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Karyopharm Therapeutics (KPTI) Competitors

Karyopharm Therapeutics logo
$1.87 -0.07 (-3.61%)
As of 08/28/2026 04:00 PM Eastern

KPTI vs. LFCR, MENS, UNCY, NRXP, and AARD

Should you buy Karyopharm Therapeutics stock or one of its competitors? Karyopharm Therapeutics's main competitors and comparable companies include Lifecore Biomedical (LFCR), Jyong Biotech (MENS), Unicycive Therapeutics (UNCY), NRx Pharmaceuticals (NRXP), and Aardvark Therapeutics (AARD). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "pharmaceuticals" industry.

How does Karyopharm Therapeutics compare to Lifecore Biomedical?

Lifecore Biomedical (NASDAQ:LFCR) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their earnings, institutional ownership, valuation, risk, dividends, profitability, media sentiment and analyst recommendations.

Lifecore Biomedical presently has a consensus price target of $6.50, suggesting a potential upside of 43.17%. Karyopharm Therapeutics has a consensus price target of $11.50, suggesting a potential upside of 514.97%. Given Karyopharm Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Karyopharm Therapeutics is more favorable than Lifecore Biomedical.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Lifecore Biomedical
1 Sell rating(s)
2 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Karyopharm Therapeutics
1 Sell rating(s)
2 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.57

In the previous week, Karyopharm Therapeutics had 3 more articles in the media than Lifecore Biomedical. MarketBeat recorded 4 mentions for Karyopharm Therapeutics and 1 mentions for Lifecore Biomedical. Lifecore Biomedical's average media sentiment score of 1.89 beat Karyopharm Therapeutics' score of 0.47 indicating that Lifecore Biomedical is being referred to more favorably in the media.

Company Overall Sentiment
Lifecore Biomedical Very Positive
Karyopharm Therapeutics Neutral

Lifecore Biomedical has a beta of 1.08, indicating that its share price is 8% more volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.9, indicating that its share price is 10% less volatile than the broader market.

Lifecore Biomedical has higher earnings, but lower revenue than Karyopharm Therapeutics. Lifecore Biomedical is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Lifecore Biomedical$128.87M1.33-$40.50M-$1.07N/A
Karyopharm Therapeutics$146.07M0.29-$196.04M-$13.09N/A

Lifecore Biomedical has a net margin of -29.93% compared to Karyopharm Therapeutics' net margin of -153.28%.

Company Net Margins Return on Equity Return on Assets
Lifecore Biomedical-29.93% N/A -16.16%
Karyopharm Therapeutics -153.28%N/A -145.18%

83.4% of Lifecore Biomedical shares are owned by institutional investors. Comparatively, 66.4% of Karyopharm Therapeutics shares are owned by institutional investors. 32.7% of Lifecore Biomedical shares are owned by company insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Summary

Lifecore Biomedical beats Karyopharm Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Jyong Biotech?

Jyong Biotech (NASDAQ:MENS) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap healthcare companies, but which is the better investment? We will compare the two companies based on the strength of their institutional ownership, analyst recommendations, valuation, profitability, media sentiment, risk, dividends and earnings.

Jyong Biotech has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -153.28%.

Company Net Margins Return on Equity Return on Assets
Jyong BiotechN/A N/A N/A
Karyopharm Therapeutics -153.28%N/A -145.18%

66.4% of Karyopharm Therapeutics shares are held by institutional investors. 1.7% of Karyopharm Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Karyopharm Therapeutics has a consensus target price of $11.50, suggesting a potential upside of 514.97%. Given Karyopharm Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Karyopharm Therapeutics is more favorable than Jyong Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Jyong Biotech
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Karyopharm Therapeutics
1 Sell rating(s)
2 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.57

In the previous week, Karyopharm Therapeutics had 3 more articles in the media than Jyong Biotech. MarketBeat recorded 4 mentions for Karyopharm Therapeutics and 1 mentions for Jyong Biotech. Jyong Biotech's average media sentiment score of 1.89 beat Karyopharm Therapeutics' score of 0.47 indicating that Jyong Biotech is being referred to more favorably in the media.

Company Overall Sentiment
Jyong Biotech Very Positive
Karyopharm Therapeutics Neutral

Jyong Biotech has higher earnings, but lower revenue than Karyopharm Therapeutics.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Jyong BiotechN/AN/A-$4.67MN/AN/A
Karyopharm Therapeutics$146.07M0.29-$196.04M-$13.09N/A

Jyong Biotech has a beta of 2.29, meaning that its share price is 129% more volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.9, meaning that its share price is 10% less volatile than the broader market.

Summary

Karyopharm Therapeutics beats Jyong Biotech on 8 of the 13 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Unicycive Therapeutics?

Unicycive Therapeutics (NASDAQ:UNCY) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap healthcare companies, but which is the superior business? We will compare the two businesses based on the strength of their media sentiment, risk, institutional ownership, analyst recommendations, dividends, valuation, earnings and profitability.

Unicycive Therapeutics has a beta of 1.79, indicating that its stock price is 79% more volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.9, indicating that its stock price is 10% less volatile than the broader market.

In the previous week, Karyopharm Therapeutics had 3 more articles in the media than Unicycive Therapeutics. MarketBeat recorded 4 mentions for Karyopharm Therapeutics and 1 mentions for Unicycive Therapeutics. Unicycive Therapeutics' average media sentiment score of 1.87 beat Karyopharm Therapeutics' score of 0.47 indicating that Unicycive Therapeutics is being referred to more favorably in the media.

Company Overall Sentiment
Unicycive Therapeutics Very Positive
Karyopharm Therapeutics Neutral

Unicycive Therapeutics currently has a consensus price target of $18.75, suggesting a potential upside of 256.46%. Karyopharm Therapeutics has a consensus price target of $11.50, suggesting a potential upside of 514.97%. Given Karyopharm Therapeutics' higher possible upside, analysts plainly believe Karyopharm Therapeutics is more favorable than Unicycive Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Unicycive Therapeutics
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.57
Karyopharm Therapeutics
1 Sell rating(s)
2 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.57

Unicycive Therapeutics has higher earnings, but lower revenue than Karyopharm Therapeutics. Unicycive Therapeutics is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Unicycive Therapeutics$680K215.43-$26.56M-$1.75N/A
Karyopharm Therapeutics$146.07M0.29-$196.04M-$13.09N/A

40.4% of Unicycive Therapeutics shares are held by institutional investors. Comparatively, 66.4% of Karyopharm Therapeutics shares are held by institutional investors. 6.0% of Unicycive Therapeutics shares are held by company insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock is poised for long-term growth.

Unicycive Therapeutics has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -153.28%. Karyopharm Therapeutics' return on equity of 0.00% beat Unicycive Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Unicycive TherapeuticsN/A -91.50% -61.47%
Karyopharm Therapeutics -153.28%N/A -145.18%

Summary

Unicycive Therapeutics beats Karyopharm Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to NRx Pharmaceuticals?

NRx Pharmaceuticals (NASDAQ:NRXP) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their earnings, analyst recommendations, valuation, risk, media sentiment, dividends, institutional ownership and profitability.

Karyopharm Therapeutics has a net margin of -153.28% compared to NRx Pharmaceuticals' net margin of -691.81%.

Company Net Margins Return on Equity Return on Assets
NRx Pharmaceuticals-691.81% N/A -63.92%
Karyopharm Therapeutics -153.28%N/A -145.18%

NRx Pharmaceuticals has a beta of 2.18, suggesting that its share price is 118% more volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.9, suggesting that its share price is 10% less volatile than the broader market.

In the previous week, NRx Pharmaceuticals had 14 more articles in the media than Karyopharm Therapeutics. MarketBeat recorded 18 mentions for NRx Pharmaceuticals and 4 mentions for Karyopharm Therapeutics. Karyopharm Therapeutics' average media sentiment score of 0.47 beat NRx Pharmaceuticals' score of -0.30 indicating that Karyopharm Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
NRx Pharmaceuticals
2 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral
Karyopharm Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

4.3% of NRx Pharmaceuticals shares are held by institutional investors. Comparatively, 66.4% of Karyopharm Therapeutics shares are held by institutional investors. 6.4% of NRx Pharmaceuticals shares are held by insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

NRx Pharmaceuticals has higher earnings, but lower revenue than Karyopharm Therapeutics. NRx Pharmaceuticals is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
NRx Pharmaceuticals$1.23M124.97-$28.62M-$0.55N/A
Karyopharm Therapeutics$146.07M0.29-$196.04M-$13.09N/A

NRx Pharmaceuticals currently has a consensus target price of $34.50, indicating a potential upside of 871.83%. Karyopharm Therapeutics has a consensus target price of $11.50, indicating a potential upside of 514.97%. Given NRx Pharmaceuticals' higher probable upside, equities research analysts plainly believe NRx Pharmaceuticals is more favorable than Karyopharm Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
NRx Pharmaceuticals
2 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.43
Karyopharm Therapeutics
1 Sell rating(s)
2 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.57

Summary

NRx Pharmaceuticals beats Karyopharm Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Karyopharm Therapeutics compare to Aardvark Therapeutics?

Aardvark Therapeutics (NASDAQ:AARD) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their media sentiment, earnings, dividends, profitability, institutional ownership, risk, analyst recommendations and valuation.

Aardvark Therapeutics has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -153.28%. Karyopharm Therapeutics' return on equity of 0.00% beat Aardvark Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Aardvark TherapeuticsN/A -71.54% -64.94%
Karyopharm Therapeutics -153.28%N/A -145.18%

Aardvark Therapeutics presently has a consensus target price of $15.33, suggesting a potential upside of 164.82%. Karyopharm Therapeutics has a consensus target price of $11.50, suggesting a potential upside of 514.97%. Given Karyopharm Therapeutics' stronger consensus rating and higher probable upside, analysts plainly believe Karyopharm Therapeutics is more favorable than Aardvark Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Aardvark Therapeutics
2 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.42
Karyopharm Therapeutics
1 Sell rating(s)
2 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.57

66.4% of Karyopharm Therapeutics shares are owned by institutional investors. 17.8% of Aardvark Therapeutics shares are owned by insiders. Comparatively, 1.7% of Karyopharm Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Aardvark Therapeutics has higher earnings, but lower revenue than Karyopharm Therapeutics. Aardvark Therapeutics is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Aardvark TherapeuticsN/AN/A-$57.59M-$3.21N/A
Karyopharm Therapeutics$146.07M0.29-$196.04M-$13.09N/A

In the previous week, Aardvark Therapeutics had 27 more articles in the media than Karyopharm Therapeutics. MarketBeat recorded 31 mentions for Aardvark Therapeutics and 4 mentions for Karyopharm Therapeutics. Karyopharm Therapeutics' average media sentiment score of 0.47 beat Aardvark Therapeutics' score of 0.04 indicating that Karyopharm Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Aardvark Therapeutics
2 Very Positive mention(s)
1 Positive mention(s)
25 Neutral mention(s)
0 Negative mention(s)
2 Very Negative mention(s)
Neutral
Karyopharm Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Aardvark Therapeutics has a beta of 3.81, suggesting that its stock price is 281% more volatile than the broader market. Comparatively, Karyopharm Therapeutics has a beta of 0.9, suggesting that its stock price is 10% less volatile than the broader market.

Summary

Aardvark Therapeutics beats Karyopharm Therapeutics on 8 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding KPTI and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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KPTI vs. The Competition

MetricKaryopharm TherapeuticsPharmaceuticals IndustryHealthcare SectorNASDAQ Exchange
Market Cap$42.41M$12.17B$7.21B$12.90B
Dividend YieldN/A2.62%2.54%11.28%
P/E Ratio-0.14787.65273.1625.42
Price / Sales0.29755.84630.8194.42
Price / CashN/A15.3228.7436.03
Price / Book-0.1210.4911.086.36
Net Income-$196.04M$2.83B$3.48B$349.79M
7 Day Performance-4.59%0.39%0.13%-0.80%
1 Month Performance-73.32%5.34%7.08%4.13%
1 Year Performance-73.70%6.05%24.67%15.17%

Karyopharm Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
KPTI
Karyopharm Therapeutics
2.4957 of 5 stars
$1.87
-3.6%
$11.50
+515.0%
-73.7%$42.41M$146.07MN/A380
LFCR
Lifecore Biomedical
2.4564 of 5 stars
$4.55
+0.2%
$6.50
+42.9%
-40.3%$171.85M$128.87MN/A690
MENS
Jyong Biotech
N/A$2.22
+1.8%
N/A-95.7%$165.74MN/AN/A31
UNCY
Unicycive Therapeutics
3.2118 of 5 stars
$5.34
-5.2%
$18.75
+251.1%
+25.5%$156.82MN/AN/A9
NRXP
NRx Pharmaceuticals
1.8856 of 5 stars
$3.45
-3.1%
$34.50
+900.0%
+53.0%$154.13M$1.23MN/A2

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This page (NASDAQ:KPTI) was last updated on 8/30/2026 by MarketBeat.com Staff.
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