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Upstream Bio (UPB) Competitors

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$6.64 +0.23 (+3.50%)
As of 10:30 AM Eastern
This is a fair market value price provided by Massive. Learn more.

UPB vs. AKTS, ARDX, ORIC, AVLN, and INBX

Should you buy Upstream Bio stock or one of its competitors? MarketBeat compares Upstream Bio with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Upstream Bio include Aktis Oncology (AKTS), Ardelyx (ARDX), Oric Pharmaceuticals (ORIC), Avalyn Pharma (AVLN), and Inhibrx Biosciences (INBX).

How does Upstream Bio compare to Aktis Oncology?

Aktis Oncology (NASDAQ:AKTS) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their earnings, valuation, profitability, analyst recommendations, dividends, media sentiment, institutional ownership and risk.

Aktis Oncology currently has a consensus target price of $34.60, suggesting a potential upside of 54.43%. Upstream Bio has a consensus target price of $33.17, suggesting a potential upside of 399.12%. Given Upstream Bio's higher probable upside, analysts clearly believe Upstream Bio is more favorable than Aktis Oncology.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Aktis Oncology
1 Sell rating(s)
0 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.88
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

Aktis Oncology has a net margin of 0.00% compared to Upstream Bio's net margin of -4,718.96%. Aktis Oncology's return on equity of 0.00% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Aktis OncologyN/A N/A N/A
Upstream Bio -4,718.96%-43.82%-42.27%

28.8% of Aktis Oncology shares are owned by institutional investors. 16.5% of Upstream Bio shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

Aktis Oncology has higher revenue and earnings than Upstream Bio. Aktis Oncology is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Aktis Oncology$6.50M184.07-$63.73M-$0.38N/A
Upstream Bio$3.32M108.86-$143.44M-$2.91N/A

In the previous week, Aktis Oncology had 1 more articles in the media than Upstream Bio. MarketBeat recorded 4 mentions for Aktis Oncology and 3 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 0.90 beat Aktis Oncology's score of 0.41 indicating that Upstream Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Aktis Oncology
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Upstream Bio
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Aktis Oncology beats Upstream Bio on 12 of the 16 factors compared between the two stocks.

How does Upstream Bio compare to Ardelyx?

Upstream Bio (NASDAQ:UPB) and Ardelyx (NASDAQ:ARDX) are both small-cap healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their media sentiment, valuation, analyst recommendations, earnings, risk, institutional ownership, profitability and dividends.

In the previous week, Ardelyx had 4 more articles in the media than Upstream Bio. MarketBeat recorded 7 mentions for Ardelyx and 3 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 0.90 beat Ardelyx's score of 0.74 indicating that Upstream Bio is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Upstream Bio
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Ardelyx
5 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Upstream Bio currently has a consensus target price of $33.17, indicating a potential upside of 399.12%. Ardelyx has a consensus target price of $15.73, indicating a potential upside of 224.61%. Given Upstream Bio's higher probable upside, research analysts plainly believe Upstream Bio is more favorable than Ardelyx.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43
Ardelyx
2 Sell rating(s)
0 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.75

58.9% of Ardelyx shares are held by institutional investors. 16.5% of Upstream Bio shares are held by company insiders. Comparatively, 5.3% of Ardelyx shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Ardelyx has higher revenue and earnings than Upstream Bio. Ardelyx is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Upstream Bio$3.32M108.86-$143.44M-$2.91N/A
Ardelyx$407.32M2.94-$61.60M-$0.23N/A

Upstream Bio has a beta of 1.23, meaning that its share price is 23% more volatile than the broader market. Comparatively, Ardelyx has a beta of 0.7, meaning that its share price is 30% less volatile than the broader market.

Ardelyx has a net margin of -13.58% compared to Upstream Bio's net margin of -4,718.96%. Ardelyx's return on equity of -38.11% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Upstream Bio-4,718.96% -43.82% -42.27%
Ardelyx -13.58%-38.11%-11.85%

Summary

Ardelyx beats Upstream Bio on 11 of the 17 factors compared between the two stocks.

How does Upstream Bio compare to Oric Pharmaceuticals?

Oric Pharmaceuticals (NASDAQ:ORIC) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the better business? We will compare the two businesses based on the strength of their risk, analyst recommendations, earnings, media sentiment, dividends, profitability, institutional ownership and valuation.

95.1% of Oric Pharmaceuticals shares are held by institutional investors. 5.7% of Oric Pharmaceuticals shares are held by company insiders. Comparatively, 16.5% of Upstream Bio shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Oric Pharmaceuticals currently has a consensus price target of $19.27, indicating a potential upside of 62.98%. Upstream Bio has a consensus price target of $33.17, indicating a potential upside of 399.12%. Given Upstream Bio's higher probable upside, analysts plainly believe Upstream Bio is more favorable than Oric Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Oric Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

Oric Pharmaceuticals has a net margin of 0.00% compared to Upstream Bio's net margin of -4,718.96%. Oric Pharmaceuticals' return on equity of -35.33% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Oric PharmaceuticalsN/A -35.33% -33.31%
Upstream Bio -4,718.96%-43.82%-42.27%

Oric Pharmaceuticals has higher earnings, but lower revenue than Upstream Bio. Oric Pharmaceuticals is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Oric PharmaceuticalsN/AN/A-$129.47M-$1.44N/A
Upstream Bio$3.32M108.86-$143.44M-$2.91N/A

Oric Pharmaceuticals has a beta of 1.02, meaning that its share price is 2% more volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.23, meaning that its share price is 23% more volatile than the broader market.

In the previous week, Oric Pharmaceuticals had 2 more articles in the media than Upstream Bio. MarketBeat recorded 5 mentions for Oric Pharmaceuticals and 3 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 0.90 beat Oric Pharmaceuticals' score of 0.44 indicating that Upstream Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Oric Pharmaceuticals
2 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Upstream Bio
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Oric Pharmaceuticals beats Upstream Bio on 9 of the 15 factors compared between the two stocks.

How does Upstream Bio compare to Avalyn Pharma?

Avalyn Pharma (NASDAQ:AVLN) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the superior business? We will contrast the two companies based on the strength of their risk, dividends, profitability, valuation, institutional ownership, earnings, media sentiment and analyst recommendations.

Avalyn Pharma has a net margin of 0.00% compared to Upstream Bio's net margin of -4,718.96%. Avalyn Pharma's return on equity of 0.00% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Avalyn PharmaN/A N/A N/A
Upstream Bio -4,718.96%-43.82%-42.27%

Avalyn Pharma has higher earnings, but lower revenue than Upstream Bio. Upstream Bio is trading at a lower price-to-earnings ratio than Avalyn Pharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Avalyn PharmaN/AN/AN/A-$21.83N/A
Upstream Bio$3.32M108.86-$143.44M-$2.91N/A

In the previous week, Upstream Bio had 1 more articles in the media than Avalyn Pharma. MarketBeat recorded 3 mentions for Upstream Bio and 2 mentions for Avalyn Pharma. Upstream Bio's average media sentiment score of 0.90 beat Avalyn Pharma's score of 0.05 indicating that Upstream Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Avalyn Pharma
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Upstream Bio
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Avalyn Pharma currently has a consensus price target of $59.00, suggesting a potential upside of 100.75%. Upstream Bio has a consensus price target of $33.17, suggesting a potential upside of 399.12%. Given Upstream Bio's higher probable upside, analysts clearly believe Upstream Bio is more favorable than Avalyn Pharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Avalyn Pharma
0 Sell rating(s)
1 Hold rating(s)
2 Buy rating(s)
2 Strong Buy rating(s)
3.20
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

Summary

Avalyn Pharma and Upstream Bio tied by winning 6 of the 12 factors compared between the two stocks.

How does Upstream Bio compare to Inhibrx Biosciences?

Inhibrx Biosciences (NASDAQ:INBX) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the better business? We will compare the two businesses based on the strength of their institutional ownership, analyst recommendations, valuation, profitability, risk, dividends, media sentiment and earnings.

Inhibrx Biosciences has higher earnings, but lower revenue than Upstream Bio. Inhibrx Biosciences is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Inhibrx Biosciences$1.30M940.10-$140.05M-$8.39N/A
Upstream Bio$3.32M108.86-$143.44M-$2.91N/A

Inhibrx Biosciences has a beta of 3.51, suggesting that its stock price is 251% more volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.23, suggesting that its stock price is 23% more volatile than the broader market.

Inhibrx Biosciences has a net margin of 0.00% compared to Upstream Bio's net margin of -4,718.96%. Upstream Bio's return on equity of -43.82% beat Inhibrx Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Inhibrx BiosciencesN/A -563.90% -72.32%
Upstream Bio -4,718.96%-43.82%-42.27%

Inhibrx Biosciences currently has a consensus target price of $150.00, indicating a potential upside of 80.05%. Upstream Bio has a consensus target price of $33.17, indicating a potential upside of 399.12%. Given Upstream Bio's stronger consensus rating and higher probable upside, analysts plainly believe Upstream Bio is more favorable than Inhibrx Biosciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Inhibrx Biosciences
1 Sell rating(s)
3 Hold rating(s)
1 Buy rating(s)
1 Strong Buy rating(s)
2.33
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

In the previous week, Inhibrx Biosciences had 1 more articles in the media than Upstream Bio. MarketBeat recorded 4 mentions for Inhibrx Biosciences and 3 mentions for Upstream Bio. Inhibrx Biosciences' average media sentiment score of 0.91 beat Upstream Bio's score of 0.90 indicating that Inhibrx Biosciences is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Inhibrx Biosciences
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Upstream Bio
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

82.5% of Inhibrx Biosciences shares are owned by institutional investors. 18.3% of Inhibrx Biosciences shares are owned by insiders. Comparatively, 16.5% of Upstream Bio shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Summary

Inhibrx Biosciences beats Upstream Bio on 9 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding UPB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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UPB vs. The Competition

MetricUpstream BioBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$361.78M$3.53B$6.79B$12.85B
Dividend YieldN/A3.79%2.60%10.03%
P/E Ratio-2.287.36280.1925.31
Price / Sales108.861,266.96645.11114.43
Price / CashN/A44.8028.6434.82
Price / Book1.0616.9011.016.29
Net Income-$143.44M-$12.52M$3.48B$347.49M
7 Day Performance3.83%1.39%1.81%2.25%
1 Month Performance-11.52%-6.48%-3.36%-2.82%
1 Year Performance-57.43%48.83%62.28%19.84%

Upstream Bio Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
UPB
Upstream Bio
2.7767 of 5 stars
$6.65
+3.5%
$33.17
+399.1%
-58.7%$361.78M$3.32MN/A38
AKTS
Aktis Oncology
2.2215 of 5 stars
$22.97
-5.1%
$34.60
+50.6%
N/A$1.29B$6.50MN/A76
ARDX
Ardelyx
2.5953 of 5 stars
$5.09
+0.6%
$15.73
+209.0%
+15.0%$1.25B$407.32MN/A90
ORIC
Oric Pharmaceuticals
2.3277 of 5 stars
$11.91
-0.9%
$19.27
+61.8%
+4.7%$1.24BN/AN/A80
AVLN
Avalyn Pharma
2.8665 of 5 stars
$27.79
+0.6%
$59.00
+112.3%
N/A$1.23BN/AN/A51

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This page (NASDAQ:UPB) was last updated on 8/4/2026 by MarketBeat.com Staff.
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