TransCode Therapeutics, Inc. is a clinical‐stage biotechnology company focused on the development of nonviral, receptor‐targeted nanocomplexes for gene therapy applications. The company’s proprietary platform is designed to deliver nucleic acid payloads—including plasmid DNA, messenger RNA (mRNA) and gene editing tools—to specific cell types by exploiting naturally occurring cell‐surface receptors. This approach aims to enhance both the precision and efficacy of genetic medicines while avoiding some of the safety limitations associated with viral vectors.
The company’s technology leverages modular nanoparticle formulations that can be tailored to target different tissues and disease indications. By combining targeting ligands with biodegradable polymer backbones, TransCode’s nanocomplexes are engineered to achieve receptor‐mediated uptake and endosomal escape, facilitating the intracellular delivery of therapeutic payloads. This receptor‐targeted strategy underpins preclinical programs across areas such as rare genetic disorders, oncology and metabolic diseases.
TransCode’s pipeline includes multiple preclinical and early clinical candidates aimed at underserved patient populations. Collaborations with academic institutions and industry partners support the advancement of these programs, as the company seeks to validate its platform in both in vitro and in vivo models. Its lead candidates are being evaluated for their potential to restore or modulate gene expression in specific cell types, with an eye toward chronic, systemic and localized treatment approaches.
Headquartered in the United States, TransCode Therapeutics operates research and development facilities dedicated to nanoparticle manufacturing and characterization. The company is led by a management team with experience in nanomedicine, gene therapy and pharmaceutical development. Through ongoing investment in manufacturing scale‐up and formulation science, TransCode is positioning itself to address key challenges in the delivery of next‐generation genetic therapies.
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