| 7/28/2020 | Zurcher Kantonalbank Zurich Cantonalbank | 193,803 | $1.14M | 0.0% | +23.5% | 0.399% | |
| 7/16/2020 | Wedbush Securities Inc. | 149,796 | $0.88M | 0.1% | +8.5% | 0.308% | |
| 5/15/2020 | Two Sigma Investments LP | 57,500 | $0.14M | 0.0% | +114.6% | 0.118% | |
| 5/15/2020 | Two Sigma Advisers LP | 29,500 | $71K | 0.0% | +189.2% | 0.061% | |
| 5/15/2020 | Rock Springs Capital Management LP | 1,400,000 | $3.37M | 0.1% | +77.3% | 2.883% | |
| 5/14/2020 | Deutsche Bank AG | 109,554 | $0.26M | 0.0% | +345.8% | 0.226% | |
| 5/12/2020 | Spark Investment Management LLC | 18,518 | $44K | 0.0% | N/A | 0.038% | |
| 5/6/2020 | Zurcher Kantonalbank Zurich Cantonalbank | 156,944 | $0.38M | 0.0% | +63.6% | 0.323% | |
| 5/1/2020 | BlackRock Inc. | 16,250 | $39K | 0.0% | +52.7% | 0.033% | |
| 2/20/2020 | Geode Capital Management LLC | 40,309 | $0.15M | 0.0% | +98.9% | 0.089% | |
|
| 2/14/2020 | Point72 Asset Management L.P. | 450,000 | $1.72M | 0.0% | +98.0% | 0.990% | |
| 2/14/2020 | Cubist Systematic Strategies LLC | 6,677 | $26K | 0.0% | +531.7% | 0.015% | |
| 2/14/2020 | Goldman Sachs Group Inc. | 47,439 | $0.18M | 0.0% | -50.8% | 0.104% | |
| 2/14/2020 | UBS Group AG | 14,497 | $55K | 0.0% | +33.1% | 0.032% | |
| 2/13/2020 | Renaissance Technologies LLC | 224,100 | $0.86M | 0.0% | +154.7% | 0.493% | |
| 2/12/2020 | Credit Suisse AG | 345,236 | $1.32M | 0.0% | +2.9% | 0.759% | |
| 2/12/2020 | Pictet Asset Management Ltd. | 149,106 | $0.57M | 0.0% | N/A | 0.328% | |
| 2/7/2020 | FMR LLC | 661,655 | $2.53M | 0.0% | -42.3% | 1.455% | |
| 2/7/2020 | Tower Research Capital LLC TRC | 6,611 | $25K | 0.0% | +1,838.7% | 0.015% | |
| 2/6/2020 | Acadian Asset Management LLC | 15,696 | $60K | 0.0% | N/A | 0.035% | |
| 1/31/2020 | Ikarian Capital LLC | 82,573 | $0.32M | 0.1% | N/A | 0.182% | |
| 1/21/2020 | Zurcher Kantonalbank Zurich Cantonalbank | 95,923 | $0.37M | 0.0% | +96.1% | 0.211% | |
| 1/16/2020 | Wedbush Securities Inc. | 137,346 | $0.53M | 0.0% | +242.4% | 0.302% | |
| 11/27/2019 | Point72 Asset Management L.P. | 227,239 | $1.89M | 0.0% | -7.9% | 0.500% | |
| 10/17/2019 | Wedbush Securities Inc. | 40,108 | $0.33M | 0.0% | +54.2% | 0.088% | |
| 8/16/2019 | First Manhattan Co. | 2,066,312 | $23.37M | 0.1% | -0.3% | 4.544% | |
| 8/14/2019 | Cubist Systematic Strategies LLC | 3,272 | $37K | 0.0% | +263.6% | 0.007% | |
| 8/14/2019 | Point72 Asset Management L.P. | 246,700 | $2.79M | 0.0% | -8.6% | 0.542% | |
| 8/14/2019 | Morgan Stanley | 3,100 | $35K | 0.0% | +358.6% | 0.007% | |
| 8/13/2019 | AXA | 500,313 | $5.66M | 0.0% | +7.8% | 1.100% | |
| 8/12/2019 | Renaissance Technologies LLC | 79,600 | $0.90M | 0.0% | +7.6% | 0.175% | |
| 8/8/2019 | Capital Investment Advisory Services LLC | 4,000 | $40K | 0.0% | N/A | 0.009% | |
| 8/1/2019 | Wedbush Securities Inc. | 26,008 | $0.29M | 0.0% | -33.0% | 0.057% | |
| 6/16/2019 | FMR LLC | 1,373,362 | $17.57M | 0.0% | -3.9% | 3.020% | |
| 5/10/2019 | Fosun International Ltd | 194,991 | $2.49M | 0.2% | N/A | 0.429% | |
| 4/17/2019 | Wedbush Securities Inc. | 38,790 | $0.50M | 0.1% | +86.1% | 0.085% | |
| 4/12/2019 | First Manhattan Co. | 2,072,112 | $26.50M | 0.2% | -2.1% | 4.556% | |
| 2/15/2019 | Millennium Management LLC | 17,764 | $0.23M | 0.0% | -86.7% | 0.049% | |
| 2/15/2019 | Jane Street Group LLC | 17,241 | $0.22M | 0.0% | N/A | 0.047% | |
| 2/14/2019 | Weiss Multi Strategy Advisers LLC | 21,000 | $0.27M | 0.0% | +4.5% | 0.058% | |
| 2/14/2019 | Barclays PLC | 10,118 | $0.13M | 0.0% | +331.1% | 0.028% | |
| 2/14/2019 | Polar Capital LLP | 175,000 | $2.22M | 0.0% | +16.7% | 0.480% | |
| 2/13/2019 | Geode Capital Management LLC | 12,604 | $0.16M | 0.0% | N/A | 0.035% | |
| 2/13/2019 | Dimensional Fund Advisors LP | 70,573 | $0.89M | 0.0% | +274.6% | 0.194% | |
| 2/13/2019 | United Services Automobile Association | 26,480 | $0.34M | 0.0% | +132.3% | 0.073% | |
| 2/8/2019 | Gables Capital Management Inc. | 2,000 | $25K | 0.0% | N/A | 0.005% | |
| 2/8/2019 | Aisling Capital Management LP | 1,386,338 | $17.55M | 18.5% | N/A | 3.804% | |
| 1/31/2019 | Wedbush Securities Inc. | 20,840 | $0.26M | 0.0% | N/A | 0.057% | |
| 1/30/2019 | First Manhattan Co. | 2,117,112 | $26.80M | 0.2% | +38.2% | 5.810% | |
| 11/15/2018 | Point72 Asset Management L.P. | 175,000 | $3.16M | 0.0% | -12.5% | 0.480% | |
| 11/13/2018 | Laurion Capital Management LP | 69,832 | $1.26M | 0.0% | -53.4% | 0.192% | |
| 11/13/2018 | VHCP Management III LLC | 1,159,789 | $20.91M | 15.8% | N/A | 3.183% | |
| 11/13/2018 | Renaissance Technologies LLC | 100,100 | $1.81M | 0.0% | +191.8% | 0.275% | |
| 11/13/2018 | Citadel Advisors LLC | 40,378 | $0.73M | 0.0% | N/A | 0.111% | |
| 11/13/2018 | Vivo Capital LLC | 937,147 | $16.90M | 1.7% | +1.3% | 2.572% | |
| 11/13/2018 | GSA Capital Partners LLP | 39,915 | $0.72M | 0.0% | N/A | 0.110% | |
| 11/13/2018 | United Services Automobile Association | 11,400 | $0.21M | 0.0% | N/A | 0.031% | |
| 11/13/2018 | Dimensional Fund Advisors LP | 18,840 | $0.34M | 0.0% | N/A | 0.052% | |
| 11/13/2018 | Credit Suisse AG | 286,311 | $5.16M | 0.0% | N/A | 0.786% | |
| 11/9/2018 | Zurcher Kantonalbank Zurich Cantonalbank | 48,911 | $0.88M | 0.0% | N/A | 0.134% | |
| 11/9/2018 | FMR LLC | 1,429,562 | $25.78M | 0.0% | -20.6% | 3.923% | |
| 10/15/2018 | First Manhattan Co. | 1,532,466 | $27.63M | 0.1% | +1.6% | 4.205% | |
| 8/15/2018 | Jane Street Group LLC | 23,074 | $0.35M | 0.0% | N/A | 0.063% | |
| 8/15/2018 | Millennium Management LLC | 162,425 | $2.46M | 0.0% | N/A | 0.446% | |
| 8/15/2018 | Acuta Capital Partners LLC | 424,300 | $6.42M | 1.1% | N/A | 1.164% | |
| 8/14/2018 | Point72 Asset Management L.P. | 200,000 | $3.03M | 0.0% | N/A | 0.549% | |
| 8/14/2018 | DRW Securities LLC | 33,812 | $0.51M | 0.0% | +55.0% | 0.093% | |
| 8/13/2018 | Laurion Capital Management LP | 150,000 | $2.27M | 0.0% | N/A | 0.412% | |
| 8/13/2018 | Renaissance Technologies LLC | 34,300 | $0.52M | 0.0% | N/A | 0.094% | |
| 8/13/2018 | VHCP Management II LLC | 2,252,460 | $34.10M | 10.2% | +5.1% | 6.181% | |
| 8/13/2018 | DAFNA Capital Management LLC | 64,977 | $0.98M | 0.5% | +857.7% | 0.178% | |
| 8/11/2018 | Vivo Capital LLC | 925,000 | $14.01M | 1.8% | N/A | 2.538% | |
| 8/10/2018 | FMR LLC | 1,800,105 | $27.25M | 0.0% | N/A | 4.940% | |
| 8/10/2018 | Tiverton Asset Management LLC | 14,767 | $0.22M | 0.0% | N/A | 0.041% | |
| 8/8/2018 | US Bancorp DE | 13,000 | $0.20M | 0.0% | N/A | 0.036% | |
| 8/1/2018 | First Manhattan Co. | 1,508,966 | $22.85M | 0.1% | +50.9% | 4.141% | |
| 5/15/2018 | Sofinnova Ventures Inc | 4,749,623 | $64.10M | 11.0% | N/A | 12.792% | |
| 5/14/2018 | DRW Securities LLC | 21,812 | $0.29M | 0.0% | +39.7% | 0.059% | |
| 5/14/2018 | VHCP Management II LLC | 2,143,843 | $28.92M | 7.0% | +7.8% | 5.774% | |
| 5/10/2018 | Sphera Funds Management LTD. | 745,197 | $10.05M | 1.5% | +36.1% | 2.007% | |
| 2/14/2018 | Sofinnova Management VIII L.L.C. | 4,749,623 | $46.36M | 25.3% | +26.7% | 12.792% | |
| 2/13/2018 | VHCP Management II LLC | 1,988,843 | $19.41M | 4.7% | +41.9% | 5.356% | |
| 2/12/2018 | Sphera Funds Management LTD. | 547,697 | $5.35M | 0.6% | +110.5% | 1.475% | |
| 2/5/2018 | Omega Fund Management LLC | 1,000,000 | $9.76M | 7.1% | N/A | 2.693% | |
| 1/22/2018 | First Manhattan Co. | 1,000,000 | $9.76M | 0.1% | N/A | 2.693% | |
| 11/16/2017 | Iguana Healthcare Management LLC | 50,000 | $0.41M | 0.2% | +66.7% | 0.169% | |
| 11/14/2017 | Abingworth LLP | 440,000 | $3.48M | 2.4% | N/A | 1.485% | |
| 11/13/2017 | VHCP Management II LLC | 1,401,343 | $11.41M | 3.2% | +834.2% | 4.729% | |
| 11/9/2017 | Sphera Funds Management LTD. | 260,197 | $2.12M | 0.3% | +12.4% | 0.878% | |
| 8/14/2017 | DAFNA Capital Management LLC | 25,000 | $0.21M | 0.2% | No Change | 0.094% | |
| 8/14/2017 | Nexthera Capital LP | 35,000 | $0.30M | 0.1% | -30.0% | 0.131% | |
| 8/14/2017 | Sectoral Asset Management Inc | 212,831 | $1.82M | 0.2% | +181.9% | 0.799% | |
| 8/14/2017 | UBS Oconnor LLC | 91,545 | $0.78M | 0.0% | -6.3% | 0.344% | |
| 8/11/2017 | VHCP Management II LLC | 150,000 | $1.28M | 0.5% | N/A | 0.563% | |
| 8/9/2017 | Sphera Funds Management LTD. | 231,497 | $1.98M | 0.3% | +9.7% | 0.870% | |
| 7/27/2017 | Spark Investment Management LLC | 11,700 | $100K | 0.0% | -76.5% | 0.044% | |
| 7/26/2017 | NEA Management Company LLC | 3,336,563 | $28.53M | 1.0% | No Change | 12.533% | |
| 7/19/2017 | Sofinnova Management VIII L.L.C. | 3,749,623 | $32.06M | 18.0% | No Change | 12.654% | |
| 5/30/2017 | UBS Oconnor LLC | 97,700 | $1.02M | 0.0% | N/A | 0.330% | |
| 5/15/2017 | Baker Avenue Asset Management LP | 10,000 | $0.10M | 0.0% | N/A | 0.034% | |
