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Denali Therapeutics (DNLI) Competitors

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$20.00 -0.53 (-2.58%)
Closing price 04:00 PM Eastern
Extended Trading
$20.00 +0.00 (+0.02%)
As of 04:21 PM Eastern
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DNLI vs. BEAM, BMRN, MDGL, KRYS, and KYMR

Should you buy Denali Therapeutics stock or one of its competitors? Denali Therapeutics's main competitors and comparable companies include Beam Therapeutics (BEAM), BioMarin Pharmaceutical (BMRN), Madrigal Pharmaceuticals (MDGL), Krystal Biotech (KRYS), and Kymera Therapeutics (KYMR). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Denali Therapeutics compare to Beam Therapeutics?

Beam Therapeutics (NASDAQ:BEAM) and Denali Therapeutics (NASDAQ:DNLI) are both mid-cap healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their media sentiment, earnings, dividends, profitability, institutional ownership, risk, analyst recommendations and valuation.

99.7% of Beam Therapeutics shares are owned by institutional investors. Comparatively, 92.9% of Denali Therapeutics shares are owned by institutional investors. 3.8% of Beam Therapeutics shares are owned by insiders. Comparatively, 9.7% of Denali Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Denali Therapeutics has a net margin of 0.00% compared to Beam Therapeutics' net margin of -54.75%. Beam Therapeutics' return on equity of -30.71% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Beam Therapeutics-54.75% -30.71% -24.07%
Denali Therapeutics N/A -55.27%-44.24%

Beam Therapeutics presently has a consensus target price of $49.00, suggesting a potential upside of 100.69%. Denali Therapeutics has a consensus target price of $35.85, suggesting a potential upside of 77.29%. Given Beam Therapeutics' stronger consensus rating and higher probable upside, analysts plainly believe Beam Therapeutics is more favorable than Denali Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Beam Therapeutics
1 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.79
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75

Beam Therapeutics has a beta of 2.2, suggesting that its stock price is 120% more volatile than the broader market. Comparatively, Denali Therapeutics has a beta of 1.02, suggesting that its stock price is 2% more volatile than the broader market.

Beam Therapeutics has higher earnings, but lower revenue than Denali Therapeutics. Beam Therapeutics is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Beam Therapeutics$139.74M18.05-$79.99M-$0.86N/A
Denali Therapeutics$330.53M9.78-$512.54M-$2.84N/A

In the previous week, Beam Therapeutics had 4 more articles in the media than Denali Therapeutics. MarketBeat recorded 7 mentions for Beam Therapeutics and 3 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 0.45 beat Beam Therapeutics' score of 0.23 indicating that Denali Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Beam Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
6 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

Beam Therapeutics beats Denali Therapeutics on 11 of the 17 factors compared between the two stocks.

How does Denali Therapeutics compare to BioMarin Pharmaceutical?

Denali Therapeutics (NASDAQ:DNLI) and BioMarin Pharmaceutical (NASDAQ:BMRN) are both healthcare companies, but which is the superior business? We will compare the two businesses based on the strength of their valuation, institutional ownership, dividends, risk, earnings, media sentiment, analyst recommendations and profitability.

BioMarin Pharmaceutical has higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than BioMarin Pharmaceutical, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M9.78-$512.54M-$2.84N/A
BioMarin Pharmaceutical$3.22B3.46$348.90M$0.37155.81

In the previous week, BioMarin Pharmaceutical had 6 more articles in the media than Denali Therapeutics. MarketBeat recorded 9 mentions for BioMarin Pharmaceutical and 3 mentions for Denali Therapeutics. BioMarin Pharmaceutical's average media sentiment score of 0.68 beat Denali Therapeutics' score of 0.45 indicating that BioMarin Pharmaceutical is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
BioMarin Pharmaceutical
3 Very Positive mention(s)
2 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Denali Therapeutics has a beta of 1.02, indicating that its stock price is 2% more volatile than the broader market. Comparatively, BioMarin Pharmaceutical has a beta of 0.22, indicating that its stock price is 78% less volatile than the broader market.

Denali Therapeutics presently has a consensus price target of $35.85, suggesting a potential upside of 77.29%. BioMarin Pharmaceutical has a consensus price target of $89.17, suggesting a potential upside of 54.68%. Given Denali Therapeutics' stronger consensus rating and higher possible upside, equities analysts plainly believe Denali Therapeutics is more favorable than BioMarin Pharmaceutical.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75
BioMarin Pharmaceutical
1 Sell rating(s)
7 Hold rating(s)
15 Buy rating(s)
1 Strong Buy rating(s)
2.67

92.9% of Denali Therapeutics shares are held by institutional investors. Comparatively, 98.7% of BioMarin Pharmaceutical shares are held by institutional investors. 9.7% of Denali Therapeutics shares are held by insiders. Comparatively, 0.7% of BioMarin Pharmaceutical shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

BioMarin Pharmaceutical has a net margin of 2.14% compared to Denali Therapeutics' net margin of 0.00%. BioMarin Pharmaceutical's return on equity of 5.32% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -55.27% -44.24%
BioMarin Pharmaceutical 2.14%5.32%3.69%

Summary

BioMarin Pharmaceutical beats Denali Therapeutics on 12 of the 17 factors compared between the two stocks.

How does Denali Therapeutics compare to Madrigal Pharmaceuticals?

Denali Therapeutics (NASDAQ:DNLI) and Madrigal Pharmaceuticals (NASDAQ:MDGL) are both healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their dividends, institutional ownership, media sentiment, valuation, risk, earnings, analyst recommendations and profitability.

92.9% of Denali Therapeutics shares are held by institutional investors. Comparatively, 98.5% of Madrigal Pharmaceuticals shares are held by institutional investors. 9.7% of Denali Therapeutics shares are held by company insiders. Comparatively, 17.6% of Madrigal Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Madrigal Pharmaceuticals has higher revenue and earnings than Denali Therapeutics. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M9.78-$512.54M-$2.84N/A
Madrigal Pharmaceuticals$958.40M11.95-$288.28M-$12.89N/A

Denali Therapeutics has a beta of 1.02, indicating that its stock price is 2% more volatile than the broader market. Comparatively, Madrigal Pharmaceuticals has a beta of -1.04, indicating that its stock price is 204% less volatile than the broader market.

Denali Therapeutics has a net margin of 0.00% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Denali Therapeutics' return on equity of -55.27% beat Madrigal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -55.27% -44.24%
Madrigal Pharmaceuticals -25.32%-56.65%-25.53%

Denali Therapeutics currently has a consensus target price of $35.85, suggesting a potential upside of 77.29%. Madrigal Pharmaceuticals has a consensus target price of $710.20, suggesting a potential upside of 43.24%. Given Denali Therapeutics' higher possible upside, equities research analysts clearly believe Denali Therapeutics is more favorable than Madrigal Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78

In the previous week, Denali Therapeutics had 1 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 3 mentions for Denali Therapeutics and 2 mentions for Madrigal Pharmaceuticals. Madrigal Pharmaceuticals' average media sentiment score of 0.57 beat Denali Therapeutics' score of 0.45 indicating that Madrigal Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Madrigal Pharmaceuticals
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Madrigal Pharmaceuticals beats Denali Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Denali Therapeutics compare to Krystal Biotech?

Denali Therapeutics (NASDAQ:DNLI) and Krystal Biotech (NASDAQ:KRYS) are both mid-cap healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their earnings, risk, analyst recommendations, dividends, valuation, profitability, media sentiment and institutional ownership.

In the previous week, Denali Therapeutics had 1 more articles in the media than Krystal Biotech. MarketBeat recorded 3 mentions for Denali Therapeutics and 2 mentions for Krystal Biotech. Denali Therapeutics' average media sentiment score of 0.45 beat Krystal Biotech's score of 0.25 indicating that Denali Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Krystal Biotech
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Krystal Biotech has higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M9.78-$512.54M-$2.84N/A
Krystal Biotech$389.13M24.98$204.83M$7.9841.15

Denali Therapeutics presently has a consensus price target of $35.85, indicating a potential upside of 77.29%. Krystal Biotech has a consensus price target of $377.20, indicating a potential upside of 14.87%. Given Denali Therapeutics' higher probable upside, equities research analysts clearly believe Denali Therapeutics is more favorable than Krystal Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00

92.9% of Denali Therapeutics shares are held by institutional investors. Comparatively, 86.3% of Krystal Biotech shares are held by institutional investors. 9.7% of Denali Therapeutics shares are held by company insiders. Comparatively, 13.1% of Krystal Biotech shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Denali Therapeutics has a beta of 1.02, suggesting that its share price is 2% more volatile than the broader market. Comparatively, Krystal Biotech has a beta of 0.5, suggesting that its share price is 50% less volatile than the broader market.

Krystal Biotech has a net margin of 54.82% compared to Denali Therapeutics' net margin of 0.00%. Krystal Biotech's return on equity of 19.34% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -55.27% -44.24%
Krystal Biotech 54.82%19.34%17.65%

Summary

Krystal Biotech beats Denali Therapeutics on 11 of the 17 factors compared between the two stocks.

How does Denali Therapeutics compare to Kymera Therapeutics?

Denali Therapeutics (NASDAQ:DNLI) and Kymera Therapeutics (NASDAQ:KYMR) are both mid-cap healthcare companies, but which is the superior stock? We will compare the two companies based on the strength of their profitability, risk, analyst recommendations, dividends, media sentiment, earnings, institutional ownership and valuation.

Denali Therapeutics has a net margin of 0.00% compared to Kymera Therapeutics' net margin of -285.33%. Kymera Therapeutics' return on equity of -21.22% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -55.27% -44.24%
Kymera Therapeutics -285.33%-21.22%-19.21%

Denali Therapeutics presently has a consensus price target of $35.85, indicating a potential upside of 77.29%. Kymera Therapeutics has a consensus price target of $133.21, indicating a potential upside of 21.76%. Given Denali Therapeutics' higher possible upside, research analysts clearly believe Denali Therapeutics is more favorable than Kymera Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75
Kymera Therapeutics
1 Sell rating(s)
2 Hold rating(s)
22 Buy rating(s)
1 Strong Buy rating(s)
2.88

92.9% of Denali Therapeutics shares are owned by institutional investors. 9.7% of Denali Therapeutics shares are owned by company insiders. Comparatively, 16.0% of Kymera Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Kymera Therapeutics has lower revenue, but higher earnings than Denali Therapeutics. Kymera Therapeutics is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M9.78-$512.54M-$2.84N/A
Kymera Therapeutics$39.21M232.00-$311.35M-$3.24N/A

In the previous week, Kymera Therapeutics had 1 more articles in the media than Denali Therapeutics. MarketBeat recorded 4 mentions for Kymera Therapeutics and 3 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 0.45 beat Kymera Therapeutics' score of 0.34 indicating that Denali Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Kymera Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Denali Therapeutics has a beta of 1.02, suggesting that its share price is 2% more volatile than the broader market. Comparatively, Kymera Therapeutics has a beta of 1.98, suggesting that its share price is 98% more volatile than the broader market.

Summary

Kymera Therapeutics beats Denali Therapeutics on 10 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding DNLI and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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DNLI vs. The Competition

MetricDenali TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$3.20B$3.84B$7.11B$13.24B
Dividend YieldN/A3.64%2.53%15.88%
P/E Ratio-7.0413.44274.4226.03
Price / Sales9.671,285.38600.7289.51
Price / CashN/A121.7677.3851.25
Price / Book2.8916.6410.926.32
Net Income-$512.54M-$22.67M$3.50B$361.43M
7 Day Performance-1.91%-2.99%-2.07%-1.66%
1 Month Performance-12.47%-10.68%-6.32%-3.93%
1 Year Performance31.58%21.44%8.92%2.82%

Denali Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
DNLI
Denali Therapeutics
2.6824 of 5 stars
$20.00
-2.6%
$35.85
+79.2%
+37.7%$3.20B$330.53MN/A507
BEAM
Beam Therapeutics
2.5915 of 5 stars
$25.26
+1.2%
$49.00
+94.0%
+1.1%$2.58B$139.74MN/A540
BMRN
BioMarin Pharmaceutical
4.4597 of 5 stars
$64.06
+0.2%
$89.17
+39.2%
+6.5%$12.38B$3.22B173.143,221
MDGL
Madrigal Pharmaceuticals
3.0237 of 5 stars
$521.96
-1.8%
$699.64
+34.0%
+11.3%$12.28B$958.40MN/A915
KRYS
Krystal Biotech
4.0372 of 5 stars
$333.85
-0.8%
$365.80
+9.6%
+81.1%$9.97B$389.13M41.84295

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This page (NASDAQ:DNLI) was last updated on 10/2/2026 by MarketBeat.com Staff.
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