NASDAQ:PALI Palisade Bio (PALI) Stock Price, News & Analysis $1.87 0.00 (0.00%) Closing price 06/18/2026 04:00 PM EasternExtended Trading$1.86 -0.01 (-0.27%) As of 06/18/2026 05:42 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOwnershipSEC FilingsShort InterestTrendsBuy This Stock About Palisade Bio Stock (NASDAQ:PALI) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Palisade Bio alerts:Sign Up Key Stats Today's Range$1.79▼$1.9350-Day Range$1.68▼$2.8052-Week Range$0.53▼$2.86Volume4.04 million shsAverage Volume2.59 million shsMarket Capitalization$324.59 millionP/E RatioN/ADividend YieldN/APrice Target$10.20Consensus RatingModerate Buy Company Overview Palisade Bio, Inc. is a clinical‐stage biotechnology company focused on pioneering localized immunotherapies for the treatment of cancer and inflammatory diseases. The company leverages a proprietary prodrug platform designed to activate therapeutic agents selectively within the tumor microenvironment or sites of inflammation. Its core strategy centers on stimulating the innate immune system via toll‐like receptor 9 (TLR9) agonism to drive targeted immune responses while minimizing systemic exposure and toxicity. The company’s lead product candidate, PDS0108, is an intratumoral TLR9 agonist prodrug currently in Phase 1/2 clinical trials for patients with advanced solid tumors. Palisade Bio is also advancing a pipeline of next‐generation candidates designed to support combination approaches with checkpoint inhibitors, adoptive cell therapies and other standard‐of‐care modalities. The platform’s modular design enables the development of both injectable and implantable formats to address a variety of tumor types and anatomic locations. Palisade Bio operates out of facilities in the United States and collaborates with academic research centers, contract research organizations and biotechnology partners to accelerate its clinical programs. The company maintains a management team with extensive experience in oncology drug development, immunology and precision medicine. As it progresses through clinical milestones, Palisade Bio aims to validate its platform’s capacity to enhance anti‐tumor efficacy while reducing systemic immune‐related adverse events. AI Generated. May Contain Errors. Read More Palisade Bio Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks28th Percentile Overall ScorePALI MarketRank™: Palisade Bio scored higher than 28% of companies evaluated by MarketBeat, and ranked 733rd out of 851 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.0 / 5Analyst RatingModerate Buy Consensus RatingPalisade Bio has received a consensus rating of Moderate Buy. The company's average rating score is 2.88, and is based on 1 strong buy rating, 6 buy ratings, no hold ratings, and 1 sell rating.Upside PotentialPalisade Bio has a consensus price target of $10.20, representing about 445.5% upside from its current price of $1.87.Amount of Analyst CoveragePalisade Bio has only been the subject of 3 research reports in the past 90 days.Read more about Palisade Bio's stock forecast and price target. Earnings and Valuation0.0 / 5Proj. Earnings GrowthDecreasing Earnings GrowthEarnings for Palisade Bio are expected to decrease in the coming year, from ($0.21) to ($0.23) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Palisade Bio is -1.85, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Palisade Bio is -1.85, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioPalisade Bio has a P/B Ratio of 2.15. P/B Ratios below 3 indicates that a company is reasonably valued with respect to its assets and liabilities.Read more about Palisade Bio's valuation and earnings. Short Interest0.0 / 5Short Interest LevelBearish Percentage of Shares Shorted17.76% of the float of Palisade Bio has been sold short.Short Interest Ratio / Days to CoverPalisade Bio has a short interest ratio ("days to cover") of 10.79, which indicates bearish sentiment.Change versus previous monthShort interest in Palisade Bio has recently increased by 14.44%, indicating that investor sentiment is decreasing significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldPalisade Bio does not currently pay a dividend.Dividend GrowthPalisade Bio does not have a long track record of dividend growth. News and Social Media0.6 / 5News SentimentN/A Search InterestOnly 18 people have searched for PALI on MarketBeat in the last 30 days. This is a decrease of -28% compared to the previous 30 days.MarketBeat Follows4 people have added Palisade Bio to their MarketBeat watchlist in the last 30 days. This is an increase of 100% compared to the previous 30 days. Company Ownership0.1 / 5Insider TradingN/A Insider Buying vs. Insider SellingIn the past three months, Palisade Bio insiders have not sold or bought any company stock.Percentage Held by Insiders0.07% of the stock of Palisade Bio is held by insiders.Percentage Held by Institutions11.79% of the stock of Palisade Bio is held by institutions.Read more about Palisade Bio's insider trading history. Receive PALI Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Palisade Bio and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. 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PALI Stock News HeadlinesPalisade Bio Welcomes Biopharmaceutical Industry Veterans Robert Baltera and Jordan Zwick to its Board of DirectorsJune 11, 2026 | globenewswire.comPalisade Bio to Present on the Potential of PALI-2108 for Fibrostenotic Crohn’s Disease at New York Academy of Sciences SymposiumJune 9, 2026 | markets.businessinsider.comThe last time Wall Street was late: +1,700%When Wall Street was slow to grasp AI's power demands, Vertiv surged 1,700% in under two years - turning $10,000 into $180,000. Modine ran 1,900%. Neither was a chip company or a household name. That was the first wave. The wave hitting now is more than three times larger, running straight through one small supplier almost no one has connected to Elon Musk yet.June 20 at 1:00 AM | Behind the Markets (Ad)Palisade Bio, Inc. to Present on PDE4 Inhibitor Prodrug Approach for Fibrostenotic Crohn's Disease at NYAS SymposiumJune 9, 2026 | quiverquant.comQPalisade Bio to Present on the Potential of PALI-2108 for Fibrostenotic Crohn's Disease at New York Academy of Sciences SymposiumJune 9, 2026 | globenewswire.comPalisade Bio (PALI) Gets a Buy from B. Riley SecuritiesJune 7, 2026 | theglobeandmail.comPalisade Bio to Participate in the Jefferies Global Healthcare ConferenceMay 27, 2026 | globenewswire.comPalisade Bio (PALI) Reports Q1 2026 Results as R&D Expenses Rise to $6.4MMay 18, 2026 | finance.yahoo.comSee More Headlines PALI Stock Analysis - Frequently Asked Questions How have PALI shares performed this year? Palisade Bio's stock was trading at $2.35 at the start of the year. Since then, PALI shares have decreased by 20.4% and is now trading at $1.87. How were Palisade Bio's earnings last quarter? Palisade Bio, Inc. (NASDAQ:PALI) posted its quarterly earnings results on Tuesday, May, 12th. The company reported ($0.05) earnings per share (EPS) for the quarter, missing the consensus estimate of ($0.04) by $0.01. When did Palisade Bio's stock split? Shares of Palisade Bio reverse split on the morning of Monday, April 8th 2024.The 1-15 reverse split was announced on Monday, April 8th 2024. The number of shares owned by shareholders was adjusted after the closing bell on Monday, April 8th 2024. An investor that had 100 shares of stock prior to the reverse split would have 7 shares after the split. Who are Palisade Bio's major shareholders? Top institutional investors of Palisade Bio include Janus Henderson Group PLC (6.16%), Octagon Capital Advisors LP (6.14%), Perceptive Advisors LLC (5.14%) and Commodore Capital LP (4.14%). Insiders that own company stock include John David Finley, Mitchell Lawrence Jones, Donald Allen Williams and Robert J Trenschel. View institutional ownership trends. How do I buy shares of Palisade Bio? Shares of PALI stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Palisade Bio own? Based on aggregate information from My MarketBeat watchlists, some other companies that Palisade Bio investors own include Iterum Therapeutics (ITRM), Oncobiologics (OTLK), Bionano Genomics (BNGO), PayPal (PYPL) and Tesla (TSLA). Company Calendar Last Earnings5/12/2026Today6/20/2026Next Earnings (Estimated)8/10/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Green Zone (8m+) 1-Year History Jun 25 Sep 25 Dec 25 Mar 26 Jun 26 PALI's financial health is in the Green zone, according to TradeSmith. PALI has been in this zone for over 8 months. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorMedical Industry MED - BIOMED/GENE Sub-IndustryPharmaceutical Products Current SymbolNASDAQ:PALI CIK1357459 Webwww.palisadebio.com Phone(858) 704-4900FaxN/AEmployees10Year Founded2005Price Target and Rating Average Price Target for Palisade Bio$10.20 High Price Target$25.00 Low Price Target$5.00 Potential Upside/Downside+445.5%Consensus RatingModerate Buy Rating Score (0-4)2.88 Research Coverage8 Analysts Profitability EPS (Trailing Twelve Months)($1.01) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$16.78 million Net MarginsN/A Pretax MarginN/A Return on Equity-36.79% Return on Assets-34.34% Debt Debt-to-Equity RatioN/A Current Ratio23.71 Quick Ratio23.71 Sales & Book Value Annual Sales$250 thousand Price / Sales1,298.38 Cash FlowN/A Price / Cash FlowN/A Book Value$0.87 per share Price / Book2.15Miscellaneous Outstanding Shares173,580,000Free Float173,458,000Market Cap$324.59 million OptionableNot Optionable Beta1.52 Social Links 7 Energy Stocks to Buy and Hold ForeverWith the proliferation of data centers and electric vehicles, the electric grid will only get more strained. 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