Denali Therapeutics (DNLI) Competitors

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$24.77 +0.72 (+2.99%)
Closing price 04:00 PM Eastern
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$24.87 +0.10 (+0.42%)
As of 07:58 PM Eastern
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DNLI vs. BEAM, ASND, AXSM, BBIO, and ELAN

Should you buy Denali Therapeutics stock or one of its competitors? MarketBeat compares Denali Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Denali Therapeutics include Beam Therapeutics (BEAM), Ascendis Pharma A/S (ASND), Axsome Therapeutics (AXSM), BridgeBio Pharma (BBIO), and Elanco Animal Health (ELAN). These companies are all part of the "pharmaceutical products" industry.

How does Denali Therapeutics compare to Beam Therapeutics?

Denali Therapeutics (NASDAQ:DNLI) and Beam Therapeutics (NASDAQ:BEAM) are both mid-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their dividends, valuation, analyst recommendations, profitability, risk, media sentiment, earnings and institutional ownership.

Denali Therapeutics has a beta of 1.03, indicating that its stock price is 3% more volatile than the broader market. Comparatively, Beam Therapeutics has a beta of 2.25, indicating that its stock price is 125% more volatile than the broader market.

Denali Therapeutics currently has a consensus price target of $34.25, indicating a potential upside of 38.27%. Beam Therapeutics has a consensus price target of $46.83, indicating a potential upside of 41.06%. Given Beam Therapeutics' higher probable upside, analysts clearly believe Beam Therapeutics is more favorable than Denali Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.81
Beam Therapeutics
1 Sell rating(s)
3 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.71

Beam Therapeutics has lower revenue, but higher earnings than Denali Therapeutics. Beam Therapeutics is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M11.89-$512.54M-$2.88N/A
Beam Therapeutics$139.74M24.44-$79.99M-$0.68N/A

Denali Therapeutics has a net margin of 0.00% compared to Beam Therapeutics' net margin of -39.66%. Beam Therapeutics' return on equity of -29.00% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -52.20% -43.86%
Beam Therapeutics -39.66%-29.00%-22.61%

92.9% of Denali Therapeutics shares are owned by institutional investors. Comparatively, 99.7% of Beam Therapeutics shares are owned by institutional investors. 12.5% of Denali Therapeutics shares are owned by insiders. Comparatively, 3.8% of Beam Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

In the previous week, Beam Therapeutics had 5 more articles in the media than Denali Therapeutics. MarketBeat recorded 7 mentions for Beam Therapeutics and 2 mentions for Denali Therapeutics. Beam Therapeutics' average media sentiment score of 0.92 beat Denali Therapeutics' score of 0.33 indicating that Beam Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Beam Therapeutics
3 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Beam Therapeutics beats Denali Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Denali Therapeutics compare to Ascendis Pharma A/S?

Denali Therapeutics (NASDAQ:DNLI) and Ascendis Pharma A/S (NASDAQ:ASND) are both medical companies, but which is the superior business? We will compare the two companies based on the strength of their media sentiment, analyst recommendations, profitability, risk, valuation, earnings, institutional ownership and dividends.

Denali Therapeutics has a beta of 1.03, indicating that its share price is 3% more volatile than the broader market. Comparatively, Ascendis Pharma A/S has a beta of 0.39, indicating that its share price is 61% less volatile than the broader market.

In the previous week, Ascendis Pharma A/S had 8 more articles in the media than Denali Therapeutics. MarketBeat recorded 10 mentions for Ascendis Pharma A/S and 2 mentions for Denali Therapeutics. Ascendis Pharma A/S's average media sentiment score of 1.16 beat Denali Therapeutics' score of 0.33 indicating that Ascendis Pharma A/S is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Ascendis Pharma A/S
8 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

92.9% of Denali Therapeutics shares are owned by institutional investors. 12.5% of Denali Therapeutics shares are owned by company insiders. Comparatively, 40.0% of Ascendis Pharma A/S shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Denali Therapeutics presently has a consensus target price of $34.25, indicating a potential upside of 38.27%. Ascendis Pharma A/S has a consensus target price of $295.39, indicating a potential upside of 23.81%. Given Denali Therapeutics' higher possible upside, research analysts plainly believe Denali Therapeutics is more favorable than Ascendis Pharma A/S.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.81
Ascendis Pharma A/S
1 Sell rating(s)
0 Hold rating(s)
16 Buy rating(s)
2 Strong Buy rating(s)
3.00

Ascendis Pharma A/S has higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than Ascendis Pharma A/S, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M11.89-$512.54M-$2.88N/A
Ascendis Pharma A/S$814.57M18.27-$258M$8.6727.52

Ascendis Pharma A/S has a net margin of 57.87% compared to Denali Therapeutics' net margin of 0.00%. Ascendis Pharma A/S's return on equity of 0.00% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -52.20% -43.86%
Ascendis Pharma A/S 57.87%N/A -8.37%

Summary

Ascendis Pharma A/S beats Denali Therapeutics on 14 of the 17 factors compared between the two stocks.

How does Denali Therapeutics compare to Axsome Therapeutics?

Denali Therapeutics (NASDAQ:DNLI) and Axsome Therapeutics (NASDAQ:AXSM) are both medical companies, but which is the better investment? We will compare the two businesses based on the strength of their dividends, risk, earnings, profitability, institutional ownership, valuation, media sentiment and analyst recommendations.

In the previous week, Axsome Therapeutics had 7 more articles in the media than Denali Therapeutics. MarketBeat recorded 9 mentions for Axsome Therapeutics and 2 mentions for Denali Therapeutics. Axsome Therapeutics' average media sentiment score of 1.01 beat Denali Therapeutics' score of 0.33 indicating that Axsome Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Axsome Therapeutics
4 Very Positive mention(s)
1 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Axsome Therapeutics has higher revenue and earnings than Denali Therapeutics. Axsome Therapeutics is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M11.89-$512.54M-$2.88N/A
Axsome Therapeutics$638.50M19.50-$183.17M-$3.73N/A

Denali Therapeutics currently has a consensus price target of $34.25, suggesting a potential upside of 38.27%. Axsome Therapeutics has a consensus price target of $258.95, suggesting a potential upside of 7.02%. Given Denali Therapeutics' higher probable upside, equities research analysts clearly believe Denali Therapeutics is more favorable than Axsome Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.81
Axsome Therapeutics
1 Sell rating(s)
0 Hold rating(s)
19 Buy rating(s)
1 Strong Buy rating(s)
2.95

92.9% of Denali Therapeutics shares are owned by institutional investors. Comparatively, 81.5% of Axsome Therapeutics shares are owned by institutional investors. 12.5% of Denali Therapeutics shares are owned by insiders. Comparatively, 20.6% of Axsome Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Denali Therapeutics has a beta of 1.03, suggesting that its stock price is 3% more volatile than the broader market. Comparatively, Axsome Therapeutics has a beta of 0.61, suggesting that its stock price is 39% less volatile than the broader market.

Denali Therapeutics has a net margin of 0.00% compared to Axsome Therapeutics' net margin of -26.59%. Denali Therapeutics' return on equity of -52.20% beat Axsome Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -52.20% -43.86%
Axsome Therapeutics -26.59%-267.16%-28.53%

Summary

Axsome Therapeutics beats Denali Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Denali Therapeutics compare to BridgeBio Pharma?

BridgeBio Pharma (NASDAQ:BBIO) and Denali Therapeutics (NASDAQ:DNLI) are both medical companies, but which is the better business? We will compare the two businesses based on the strength of their dividends, earnings, risk, analyst recommendations, valuation, institutional ownership, profitability and media sentiment.

Denali Therapeutics has lower revenue, but higher earnings than BridgeBio Pharma. BridgeBio Pharma is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BridgeBio Pharma$502.08M26.77-$724.93M-$3.74N/A
Denali Therapeutics$330.53M11.89-$512.54M-$2.88N/A

BridgeBio Pharma has a beta of 0.97, indicating that its stock price is 3% less volatile than the broader market. Comparatively, Denali Therapeutics has a beta of 1.03, indicating that its stock price is 3% more volatile than the broader market.

99.9% of BridgeBio Pharma shares are held by institutional investors. Comparatively, 92.9% of Denali Therapeutics shares are held by institutional investors. 14.2% of BridgeBio Pharma shares are held by company insiders. Comparatively, 12.5% of Denali Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Denali Therapeutics has a net margin of 0.00% compared to BridgeBio Pharma's net margin of -124.42%. BridgeBio Pharma's return on equity of 0.00% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
BridgeBio Pharma-124.42% N/A -65.81%
Denali Therapeutics N/A -52.20%-43.86%

BridgeBio Pharma presently has a consensus price target of $91.05, suggesting a potential upside of 32.66%. Denali Therapeutics has a consensus price target of $34.25, suggesting a potential upside of 38.27%. Given Denali Therapeutics' higher possible upside, analysts clearly believe Denali Therapeutics is more favorable than BridgeBio Pharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BridgeBio Pharma
1 Sell rating(s)
2 Hold rating(s)
22 Buy rating(s)
0 Strong Buy rating(s)
2.84
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.81

In the previous week, BridgeBio Pharma had 11 more articles in the media than Denali Therapeutics. MarketBeat recorded 13 mentions for BridgeBio Pharma and 2 mentions for Denali Therapeutics. BridgeBio Pharma's average media sentiment score of 0.86 beat Denali Therapeutics' score of 0.33 indicating that BridgeBio Pharma is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BridgeBio Pharma
8 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Denali Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

BridgeBio Pharma beats Denali Therapeutics on 9 of the 17 factors compared between the two stocks.

How does Denali Therapeutics compare to Elanco Animal Health?

Elanco Animal Health (NYSE:ELAN) and Denali Therapeutics (NASDAQ:DNLI) are both medical companies, but which is the better business? We will contrast the two companies based on the strength of their profitability, earnings, institutional ownership, dividends, valuation, media sentiment, analyst recommendations and risk.

97.5% of Elanco Animal Health shares are held by institutional investors. Comparatively, 92.9% of Denali Therapeutics shares are held by institutional investors. 1.1% of Elanco Animal Health shares are held by insiders. Comparatively, 12.5% of Denali Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Elanco Animal Health has a beta of 1.69, meaning that its stock price is 69% more volatile than the broader market. Comparatively, Denali Therapeutics has a beta of 1.03, meaning that its stock price is 3% more volatile than the broader market.

Denali Therapeutics has a net margin of 0.00% compared to Elanco Animal Health's net margin of -4.95%. Elanco Animal Health's return on equity of 7.42% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Elanco Animal Health-4.95% 7.42% 3.66%
Denali Therapeutics N/A -52.20%-43.86%

Elanco Animal Health presently has a consensus price target of $28.55, suggesting a potential upside of 22.99%. Denali Therapeutics has a consensus price target of $34.25, suggesting a potential upside of 38.27%. Given Denali Therapeutics' stronger consensus rating and higher probable upside, analysts plainly believe Denali Therapeutics is more favorable than Elanco Animal Health.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Elanco Animal Health
1 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.79
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.81

In the previous week, Elanco Animal Health had 5 more articles in the media than Denali Therapeutics. MarketBeat recorded 7 mentions for Elanco Animal Health and 2 mentions for Denali Therapeutics. Elanco Animal Health's average media sentiment score of 0.88 beat Denali Therapeutics' score of 0.33 indicating that Elanco Animal Health is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Elanco Animal Health
4 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Denali Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Elanco Animal Health has higher revenue and earnings than Denali Therapeutics. Elanco Animal Health is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Elanco Animal Health$4.72B2.46-$232M-$0.50N/A
Denali Therapeutics$330.53M11.89-$512.54M-$2.88N/A

Summary

Elanco Animal Health beats Denali Therapeutics on 9 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding DNLI and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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DNLI vs. The Competition

MetricDenali TherapeuticsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$3.82B$3.45B$6.45B$12.39B
Dividend YieldN/A2.30%2.69%5.83%
P/E Ratio-8.6011.0721.0722.20
Price / Sales11.89334.82530.36110.15
Price / CashN/A128.5644.8254.51
Price / Book3.588.2910.796.50
Net Income-$512.54M$23.85M$3.56B$336.88M
7 Day Performance12.95%5.21%1.67%-0.22%
1 Month Performance32.89%2.19%0.43%0.77%
1 Year Performance81.86%60.99%32.84%31.57%

Denali Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
DNLI
Denali Therapeutics
3.1701 of 5 stars
$24.77
+3.0%
$34.25
+38.3%
+73.1%$3.82B$330.53MN/A430
BEAM
Beam Therapeutics
3.2842 of 5 stars
$31.12
+7.2%
$46.83
+50.5%
+112.0%$2.99B$139.74MN/A510
ASND
Ascendis Pharma A/S
4.9172 of 5 stars
$223.29
+2.4%
$295.39
+32.3%
+28.9%$13.60B$814.57M25.751,189
AXSM
Axsome Therapeutics
2.5181 of 5 stars
$253.40
-0.7%
$256.79
+1.3%
+146.2%$13.13B$638.50MN/A380
BBIO
BridgeBio Pharma
3.4915 of 5 stars
$68.00
+1.8%
$89.59
+31.8%
+65.2%$13.08B$502.08MN/A400

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This page (NASDAQ:DNLI) was last updated on 6/23/2026 by MarketBeat.com Staff.
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