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Upstream Bio (UPB) Competitors

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$7.40 -0.23 (-3.04%)
As of 01:22 PM Eastern
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UPB vs. LKFT, NRIX, RAPP, OCUL, and SRPT

Should you buy Upstream Bio stock or one of its competitors? MarketBeat compares Upstream Bio with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Upstream Bio include Lakefront Biotherapeutics American Depositary Shares (LKFT), Nurix Therapeutics (NRIX), Rapport Therapeutics (RAPP), Ocular Therapeutix (OCUL), and Sarepta Therapeutics (SRPT). These companies are all part of the "pharmaceutical products" industry.

How does Upstream Bio compare to Lakefront Biotherapeutics American Depositary Shares?

Upstream Bio (NASDAQ:UPB) and Lakefront Biotherapeutics American Depositary Shares (NASDAQ:LKFT) are both small-cap medical companies, but which is the better stock? We will contrast the two businesses based on the strength of their media sentiment, analyst recommendations, earnings, dividends, profitability, institutional ownership, risk and valuation.

32.5% of Lakefront Biotherapeutics American Depositary Shares shares are held by institutional investors. 16.5% of Upstream Bio shares are held by company insiders. Comparatively, 2.9% of Lakefront Biotherapeutics American Depositary Shares shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Upstream Bio presently has a consensus price target of $38.20, indicating a potential upside of 416.36%. Lakefront Biotherapeutics American Depositary Shares has a consensus price target of $36.50, indicating a potential upside of 30.50%. Given Upstream Bio's stronger consensus rating and higher possible upside, analysts plainly believe Upstream Bio is more favorable than Lakefront Biotherapeutics American Depositary Shares.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Upstream Bio
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.67
Lakefront Biotherapeutics American Depositary Shares
2 Sell rating(s)
5 Hold rating(s)
0 Buy rating(s)
1 Strong Buy rating(s)
2.00

Lakefront Biotherapeutics American Depositary Shares has higher revenue and earnings than Upstream Bio. Lakefront Biotherapeutics American Depositary Shares is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Upstream Bio$2.85M141.26-$143.44M-$2.91N/A
Lakefront Biotherapeutics American Depositary Shares$1.26B1.47$363.05M-$1.41N/A

Upstream Bio has a beta of 1.1, indicating that its stock price is 10% more volatile than the broader market. Comparatively, Lakefront Biotherapeutics American Depositary Shares has a beta of 0.26, indicating that its stock price is 74% less volatile than the broader market.

In the previous week, Upstream Bio had 1 more articles in the media than Lakefront Biotherapeutics American Depositary Shares. MarketBeat recorded 3 mentions for Upstream Bio and 2 mentions for Lakefront Biotherapeutics American Depositary Shares. Upstream Bio's average media sentiment score of 1.23 beat Lakefront Biotherapeutics American Depositary Shares' score of 0.61 indicating that Upstream Bio is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Lakefront Biotherapeutics American Depositary Shares
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Lakefront Biotherapeutics American Depositary Shares has a net margin of 0.00% compared to Upstream Bio's net margin of -4,718.96%. Lakefront Biotherapeutics American Depositary Shares' return on equity of 0.00% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Upstream Bio-4,718.96% -43.82% -42.27%
Lakefront Biotherapeutics American Depositary Shares N/A N/A N/A

Summary

Upstream Bio beats Lakefront Biotherapeutics American Depositary Shares on 9 of the 16 factors compared between the two stocks.

How does Upstream Bio compare to Nurix Therapeutics?

Nurix Therapeutics (NASDAQ:NRIX) and Upstream Bio (NASDAQ:UPB) are both small-cap medical companies, but which is the superior stock? We will contrast the two businesses based on the strength of their institutional ownership, media sentiment, earnings, risk, analyst recommendations, profitability, dividends and valuation.

Nurix Therapeutics has a net margin of -411.37% compared to Upstream Bio's net margin of -4,718.96%. Upstream Bio's return on equity of -43.82% beat Nurix Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Nurix Therapeutics-411.37% -64.21% -48.44%
Upstream Bio -4,718.96%-43.82%-42.27%

Upstream Bio has lower revenue, but higher earnings than Nurix Therapeutics. Nurix Therapeutics is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Nurix Therapeutics$83.98M19.14-$264.46M-$3.16N/A
Upstream Bio$2.85M141.26-$143.44M-$2.91N/A

Nurix Therapeutics has a beta of 1.86, suggesting that its share price is 86% more volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.1, suggesting that its share price is 10% more volatile than the broader market.

Nurix Therapeutics currently has a consensus price target of $30.46, suggesting a potential upside of 95.98%. Upstream Bio has a consensus price target of $38.20, suggesting a potential upside of 416.36%. Given Upstream Bio's higher probable upside, analysts clearly believe Upstream Bio is more favorable than Nurix Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Nurix Therapeutics
1 Sell rating(s)
0 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.93
Upstream Bio
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.67

In the previous week, Upstream Bio had 3 more articles in the media than Nurix Therapeutics. MarketBeat recorded 3 mentions for Upstream Bio and 0 mentions for Nurix Therapeutics. Nurix Therapeutics' average media sentiment score of 1.89 beat Upstream Bio's score of 1.23 indicating that Nurix Therapeutics is being referred to more favorably in the media.

Company Overall Sentiment
Nurix Therapeutics Very Positive
Upstream Bio Positive

Summary

Upstream Bio beats Nurix Therapeutics on 8 of the 14 factors compared between the two stocks.

How does Upstream Bio compare to Rapport Therapeutics?

Rapport Therapeutics (NASDAQ:RAPP) and Upstream Bio (NASDAQ:UPB) are both small-cap medical companies, but which is the superior stock? We will compare the two companies based on the strength of their media sentiment, profitability, valuation, risk, analyst recommendations, earnings, dividends and institutional ownership.

Rapport Therapeutics currently has a consensus target price of $58.83, suggesting a potential upside of 57.43%. Upstream Bio has a consensus target price of $38.20, suggesting a potential upside of 416.36%. Given Upstream Bio's higher possible upside, analysts clearly believe Upstream Bio is more favorable than Rapport Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Rapport Therapeutics
1 Sell rating(s)
0 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.90
Upstream Bio
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.67

Rapport Therapeutics has higher earnings, but lower revenue than Upstream Bio. Rapport Therapeutics is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Rapport TherapeuticsN/AN/A-$111.48M-$2.60N/A
Upstream Bio$2.85M141.26-$143.44M-$2.91N/A

In the previous week, Rapport Therapeutics had 1 more articles in the media than Upstream Bio. MarketBeat recorded 4 mentions for Rapport Therapeutics and 3 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 1.23 beat Rapport Therapeutics' score of 0.58 indicating that Upstream Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Rapport Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Rapport Therapeutics has a net margin of 0.00% compared to Upstream Bio's net margin of -4,718.96%. Rapport Therapeutics' return on equity of -24.78% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Rapport TherapeuticsN/A -24.78% -23.44%
Upstream Bio -4,718.96%-43.82%-42.27%

Rapport Therapeutics has a beta of 0.97, suggesting that its share price is 3% less volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.1, suggesting that its share price is 10% more volatile than the broader market.

Summary

Rapport Therapeutics beats Upstream Bio on 8 of the 13 factors compared between the two stocks.

How does Upstream Bio compare to Ocular Therapeutix?

Upstream Bio (NASDAQ:UPB) and Ocular Therapeutix (NASDAQ:OCUL) are both small-cap medical companies, but which is the better stock? We will contrast the two businesses based on the strength of their profitability, analyst recommendations, institutional ownership, earnings, media sentiment, risk, dividends and valuation.

In the previous week, Ocular Therapeutix had 5 more articles in the media than Upstream Bio. MarketBeat recorded 8 mentions for Ocular Therapeutix and 3 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 1.23 beat Ocular Therapeutix's score of -0.17 indicating that Upstream Bio is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Ocular Therapeutix
2 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Upstream Bio presently has a consensus price target of $38.20, suggesting a potential upside of 416.36%. Ocular Therapeutix has a consensus price target of $23.78, suggesting a potential upside of 169.74%. Given Upstream Bio's higher possible upside, equities research analysts plainly believe Upstream Bio is more favorable than Ocular Therapeutix.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Upstream Bio
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.67
Ocular Therapeutix
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
0 Strong Buy rating(s)
2.79

Ocular Therapeutix has a net margin of -558.24% compared to Upstream Bio's net margin of -4,718.96%. Upstream Bio's return on equity of -43.82% beat Ocular Therapeutix's return on equity.

Company Net Margins Return on Equity Return on Assets
Upstream Bio-4,718.96% -43.82% -42.27%
Ocular Therapeutix -558.24%-64.28%-48.15%

59.2% of Ocular Therapeutix shares are held by institutional investors. 16.5% of Upstream Bio shares are held by company insiders. Comparatively, 2.3% of Ocular Therapeutix shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Upstream Bio has a beta of 1.1, indicating that its stock price is 10% more volatile than the broader market. Comparatively, Ocular Therapeutix has a beta of 0.89, indicating that its stock price is 11% less volatile than the broader market.

Upstream Bio has higher earnings, but lower revenue than Ocular Therapeutix. Ocular Therapeutix is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Upstream Bio$2.85M141.26-$143.44M-$2.91N/A
Ocular Therapeutix$51.95M37.15-$265.94M-$1.46N/A

Summary

Upstream Bio beats Ocular Therapeutix on 10 of the 17 factors compared between the two stocks.

How does Upstream Bio compare to Sarepta Therapeutics?

Sarepta Therapeutics (NASDAQ:SRPT) and Upstream Bio (NASDAQ:UPB) are both small-cap medical companies, but which is the better investment? We will compare the two businesses based on the strength of their media sentiment, profitability, valuation, institutional ownership, risk, dividends, earnings and analyst recommendations.

86.7% of Sarepta Therapeutics shares are held by institutional investors. 6.9% of Sarepta Therapeutics shares are held by company insiders. Comparatively, 16.5% of Upstream Bio shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Upstream Bio has lower revenue, but higher earnings than Sarepta Therapeutics. Sarepta Therapeutics is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Sarepta Therapeutics$2.20B0.80-$713.41M-$0.96N/A
Upstream Bio$2.85M141.26-$143.44M-$2.91N/A

Sarepta Therapeutics currently has a consensus price target of $27.17, indicating a potential upside of 63.70%. Upstream Bio has a consensus price target of $38.20, indicating a potential upside of 416.36%. Given Upstream Bio's stronger consensus rating and higher possible upside, analysts plainly believe Upstream Bio is more favorable than Sarepta Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Sarepta Therapeutics
6 Sell rating(s)
13 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.11
Upstream Bio
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.67

Sarepta Therapeutics has a beta of 0.21, meaning that its share price is 79% less volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.1, meaning that its share price is 10% more volatile than the broader market.

In the previous week, Sarepta Therapeutics had 1 more articles in the media than Upstream Bio. MarketBeat recorded 4 mentions for Sarepta Therapeutics and 3 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 1.23 beat Sarepta Therapeutics' score of 0.82 indicating that Upstream Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Sarepta Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Sarepta Therapeutics has a net margin of -2.94% compared to Upstream Bio's net margin of -4,718.96%. Sarepta Therapeutics' return on equity of 7.56% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Sarepta Therapeutics-2.94% 7.56% 2.94%
Upstream Bio -4,718.96%-43.82%-42.27%

Summary

Upstream Bio beats Sarepta Therapeutics on 9 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding UPB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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UPB vs. The Competition

MetricUpstream BioMED IndustryMedical SectorNASDAQ Exchange
Market Cap$403.80M$3.34B$6.43B$12.45B
Dividend YieldN/A2.37%2.69%5.22%
P/E Ratio-2.5518.8023.8524.37
Price / Sales141.26320.09522.03117.40
Price / CashN/A110.4041.2757.13
Price / Book1.186.8310.046.75
Net Income-$143.44M$24.09M$3.56B$337.03M
7 Day Performance-11.08%-2.36%-0.82%0.08%
1 Month PerformanceN/AN/AN/A-1.66%
1 Year Performance-31.88%48.79%28.88%34.01%

Upstream Bio Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
UPB
Upstream Bio
2.3949 of 5 stars
$7.40
-3.0%
$38.20
+416.4%
-29.6%$403.80M$2.85MN/A38
LKFT
Lakefront Biotherapeutics American Depositary Shares
2.399 of 5 stars
$27.67
+0.7%
$36.50
+31.9%
-3.9%$1.81B$1.26BN/A1,310
NRIX
Nurix Therapeutics
3.1162 of 5 stars
$17.38
-0.7%
$30.46
+75.3%
+28.1%$1.81B$83.98MN/A300
RAPP
Rapport Therapeutics
3.1273 of 5 stars
$39.71
+5.3%
$58.83
+48.2%
+202.3%$1.80BN/AN/AN/A
OCUL
Ocular Therapeutix
2.7417 of 5 stars
$8.29
+0.7%
$23.78
+186.8%
+0.2%$1.80B$52.04MN/A230

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This page (NASDAQ:UPB) was last updated on 6/4/2026 by MarketBeat.com Staff.
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