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Karyopharm Therapeutics (KPTI) Competitors

Karyopharm Therapeutics logo
$10.22 +0.01 (+0.05%)
Closing price 06/26/2026 03:59 PM Eastern
Extended Trading
$10.15 -0.06 (-0.64%)
As of 05:02 AM Eastern
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KPTI vs. TBPH, ORIC, CGEM, ABUS, and PHAT

Should you buy Karyopharm Therapeutics stock or one of its competitors? MarketBeat compares Karyopharm Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Karyopharm Therapeutics include Theravance Biopharma (TBPH), Oric Pharmaceuticals (ORIC), Cullinan Therapeutics (CGEM), Arbutus Biopharma (ABUS), and Phathom Pharmaceuticals (PHAT). These companies are all part of the "pharmaceutical products" industry.

How does Karyopharm Therapeutics compare to Theravance Biopharma?

Theravance Biopharma (NASDAQ:TBPH) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their institutional ownership, analyst recommendations, valuation, profitability, risk, media sentiment, dividends and earnings.

Theravance Biopharma has higher earnings, but lower revenue than Karyopharm Therapeutics. Karyopharm Therapeutics is trading at a lower price-to-earnings ratio than Theravance Biopharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Theravance Biopharma$109.78M8.28$105.89M$2.208.01
Karyopharm Therapeutics$151.12M1.53-$196.04M-$15.09N/A

99.1% of Theravance Biopharma shares are owned by institutional investors. Comparatively, 66.4% of Karyopharm Therapeutics shares are owned by institutional investors. 7.7% of Theravance Biopharma shares are owned by company insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

In the previous week, Karyopharm Therapeutics had 1 more articles in the media than Theravance Biopharma. MarketBeat recorded 2 mentions for Karyopharm Therapeutics and 1 mentions for Theravance Biopharma. Theravance Biopharma's average media sentiment score of 1.87 beat Karyopharm Therapeutics' score of 0.94 indicating that Theravance Biopharma is being referred to more favorably in the media.

Company Overall Sentiment
Theravance Biopharma Very Positive
Karyopharm Therapeutics Positive

Theravance Biopharma presently has a consensus target price of $21.40, indicating a potential upside of 21.38%. Karyopharm Therapeutics has a consensus target price of $17.17, indicating a potential upside of 68.05%. Given Karyopharm Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Karyopharm Therapeutics is more favorable than Theravance Biopharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Theravance Biopharma
0 Sell rating(s)
5 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.29
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86

Theravance Biopharma has a beta of 0.17, meaning that its share price is 83% less volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.83, meaning that its share price is 17% less volatile than the broader market.

Theravance Biopharma has a net margin of 104.34% compared to Karyopharm Therapeutics' net margin of -129.02%. Theravance Biopharma's return on equity of 18.84% beat Karyopharm Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Theravance Biopharma104.34% 18.84% 10.94%
Karyopharm Therapeutics -129.02%N/A -120.29%

Summary

Theravance Biopharma beats Karyopharm Therapeutics on 10 of the 17 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Oric Pharmaceuticals?

Oric Pharmaceuticals (NASDAQ:ORIC) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their media sentiment, institutional ownership, dividends, analyst recommendations, profitability, risk, valuation and earnings.

In the previous week, Karyopharm Therapeutics had 1 more articles in the media than Oric Pharmaceuticals. MarketBeat recorded 2 mentions for Karyopharm Therapeutics and 1 mentions for Oric Pharmaceuticals. Oric Pharmaceuticals' average media sentiment score of 1.89 beat Karyopharm Therapeutics' score of 0.94 indicating that Oric Pharmaceuticals is being referred to more favorably in the media.

Company Overall Sentiment
Oric Pharmaceuticals Very Positive
Karyopharm Therapeutics Positive

95.1% of Oric Pharmaceuticals shares are owned by institutional investors. Comparatively, 66.4% of Karyopharm Therapeutics shares are owned by institutional investors. 5.7% of Oric Pharmaceuticals shares are owned by insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Oric Pharmaceuticals has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -129.02%. Karyopharm Therapeutics' return on equity of 0.00% beat Oric Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Oric PharmaceuticalsN/A -35.33% -33.31%
Karyopharm Therapeutics -129.02%N/A -120.29%

Oric Pharmaceuticals has higher earnings, but lower revenue than Karyopharm Therapeutics. Oric Pharmaceuticals is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Oric PharmaceuticalsN/AN/A-$129.47M-$1.44N/A
Karyopharm Therapeutics$151.12M1.53-$196.04M-$15.09N/A

Oric Pharmaceuticals currently has a consensus price target of $18.92, indicating a potential upside of 98.50%. Karyopharm Therapeutics has a consensus price target of $17.17, indicating a potential upside of 68.05%. Given Oric Pharmaceuticals' higher probable upside, equities research analysts plainly believe Oric Pharmaceuticals is more favorable than Karyopharm Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Oric Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
14 Buy rating(s)
0 Strong Buy rating(s)
2.76
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86

Oric Pharmaceuticals has a beta of 1.04, meaning that its stock price is 4% more volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.83, meaning that its stock price is 17% less volatile than the broader market.

Summary

Oric Pharmaceuticals beats Karyopharm Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Cullinan Therapeutics?

Karyopharm Therapeutics (NASDAQ:KPTI) and Cullinan Therapeutics (NASDAQ:CGEM) are both small-cap medical companies, but which is the better business? We will contrast the two companies based on the strength of their institutional ownership, analyst recommendations, risk, profitability, media sentiment, dividends, valuation and earnings.

Karyopharm Therapeutics presently has a consensus target price of $17.17, indicating a potential upside of 68.05%. Cullinan Therapeutics has a consensus target price of $32.00, indicating a potential upside of 73.91%. Given Cullinan Therapeutics' higher probable upside, analysts plainly believe Cullinan Therapeutics is more favorable than Karyopharm Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86
Cullinan Therapeutics
1 Sell rating(s)
1 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.63

Cullinan Therapeutics has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -129.02%. Karyopharm Therapeutics' return on equity of 0.00% beat Cullinan Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Karyopharm Therapeutics-129.02% N/A -120.29%
Cullinan Therapeutics N/A -51.45%-47.64%

Karyopharm Therapeutics has higher revenue and earnings than Cullinan Therapeutics. Cullinan Therapeutics is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Karyopharm Therapeutics$151.12M1.53-$196.04M-$15.09N/A
Cullinan TherapeuticsN/AN/A-$219.88M-$3.36N/A

In the previous week, Cullinan Therapeutics had 1 more articles in the media than Karyopharm Therapeutics. MarketBeat recorded 3 mentions for Cullinan Therapeutics and 2 mentions for Karyopharm Therapeutics. Karyopharm Therapeutics' average media sentiment score of 0.94 beat Cullinan Therapeutics' score of 0.60 indicating that Karyopharm Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Karyopharm Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Cullinan Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Karyopharm Therapeutics has a beta of 0.83, meaning that its share price is 17% less volatile than the broader market. Comparatively, Cullinan Therapeutics has a beta of -0.01, meaning that its share price is 101% less volatile than the broader market.

66.4% of Karyopharm Therapeutics shares are owned by institutional investors. Comparatively, 86.3% of Cullinan Therapeutics shares are owned by institutional investors. 1.7% of Karyopharm Therapeutics shares are owned by company insiders. Comparatively, 8.6% of Cullinan Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Summary

Karyopharm Therapeutics and Cullinan Therapeutics tied by winning 8 of the 16 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Arbutus Biopharma?

Arbutus Biopharma (NASDAQ:ABUS) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap medical companies, but which is the superior business? We will compare the two businesses based on the strength of their dividends, valuation, risk, analyst recommendations, institutional ownership, earnings, profitability and media sentiment.

Arbutus Biopharma has higher earnings, but lower revenue than Karyopharm Therapeutics. Karyopharm Therapeutics is trading at a lower price-to-earnings ratio than Arbutus Biopharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Arbutus Biopharma$14.08M64.05-$33.50M$0.835.50
Karyopharm Therapeutics$151.12M1.53-$196.04M-$15.09N/A

Arbutus Biopharma currently has a consensus price target of $5.00, suggesting a potential upside of 9.53%. Karyopharm Therapeutics has a consensus price target of $17.17, suggesting a potential upside of 68.05%. Given Karyopharm Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Karyopharm Therapeutics is more favorable than Arbutus Biopharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Arbutus Biopharma
1 Sell rating(s)
0 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86

In the previous week, Arbutus Biopharma and Arbutus Biopharma both had 2 articles in the media. Karyopharm Therapeutics' average media sentiment score of 0.94 beat Arbutus Biopharma's score of 0.93 indicating that Karyopharm Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Arbutus Biopharma
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Karyopharm Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

43.8% of Arbutus Biopharma shares are held by institutional investors. Comparatively, 66.4% of Karyopharm Therapeutics shares are held by institutional investors. 19.9% of Arbutus Biopharma shares are held by insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Arbutus Biopharma has a net margin of 83.95% compared to Karyopharm Therapeutics' net margin of -129.02%. Arbutus Biopharma's return on equity of 129.32% beat Karyopharm Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Arbutus Biopharma83.95% 129.32% 112.24%
Karyopharm Therapeutics -129.02%N/A -120.29%

Arbutus Biopharma has a beta of 0.63, indicating that its stock price is 37% less volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.83, indicating that its stock price is 17% less volatile than the broader market.

Summary

Arbutus Biopharma and Karyopharm Therapeutics tied by winning 8 of the 16 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Phathom Pharmaceuticals?

Karyopharm Therapeutics (NASDAQ:KPTI) and Phathom Pharmaceuticals (NASDAQ:PHAT) are both small-cap medical companies, but which is the superior business? We will compare the two businesses based on the strength of their earnings, dividends, risk, institutional ownership, profitability, analyst recommendations, valuation and media sentiment.

66.4% of Karyopharm Therapeutics shares are owned by institutional investors. Comparatively, 99.0% of Phathom Pharmaceuticals shares are owned by institutional investors. 1.7% of Karyopharm Therapeutics shares are owned by company insiders. Comparatively, 9.3% of Phathom Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Phathom Pharmaceuticals has a net margin of -76.77% compared to Karyopharm Therapeutics' net margin of -129.02%.

Company Net Margins Return on Equity Return on Assets
Karyopharm Therapeutics-129.02% N/A -120.29%
Phathom Pharmaceuticals -76.77%N/A -44.29%

Karyopharm Therapeutics presently has a consensus target price of $17.17, indicating a potential upside of 68.05%. Phathom Pharmaceuticals has a consensus target price of $24.50, indicating a potential upside of 128.54%. Given Phathom Pharmaceuticals' higher probable upside, analysts plainly believe Phathom Pharmaceuticals is more favorable than Karyopharm Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86
Phathom Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86

Karyopharm Therapeutics has higher earnings, but lower revenue than Phathom Pharmaceuticals. Phathom Pharmaceuticals is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Karyopharm Therapeutics$151.12M1.53-$196.04M-$15.09N/A
Phathom Pharmaceuticals$175.11M4.88-$221.25M-$2.12N/A

Karyopharm Therapeutics has a beta of 0.83, indicating that its stock price is 17% less volatile than the broader market. Comparatively, Phathom Pharmaceuticals has a beta of 0.51, indicating that its stock price is 49% less volatile than the broader market.

In the previous week, Phathom Pharmaceuticals had 1 more articles in the media than Karyopharm Therapeutics. MarketBeat recorded 3 mentions for Phathom Pharmaceuticals and 2 mentions for Karyopharm Therapeutics. Karyopharm Therapeutics' average media sentiment score of 0.94 beat Phathom Pharmaceuticals' score of 0.63 indicating that Karyopharm Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Karyopharm Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Phathom Pharmaceuticals
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Phathom Pharmaceuticals beats Karyopharm Therapeutics on 9 of the 13 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding KPTI and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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KPTI vs. The Competition

MetricKaryopharm TherapeuticsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$231.39M$3.02B$6.83B$12.17B
Dividend YieldN/A1.88%2.66%6.11%
P/E Ratio-0.6819.5425.8924.17
Price / Sales1.53330.40547.76101.00
Price / CashN/A56.8529.0936.93
Price / Book-0.644.2110.756.38
Net Income-$196.04M$64.45M$3.58B$337.00M
7 Day Performance13.50%1.32%1.97%-0.20%
1 Month Performance12.25%-1.07%-0.24%-1.40%
1 Year Performance132.69%29.70%34.39%27.76%

Karyopharm Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
KPTI
Karyopharm Therapeutics
2.2685 of 5 stars
$10.22
+0.0%
$17.17
+68.1%
+132.7%$231.39M$151.12MN/A380
TBPH
Theravance Biopharma
3.4698 of 5 stars
$16.32
-1.9%
$21.83
+33.8%
+57.1%$857.84M$107.46M7.42110
ORIC
Oric Pharmaceuticals
2.3386 of 5 stars
$8.40
+1.6%
$18.92
+125.2%
-7.6%$856.09MN/AN/A80
CGEM
Cullinan Therapeutics
2.6857 of 5 stars
$13.61
-0.7%
$32.00
+135.1%
+137.1%$841.97MN/AN/A30
ABUS
Arbutus Biopharma
1.22 of 5 stars
$4.32
+1.4%
$5.00
+15.7%
+45.8%$841.51M$14.08M5.2090

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This page (NASDAQ:KPTI) was last updated on 6/29/2026 by MarketBeat.com Staff.
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