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Upstream Bio (UPB) Competitors

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$5.04 0.00 (0.00%)
Closing price 10/2/2026 04:00 PM Eastern
Extended Trading
$5.04 +0.00 (+0.10%)
As of 10/2/2026 07:30 PM Eastern
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UPB vs. AKTS, MNKD, SVRA, ODTX, and MLTX

Should you buy Upstream Bio stock or one of its competitors? Upstream Bio's main competitors and comparable companies include Aktis Oncology (AKTS), MannKind (MNKD), Savara (SVRA), Odyssey Therapeutics (ODTX), and MoonLake Immunotherapeutics (MLTX). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Upstream Bio compare to Aktis Oncology?

Upstream Bio (NASDAQ:UPB) and Aktis Oncology (NASDAQ:AKTS) are both small-cap healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their risk, earnings, profitability, dividends, analyst recommendations, valuation, media sentiment and institutional ownership.

28.8% of Aktis Oncology shares are owned by institutional investors. 16.5% of Upstream Bio shares are owned by company insiders. Comparatively, 3.3% of Aktis Oncology shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

Upstream Bio currently has a consensus price target of $29.67, indicating a potential upside of 488.62%. Aktis Oncology has a consensus price target of $35.63, indicating a potential upside of 92.36%. Given Upstream Bio's higher possible upside, analysts clearly believe Upstream Bio is more favorable than Aktis Oncology.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43
Aktis Oncology
1 Sell rating(s)
0 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.91

Aktis Oncology has a net margin of 0.00% compared to Upstream Bio's net margin of -4,955.67%. Aktis Oncology's return on equity of 0.00% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Upstream Bio-4,955.67% -48.40% -46.57%
Aktis Oncology N/A N/A N/A

Aktis Oncology has higher revenue and earnings than Upstream Bio. Aktis Oncology is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Upstream Bio$2.85M96.86-$143.44M-$2.90N/A
Aktis Oncology$6.50M153.15-$63.73M-$0.82N/A

In the previous week, Aktis Oncology had 3 more articles in the media than Upstream Bio. MarketBeat recorded 5 mentions for Aktis Oncology and 2 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 0.90 beat Aktis Oncology's score of 0.15 indicating that Upstream Bio is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Aktis Oncology
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

Aktis Oncology beats Upstream Bio on 12 of the 16 factors compared between the two stocks.

How does Upstream Bio compare to MannKind?

Upstream Bio (NASDAQ:UPB) and MannKind (NASDAQ:MNKD) are both small-cap healthcare companies, but which is the better business? We will compare the two companies based on the strength of their media sentiment, institutional ownership, valuation, risk, analyst recommendations, profitability, dividends and earnings.

49.6% of MannKind shares are owned by institutional investors. 16.5% of Upstream Bio shares are owned by insiders. Comparatively, 2.6% of MannKind shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Upstream Bio has a beta of 1.38, indicating that its share price is 38% more volatile than the broader market. Comparatively, MannKind has a beta of 1.09, indicating that its share price is 9% more volatile than the broader market.

MannKind has higher revenue and earnings than Upstream Bio. MannKind is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Upstream Bio$2.85M96.86-$143.44M-$2.90N/A
MannKind$348.97M3.50$5.86M-$0.13N/A

Upstream Bio presently has a consensus target price of $29.67, indicating a potential upside of 488.62%. MannKind has a consensus target price of $8.34, indicating a potential upside of 119.57%. Given Upstream Bio's higher probable upside, equities analysts clearly believe Upstream Bio is more favorable than MannKind.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43
MannKind
2 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.50

MannKind has a net margin of -11.08% compared to Upstream Bio's net margin of -4,955.67%. MannKind's return on equity of 0.00% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Upstream Bio-4,955.67% -48.40% -46.57%
MannKind -11.08%N/A -6.31%

In the previous week, MannKind had 6 more articles in the media than Upstream Bio. MarketBeat recorded 8 mentions for MannKind and 2 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 0.90 beat MannKind's score of 0.41 indicating that Upstream Bio is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
MannKind
4 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

MannKind beats Upstream Bio on 10 of the 16 factors compared between the two stocks.

How does Upstream Bio compare to Savara?

Savara (NASDAQ:SVRA) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their profitability, earnings, analyst recommendations, risk, valuation, dividends, media sentiment and institutional ownership.

In the previous week, Savara and Savara both had 2 articles in the media. Upstream Bio's average media sentiment score of 0.90 beat Savara's score of 0.45 indicating that Upstream Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Savara
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Savara has higher earnings, but lower revenue than Upstream Bio. Savara is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
SavaraN/AN/A-$118.84M-$0.58N/A
Upstream Bio$2.85M96.86-$143.44M-$2.90N/A

Savara has a beta of 0.2, indicating that its stock price is 80% less volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.38, indicating that its stock price is 38% more volatile than the broader market.

87.9% of Savara shares are held by institutional investors. 5.3% of Savara shares are held by company insiders. Comparatively, 16.5% of Upstream Bio shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Savara has a net margin of 0.00% compared to Upstream Bio's net margin of -4,955.67%. Upstream Bio's return on equity of -48.40% beat Savara's return on equity.

Company Net Margins Return on Equity Return on Assets
SavaraN/A -90.28% -68.95%
Upstream Bio -4,955.67%-48.40%-46.57%

Savara presently has a consensus price target of $10.00, suggesting a potential upside of 107.90%. Upstream Bio has a consensus price target of $29.67, suggesting a potential upside of 488.62%. Given Upstream Bio's higher possible upside, analysts plainly believe Upstream Bio is more favorable than Savara.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Savara
1 Sell rating(s)
0 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.88
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

Summary

Upstream Bio beats Savara on 8 of the 15 factors compared between the two stocks.

How does Upstream Bio compare to Odyssey Therapeutics?

Odyssey Therapeutics (NASDAQ:ODTX) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the better investment? We will compare the two companies based on the strength of their institutional ownership, profitability, valuation, analyst recommendations, dividends, media sentiment, earnings and risk.

Odyssey Therapeutics has higher earnings, but lower revenue than Upstream Bio. Odyssey Therapeutics is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Odyssey TherapeuticsN/AN/AN/A-$6.77N/A
Upstream Bio$2.85M96.86-$143.44M-$2.90N/A

Odyssey Therapeutics has a net margin of 0.00% compared to Upstream Bio's net margin of -4,955.67%. Odyssey Therapeutics' return on equity of 0.00% beat Upstream Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Odyssey TherapeuticsN/A N/A N/A
Upstream Bio -4,955.67%-48.40%-46.57%

In the previous week, Upstream Bio had 1 more articles in the media than Odyssey Therapeutics. MarketBeat recorded 2 mentions for Upstream Bio and 1 mentions for Odyssey Therapeutics. Odyssey Therapeutics' average media sentiment score of 1.79 beat Upstream Bio's score of 0.90 indicating that Odyssey Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Odyssey Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Odyssey Therapeutics currently has a consensus target price of $35.75, suggesting a potential upside of 72.46%. Upstream Bio has a consensus target price of $29.67, suggesting a potential upside of 488.62%. Given Upstream Bio's higher probable upside, analysts clearly believe Upstream Bio is more favorable than Odyssey Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Odyssey Therapeutics
1 Sell rating(s)
1 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.63
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

Summary

Odyssey Therapeutics beats Upstream Bio on 6 of the 11 factors compared between the two stocks.

How does Upstream Bio compare to MoonLake Immunotherapeutics?

MoonLake Immunotherapeutics (NASDAQ:MLTX) and Upstream Bio (NASDAQ:UPB) are both small-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their dividends, institutional ownership, media sentiment, earnings, analyst recommendations, risk, profitability and valuation.

93.9% of MoonLake Immunotherapeutics shares are owned by institutional investors. 10.4% of MoonLake Immunotherapeutics shares are owned by insiders. Comparatively, 16.5% of Upstream Bio shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

MoonLake Immunotherapeutics currently has a consensus target price of $28.50, indicating a potential upside of 149.78%. Upstream Bio has a consensus target price of $29.67, indicating a potential upside of 488.62%. Given Upstream Bio's higher possible upside, analysts plainly believe Upstream Bio is more favorable than MoonLake Immunotherapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
MoonLake Immunotherapeutics
3 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.43
Upstream Bio
1 Sell rating(s)
2 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.43

Upstream Bio has higher revenue and earnings than MoonLake Immunotherapeutics. MoonLake Immunotherapeutics is trading at a lower price-to-earnings ratio than Upstream Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
MoonLake ImmunotherapeuticsN/AN/A-$227.32M-$3.84N/A
Upstream Bio$2.85M96.86-$143.44M-$2.90N/A

MoonLake Immunotherapeutics has a beta of 1.08, meaning that its share price is 8% more volatile than the broader market. Comparatively, Upstream Bio has a beta of 1.38, meaning that its share price is 38% more volatile than the broader market.

MoonLake Immunotherapeutics has a net margin of 0.00% compared to Upstream Bio's net margin of -4,955.67%. Upstream Bio's return on equity of -48.40% beat MoonLake Immunotherapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
MoonLake ImmunotherapeuticsN/A -82.53% -58.17%
Upstream Bio -4,955.67%-48.40%-46.57%

In the previous week, MoonLake Immunotherapeutics had 4 more articles in the media than Upstream Bio. MarketBeat recorded 6 mentions for MoonLake Immunotherapeutics and 2 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 0.90 beat MoonLake Immunotherapeutics' score of 0.67 indicating that Upstream Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
MoonLake Immunotherapeutics
3 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Upstream Bio
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Upstream Bio beats MoonLake Immunotherapeutics on 10 of the 14 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding UPB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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UPB vs. The Competition

MetricUpstream BioBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$276.05M$3.86B$7.15B$13.28B
Dividend YieldN/A3.65%2.54%17.33%
P/E Ratio-1.7413.06275.6726.04
Price / Sales96.861,292.17656.66111.05
Price / CashN/A123.3978.8752.62
Price / Book0.8016.6310.936.31
Net Income-$143.44M-$22.71M$3.51B$362.16M
7 Day Performance-5.97%-2.99%-2.00%-1.66%
1 Month Performance-16.14%-10.81%-6.19%-4.68%
1 Year Performance-72.95%19.19%8.03%1.57%

Upstream Bio Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
UPB
Upstream Bio
2.7466 of 5 stars
$5.04
flat
$29.67
+488.6%
-72.9%$276.05M$2.85MN/A75
AKTS
Aktis Oncology
2.4923 of 5 stars
$22.11
+3.2%
$35.63
+61.1%
N/A$1.15B$6.50MN/A79
MNKD
MannKind
2.3424 of 5 stars
$3.49
-0.3%
$8.34
+139.1%
-34.0%$1.13B$348.97MN/A592
SVRA
Savara
1.8065 of 5 stars
$5.30
-2.8%
$10.00
+88.7%
+37.8%$1.12BN/AN/A70
ODTX
Odyssey Therapeutics
3.1982 of 5 stars
$23.34
+1.2%
$35.75
+53.2%
N/A$1.11BN/AN/A100

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This page (NASDAQ:UPB) was last updated on 10/4/2026 by MarketBeat.com Staff.
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