Karyopharm Therapeutics (KPTI) Stock Chart & Stock Price History $4.65 +0.42 (+9.93%) Closing price 04:00 PM EasternExtended Trading$4.62 -0.03 (-0.54%) As of 05:23 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Karyopharm Therapeutics Stock Price Performance The Karyopharm Therapeutics (KPTI) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 60.76%, with a year-to-date return of -54.16%. In the past month, the stock has increased 3.56%, reflecting recent market activity. As of the latest close, Karyopharm Therapeutics traded at $4.23 with a market cap of $36.55 million and volume of 63,670 shares. Five years ago, the stock traded at a split-adjusted price of $292.20, representing a 98.41% decrease over that period. At the time, it had a market cap of $1.43 billion and a volume of 82,346 shares. Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Email Address 5 Day Performance+0.65%1 Month Performance+3.56%3 Month Performance+17.42%Year-To-Date Performance-54.16%1 Year Performance-60.76%5 Year Performance-98.41% KPTI Stock Chart for Tuesday, July, 8, 2025 KPTI Chart by TradingView Karyopharm Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization07/08/2025$4.23$4.65+9.93%$4.80$4.24177,730 shs$40.18 million07/07/2025$4.62$4.23-8.44%$4.70$4.2363,670 shs$36.55 million07/04/2025$4.62$4.62$4.83$4.3936,017 shs$39.92 million07/03/2025$4.61$4.62+0.22%$4.83$4.3936,017 shs$39.92 million07/02/2025$4.36$4.61+5.73%$4.85$4.30112,653 shs$39.83 million07/01/2025$4.31$4.36+1.16%$4.48$4.2534,694 shs$37.67 million06/30/2025$4.39$4.31-1.82%$4.42$4.2575,082 shs$37.24 million06/27/2025$4.49$4.39-2.23%$4.64$4.2632,788 shs$37.93 million06/26/2025$4.49$4.49$4.56$4.3438,341 shs$38.79 million06/25/2025$4.65$4.49-3.44%$4.67$4.3437,953 shs$38.79 million Get the Latest News and Ratings for KPTI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 06/24/2025$4.33$4.65+7.39%$4.65$4.3045,928 shs$40.18 million06/23/2025$4.38$4.33-1.14%$4.42$4.1235,264 shs$37.41 million06/20/2025$4.44$4.38-1.35%$4.56$4.2723,673 shs$37.84 million06/19/2025$4.44$4.44$4.59$4.3233,949 shs$38.36 million06/18/2025$4.36$4.44+1.83%$4.59$4.3233,949 shs$38.36 million06/17/2025$4.54$4.36-3.96%$4.62$4.3231,990 shs$37.67 million06/16/2025$4.39$4.54+3.42%$4.55$4.3027,354 shs$39.23 million06/13/2025$4.36$4.39+0.69%$4.53$4.2233,104 shs$37.93 million06/12/2025$4.39$4.36-0.68%$4.43$4.2270,390 shs$37.67 million06/11/2025$4.43$4.39-0.90%$4.59$4.3074,667 shs$38.28 million06/10/2025$4.21$4.43+5.23%$4.61$4.2266,173 shs$38.28 million06/09/2025$4.49$4.21-6.24%$4.62$4.1959,574 shs$36.37 million Related Companies Molecular Partners Stock Chart Immuneering Stock Chart Theratechnologies Stock Chart Ventyx Biosciences Stock Chart Neumora Therapeutics Stock Chart Alector Stock Chart Lyell Immunopharma Stock Chart Inhibikase Therapeutics Stock Chart Black Diamond Therapeutics Stock Chart Galectin Therapeutics Stock Chart Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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