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Upstream Bio (UPB) Competitors

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$5.73 -0.02 (-0.35%)
Closing price 09/11/2026 04:00 PM Eastern
Extended Trading
$5.72 -0.01 (-0.09%)
As of 09/11/2026 07:30 PM Eastern
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UPB vs. IMTX, MNKD, MLTX, JBIO, and JANX

Should you buy Upstream Bio stock or one of its competitors? Upstream Bio's main competitors and comparable companies include Immatics (IMTX), MannKind (MNKD), MoonLake Immunotherapeutics (MLTX), Jade Biosciences (JBIO), and Janux Therapeutics (JANX). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Upstream Bio compare to Immatics?

Upstream Bio (NASDAQ:UPB) and Immatics (NASDAQ:IMTX) are both small-cap healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their earnings, media sentiment, profitability, analyst recommendations, institutional ownership, dividends, valuation and risk.

64.4% of Immatics shares are owned by institutional investors. 16.5% of Upstream Bio shares are owned by insiders. Comparatively, 3.3% of Immatics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

In the previous week, Upstream Bio had 2 more articles in the media than Immatics. MarketBeat recorded 3 mentions for Upstream Bio and 1 mentions for Immatics. Immatics' average media sentiment score of 1.87 beat Upstream Bio's score of 0.97 indicating that Immatics is being referred to more favorably in the news media.

Company Overall Sentiment
Upstream Bio Positive
Immatics Very Positive

Upstream Bio has higher earnings, but lower revenue than Immatics. Immatics is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Upstream Bio$2.85M110.12-$143.44M-$2.90N/A
Immatics$54.60M22.01-$222.26M-$1.86N/A

Upstream Bio currently has a consensus price target of $29.67, indicating a potential upside of 417.74%. Immatics has a consensus price target of $20.60, indicating a potential upside of 134.36%. Given Upstream Bio's higher possible upside, equities research analysts clearly believe Upstream Bio is more favorable than Immatics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43
Immatics
1 Sell rating(s)
1 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.63

Immatics has a net margin of -495.71% compared to Upstream Bio's net margin of -4,955.67%. Immatics' return on equity of -47.41% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Upstream Bio-4,955.67% -48.40% -46.57%
Immatics -495.71%-47.41%-39.45%

Upstream Bio has a beta of 1.28, indicating that its share price is 28% more volatile than the broader market. Comparatively, Immatics has a beta of 1.33, indicating that its share price is 33% more volatile than the broader market.

Summary

Immatics beats Upstream Bio on 10 of the 16 factors compared between the two stocks.

How does Upstream Bio compare to MannKind?

Upstream Bio (NASDAQ:UPB) and MannKind (NASDAQ:MNKD) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their profitability, media sentiment, earnings, dividends, analyst recommendations, risk, valuation and institutional ownership.

MannKind has higher revenue and earnings than Upstream Bio. MannKind is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Upstream Bio$2.85M110.12-$143.44M-$2.90N/A
MannKind$393.63M3.06$5.86M-$0.13N/A

In the previous week, MannKind had 9 more articles in the media than Upstream Bio. MarketBeat recorded 12 mentions for MannKind and 3 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 0.97 beat MannKind's score of 0.53 indicating that Upstream Bio is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
MannKind
2 Very Positive mention(s)
0 Positive mention(s)
6 Neutral mention(s)
2 Negative mention(s)
0 Very Negative mention(s)
Positive

Upstream Bio has a beta of 1.28, suggesting that its share price is 28% more volatile than the broader market. Comparatively, MannKind has a beta of 1.1, suggesting that its share price is 10% more volatile than the broader market.

Upstream Bio currently has a consensus target price of $29.67, suggesting a potential upside of 417.74%. MannKind has a consensus target price of $8.34, suggesting a potential upside of 122.50%. Given Upstream Bio's higher probable upside, equities analysts plainly believe Upstream Bio is more favorable than MannKind.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43
MannKind
2 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.50

49.5% of MannKind shares are held by institutional investors. 16.5% of Upstream Bio shares are held by insiders. Comparatively, 2.6% of MannKind shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

MannKind has a net margin of -11.08% compared to Upstream Bio's net margin of -4,955.67%. MannKind's return on equity of -11.21% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Upstream Bio-4,955.67% -48.40% -46.57%
MannKind -11.08%-11.21%-6.31%

Summary

MannKind beats Upstream Bio on 10 of the 16 factors compared between the two stocks.

How does Upstream Bio compare to MoonLake Immunotherapeutics?

MoonLake Immunotherapeutics (NASDAQ:MLTX) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their earnings, valuation, dividends, risk, profitability, media sentiment, analyst recommendations and institutional ownership.

In the previous week, MoonLake Immunotherapeutics had 1 more articles in the media than Upstream Bio. MarketBeat recorded 4 mentions for MoonLake Immunotherapeutics and 3 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 0.97 beat MoonLake Immunotherapeutics' score of 0.32 indicating that Upstream Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
MoonLake Immunotherapeutics
0 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

MoonLake Immunotherapeutics currently has a consensus price target of $24.57, suggesting a potential upside of 96.41%. Upstream Bio has a consensus price target of $29.67, suggesting a potential upside of 417.74%. Given Upstream Bio's stronger consensus rating and higher probable upside, analysts plainly believe Upstream Bio is more favorable than MoonLake Immunotherapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
MoonLake Immunotherapeutics
3 Sell rating(s)
4 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.41
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

MoonLake Immunotherapeutics has a beta of 1.04, indicating that its stock price is 4% more volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.28, indicating that its stock price is 28% more volatile than the broader market.

Upstream Bio has higher revenue and earnings than MoonLake Immunotherapeutics. MoonLake Immunotherapeutics is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
MoonLake ImmunotherapeuticsN/AN/A-$227.32M-$3.84N/A
Upstream Bio$2.85M110.12-$143.44M-$2.90N/A

93.9% of MoonLake Immunotherapeutics shares are owned by institutional investors. 10.4% of MoonLake Immunotherapeutics shares are owned by company insiders. Comparatively, 16.5% of Upstream Bio shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

MoonLake Immunotherapeutics has a net margin of 0.00% compared to Upstream Bio's net margin of -4,955.67%. Upstream Bio's return on equity of -48.40% beat MoonLake Immunotherapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
MoonLake ImmunotherapeuticsN/A -82.53% -58.17%
Upstream Bio -4,955.67%-48.40%-46.57%

Summary

Upstream Bio beats MoonLake Immunotherapeutics on 11 of the 15 factors compared between the two stocks.

How does Upstream Bio compare to Jade Biosciences?

Jade Biosciences (NASDAQ:JBIO) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their earnings, risk, profitability, dividends, valuation, media sentiment, analyst recommendations and institutional ownership.

Jade Biosciences has a beta of 1.45, suggesting that its share price is 45% more volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.28, suggesting that its share price is 28% more volatile than the broader market.

Jade Biosciences has a net margin of 0.00% compared to Upstream Bio's net margin of -4,955.67%. Upstream Bio's return on equity of -48.40% beat Jade Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Jade BiosciencesN/A -49.11% -45.62%
Upstream Bio -4,955.67%-48.40%-46.57%

Jade Biosciences has higher earnings, but lower revenue than Upstream Bio. Jade Biosciences is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Jade BiosciencesN/AN/A-$127.41M-$1.92N/A
Upstream Bio$2.85M110.12-$143.44M-$2.90N/A

Jade Biosciences currently has a consensus target price of $51.75, suggesting a potential upside of 189.27%. Upstream Bio has a consensus target price of $29.67, suggesting a potential upside of 417.74%. Given Upstream Bio's higher possible upside, analysts plainly believe Upstream Bio is more favorable than Jade Biosciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Jade Biosciences
1 Sell rating(s)
1 Hold rating(s)
6 Buy rating(s)
2 Strong Buy rating(s)
2.90
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

In the previous week, Jade Biosciences had 3 more articles in the media than Upstream Bio. MarketBeat recorded 6 mentions for Jade Biosciences and 3 mentions for Upstream Bio. Jade Biosciences' average media sentiment score of 0.99 beat Upstream Bio's score of 0.97 indicating that Jade Biosciences is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Jade Biosciences
3 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Jade Biosciences beats Upstream Bio on 10 of the 14 factors compared between the two stocks.

How does Upstream Bio compare to Janux Therapeutics?

Janux Therapeutics (NASDAQ:JANX) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their earnings, institutional ownership, profitability, media sentiment, analyst recommendations, risk, dividends and valuation.

In the previous week, Janux Therapeutics had 1 more articles in the media than Upstream Bio. MarketBeat recorded 4 mentions for Janux Therapeutics and 3 mentions for Upstream Bio. Janux Therapeutics' average media sentiment score of 1.36 beat Upstream Bio's score of 0.97 indicating that Janux Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Janux Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Janux Therapeutics has a beta of 2.53, meaning that its stock price is 153% more volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.28, meaning that its stock price is 28% more volatile than the broader market.

Janux Therapeutics has higher revenue and earnings than Upstream Bio. Janux Therapeutics is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Janux Therapeutics$10M104.55-$113.62M-$1.64N/A
Upstream Bio$2.85M110.12-$143.44M-$2.90N/A

75.4% of Janux Therapeutics shares are held by institutional investors. 7.9% of Janux Therapeutics shares are held by company insiders. Comparatively, 16.5% of Upstream Bio shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Janux Therapeutics presently has a consensus target price of $36.46, suggesting a potential upside of 113.23%. Upstream Bio has a consensus target price of $29.67, suggesting a potential upside of 417.74%. Given Upstream Bio's higher probable upside, analysts plainly believe Upstream Bio is more favorable than Janux Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Janux Therapeutics
2 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.67
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

Janux Therapeutics has a net margin of 0.00% compared to Upstream Bio's net margin of -4,955.67%. Janux Therapeutics' return on equity of -11.89% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Janux TherapeuticsN/A -11.89% -11.13%
Upstream Bio -4,955.67%-48.40%-46.57%

Summary

Janux Therapeutics beats Upstream Bio on 13 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding UPB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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UPB vs. The Competition

MetricUpstream BioBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$313.84M$3.85B$7.16B$12.85B
Dividend YieldN/A3.65%2.57%11.17%
P/E Ratio-1.9814.18274.9425.36
Price / Sales110.121,374.99686.57116.78
Price / CashN/A106.5076.6551.52
Price / Book0.9115.1210.336.20
Net Income-$143.44M-$22.86M$3.50B$358.50M
7 Day Performance-4.66%-4.34%-3.32%-2.35%
1 Month Performance-17.08%0.54%-0.53%-3.23%
1 Year Performance-67.39%40.74%23.51%8.79%

Upstream Bio Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
UPB
Upstream Bio
2.6896 of 5 stars
$5.73
-0.3%
$29.67
+417.7%
-67.4%$313.84M$2.85MN/A38
IMTX
Immatics
3.3985 of 5 stars
$9.44
-1.3%
$20.60
+118.2%
+51.0%$1.31B$41.70MN/A260
MNKD
MannKind
2.9276 of 5 stars
$4.16
+2.5%
$8.39
+101.8%
-32.7%$1.31B$348.97MN/A400
MLTX
MoonLake Immunotherapeutics
1.8659 of 5 stars
$14.94
-0.5%
$24.57
+64.5%
-76.2%$1.28BN/AN/A2
JBIO
Jade Biosciences
2.2728 of 5 stars
$19.45
-2.3%
$51.75
+166.1%
+132.3%$1.27BN/AN/A20

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This page (NASDAQ:UPB) was last updated on 9/13/2026 by MarketBeat.com Staff.
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