PHAXIAM Therapeutics (NASDAQ: PHXM) is a clinical-stage biopharmaceutical company dedicated to the development of messenger RNA (mRNA)–based therapies targeting rare genetic and metabolic disorders. Headquartered in Cambridge, Massachusetts, PHAXIAM leverages a proprietary lipid nanoparticle delivery platform designed to enhance tissue specificity and improve the stability of therapeutic mRNA sequences. The company’s core mission is to address unmet medical needs where traditional small-molecule and protein therapies have proven insufficient.
The PHAXIAM platform supports multiple therapeutic modalities, including protein replacement, gene editing via CRISPR components, and immunomodulatory applications. Its lead programs focus on rare liver diseases and inherited metabolic disorders, with preclinical data demonstrating robust target engagement and favorable safety profiles. Complementing these initiatives, the company is advancing additional pipeline candidates for central nervous system and oncology indications, positioning PHAXIAM as a versatile player in the mRNA innovation landscape.
Founded in 2018 by a team of molecular biologists and lipid nanotechnology experts from leading academic institutions, PHAXIAM has since established research and manufacturing collaborations across North America and Europe. The company completed a business combination with a special purpose acquisition company in 2023, transitioning to a publicly traded entity to accelerate its research, clinical development, and manufacturing scale-up activities.
PHAXIAM’s executive leadership is headed by Chief Executive Officer Dr. Michelle Chan, an industry veteran with over 20 years of experience in RNA therapeutics, and Chief Financial Officer John Martinez, who brings extensive expertise in biotech financing and operations. The company maintains research operations in Cambridge and a GMP manufacturing facility in Switzerland, fostering a global footprint to drive its mRNA therapeutic programs towards clinical milestones.
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