Lyra Therapeutics (LYRA) Stock Price, News & Analysis

Company Overview

Lyra Therapeutics is a biotechnology company focused on developing long-acting, locally administered treatments for diseases of the ear, nose and throat. The company’s programs are designed to deliver medication directly to the nasal passages, with the goal of improving treatment duration, reducing reliance on daily therapies and addressing limitations associated with conventional nasal sprays.

Lyra’s technology is based on its proprietary, bioresorbable nasal delivery platform, which is intended to provide controlled drug release over an extended period. Its primary programs included LYR-210, an investigational device designed to deliver mometasone furoate for the treatment of chronic rhinosinusitis, and LYR-220, a later-generation product candidate developed for patients with chronic rhinosinusitis, including those with nasal polyps.

Founded in 2005 and headquartered in Waltham, Massachusetts, Lyra has conducted its development activities primarily in the United States. Its lead products remain investigational and have not been established as approved treatments. The company has also evaluated strategic alternatives and reduced its operations following setbacks in clinical development.

Key Stats

• Today's Range: $0.19 to $0.19
• 50-Day Range: $0.01 to $0.25
• 52-Week Range: $0.00 to $6.53
• Volume: 28 shs
• Average Volume: 1,072 shs
• Market Capitalization: $336.30 thousand
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: N/A
• Consensus Rating: Sell

Lyra Therapeutics Stock Analysis - MarketRank™

Lyra Therapeutics scored higher than 6% of companies evaluated by MarketBeat. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 0.5 / 5
• Analyst Rating: Sell

Consensus Rating

Lyra Therapeutics has received a consensus rating of Sell. The company's average rating score is 1.00, and is based on no strong buy ratings, no buy ratings, no hold ratings, and 1 sell rating.

Amount of Analyst Coverage

Lyra Therapeutics has received no research coverage in the past 90 days.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: N/A

Price to Earnings Ratio vs. the Market

The P/E ratio of Lyra Therapeutics is -0.01, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Lyra Therapeutics is -0.01, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Short Interest

• Score: 4.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

0.28% of the float of Lyra Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Lyra Therapeutics has a short interest ratio ("days to cover") of 2.76, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Lyra Therapeutics has recently decreased by 1.21%, indicating that investor sentiment is improving.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Lyra Therapeutics does not currently pay a dividend.

Dividend Growth

Lyra Therapeutics does not have a long track record of dividend growth.

News and Social Media

• Score: N/A
• News Sentiment: N/A

Company Ownership

• Score: 0.8 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Lyra Therapeutics insiders have not sold or bought any company stock.

Percentage Held by Insiders

3.25% of the stock of Lyra Therapeutics is held by insiders.

Percentage Held by Institutions

95.62% of the stock of Lyra Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

Company Calendar

• Last Earnings: 11/12/2025
• Today: 11/04/2026
• Next Earnings (Estimated): 11/17/2026
• Fiscal Year End: 12/31/2026

Industry, Sector and Symbol

• Stock Exchange: OTCMKTS
• Sector: Healthcare
• Industry: Pharmaceuticals
• Sub-Industry: Pharmaceuticals
• Current Symbol: OTCMKTS:LYRA
• Previous Symbol: NASDAQ:LYRA
• CIK: 1327273
• Web: www.lyratherapeutics.com
• Phone: 617-393-4600
• Fax: N/A
• Employees: 50
• Year Founded: 2005

Profitability

• EPS (Trailing Twelve Months): N/A
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: N/A
• Net Margins: N/A
• Pretax Margin: N/A
• Return on Equity: N/A
• Return on Assets: N/A

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: N/A
• Quick Ratio: N/A

Sales & Book Value

• Annual Sales: $400 thousand
• Price / Sales: 0.84
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: ($6.04) per share
• Price / Book: -0.03

Miscellaneous

• Outstanding Shares: 1,770,000
• Free Float: 1,717,000
• Market Cap: $336.30 thousand
• Optionable: No Data
• Beta: -0.29