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Prime Medicine (PRME) Competitors

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$3.13 -0.22 (-6.57%)
Closing price 09/11/2026 04:00 PM Eastern
Extended Trading
$3.18 +0.05 (+1.50%)
As of 09/11/2026 07:58 PM Eastern
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PRME vs. BEAM, CRSP, BCRX, CDNA, and RARE

Should you buy Prime Medicine stock or one of its competitors? Prime Medicine's main competitors and comparable companies include Beam Therapeutics (BEAM), CRISPR Therapeutics (CRSP), BioCryst Pharmaceuticals (BCRX), CareDx (CDNA), and Ultragenyx Pharmaceutical (RARE). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Prime Medicine compare to Beam Therapeutics?

Beam Therapeutics (NASDAQ:BEAM) and Prime Medicine (NASDAQ:PRME) are both healthcare companies, but which is the better investment? We will compare the two companies based on the strength of their profitability, dividends, analyst recommendations, risk, institutional ownership, earnings, media sentiment and valuation.

In the previous week, Beam Therapeutics had 22 more articles in the media than Prime Medicine. MarketBeat recorded 26 mentions for Beam Therapeutics and 4 mentions for Prime Medicine. Prime Medicine's average media sentiment score of 0.94 beat Beam Therapeutics' score of 0.49 indicating that Prime Medicine is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Beam Therapeutics
5 Very Positive mention(s)
3 Positive mention(s)
15 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Prime Medicine
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Beam Therapeutics has a beta of 2.22, indicating that its stock price is 122% more volatile than the broader market. Comparatively, Prime Medicine has a beta of 2.34, indicating that its stock price is 134% more volatile than the broader market.

Beam Therapeutics has higher revenue and earnings than Prime Medicine. Beam Therapeutics is trading at a lower price-to-earnings ratio than Prime Medicine, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Beam Therapeutics$156.04M15.88-$79.99M-$0.86N/A
Prime Medicine$4.07M139.38-$201.14M-$1.06N/A

Beam Therapeutics pays an annual dividend of $0.90 per share and has a dividend yield of 3.8%. Prime Medicine pays an annual dividend of $1.4460 per share and has a dividend yield of 46.2%. Beam Therapeutics pays out -104.7% of its earnings in the form of a dividend. Prime Medicine pays out -136.4% of its earnings in the form of a dividend. Both companies have healthy payout ratios and should be able to cover their dividend payments with earnings for the next several years. Prime Medicine is clearly the better dividend stock, given its higher yield and lower payout ratio.

Beam Therapeutics has a net margin of -54.75% compared to Prime Medicine's net margin of -4,613.11%. Beam Therapeutics' return on equity of -30.71% beat Prime Medicine's return on equity.

Company Net Margins Return on Equity Return on Assets
Beam Therapeutics-54.75% -30.71% -24.07%
Prime Medicine -4,613.11%-188.27%-59.11%

99.7% of Beam Therapeutics shares are held by institutional investors. Comparatively, 70.4% of Prime Medicine shares are held by institutional investors. 3.8% of Beam Therapeutics shares are held by insiders. Comparatively, 16.0% of Prime Medicine shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Beam Therapeutics presently has a consensus price target of $49.00, suggesting a potential upside of 104.25%. Prime Medicine has a consensus price target of $7.47, suggesting a potential upside of 138.73%. Given Prime Medicine's stronger consensus rating and higher probable upside, analysts clearly believe Prime Medicine is more favorable than Beam Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Beam Therapeutics
1 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.69
Prime Medicine
1 Sell rating(s)
0 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.89

Summary

Prime Medicine beats Beam Therapeutics on 10 of the 19 factors compared between the two stocks.

How does Prime Medicine compare to CRISPR Therapeutics?

Prime Medicine (NASDAQ:PRME) and CRISPR Therapeutics (NASDAQ:CRSP) are both healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their profitability, media sentiment, earnings, dividends, analyst recommendations, risk, valuation and institutional ownership.

CRISPR Therapeutics has a net margin of -3,368.72% compared to Prime Medicine's net margin of -4,613.11%. CRISPR Therapeutics' return on equity of -24.39% beat Prime Medicine's return on equity.

Company Net Margins Return on Equity Return on Assets
Prime Medicine-4,613.11% -188.27% -59.11%
CRISPR Therapeutics -3,368.72%-24.39%-18.25%

Prime Medicine has a beta of 2.34, meaning that its share price is 134% more volatile than the broader market. Comparatively, CRISPR Therapeutics has a beta of 1.76, meaning that its share price is 76% more volatile than the broader market.

Prime Medicine presently has a consensus price target of $7.47, suggesting a potential upside of 138.73%. CRISPR Therapeutics has a consensus price target of $68.06, suggesting a potential upside of 31.58%. Given Prime Medicine's stronger consensus rating and higher possible upside, equities analysts plainly believe Prime Medicine is more favorable than CRISPR Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prime Medicine
1 Sell rating(s)
0 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.89
CRISPR Therapeutics
1 Sell rating(s)
6 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.61

Prime Medicine has higher revenue and earnings than CRISPR Therapeutics. CRISPR Therapeutics is trading at a lower price-to-earnings ratio than Prime Medicine, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prime Medicine$4.07M139.38-$201.14M-$1.06N/A
CRISPR Therapeutics$3.51M1,424.73-$581.60M-$4.76N/A

In the previous week, CRISPR Therapeutics had 4 more articles in the media than Prime Medicine. MarketBeat recorded 8 mentions for CRISPR Therapeutics and 4 mentions for Prime Medicine. Prime Medicine's average media sentiment score of 0.94 beat CRISPR Therapeutics' score of 0.85 indicating that Prime Medicine is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prime Medicine
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
CRISPR Therapeutics
1 Very Positive mention(s)
3 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

70.4% of Prime Medicine shares are held by institutional investors. Comparatively, 69.2% of CRISPR Therapeutics shares are held by institutional investors. 16.0% of Prime Medicine shares are held by company insiders. Comparatively, 5.2% of CRISPR Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Summary

Prime Medicine beats CRISPR Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Prime Medicine compare to BioCryst Pharmaceuticals?

BioCryst Pharmaceuticals (NASDAQ:BCRX) and Prime Medicine (NASDAQ:PRME) are both healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their analyst recommendations, profitability, institutional ownership, valuation, dividends, risk, media sentiment and earnings.

In the previous week, BioCryst Pharmaceuticals had 14 more articles in the media than Prime Medicine. MarketBeat recorded 18 mentions for BioCryst Pharmaceuticals and 4 mentions for Prime Medicine. Prime Medicine's average media sentiment score of 0.94 beat BioCryst Pharmaceuticals' score of 0.55 indicating that Prime Medicine is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioCryst Pharmaceuticals
3 Very Positive mention(s)
7 Positive mention(s)
1 Neutral mention(s)
4 Negative mention(s)
0 Very Negative mention(s)
Positive
Prime Medicine
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

BioCryst Pharmaceuticals currently has a consensus price target of $20.40, suggesting a potential upside of 151.23%. Prime Medicine has a consensus price target of $7.47, suggesting a potential upside of 138.73%. Given BioCryst Pharmaceuticals' higher possible upside, research analysts clearly believe BioCryst Pharmaceuticals is more favorable than Prime Medicine.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioCryst Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.58
Prime Medicine
1 Sell rating(s)
0 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.89

BioCryst Pharmaceuticals has higher revenue and earnings than Prime Medicine. BioCryst Pharmaceuticals is trading at a lower price-to-earnings ratio than Prime Medicine, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioCryst Pharmaceuticals$874.84M2.37$263.86M-$1.50N/A
Prime Medicine$4.07M139.38-$201.14M-$1.06N/A

BioCryst Pharmaceuticals has a net margin of -40.90% compared to Prime Medicine's net margin of -4,613.11%. BioCryst Pharmaceuticals' return on equity of -86.89% beat Prime Medicine's return on equity.

Company Net Margins Return on Equity Return on Assets
BioCryst Pharmaceuticals-40.90% -86.89% 66.37%
Prime Medicine -4,613.11%-188.27%-59.11%

BioCryst Pharmaceuticals has a beta of 0.57, meaning that its share price is 43% less volatile than the broader market. Comparatively, Prime Medicine has a beta of 2.34, meaning that its share price is 134% more volatile than the broader market.

85.9% of BioCryst Pharmaceuticals shares are held by institutional investors. Comparatively, 70.4% of Prime Medicine shares are held by institutional investors. 3.8% of BioCryst Pharmaceuticals shares are held by company insiders. Comparatively, 16.0% of Prime Medicine shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Summary

BioCryst Pharmaceuticals and Prime Medicine tied by winning 8 of the 16 factors compared between the two stocks.

How does Prime Medicine compare to CareDx?

CareDx (NASDAQ:CDNA) and Prime Medicine (NASDAQ:PRME) are both healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their media sentiment, risk, analyst recommendations, profitability, valuation, dividends, institutional ownership and earnings.

In the previous week, Prime Medicine had 1 more articles in the media than CareDx. MarketBeat recorded 4 mentions for Prime Medicine and 3 mentions for CareDx. Prime Medicine's average media sentiment score of 0.94 beat CareDx's score of 0.91 indicating that Prime Medicine is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
CareDx
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Prime Medicine
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

70.4% of Prime Medicine shares are owned by institutional investors. 2.4% of CareDx shares are owned by company insiders. Comparatively, 16.0% of Prime Medicine shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

CareDx presently has a consensus target price of $51.20, indicating a potential upside of 1.87%. Prime Medicine has a consensus target price of $7.47, indicating a potential upside of 138.73%. Given Prime Medicine's stronger consensus rating and higher possible upside, analysts clearly believe Prime Medicine is more favorable than CareDx.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
CareDx
0 Sell rating(s)
4 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.63
Prime Medicine
1 Sell rating(s)
0 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.89

CareDx has a net margin of 24.23% compared to Prime Medicine's net margin of -4,613.11%. CareDx's return on equity of 2.87% beat Prime Medicine's return on equity.

Company Net Margins Return on Equity Return on Assets
CareDx24.23% 2.87% 2.17%
Prime Medicine -4,613.11%-188.27%-59.11%

CareDx has a beta of 2.43, meaning that its stock price is 143% more volatile than the broader market. Comparatively, Prime Medicine has a beta of 2.34, meaning that its stock price is 134% more volatile than the broader market.

CareDx has higher revenue and earnings than Prime Medicine. Prime Medicine is trading at a lower price-to-earnings ratio than CareDx, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
CareDx$379.80M6.85-$21.35M$2.0724.28
Prime Medicine$4.07M139.38-$201.14M-$1.06N/A

Summary

CareDx and Prime Medicine tied by winning 8 of the 16 factors compared between the two stocks.

How does Prime Medicine compare to Ultragenyx Pharmaceutical?

Prime Medicine (NASDAQ:PRME) and Ultragenyx Pharmaceutical (NASDAQ:RARE) are both small-cap healthcare companies, but which is the better business? We will compare the two companies based on the strength of their analyst recommendations, institutional ownership, valuation, earnings, risk, media sentiment, dividends and profitability.

Prime Medicine currently has a consensus target price of $7.47, suggesting a potential upside of 138.73%. Ultragenyx Pharmaceutical has a consensus target price of $36.63, suggesting a potential upside of 156.16%. Given Ultragenyx Pharmaceutical's higher probable upside, analysts plainly believe Ultragenyx Pharmaceutical is more favorable than Prime Medicine.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prime Medicine
1 Sell rating(s)
0 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.89
Ultragenyx Pharmaceutical
1 Sell rating(s)
9 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.52

Prime Medicine has higher earnings, but lower revenue than Ultragenyx Pharmaceutical. Prime Medicine is trading at a lower price-to-earnings ratio than Ultragenyx Pharmaceutical, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prime Medicine$4.07M139.38-$201.14M-$1.06N/A
Ultragenyx Pharmaceutical$673M2.09-$575M-$5.84N/A

Ultragenyx Pharmaceutical has a net margin of -81.79% compared to Prime Medicine's net margin of -4,613.11%. Prime Medicine's return on equity of -188.27% beat Ultragenyx Pharmaceutical's return on equity.

Company Net Margins Return on Equity Return on Assets
Prime Medicine-4,613.11% -188.27% -59.11%
Ultragenyx Pharmaceutical -81.79%-1,024.42%-44.40%

Prime Medicine has a beta of 2.34, suggesting that its stock price is 134% more volatile than the broader market. Comparatively, Ultragenyx Pharmaceutical has a beta of 0.31, suggesting that its stock price is 69% less volatile than the broader market.

In the previous week, Ultragenyx Pharmaceutical had 6 more articles in the media than Prime Medicine. MarketBeat recorded 10 mentions for Ultragenyx Pharmaceutical and 4 mentions for Prime Medicine. Prime Medicine's average media sentiment score of 0.94 beat Ultragenyx Pharmaceutical's score of -0.19 indicating that Prime Medicine is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prime Medicine
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Ultragenyx Pharmaceutical
1 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
3 Negative mention(s)
0 Very Negative mention(s)
Neutral

70.4% of Prime Medicine shares are owned by institutional investors. Comparatively, 97.7% of Ultragenyx Pharmaceutical shares are owned by institutional investors. 16.0% of Prime Medicine shares are owned by company insiders. Comparatively, 5.2% of Ultragenyx Pharmaceutical shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

Summary

Prime Medicine and Ultragenyx Pharmaceutical tied by winning 8 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PRME and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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PRME vs. The Competition

MetricPrime MedicineBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$567.71M$3.84B$7.14B$12.72B
Dividend YieldN/A3.63%2.56%11.15%
P/E Ratio-2.9514.25275.2425.29
Price / Sales139.381,473.16656.0298.94
Price / CashN/A106.6877.0451.44
Price / Book4.6715.1210.336.20
Net Income-$201.14M-$22.86M$3.50B$358.50M
7 Day Performance-15.41%-4.34%-3.32%-2.35%
1 Month Performance-2.19%-0.02%-0.41%-2.77%
1 Year Performance-23.10%40.64%19.21%7.63%

Prime Medicine Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PRME
Prime Medicine
2.8077 of 5 stars
$3.13
-6.6%
$7.47
+138.7%
-23.3%$567.71M$4.07MN/AN/A
BEAM
Beam Therapeutics
2.3429 of 5 stars
$29.59
+2.0%
$49.00
+65.6%
+11.3%$3.05B$156.04MN/A510
CRSP
CRISPR Therapeutics
2.3557 of 5 stars
$57.24
+0.7%
$68.06
+18.9%
-7.5%$5.52B$11MN/A460
BCRX
BioCryst Pharmaceuticals
2.4753 of 5 stars
$9.99
+0.7%
$20.60
+106.2%
+0.6%$2.56B$874.84MN/A530
CDNA
CareDx
2.4911 of 5 stars
$49.19
+0.4%
$51.20
+4.1%
+271.5%$2.55B$458.09M23.82740

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This page (NASDAQ:PRME) was last updated on 9/12/2026 by MarketBeat.com Staff.
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