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Karyopharm Therapeutics (KPTI) Competitors

Karyopharm Therapeutics logo
$9.51 +0.13 (+1.39%)
Closing price 07/17/2026 04:00 PM Eastern
Extended Trading
$9.11 -0.40 (-4.24%)
As of 07/17/2026 07:49 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

KPTI vs. ANRO, REPL, GLAS, IVA, and TBPH

Should you buy Karyopharm Therapeutics stock or one of its competitors? MarketBeat compares Karyopharm Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Karyopharm Therapeutics include Alto Neuroscience (ANRO), Replimune Group (REPL), Glass House Brands (GLAS), Inventiva (IVA), and Theravance Biopharma (TBPH). These companies are all part of the "pharmaceutical products" industry.

How does Karyopharm Therapeutics compare to Alto Neuroscience?

Alto Neuroscience (NYSE:ANRO) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap medical companies, but which is the better business? We will contrast the two businesses based on the strength of their media sentiment, risk, valuation, earnings, dividends, institutional ownership, profitability and analyst recommendations.

Alto Neuroscience currently has a consensus target price of $35.25, suggesting a potential upside of 27.98%. Karyopharm Therapeutics has a consensus target price of $17.17, suggesting a potential upside of 80.51%. Given Karyopharm Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Karyopharm Therapeutics is more favorable than Alto Neuroscience.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alto Neuroscience
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.70
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86

Alto Neuroscience has higher earnings, but lower revenue than Karyopharm Therapeutics. Alto Neuroscience is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alto NeuroscienceN/AN/A-$63.24M-$2.42N/A
Karyopharm Therapeutics$146.07M1.48-$196.04M-$15.09N/A

In the previous week, Alto Neuroscience had 5 more articles in the media than Karyopharm Therapeutics. MarketBeat recorded 7 mentions for Alto Neuroscience and 2 mentions for Karyopharm Therapeutics. Karyopharm Therapeutics' average media sentiment score of 1.34 beat Alto Neuroscience's score of 0.55 indicating that Karyopharm Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alto Neuroscience
2 Very Positive mention(s)
3 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Karyopharm Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

66.4% of Karyopharm Therapeutics shares are owned by institutional investors. 11.3% of Alto Neuroscience shares are owned by insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Alto Neuroscience has a beta of 1.04, meaning that its stock price is 4% more volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.8, meaning that its stock price is 20% less volatile than the broader market.

Alto Neuroscience has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -129.02%. Karyopharm Therapeutics' return on equity of 0.00% beat Alto Neuroscience's return on equity.

Company Net Margins Return on Equity Return on Assets
Alto NeuroscienceN/A -47.22% -38.81%
Karyopharm Therapeutics -129.02%N/A -120.29%

Summary

Alto Neuroscience and Karyopharm Therapeutics tied by winning 8 of the 16 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Replimune Group?

Replimune Group (NASDAQ:REPL) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap medical companies, but which is the superior investment? We will contrast the two businesses based on the strength of their dividends, risk, earnings, institutional ownership, media sentiment, profitability, valuation and analyst recommendations.

92.5% of Replimune Group shares are owned by institutional investors. Comparatively, 66.4% of Karyopharm Therapeutics shares are owned by institutional investors. 5.2% of Replimune Group shares are owned by company insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Replimune Group has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -129.02%. Karyopharm Therapeutics' return on equity of 0.00% beat Replimune Group's return on equity.

Company Net Margins Return on Equity Return on Assets
Replimune GroupN/A -128.57% -82.35%
Karyopharm Therapeutics -129.02%N/A -120.29%

Replimune Group currently has a consensus price target of $8.13, suggesting a potential downside of 20.58%. Karyopharm Therapeutics has a consensus price target of $17.17, suggesting a potential upside of 80.51%. Given Karyopharm Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Karyopharm Therapeutics is more favorable than Replimune Group.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Replimune Group
2 Sell rating(s)
6 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.00
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86

Replimune Group has a beta of 0.86, indicating that its share price is 14% less volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.8, indicating that its share price is 20% less volatile than the broader market.

Karyopharm Therapeutics has higher revenue and earnings than Replimune Group. Replimune Group is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Replimune GroupN/AN/A-$313.94M-$3.38N/A
Karyopharm Therapeutics$146.07M1.48-$196.04M-$15.09N/A

In the previous week, Replimune Group had 5 more articles in the media than Karyopharm Therapeutics. MarketBeat recorded 7 mentions for Replimune Group and 2 mentions for Karyopharm Therapeutics. Karyopharm Therapeutics' average media sentiment score of 1.34 beat Replimune Group's score of 0.95 indicating that Karyopharm Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Replimune Group
3 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Karyopharm Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Karyopharm Therapeutics beats Replimune Group on 9 of the 16 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Glass House Brands?

Glass House Brands (NYSE:GLAS) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap pharmaceutical products companies, but which is the superior business? We will compare the two companies based on the strength of their media sentiment, risk, institutional ownership, earnings, profitability, dividends, valuation and analyst recommendations.

Glass House Brands has higher revenue and earnings than Karyopharm Therapeutics.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Glass House Brands$176.02M4.92N/AN/AN/A
Karyopharm Therapeutics$146.07M1.48-$196.04M-$15.09N/A

In the previous week, Glass House Brands had 1 more articles in the media than Karyopharm Therapeutics. MarketBeat recorded 3 mentions for Glass House Brands and 2 mentions for Karyopharm Therapeutics. Karyopharm Therapeutics' average media sentiment score of 1.34 beat Glass House Brands' score of 0.15 indicating that Karyopharm Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Glass House Brands
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Karyopharm Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Glass House Brands presently has a consensus target price of $17.00, suggesting a potential upside of 57.70%. Karyopharm Therapeutics has a consensus target price of $17.17, suggesting a potential upside of 80.51%. Given Karyopharm Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Karyopharm Therapeutics is more favorable than Glass House Brands.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Glass House Brands
1 Sell rating(s)
0 Hold rating(s)
1 Buy rating(s)
1 Strong Buy rating(s)
2.67
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86

66.4% of Karyopharm Therapeutics shares are owned by institutional investors. 1.7% of Karyopharm Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.

Glass House Brands has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -129.02%.

Company Net Margins Return on Equity Return on Assets
Glass House BrandsN/A N/A N/A
Karyopharm Therapeutics -129.02%N/A -120.29%

Summary

Karyopharm Therapeutics beats Glass House Brands on 6 of the 11 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Inventiva?

Inventiva (NASDAQ:IVA) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap medical companies, but which is the better stock? We will contrast the two companies based on the strength of their media sentiment, institutional ownership, dividends, risk, analyst recommendations, profitability, valuation and earnings.

Inventiva has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -129.02%.

Company Net Margins Return on Equity Return on Assets
InventivaN/A N/A N/A
Karyopharm Therapeutics -129.02%N/A -120.29%

19.1% of Inventiva shares are owned by institutional investors. Comparatively, 66.4% of Karyopharm Therapeutics shares are owned by institutional investors. 32.0% of Inventiva shares are owned by company insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Inventiva has a beta of 0.72, suggesting that its stock price is 28% less volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.8, suggesting that its stock price is 20% less volatile than the broader market.

Karyopharm Therapeutics has higher revenue and earnings than Inventiva.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Inventiva$4.48M214.05-$400.67MN/AN/A
Karyopharm Therapeutics$146.07M1.48-$196.04M-$15.09N/A

In the previous week, Inventiva had 4 more articles in the media than Karyopharm Therapeutics. MarketBeat recorded 6 mentions for Inventiva and 2 mentions for Karyopharm Therapeutics. Karyopharm Therapeutics' average media sentiment score of 1.34 beat Inventiva's score of 0.26 indicating that Karyopharm Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Inventiva
1 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Karyopharm Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Inventiva presently has a consensus price target of $16.56, indicating a potential upside of 258.35%. Karyopharm Therapeutics has a consensus price target of $17.17, indicating a potential upside of 80.51%. Given Inventiva's stronger consensus rating and higher probable upside, analysts plainly believe Inventiva is more favorable than Karyopharm Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Inventiva
1 Sell rating(s)
0 Hold rating(s)
7 Buy rating(s)
3 Strong Buy rating(s)
3.09
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86

Summary

Inventiva beats Karyopharm Therapeutics on 9 of the 14 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Theravance Biopharma?

Karyopharm Therapeutics (NASDAQ:KPTI) and Theravance Biopharma (NASDAQ:TBPH) are both small-cap medical companies, but which is the superior business? We will compare the two businesses based on the strength of their dividends, media sentiment, analyst recommendations, earnings, risk, valuation, profitability and institutional ownership.

Theravance Biopharma has lower revenue, but higher earnings than Karyopharm Therapeutics. Karyopharm Therapeutics is trading at a lower price-to-earnings ratio than Theravance Biopharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Karyopharm Therapeutics$146.07M1.48-$196.04M-$15.09N/A
Theravance Biopharma$107.46M8.12$105.89M$2.207.70

In the previous week, Theravance Biopharma had 2 more articles in the media than Karyopharm Therapeutics. MarketBeat recorded 4 mentions for Theravance Biopharma and 2 mentions for Karyopharm Therapeutics. Karyopharm Therapeutics' average media sentiment score of 1.34 beat Theravance Biopharma's score of 0.20 indicating that Karyopharm Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Karyopharm Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Theravance Biopharma
1 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

66.4% of Karyopharm Therapeutics shares are owned by institutional investors. Comparatively, 99.1% of Theravance Biopharma shares are owned by institutional investors. 1.7% of Karyopharm Therapeutics shares are owned by insiders. Comparatively, 7.7% of Theravance Biopharma shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Karyopharm Therapeutics has a beta of 0.8, indicating that its share price is 20% less volatile than the broader market. Comparatively, Theravance Biopharma has a beta of 0.17, indicating that its share price is 83% less volatile than the broader market.

Karyopharm Therapeutics currently has a consensus target price of $17.17, indicating a potential upside of 80.51%. Theravance Biopharma has a consensus target price of $19.40, indicating a potential upside of 14.59%. Given Karyopharm Therapeutics' stronger consensus rating and higher possible upside, research analysts plainly believe Karyopharm Therapeutics is more favorable than Theravance Biopharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Karyopharm Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86
Theravance Biopharma
0 Sell rating(s)
8 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
2.00

Theravance Biopharma has a net margin of 104.34% compared to Karyopharm Therapeutics' net margin of -129.02%. Theravance Biopharma's return on equity of 18.84% beat Karyopharm Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Karyopharm Therapeutics-129.02% N/A -120.29%
Theravance Biopharma 104.34%18.84%10.94%

Summary

Theravance Biopharma beats Karyopharm Therapeutics on 10 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding KPTI and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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KPTI vs. The Competition

MetricKaryopharm TherapeuticsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$215.53M$3.06B$6.87B$12.28B
Dividend YieldN/A2.06%2.67%9.34%
P/E Ratio-0.6320.1727.2523.92
Price / Sales1.48348.29492.8872.75
Price / CashN/A57.2652.9960.41
Price / Book-0.594.2610.696.18
Net Income-$196.04M$65.46M$3.59B$332.29M
7 Day Performance-8.03%-3.20%-2.20%-2.05%
1 Month Performance5.43%0.70%1.63%-2.18%
1 Year Performance147.01%19.10%25.64%17.67%

Karyopharm Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
KPTI
Karyopharm Therapeutics
2.5438 of 5 stars
$9.51
+1.4%
$17.17
+80.5%
+147.0%$215.53M$146.07MN/A380
ANRO
Alto Neuroscience
2.4698 of 5 stars
$28.10
+6.1%
$35.25
+25.5%
+890.8%$929.29MN/AN/AN/A
REPL
Replimune Group
1.2032 of 5 stars
$9.94
-9.6%
$8.13
-18.3%
-15.4%$922.56MN/AN/A210
GLAS
Glass House Brands
N/A$11.45
-3.0%
$17.00
+48.5%
N/A$919.20M$176.02MN/AN/A
IVA
Inventiva
2.5214 of 5 stars
$4.30
flat
$16.56
+285.0%
+40.6%$893.14M$5.07MN/A100

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This page (NASDAQ:KPTI) was last updated on 7/19/2026 by MarketBeat.com Staff.
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