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Denali Therapeutics (DNLI) Competitors

Denali Therapeutics logo
$24.92 -0.03 (-0.12%)
As of 08/21/2026 04:00 PM Eastern

DNLI vs. BEAM, ASND, BMRN, EXEL, and ARWR

Should you buy Denali Therapeutics stock or one of its competitors? Denali Therapeutics's main competitors and comparable companies include Beam Therapeutics (BEAM), Ascendis Pharma A/S (ASND), BioMarin Pharmaceutical (BMRN), Exelixis (EXEL), and Arrowhead Pharmaceuticals (ARWR). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Denali Therapeutics compare to Beam Therapeutics?

Beam Therapeutics (NASDAQ:BEAM) and Denali Therapeutics (NASDAQ:DNLI) are both mid-cap healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their media sentiment, institutional ownership, valuation, profitability, analyst recommendations, risk, dividends and earnings.

99.7% of Beam Therapeutics shares are owned by institutional investors. Comparatively, 92.9% of Denali Therapeutics shares are owned by institutional investors. 3.8% of Beam Therapeutics shares are owned by company insiders. Comparatively, 9.7% of Denali Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Beam Therapeutics has a beta of 2.23, suggesting that its stock price is 123% more volatile than the broader market. Comparatively, Denali Therapeutics has a beta of 1.01, suggesting that its stock price is 1% more volatile than the broader market.

Beam Therapeutics has higher earnings, but lower revenue than Denali Therapeutics. Beam Therapeutics is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Beam Therapeutics$139.74M22.00-$79.99M-$0.86N/A
Denali Therapeutics$330.53M12.05-$512.54M-$2.84N/A

In the previous week, Denali Therapeutics had 2 more articles in the media than Beam Therapeutics. MarketBeat recorded 7 mentions for Denali Therapeutics and 5 mentions for Beam Therapeutics. Denali Therapeutics' average media sentiment score of 1.32 beat Beam Therapeutics' score of 1.17 indicating that Denali Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Beam Therapeutics
4 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Denali Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Denali Therapeutics has a net margin of 0.00% compared to Beam Therapeutics' net margin of -54.75%. Beam Therapeutics' return on equity of -30.71% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Beam Therapeutics-54.75% -30.71% -24.07%
Denali Therapeutics N/A -55.27%-44.24%

Beam Therapeutics currently has a consensus price target of $49.00, indicating a potential upside of 64.65%. Denali Therapeutics has a consensus price target of $35.92, indicating a potential upside of 44.13%. Given Beam Therapeutics' higher probable upside, equities analysts plainly believe Beam Therapeutics is more favorable than Denali Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Beam Therapeutics
1 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.69
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75

Summary

Beam Therapeutics and Denali Therapeutics tied by winning 8 of the 16 factors compared between the two stocks.

How does Denali Therapeutics compare to Ascendis Pharma A/S?

Denali Therapeutics (NASDAQ:DNLI) and Ascendis Pharma A/S (NASDAQ:ASND) are both healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their earnings, media sentiment, profitability, analyst recommendations, institutional ownership, dividends, valuation and risk.

Denali Therapeutics has a beta of 1.01, indicating that its share price is 1% more volatile than the broader market. Comparatively, Ascendis Pharma A/S has a beta of 0.39, indicating that its share price is 61% less volatile than the broader market.

Denali Therapeutics currently has a consensus price target of $35.92, indicating a potential upside of 44.13%. Ascendis Pharma A/S has a consensus price target of $300.33, indicating a potential upside of 18.57%. Given Denali Therapeutics' higher possible upside, equities research analysts clearly believe Denali Therapeutics is more favorable than Ascendis Pharma A/S.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75
Ascendis Pharma A/S
0 Sell rating(s)
1 Hold rating(s)
16 Buy rating(s)
2 Strong Buy rating(s)
3.05

In the previous week, Ascendis Pharma A/S had 2 more articles in the media than Denali Therapeutics. MarketBeat recorded 9 mentions for Ascendis Pharma A/S and 7 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 1.32 beat Ascendis Pharma A/S's score of 1.04 indicating that Denali Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Ascendis Pharma A/S
3 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Ascendis Pharma A/S has higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than Ascendis Pharma A/S, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M12.05-$512.54M-$2.84N/A
Ascendis Pharma A/S$1.05B15.09-$258M$12.8919.65

Ascendis Pharma A/S has a net margin of 70.99% compared to Denali Therapeutics' net margin of 0.00%. Ascendis Pharma A/S's return on equity of 32.54% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -55.27% -44.24%
Ascendis Pharma A/S 70.99%32.54%7.71%

92.9% of Denali Therapeutics shares are owned by institutional investors. 9.7% of Denali Therapeutics shares are owned by insiders. Comparatively, 40.0% of Ascendis Pharma A/S shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Summary

Ascendis Pharma A/S beats Denali Therapeutics on 13 of the 17 factors compared between the two stocks.

How does Denali Therapeutics compare to BioMarin Pharmaceutical?

BioMarin Pharmaceutical (NASDAQ:BMRN) and Denali Therapeutics (NASDAQ:DNLI) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, analyst recommendations, profitability, dividends, institutional ownership, earnings, media sentiment and valuation.

98.7% of BioMarin Pharmaceutical shares are owned by institutional investors. Comparatively, 92.9% of Denali Therapeutics shares are owned by institutional investors. 0.7% of BioMarin Pharmaceutical shares are owned by insiders. Comparatively, 9.7% of Denali Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

BioMarin Pharmaceutical currently has a consensus price target of $88.83, indicating a potential upside of 33.17%. Denali Therapeutics has a consensus price target of $35.92, indicating a potential upside of 44.13%. Given Denali Therapeutics' higher possible upside, analysts clearly believe Denali Therapeutics is more favorable than BioMarin Pharmaceutical.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioMarin Pharmaceutical
1 Sell rating(s)
6 Hold rating(s)
15 Buy rating(s)
2 Strong Buy rating(s)
2.75
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75

BioMarin Pharmaceutical has a net margin of 2.14% compared to Denali Therapeutics' net margin of 0.00%. BioMarin Pharmaceutical's return on equity of 5.32% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
BioMarin Pharmaceutical2.14% 5.32% 3.69%
Denali Therapeutics N/A -55.27%-44.24%

BioMarin Pharmaceutical has higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than BioMarin Pharmaceutical, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioMarin Pharmaceutical$3.22B4.01$348.90M$0.37180.27
Denali Therapeutics$330.53M12.05-$512.54M-$2.84N/A

BioMarin Pharmaceutical has a beta of 0.24, suggesting that its share price is 76% less volatile than the broader market. Comparatively, Denali Therapeutics has a beta of 1.01, suggesting that its share price is 1% more volatile than the broader market.

In the previous week, BioMarin Pharmaceutical had 27 more articles in the media than Denali Therapeutics. MarketBeat recorded 34 mentions for BioMarin Pharmaceutical and 7 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 1.32 beat BioMarin Pharmaceutical's score of 0.73 indicating that Denali Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioMarin Pharmaceutical
13 Very Positive mention(s)
5 Positive mention(s)
9 Neutral mention(s)
2 Negative mention(s)
0 Very Negative mention(s)
Positive
Denali Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

BioMarin Pharmaceutical beats Denali Therapeutics on 11 of the 16 factors compared between the two stocks.

How does Denali Therapeutics compare to Exelixis?

Denali Therapeutics (NASDAQ:DNLI) and Exelixis (NASDAQ:EXEL) are both healthcare companies, but which is the superior investment? We will compare the two companies based on the strength of their risk, analyst recommendations, earnings, valuation, profitability, dividends, media sentiment and institutional ownership.

Denali Therapeutics has a beta of 1.01, indicating that its share price is 1% more volatile than the broader market. Comparatively, Exelixis has a beta of 0.44, indicating that its share price is 56% less volatile than the broader market.

92.9% of Denali Therapeutics shares are owned by institutional investors. Comparatively, 85.3% of Exelixis shares are owned by institutional investors. 9.7% of Denali Therapeutics shares are owned by company insiders. Comparatively, 2.6% of Exelixis shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Exelixis has higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than Exelixis, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M12.05-$512.54M-$2.84N/A
Exelixis$2.32B5.78$782.57M$3.1817.01

Denali Therapeutics currently has a consensus target price of $35.92, indicating a potential upside of 44.13%. Exelixis has a consensus target price of $50.07, indicating a potential downside of 7.42%. Given Denali Therapeutics' stronger consensus rating and higher possible upside, equities research analysts clearly believe Denali Therapeutics is more favorable than Exelixis.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75
Exelixis
2 Sell rating(s)
11 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.30

Exelixis has a net margin of 35.33% compared to Denali Therapeutics' net margin of 0.00%. Exelixis' return on equity of 42.17% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -55.27% -44.24%
Exelixis 35.33%42.17%31.76%

In the previous week, Exelixis had 9 more articles in the media than Denali Therapeutics. MarketBeat recorded 16 mentions for Exelixis and 7 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 1.32 beat Exelixis' score of 1.18 indicating that Denali Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Exelixis
11 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Exelixis beats Denali Therapeutics on 9 of the 17 factors compared between the two stocks.

How does Denali Therapeutics compare to Arrowhead Pharmaceuticals?

Denali Therapeutics (NASDAQ:DNLI) and Arrowhead Pharmaceuticals (NASDAQ:ARWR) are both healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their valuation, earnings, analyst recommendations, institutional ownership, dividends, profitability, media sentiment and risk.

Denali Therapeutics presently has a consensus target price of $35.92, indicating a potential upside of 44.13%. Arrowhead Pharmaceuticals has a consensus target price of $97.33, indicating a potential upside of 11.74%. Given Denali Therapeutics' stronger consensus rating and higher probable upside, equities analysts clearly believe Denali Therapeutics is more favorable than Arrowhead Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75
Arrowhead Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.62

Arrowhead Pharmaceuticals has higher revenue and earnings than Denali Therapeutics. Arrowhead Pharmaceuticals is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M12.05-$512.54M-$2.84N/A
Arrowhead Pharmaceuticals$829.45M14.79-$1.63M-$2.25N/A

In the previous week, Arrowhead Pharmaceuticals had 8 more articles in the media than Denali Therapeutics. MarketBeat recorded 15 mentions for Arrowhead Pharmaceuticals and 7 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 1.32 beat Arrowhead Pharmaceuticals' score of 0.90 indicating that Denali Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Arrowhead Pharmaceuticals
10 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Denali Therapeutics has a net margin of 0.00% compared to Arrowhead Pharmaceuticals' net margin of -47.79%. Denali Therapeutics' return on equity of -55.27% beat Arrowhead Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -55.27% -44.24%
Arrowhead Pharmaceuticals -47.79%-60.06%-17.37%

Denali Therapeutics has a beta of 1.01, meaning that its share price is 1% more volatile than the broader market. Comparatively, Arrowhead Pharmaceuticals has a beta of 1.27, meaning that its share price is 27% more volatile than the broader market.

92.9% of Denali Therapeutics shares are held by institutional investors. Comparatively, 62.6% of Arrowhead Pharmaceuticals shares are held by institutional investors. 9.7% of Denali Therapeutics shares are held by insiders. Comparatively, 3.6% of Arrowhead Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Summary

Denali Therapeutics beats Arrowhead Pharmaceuticals on 9 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding DNLI and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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DNLI vs. The Competition

MetricDenali TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$3.98B$4.01B$7.37B$12.85B
Dividend YieldN/A3.64%2.53%11.08%
P/E Ratio-8.7711.62272.6024.24
Price / Sales12.051,338.17618.9699.78
Price / CashN/A105.1478.6253.99
Price / Book4.7716.8013.056.20
Net Income-$512.54M-$12.50M$3.47B$348.59M
7 Day Performance2.13%3.29%2.09%0.08%
1 Month Performance6.40%8.23%6.64%3.88%
1 Year Performance60.88%55.05%25.02%16.98%

Denali Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
DNLI
Denali Therapeutics
3.3975 of 5 stars
$24.92
-0.1%
$35.92
+44.1%
+60.9%$3.98B$330.53MN/A430
BEAM
Beam Therapeutics
2.1691 of 5 stars
$27.10
+1.3%
$49.00
+80.8%
+78.8%$2.76B$139.74MN/A510
ASND
Ascendis Pharma A/S
4.6109 of 5 stars
$247.40
-0.4%
$299.24
+21.0%
+30.4%$15.50B$814.57M19.191,189
BMRN
BioMarin Pharmaceutical
4.8149 of 5 stars
$66.64
-1.1%
$88.45
+32.7%
+13.9%$13.04B$3.41B180.113,221
EXEL
Exelixis
3.3916 of 5 stars
$52.32
+2.1%
$49.79
-4.8%
+40.0%$12.70B$2.32B16.451,077

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This page (NASDAQ:DNLI) was last updated on 8/23/2026 by MarketBeat.com Staff.
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