/A0.086%
5/15/2026 Affinity Asset Advisors LLC500,000$2.79M0.1%-43.8%2.217%
5/14/2026 Renaissance Technologies LLC105,414$587K0.0%+75.9%0.467%
4/30/2026 Hsbc Holdings PLC11,495$66K0.0%N/A0.051%
3/9/2026 Corient Private Wealth LLC10,039$74K0.0%N/A0.055%
2/19/2026 T. Rowe Price Investment Management Inc.1,491,409$10.98M0.0%+112.8%8.132%
2/19/2026 Corient Private Wealth LLC10,039$74K0.0%N/A0.055%
2/18/2026 XTX Topco Ltd11,904$88K0.0%-17.3%0.065%
2/18/2026 Ikarian Capital LLC544,554$4.01M0.3%+1,897.9%2.974%
2/18/2026 Tudor Investment Corp ET AL12,922$95K0.0%N/A0.071%
2/18/2026 Quadrature Capital Ltd59,708$439K0.0%N/A0.326%
2/18/2026 Opaleye Management Inc.930,000$6.85M0.9%-84.5%5.079%
2/18/2026 Bridgeway Capital Management LLC65,873$485K0.0%+88.9%0.360%
2/18/2026 Boothbay Fund Management LLC144,628$1.06M0.0%N/A0.790%
2/17/2026 ADAR1 Capital Management LLC50,000$368K0.0%+100.0%0.273%
2/17/2026 Braidwell LP303,370$2.23M0.1%-99.4%1.657%
2/17/2026 Trexquant Investment LP41,733$307K0.0%N/A0.228%
2/17/2026 Jump Financial LLC53,816$396K0.0%N/A0.294%
2/17/2026 T. Rowe Price Investment Management Inc.585,908$4.31M0.0%-16.4%3.200%
2/17/2026 Royal Bank of Canada58,000$427K0.0%+761.3%0.317%
2/17/2026 Persistent Asset Partners Ltd18,316$135K0.1%N/A0.100%
2/16/2026 Context Capital Management LLC62,995$464K0.0%N/A0.344%
2/13/2026 Walleye Capital LLC95,672$704K0.0%N/A0.523%
2/13/2026 Affinity Asset Advisors LLC889,575$6.55M0.4%-94.2%4.858%
2/13/2026 Exome Asset Management LLC295,541$2.18M1.0%-84.9%1.614%
2/13/2026 State Street Corp58,942$434K0.0%+27.2%0.322%
2/12/2026 Renaissance Technologies LLC59,914$441K0.0%-7.4%0.327%
2/9/2026 Geode Capital Management LLC187,734$1.38M0.0%+101.2%1.025%
11/14/2025 ADAR1 Capital Management LLC25,000$164K0.0%N/A0.147%
11/14/2025 Bridgeway Capital Management LLC34,873$228K0.0%-7.8%0.205%
11/14/2025 Silverback Asset Management LLC40,000$262K0.0%-42.9%0.235%
11/7/2025Vanguard Group Inc.408,222$2.67M0.0%-21.2%4.708%
8/15/2025 Bridgeway Capital Management LLC37,836$163K0.0%N/A0.436%
8/15/2025 Bank of America Corp DE168,534$726K0.0%+26.8%1.944%
8/13/2025 Baird Financial Group Inc.10,532$45K0.0%N/A0.122%
8/13/2025 Silverback Asset Management LLC70,000$302K0.0%+40.0%0.810%
Why this tiny stock may move before the SpaceX IPO drops (Ad)

The projected SpaceX and xAI S-1 filing hits the SEC on June 1st - and analyst Dylan Jovine says $1.75 trillion in stored capital will be looking for a home when it does. But the real opportunity isn't the IPO itself. Jovine has identified a small-cap supplier trading near $4 that sits directly in the path of xAI's Colossus infrastructure buildout - and a specific trigger in the S-1 could reprice it overnight.tc pixel

Get the ticker and full briefing before the June roadshow begins
8/12/2025 XTX Topco Ltd13,056$56K0.0%N/A0.151%
8/8/2025 Geode Capital Management LLC91,841$396K0.0%-7.8%1.063%
6/27/2025 Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.989%
5/19/2025Jane Street Group LLC11,420$43K0.0%-98.5%0.132%
5/16/2025Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.997%
5/16/2025Adage Capital Partners GP L.L.C.421,322$1.58M0.0%-93.3%4.916%
5/15/2025Birchview Capital LP27,985$105K0.1%-93.3%0.327%
5/15/2025Palo Alto Investors LP324,032$1.21M0.2%-93.4%3.781%
5/14/2025T. Rowe Price Investment Management Inc.139,646$523K0.0%N/A1.629%
5/13/2025Altium Capital Management LLC49,333$185K0.4%-93.3%0.576%
5/5/2025C WorldWide Group Holding A S100,000$374K0.0%-93.3%1.167%
4/29/2025Bank of New York Mellon Corp11,086$41K0.0%-93.3%0.129%
2/17/2025Velan Capital Investment Management LP40,000$27K0.0%N/A0.032%
2/17/2025Two Sigma Advisers LP76,600$52K0.0%+145.5%0.061%
2/17/2025Two Sigma Investments LP137,786$93K0.0%+60.3%0.109%
2/17/2025Shay Capital LLC172,153$116K0.0%N/A0.136%
2/17/2025Millennium Management LLC1,154,414$781K0.0%-8.0%0.915%
2/17/2025Focus Partners Wealth45,818$31K0.0%N/A0.036%
2/17/2025D. E. Shaw & Co. Inc.229,685$155K0.0%-78.1%0.182%
2/17/2025Cubist Systematic Strategies LLC328,807$222K0.0%-33.7%0.261%
2/17/2025Bank of America Corp DE161,708$109K0.0%-29.4%0.128%
2/17/2025BNP Paribas Financial Markets1,313,893$889K0.0%-33.7%1.041%
2/14/2025Jane Street Group LLC748,306$506K0.0%+265.5%0.593%
2/14/2025Northern Trust Corp283,729$192K0.0%+23.5%0.225%
2/14/2025Birchview Capital LP419,832$284K0.2%-10.6%0.333%
2/14/2025Opti Capital Management LP125,000$85K0.0%N/A0.099%
2/14/2025Adage Capital Partners GP L.L.C.6,319,842$4.27M0.0%+46.3%5.008%
2/14/2025Price T Rowe Associates Inc. MD64,300$44K0.0%-52.3%0.051%
2/14/2025Silverarc Capital Management LLC595,990$403K0.1%+6.7%0.472%
2/14/2025Eversept Partners LP2,088,757$1.41M0.1%-62.4%1.655%
2/14/2025TD Waterhouse Canada Inc.48,049$32K0.0%N/A0.038%
2/13/2025Marshall Wace LLP2,401,413$1.63M0.0%+15.3%1.903%
2/13/2025Renaissance Technologies LLC1,202,590$813K0.0%-3.1%0.953%
2/12/2025Geode Capital Management LLC1,392,314$942K0.0%+2.7%1.103%
11/19/2024Barclays PLC95,767$79K0.0%-89.0%0.076%
11/16/2024Geode Capital Management LLC1,355,392$1.13M0.0%+3.3%1.082%
11/15/2024Barclays PLC95,767$79K0.0%-89.0%0.076%
11/15/2024Jane Street Group LLC204,750$170K0.0%-86.8%0.163%
11/15/2024State Street Corp409,510$340K0.0%-9.8%0.327%
11/15/2024Point72 Asia Singapore Pte. Ltd.82,446$68K0.0%-50.1%0.066%
11/13/2024BNP Paribas Financial Markets1,982,354$1.65M0.0%-12.8%1.582%
11/13/2024FMR LLC369,723$307K0.0%+26.1%0.295%
11/5/2024GSA Capital Partners LLP1,775,700$1.47M0.1%+80.6%1.424%
10/10/2024Exchange Traded Concepts LLC218,791$182K0.0%+34.9%0.176%
9/16/2024Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
9/16/2024Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.456%
9/16/2024Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/15/2024AQR Capital Management LLC748,020$649K0.0%+494.5%0.600%
8/15/2024Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/14/2024Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.457%
The REAL Reason Trump is Invading Iran (Ad)

For a moment… Forget about Trump’s ties to Israel. Forget about reports of Iran’s nuclear program. Because my research has led me to believe we’re risking World War 3 with Iran for a completely different reason.tc pixel

Click here to find out what it is.
8/14/2024Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
8/14/2024Marshall Wace LLP2,580,863$2.25M0.0%-0.6%2.071%
8/12/2024XTX Topco Ltd140,576$122K0.0%-42.1%0.113%
8/9/2024Renaissance Technologies LLC756,227$656K0.0%-16.6%0.607%
8/6/2024Acadian Asset Management LLC194,168$167K0.0%N/A0.156%
8/6/2024Los Angeles Capital Management LLC354,020$307K0.0%-8.6%0.284%
7/26/2024Bank of New York Mellon Corp166,315$144K0.0%-65.9%0.133%
5/17/2024Ikarian Capital LLC409,355$618K0.1%+2.3%0.348%
5/10/2024Vanguard Group Inc.8,338,401$12.59M0.0%-4.3%7.160%
5/3/2024GSA Capital Partners LLP1,299,151$1.96M0.2%-44.4%1.115%


KPTI Institutional Ownership - Frequently Asked Questions

During the previous two years, 63 institutional investors and hedge funds held shares of Karyopharm Therapeutics. The most heavily invested institutionals were T. Rowe Price Investment Management Inc. ($10.98M), Commodore Capital LP ($10.86M), Opaleye Management Inc. ($6.85M), Ikarian Capital LLC ($4.01M), Affinity Asset Advisors LLC ($2.79M), Vanguard Group Inc. ($2.67M), and Avidity Partners Management LP ($2.58M).Learn more on Karyopharm Therapeutics' institutional investors.

66.44% of Karyopharm Therapeutics' stock is owned by institutional investors. Learn more on KPTI's institutional investor holdings.

Of the 45 institutional investors that purchased Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Adage Capital Partners GP L.L.C. ($2M), Commodore Capital LP ($1.95M), Cubist Systematic Strategies LLC ($1.14M), T. Rowe Price Investment Management Inc. ($930.06K), GSA Capital Partners LLP ($792.28K), AQR Capital Management LLC ($622.19K), and Jane Street Group LLC ($543.56K).

Institutional investors have bought a total of 4,531,912 shares in the last 24 months. This purchase volume represents approximately $28.76M in transactions.

Of the 13 institutional investors that sold Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Braidwell LP ($48.18M), Affinity Asset Advisors LLC ($14.91M), Opaleye Management Inc. ($5.07M), Exome Asset Management LLC ($1.66M), Goldman Sachs Group Inc. ($1.25M), T. Rowe Price Investment Management Inc. ($115.08K), and Vanguard Group Inc. ($110.05K).

Institutional investors have sold a total of 71,364,757 shares in the last 24 months. This volume of shares sold represents approximately $519.83M in transactions.


Related Companies

This page (NASDAQ:KPTI) was last updated on 6/19/2026 by MarketBeat.com Staff.
From Our Partners
Trump Takes Emergency Action - Plus Elon Musk's New Venture
Elon Musk has quietly launched a new venture - one that has nothing to do with rockets, EVs, or Neuralink. Tru...
Altimetry | Sponsoredtc pixel
CODE RED: AI Meltdown Imminent?
After correctly predicting the 2008 and 2020 stock market meltdowns, I believe this AI company is about to tri...
Paradigm Press | Sponsoredtc pixel
This is the worst news for stocks in 50 years
Goldman Sachs and Morgan Stanley are issuing a rare warning: what's ahead for U.S. stocks could be the worst e...
TradeSmith | Sponsoredtc pixel
The roadshow starts Monday. This stock isn't ready.
The SpaceX roadshow kicks off June 8. Goldman Sachs, the lead underwriter, will present the full S-1 to the wo...
Behind the Markets | Sponsoredtc pixel
SpaceX is chump change compared to Elon’s $20T ‘iPhone’
Early Apple investors saw peak gains as high as 7,537% after the iPhone launched. Now, multiple insider source...
StocksToTrade | Sponsoredtc pixel
Trump just signed it
A recent policy development is drawing attention from income-focused investors. According to one analyst, c...
Investors Alley | Sponsoredtc pixel
A huge SpaceX error just led one stock to 3X move!
SPCE surged roughly 300% in a single week after investors hunting SpaceX exposure piled into the wrong ticker....
InvestPub | Sponsoredtc pixel
Porter flew 3,300 miles to investigate this system
Porter Stansberry flew the Porter and Co. team 3,300 miles to Dublin to investigate a 17-year investing experi...
Porter & Company | Sponsoredtc pixel