Upstream Bio (UPB) Stock Price, News & Analysis

Company Overview

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases that focuses on severe respiratory disorders. It develops verekitug, a monoclonal antibody that targets and inhibits the thymic stromal lymphopoietin receptor. The company also develops therapies to treat severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Upstream Bio, Inc. was incorporated in 2021 and is based in Waltham, Massachusetts.

Key Stats

• Today's Range: $8.24 to $9.70
• 50-Day Range: $6.07 to $10.15
• 52-Week Range: $5.14 to $29.46
• Volume: 174,736 shs
• Average Volume: 327,151 shs
• Market Capitalization: $511.04 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $56.50
• Consensus Rating: Buy

UPB Stock Analysis - Frequently Asked Questions

How have UPB shares performed this year?

Upstream Bio's stock was trading at $16.44 at the start of the year. Since then, UPB stock has decreased by 42.2% and is now trading at $9.50.
View the best growth stocks for 2025 here.

How were Upstream Bio's earnings last quarter?

Upstream Bio, Inc. (NASDAQ:UPB) released its quarterly earnings data on Tuesday, May, 6th. The company reported ($0.51) EPS for the quarter, missing the consensus estimate of ($0.49) by $0.02. The company earned $0.57 million during the quarter, compared to analysts' expectations of $0.71 million.

When did Upstream Bio IPO?

Upstream Bio (UPB) raised $200 million in an initial public offering on Friday, October 11th 2024. The company issued 12,500,000 shares at a price of $15.00-$17.00 per share. JPMorgan, TD Cowen, Piper Sandler and William Blair served as the underwriters for the IPO.

When did Upstream Bio's lock-up period expire?

Upstream Bio's lock-up period expired on Wednesday, April 9th. Upstream Bio had issued 15,000,000 shares in its IPO on October 11th. The total size of the offering was $255,000,000 based on an initial share price of $17.00. Shares of the company owned by major shareholders and company insiders are now eligible to be traded as a result of the expiration of the lock-up period.

Who are Upstream Bio's major shareholders?

Upstream Bio's top institutional investors include Charles Schwab Investment Management Inc. (0.25%), Alps Advisors Inc. (0.07%), Nuveen LLC (0.04%) and Rhumbline Advisers (0.02%). Insiders that own company stock include Erez Chimovits and Ai Upstream Llc.
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How do I buy shares of Upstream Bio?

Shares of UPB stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

Company Calendar

• Last Earnings: 5/06/2025
• Today: 5/12/2025
• Next Earnings (Estimated): 6/11/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: Pharmaceutical preparations
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:UPB
• Previous Symbol: NASDAQ:UPB
• CIK: 2022626
• Web: upstreambio.com
• Phone: (781) 208-2466
• Fax: N/A
• Employees: 38
• Year Founded: N/A

Price Target and Rating

• Average Stock Price Target: $56.50
• High Stock Price Target: $75.00
• Low Stock Price Target: $38.00
• Potential Upside/Downside: +494.7%
• Consensus Rating: Buy
• Rating Score (0-4): 3.00
• Research Coverage: 4 Analysts

Profitability

• EPS (Most Recent Fiscal Year): N/A
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: N/A
• Net Margins: N/A
• Pretax Margin: N/A
• Return on Equity: N/A
• Return on Assets: N/A

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: N/A
• Quick Ratio: N/A

Sales & Book Value

• Annual Sales: $2.30 million
• Price / Sales: 222.58
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: N/A
• Price / Book: N/A

Miscellaneous

• Outstanding Shares: 53,794,000
• Free Float: N/A
• Market Cap: $511.04 million
• Optionable: N/A
• Beta: N/A