Promis Neurosciences (PMN) Stock Price, News & Analysis

Company Overview

Promis Neurosciences, Inc. is a clinical‐stage biopharmaceutical company focused on the discovery and development of novel therapeutics for central nervous system disorders. The company’s research programs target cognitive impairment and other neurological symptoms associated with diseases such as Alzheimer’s disease and multiple sclerosis.

Leveraging a proprietary small‐molecule discovery platform, Promis Neurosciences advances both preclinical and early clinical candidates designed to modulate neural pathways involved in memory, learning and neuroinflammation. The company’s pipeline reflects a commitment to addressing unmet needs in neurology by optimizing compound profiles for safety, selectivity and central nervous system penetration.

Promis Neurosciences collaborates with academic institutions and industry partners to accelerate its research and development efforts. These strategic alliances support biomarker identification, translational studies and clinical trial design, aiming to streamline candidate advancement and enrich patient selection strategies.

The company is headquartered in the United States and its common stock trades on the Nasdaq stock exchange under the symbol PMN.

Key Stats

• Today's Range: $0.42 to $0.45
• 50-Day Range: $0.40 to $1.12
• 52-Week Range: $0.38 to $1.59
• Volume: 531,199 shs
• Average Volume: 2.83 million shs
• Market Capitalization: $22.23 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $4.33
• Consensus Rating: Buy

Promis Neurosciences Stock Analysis - MarketRank™

Promis Neurosciences scored higher than 59% of companies evaluated by MarketBeat, and ranked 414th out of 944 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.9 / 5
• Analyst Rating: Buy

Consensus Rating

Promis Neurosciences has received a consensus rating of Buy. The company's average rating score is 3.00, and is based on 3 buy ratings, no hold ratings, and no sell ratings.

Upside Potential

Promis Neurosciences has a consensus price target of $4.33, representing about 910.1% upside from its current price of $0.43.

Amount of Analyst Coverage

Promis Neurosciences has only been the subject of 2 research reports in the past 90 days.

Earnings and Valuation

• Score: 1.3 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for Promis Neurosciences are expected to grow in the coming year, from ($0.24) to ($0.21) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Promis Neurosciences is -2.04, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Promis Neurosciences is -2.04, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Promis Neurosciences has a P/B Ratio of 0.86. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.

Short Interest

• Score: 5.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

0.33% of the float of Promis Neurosciences has been sold short.

Short Interest Ratio / Days to Cover

Promis Neurosciences has a short interest ratio ("days to cover") of 0, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Promis Neurosciences has recently decreased by 23.07%, indicating that investor sentiment is improving significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Promis Neurosciences does not currently pay a dividend.

Dividend Growth

Promis Neurosciences does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

0.33% of the float of Promis Neurosciences has been sold short.

Short Interest Ratio / Days to Cover

Promis Neurosciences has a short interest ratio ("days to cover") of 0, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Promis Neurosciences has recently decreased by 23.07%, indicating that investor sentiment is improving significantly.

News and Social Media

• Score: 0.6 / 5
• News Sentiment: N/A

Search Interest

Only 5 people have searched for PMN on MarketBeat in the last 30 days. This is a decrease of -29% compared to the previous 30 days.

MarketBeat Follows

3 people have added Promis Neurosciences to their MarketBeat watchlist in the last 30 days.

Company Ownership

• Score: 0.8 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Promis Neurosciences insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 6.11% of the stock of Promis Neurosciences is held by insiders.

Percentage Held by Institutions

50.13% of the stock of Promis Neurosciences is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

PMN Stock Analysis - Frequently Asked Questions

How have PMN shares performed this year?

Promis Neurosciences' stock was trading at $0.9478 at the beginning of 2025. Since then, PMN stock has decreased by 54.7% and is now trading at $0.4290.

How were Promis Neurosciences' earnings last quarter?

Promis Neurosciences (NASDAQ:PMN) released its quarterly earnings results on Wednesday, August, 13th. The company reported ($0.29) earnings per share (EPS) for the quarter, missing the consensus estimate of ($0.22) by $0.07.

Who are Promis Neurosciences' major shareholders?

Top institutional shareholders of Promis Neurosciences include Armistice Capital LLC (6.54%). Insiders that own company stock include Madge K Shafmaster, Patrick D Kirwin and Neil Cashman.
View institutional ownership trends.

How do I buy shares of Promis Neurosciences?

Shares of PMN stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Promis Neurosciences own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Promis Neurosciences investors own include PayPal (PYPL), Recursion Pharmaceuticals (RXRX), Pacific Biosciences of California (PACB), Editas Medicine (EDIT), Exscientia (EXAI) and Trimble (TRMB).

Company Calendar

• Last Earnings: 8/13/2025
• Today: 9/22/2025
• Next Earnings (Estimated): 11/13/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:PMN
• CIK: 1374339
• Web: www.promisneurosciences.com
• Phone: (416) 847-6898
• Fax: N/A
• Employees: 5
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Promis Neurosciences: $4.33
• High Price Target: $6.00
• Low Price Target: $3.00
• Potential Upside/Downside: +898.5%
• Consensus Rating: Buy
• Rating Score (0-4): 3.00
• Research Coverage: 3 Analysts

Profitability

• EPS (Trailing Twelve Months): ($0.21)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: $2.78 million
• Net Margins: N/A
• Pretax Margin: N/A
• Return on Equity: -266.69%
• Return on Assets: -131.59%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 0.97
• Quick Ratio: 0.97

Sales & Book Value

• Annual Sales: N/A
• Price / Sales: N/A
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $0.50 per share
• Price / Book: 0.87

Miscellaneous

• Outstanding Shares: 51,810,000
• Free Float: 48,641,000
• Market Cap: $22.49 million
• Optionable: Not Optionable
• Beta: -0.05