NASDAQ:UPB Upstream Bio (UPB) Stock Price, News & Analysis $6.10 -0.28 (-4.39%) Closing price 06/12/2026 04:00 PM EasternExtended Trading$6.32 +0.22 (+3.61%) As of 06/12/2026 07:38 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOwnershipSEC FilingsShort InterestTrendsBuy This Stock About Upstream Bio Stock (NASDAQ:UPB) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Upstream Bio alerts:Sign Up Key Stats Today's Range$5.85▼$6.4750-Day Range$6.10▼$10.4952-Week Range$5.85▼$33.68Volume1.43 million shsAverage Volume583,762 shsMarket Capitalization$331.96 millionP/E RatioN/ADividend YieldN/APrice Target$33.17Consensus RatingHold Company Overview Upstream Bio, Inc. is a clinical-stage biotechnology company focused on the development of next-generation prophylactic vaccines and immuno-oncology therapies. Leveraging a proprietary viral vector platform, the company aims to deliver optimized antigen payloads that stimulate robust and durable immune responses against both infectious diseases and cancer targets. Upstream Bio’s approach emphasizes safety, manufacturability and potential for rapid scale-up to address emerging public health challenges. The company’s research and development pipeline includes multiple viral vector-based candidates in early clinical and preclinical stages. In the immuno-oncology sphere, Upstream Bio is exploring therapeutic vaccine constructs designed to activate tumor-specific T cells, while its infectious disease programs seek to induce protective immunity against viral pathogens. By integrating translational biomarkers and adaptive clinical trial designs, the company strives to accelerate candidate selection and optimize dosing regimens. Upstream Bio operates research facilities in the United States and collaborates with academic and industry partners across several regions to advance its programs globally. The company’s leadership team comprises seasoned executives and scientists with deep expertise in virology, vaccine development and regulatory affairs. Upstream Bio is listed on the Nasdaq Global Market under the symbol UPB and continues to build strategic alliances aimed at expanding its pipeline and commercial capabilities.AI Generated. May Contain Errors. Read More Upstream Bio Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks56th Percentile Overall ScoreUPB MarketRank™: Upstream Bio scored higher than 56% of companies evaluated by MarketBeat, and ranked 373rd out of 862 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.2 / 5Analyst RatingHold Consensus RatingUpstream Bio has received a consensus rating of Hold. The company's average rating score is 2.43, and is based on no strong buy ratings, 4 buy ratings, 2 hold ratings, and 1 sell rating.Upside PotentialUpstream Bio has a consensus price target of $33.17, representing about 443.7% upside from its current price of $6.10.Amount of Analyst CoverageUpstream Bio has been the subject of 5 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Upstream Bio's stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthDecreasing Earnings GrowthEarnings for Upstream Bio are expected to decrease in the coming year, from ($2.99) to ($3.15) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Upstream Bio is -2.10, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Upstream Bio is -2.10, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioUpstream Bio has a P/B Ratio of 0.97. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.Read more about Upstream Bio's valuation and earnings. Short Interest1.0 / 5Short Interest LevelBearish Percentage of Shares Shorted8.01% of the float of Upstream Bio has been sold short.Short Interest Ratio / Days to CoverUpstream Bio has a short interest ratio ("days to cover") of 6.81.Change versus previous monthShort interest in Upstream Bio has recently increased by 7.15%, indicating that investor sentiment is decreasing significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldUpstream Bio does not currently pay a dividend.Dividend GrowthUpstream Bio does not have a long track record of dividend growth. News and Social Media2.3 / 5News Sentiment0.69 News SentimentUpstream Bio has a news sentiment score of 0.69. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.80 average news sentiment score of Medical companies.News Coverage This WeekMarketBeat has tracked 8 news articles for Upstream Bio this week, compared to 3 articles on an average week.Search InterestOnly 1 people have searched for UPB on MarketBeat in the last 30 days. This is a decrease of -50% compared to the previous 30 days. Company Ownership1.3 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Upstream Bio insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $7,915.00 in company stock.Percentage Held by Insiders16.46% of the stock of Upstream Bio is held by insiders. A high percentage of insider ownership can be a sign of company health.Percentage Held by InstitutionsUpstream Bio has minimal institutional ownership at this time.Read more about Upstream Bio's insider trading history. 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Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. UPB Stock News HeadlinesKBRA Assigns Preliminary Ratings to OBX 2026-AHC2 TrustJune 12 at 5:07 PM | businesswire.comUpstream Bio, Inc. (NASDAQ:UPB) Given Consensus Rating of "Moderate Buy" by AnalystsJune 11 at 4:22 AM | americanbankingnews.comYour book attachedBill Poulos is giving away his 'Safe Trade Options Formula' book for free - but only for a limited time through a temporary download link. He plans to charge for it soon. Download your copy now and lock it in at no cost, regardless of future pricing. | Profits Run (Ad)Upstream Bio Launches $150 Million At-The-Market ProgramJune 11 at 2:00 AM | theglobeandmail.comUpstream Bio Shareholders Elect Directors, Ratify 2026 AuditorJune 10 at 5:11 PM | tipranks.comUpstream Bio, Inc. (UPB) Presents at Goldman Sachs 47th Annual Global Healthcare Conference 2026 TranscriptJune 10 at 3:58 PM | seekingalpha.comUpstream Bio to Showcase Additional Efficacy Data from the Phase 2 VIBRANT Trial of Verekitug in CRSwNP in Oral Session at EAACI 2026June 8, 2026 | globenewswire.comUpstream Bio to Present at the Goldman Sachs 47th Annual Global Healthcare ConferenceJune 3, 2026 | globenewswire.comSee More Headlines UPB Stock Analysis - Frequently Asked Questions How have UPB shares performed this year? Upstream Bio's stock was trading at $27.15 at the beginning of 2026. Since then, UPB shares have decreased by 77.5% and is now trading at $6.10. How were Upstream Bio's earnings last quarter? Upstream Bio, Inc. (NASDAQ:UPB) announced its quarterly earnings results on Wednesday, May, 13th. The company reported ($0.75) earnings per share (EPS) for the quarter, missing the consensus estimate of ($0.73) by $0.02. The company earned $1.03 million during the quarter, compared to the consensus estimate of $1.03 million. Upstream Bio had a negative trailing twelve-month return on equity of 43.82% and a negative net margin of 4,718.96%. When did Upstream Bio IPO? Upstream Bio (UPB) raised $200 million in an initial public offering (IPO) on Friday, October 11th 2024. The company issued 12,500,000 shares at $15.00-$17.00 per share. JPMorgan, TD Cowen, Piper Sandler and William Blair acted as the underwriters for the IPO. Who are Upstream Bio's major shareholders? Top institutional shareholders of Upstream Bio include Decheng Capital LLC (5.01%), Y Intercept Hong Kong Ltd (1.84%), SEB Asset Management AB (1.61%) and Pictet Asset Management Holding SA (1.35%). Insiders that own company stock include Erez Chimovits, Ai Upstream Llc and Michael Gray. View institutional ownership trends. How do I buy shares of Upstream Bio? Shares of UPB stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. Company Calendar Last Earnings5/13/2026Today6/12/2026Next Earnings (Estimated)8/05/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Red Zone (4m+) 1-Year History Jun 25 Sep 25 Dec 25 Mar 26 Jun 26 UPB's financial health is in the Red zone, according to TradeSmith. UPB has been in this zone for over 4 months. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorMedical Industry MED - BIOMED/GENE Sub-IndustryPharmaceutical Products Current SymbolNASDAQ:UPB Previous SymbolNASDAQ:UPB CIK2022626 Webupstreambio.com Phone(781) 208-2466FaxN/AEmployees38Year Founded2021Price Target and Rating Average Price Target for Upstream Bio$33.17 High Price Target$50.00 Low Price Target$8.00 Potential Upside/Downside+443.7%Consensus RatingHold Rating Score (0-4)2.43 Research Coverage7 Analysts Profitability EPS (Trailing Twelve Months)($2.91) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$143.44 million Net Margins-4,718.96% Pretax Margin-4,718.96% Return on Equity-43.82% Return on Assets-42.27% Debt Debt-to-Equity RatioN/A Current Ratio23.14 Quick Ratio23.14 Sales & Book Value Annual Sales$2.85 million Price / Sales116.48 Cash FlowN/A Price / Cash FlowN/A Book Value$6.29 per share Price / Book0.97Miscellaneous Outstanding Shares54,420,000Free Float45,462,000Market Cap$331.96 million OptionableN/A Beta1.10 Social Links Metaverse Stocks And Why You Can't Ignore ThemThinking about investing in Meta, Roblox, or Unity? Click the link to learn what streetwise investors need to know about the metaverse and public markets before making an investment.Get This Free Report This page (NASDAQ:UPB) was last updated on 6/13/2026 by MarketBeat.com Staff. From Our PartnersTrump's gold order: the announcement they won't put on the front pageOn August 15, 1971, Nixon interrupted prime-time television and ended the gold standard in 15 minutes - no deb...Reagan Gold Group | SponsoredYour book attachedYour Download Link (Expiring) If you still haven't downloaded the free Simple Options Trading For Beginners...Profits Run | SponsoredTrump Takes Emergency Action - Plus Elon Musk's New VentureElon Musk has quietly launched a new venture - one that has nothing to do with rockets, EVs, or Neuralink. Tru...Altimetry | SponsoredHey, it's Jon Najarian. The SpaceX IPO is right around the corner. But I discovered Elon may have something BIGGER planned. 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