NASDAQ:NCNA NuCana (NCNA) Stock Price, News & Analysis $3.44 +0.13 (+3.93%) Closing price 08/22/2025 04:00 PM EasternExtended Trading$3.39 -0.05 (-1.45%) As of 08/22/2025 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesOwnershipSEC FilingsShort InterestTrendsBuy This Stock About NuCana Stock (NASDAQ:NCNA) 30 days 90 days 365 days Advanced Chart View Price History Chart DataSkip Price History Chart Get NuCana alerts:Sign Up Key Stats Today's Range$3.10▼$3.4450-Day Range$3.11▼$26.2452-Week Range$3.05▼$1,650.00Volume416,279 shsAverage Volume848,419 shsMarket Capitalization$103.20 thousandP/E RatioN/ADividend YieldN/APrice Target$5,000.00Consensus RatingModerate Buy Company Overview NuCana plc, a clinical-stage biopharmaceutical company, engages in the development of medicines to treat patients with cancer. It applies its ProTide technology to transform prescribed chemotherapy agents and nucleoside analogs into medicines. The company, through its technology, is developing ProTides medicines to overcome the limitations of nucleoside analogs and generate much higher concentrations of anti-cancer metabolites in cancer cells. Its pipeline includes NUC-3373, a chemical entity derived from the nucleoside analog 5-fluorouracil that is in Phase 1b/2 study in patients with metastatic colorectal cancer, Phase 2 clinical trial for the second-line treatment of patients with advanced colorectal cancer, and Phase 1b/2 modular clinical trial for patients with advanced solid tumors and lung cancer. It is also developing NUC-7738, a ProTide transformation of 3'-deoxyadenosine, which is in the Phase 2 part of a Phase 1/2 clinical trial for patients with advanced solid tumors. The company has an assignment, license, and collaboration agreement with Cardiff ProTides Ltd to discover, drug design, and in vitro screen purine and pyrimidine-based nucleosides as potential drug candidates. The company was formerly known as NuCana BioMed Limited and changed its name to NuCana plc in August 2017. NuCana plc was incorporated in 1997 and is headquartered in Edinburgh, the United Kingdom. Read More NuCana Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks68th Percentile Overall ScoreNCNA MarketRank™: NuCana scored higher than 68% of companies evaluated by MarketBeat. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion3.3 / 5Analyst RatingModerate Buy Consensus RatingNuCana has received a consensus rating of Moderate Buy. The company's average rating score is 2.50, and is based on 1 buy rating, 1 hold rating, and no sell ratings.Amount of Analyst CoverageNuCana has received no research coverage in the past 90 days.Read more about NuCana's stock forecast and price target. Earnings and Valuation1.3 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for NuCana are expected to grow in the coming year, from ($13.42) to ($10.52) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of NuCana is -0.01, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of NuCana is -0.01, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioNuCana has a P/B Ratio of 0.01. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities. Short Interest4.0 / 5Short Interest LevelHealthy Percentage of Shares Shorted290.48% of the float of NuCana has been sold short.Short Interest Ratio / Days to CoverNuCana has a short interest ratio ("days to cover") of 0, which is generally considered an acceptable ratio of short interest to trading volume.Change versus previous monthShort interest in NuCana has recently decreased by 99.79%, indicating that investor sentiment is improving significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldNuCana does not currently pay a dividend.Dividend GrowthNuCana does not have a long track record of dividend growth. Sustainability and ESGN/AEnvironmental ScoreN/A Percentage of Shares Shorted290.48% of the float of NuCana has been sold short.Short Interest Ratio / Days to CoverNuCana has a short interest ratio ("days to cover") of 0, which is generally considered an acceptable ratio of short interest to trading volume.Change versus previous monthShort interest in NuCana has recently decreased by 99.79%, indicating that investor sentiment is improving significantly. News and Social Media2.6 / 5News Sentiment0.75 News SentimentNuCana has a news sentiment score of 0.75. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This news sentiment score is similar to the average news sentiment of Medical companies.News Coverage This WeekMarketBeat has tracked 4 news articles for NuCana this week, compared to 1 article on an average week.Search InterestOnly 26 people have searched for NCNA on MarketBeat in the last 30 days. This is a decrease of -54% compared to the previous 30 days.MarketBeat Follows36 people have added NuCana to their MarketBeat watchlist in the last 30 days. This is an increase of 112% compared to the previous 30 days. Company Ownership2.5 / 5Insider TradingN/A Insider Buying vs. Insider SellingIn the past three months, NuCana insiders have not sold or bought any company stock.Percentage Held by Insiders31.20% of the stock of NuCana is held by insiders. A high percentage of insider ownership can be a sign of company health.Percentage Held by Institutions44.00% of the stock of NuCana is held by institutions. High institutional ownership can be a signal of strong market trust in this company.Read more about NuCana's insider trading history. Receive NCNA Stock News and Ratings via Email Sign-up to receive the latest news and ratings for NuCana and its competitors with MarketBeat's FREE daily newsletter. Email Address NCNA Stock News HeadlinesNuCana Reports Q2 2025 Financial Results Highlighting Operating LossAugust 20, 2025 | msn.comNuCana Reports Second Quarter 2025 Financial Results and Provides Business UpdateAugust 20, 2025 | globenewswire.comIs Elon's empire crumbling?The Tesla Shock Nobody Sees Coming While headlines scream "Tesla is doomed"... Jeff Brown has uncovered a revolutionary AI breakthrough buried inside Tesla's labs. One that is helping AI escape from our computer screens and manifest itself here in the real world all while creating a 25,000% growth market explosion starting as early as October 23rd. | Brownstone Research (Ad)Wall Street Zen Upgrades NuCana (NASDAQ:NCNA) to "Sell"August 19, 2025 | americanbankingnews.comNuCana PLC (ADR) trading halted, news pendingAugust 9, 2025 | msn.comNuCana Announces ADS Ratio ChangeAugust 1, 2025 | globenewswire.comNuCana plc: NuCana Cancels All Outstanding Series A Warrants Following Strategic ATM ExecutionJuly 21, 2025 | finanznachrichten.deNuCana Cancels All Outstanding Series A Warrants Following Strategic ATM ExecutionJuly 21, 2025 | globenewswire.comSee More Headlines NCNA Stock Analysis - Frequently Asked Questions How have NCNA shares performed this year? NuCana's stock was trading at $238.00 on January 1st, 2025. Since then, NCNA shares have decreased by 98.6% and is now trading at $3.44. How were NuCana's earnings last quarter? NuCana PLC Sponsored ADR (NASDAQ:NCNA) posted its quarterly earnings data on Wednesday, August, 20th. The company reported ($0.16) earnings per share for the quarter, beating analysts' consensus estimates of ($2.75) by $2.59. When did NuCana's stock split? NuCana shares reverse split before market open on Friday, August 8th 2025.The 1-200 reverse split was announced on Friday, July 11th 2025. The number of shares owned by shareholders was adjusted after the market closes on Thursday, August 7th 2025. An investor that had 100 shares of stock prior to the reverse split would have 1 shares after the split. When did NuCana IPO? NuCana (NCNA) raised $100 million in an initial public offering on Thursday, September 28th 2017. The company issued 6,700,000 shares at a price of $14.00-$16.00 per share. Citigroup, Jefferies and Cowen served as the underwriters for the IPO and William Blair was co-manager. How do I buy shares of NuCana? Shares of NCNA stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of NuCana own? Based on aggregate information from My MarketBeat watchlists, some other companies that NuCana investors own include VBI Vaccines (VBIV), Anavex Life Sciences (AVXL), Sorrento Therapeutics (SRNE), Plug Power (PLUG), SCYNEXIS (SCYX), Allena Pharmaceuticals (ALNA) and CRISPR Therapeutics (CRSP). Company Calendar Last Earnings8/20/2025Today8/24/2025Fiscal Year End12/31/2025Get Stock AlertsIndustry, Sector and Symbol Stock ExchangeNASDAQ SectorMedical Industry MED - BIOMED/GENE Sub-IndustryPharmaceutical Products Current SymbolNASDAQ:NCNA CIK1709626 Webwww.nucana.com Phone441313571111FaxN/AEmployees30Year FoundedN/APrice Target and Rating Average Price Target for NuCana$5,000.00 High Price Target$5,000.00 Low Price Target$5,000.00 Potential Upside/Downside+145,248.8%Consensus RatingModerate Buy Rating Score (0-4)2.50 Research Coverage2 Analysts Profitability EPS (Trailing Twelve Months)($646.16) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$24.28 million Net MarginsN/A Pretax MarginN/A Return on Equity-592.28% Return on Assets-208.68% Debt Debt-to-Equity RatioN/A Current Ratio1.58 Quick Ratio1.25 Sales & Book Value Annual SalesN/A Price / SalesN/A Cash FlowN/A Price / Cash FlowN/A Book Value$324.58 per share Price / Book0.01Miscellaneous Outstanding Shares30,000Free Float21,000Market Cap$103.20 thousand OptionableNot Optionable Beta1.40 Social Links Reduce the RiskMarket downturns give many investors pause, and for good reason. Wondering how to offset this risk? Enter your email address to learn more about using beta to protect your portfolio.Get This Free Report This page (NASDAQ:NCNA) was last updated on 8/24/2025 by MarketBeat.com Staff From Our PartnersNations are at war over what’s in this boxA resource known as Element 29 is quickly becoming one of the most sought-after materials on the planet. Goldm...Behind the Markets | SponsoredMusk’s Project Colossus could mint millionairesI predict this single breakthrough could make Elon the world’s first trillionaire — and mint more new milliona...Brownstone Research | SponsoredTrump’s betrayal exposedTrump’s Final Reset Inside the shocking plot to re-engineer America’s financial system…and why you need to ...Porter & Company | SponsoredTrump’s “new dollar” could shock Americans"I Made Millions in the Tech Boom. 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