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Denali Therapeutics (DNLI) Competitors

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$21.09 -0.31 (-1.45%)
Closing price 09/11/2026 04:00 PM Eastern
Extended Trading
$21.21 +0.12 (+0.56%)
As of 09/11/2026 07:59 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

DNLI vs. BEAM, SMMT, BMRN, HALO, and MDGL

Should you buy Denali Therapeutics stock or one of its competitors? Denali Therapeutics's main competitors and comparable companies include Beam Therapeutics (BEAM), Summit Therapeutics (SMMT), BioMarin Pharmaceutical (BMRN), Halozyme Therapeutics (HALO), and Madrigal Pharmaceuticals (MDGL). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Denali Therapeutics compare to Beam Therapeutics?

Beam Therapeutics (NASDAQ:BEAM) and Denali Therapeutics (NASDAQ:DNLI) are both mid-cap healthcare companies, but which is the better business? We will contrast the two businesses based on the strength of their valuation, dividends, earnings, media sentiment, analyst recommendations, profitability, institutional ownership and risk.

Beam Therapeutics currently has a consensus target price of $49.00, suggesting a potential upside of 104.25%. Denali Therapeutics has a consensus target price of $35.85, suggesting a potential upside of 69.97%. Given Beam Therapeutics' higher possible upside, research analysts plainly believe Beam Therapeutics is more favorable than Denali Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Beam Therapeutics
1 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.69
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75

Beam Therapeutics has a beta of 2.22, meaning that its share price is 122% more volatile than the broader market. Comparatively, Denali Therapeutics has a beta of 1.01, meaning that its share price is 1% more volatile than the broader market.

99.7% of Beam Therapeutics shares are held by institutional investors. Comparatively, 92.9% of Denali Therapeutics shares are held by institutional investors. 3.8% of Beam Therapeutics shares are held by company insiders. Comparatively, 9.7% of Denali Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Denali Therapeutics has a net margin of 0.00% compared to Beam Therapeutics' net margin of -54.75%. Beam Therapeutics' return on equity of -30.71% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Beam Therapeutics-54.75% -30.71% -24.07%
Denali Therapeutics N/A -55.27%-44.24%

Beam Therapeutics has higher earnings, but lower revenue than Denali Therapeutics. Beam Therapeutics is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Beam Therapeutics$156.04M15.88-$79.99M-$0.86N/A
Denali Therapeutics$330.53M10.20-$512.54M-$2.84N/A

In the previous week, Beam Therapeutics had 24 more articles in the media than Denali Therapeutics. MarketBeat recorded 26 mentions for Beam Therapeutics and 2 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 1.46 beat Beam Therapeutics' score of 0.49 indicating that Denali Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Beam Therapeutics
5 Very Positive mention(s)
3 Positive mention(s)
15 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Beam Therapeutics beats Denali Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Denali Therapeutics compare to Summit Therapeutics?

Summit Therapeutics (NASDAQ:SMMT) and Denali Therapeutics (NASDAQ:DNLI) are both healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their media sentiment, dividends, earnings, analyst recommendations, profitability, institutional ownership, valuation and risk.

4.6% of Summit Therapeutics shares are held by institutional investors. Comparatively, 92.9% of Denali Therapeutics shares are held by institutional investors. 83.5% of Summit Therapeutics shares are held by insiders. Comparatively, 9.7% of Denali Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Summit Therapeutics presently has a consensus price target of $25.91, suggesting a potential upside of 47.63%. Denali Therapeutics has a consensus price target of $35.85, suggesting a potential upside of 69.97%. Given Denali Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Denali Therapeutics is more favorable than Summit Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Summit Therapeutics
1 Sell rating(s)
8 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.47
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75

Denali Therapeutics' return on equity of -55.27% beat Summit Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Summit TherapeuticsN/A -168.94% -141.92%
Denali Therapeutics N/A -55.27%-44.24%

In the previous week, Summit Therapeutics had 7 more articles in the media than Denali Therapeutics. MarketBeat recorded 9 mentions for Summit Therapeutics and 2 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 1.46 beat Summit Therapeutics' score of 1.12 indicating that Denali Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Summit Therapeutics
6 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Denali Therapeutics has higher revenue and earnings than Summit Therapeutics. Summit Therapeutics is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Summit TherapeuticsN/AN/A-$1.08B-$1.12N/A
Denali Therapeutics$330.53M10.20-$512.54M-$2.84N/A

Summit Therapeutics has a beta of -1.24, meaning that its stock price is 224% less volatile than the broader market. Comparatively, Denali Therapeutics has a beta of 1.01, meaning that its stock price is 1% more volatile than the broader market.

Summary

Denali Therapeutics beats Summit Therapeutics on 11 of the 15 factors compared between the two stocks.

How does Denali Therapeutics compare to BioMarin Pharmaceutical?

BioMarin Pharmaceutical (NASDAQ:BMRN) and Denali Therapeutics (NASDAQ:DNLI) are both healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their analyst recommendations, earnings, valuation, risk, institutional ownership, profitability, media sentiment and dividends.

98.7% of BioMarin Pharmaceutical shares are owned by institutional investors. Comparatively, 92.9% of Denali Therapeutics shares are owned by institutional investors. 0.7% of BioMarin Pharmaceutical shares are owned by insiders. Comparatively, 9.7% of Denali Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

BioMarin Pharmaceutical has a net margin of 2.14% compared to Denali Therapeutics' net margin of 0.00%. BioMarin Pharmaceutical's return on equity of 5.32% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
BioMarin Pharmaceutical2.14% 5.32% 3.69%
Denali Therapeutics N/A -55.27%-44.24%

In the previous week, BioMarin Pharmaceutical had 17 more articles in the media than Denali Therapeutics. MarketBeat recorded 19 mentions for BioMarin Pharmaceutical and 2 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 1.46 beat BioMarin Pharmaceutical's score of 0.77 indicating that Denali Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioMarin Pharmaceutical
8 Very Positive mention(s)
3 Positive mention(s)
5 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

BioMarin Pharmaceutical has a beta of 0.24, indicating that its stock price is 76% less volatile than the broader market. Comparatively, Denali Therapeutics has a beta of 1.01, indicating that its stock price is 1% more volatile than the broader market.

BioMarin Pharmaceutical has higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than BioMarin Pharmaceutical, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioMarin Pharmaceutical$3.22B3.95$348.90M$0.37177.51
Denali Therapeutics$330.53M10.20-$512.54M-$2.84N/A

BioMarin Pharmaceutical currently has a consensus target price of $89.17, indicating a potential upside of 35.77%. Denali Therapeutics has a consensus target price of $35.85, indicating a potential upside of 69.97%. Given Denali Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Denali Therapeutics is more favorable than BioMarin Pharmaceutical.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioMarin Pharmaceutical
1 Sell rating(s)
6 Hold rating(s)
14 Buy rating(s)
2 Strong Buy rating(s)
2.74
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75

Summary

BioMarin Pharmaceutical beats Denali Therapeutics on 11 of the 17 factors compared between the two stocks.

How does Denali Therapeutics compare to Halozyme Therapeutics?

Halozyme Therapeutics (NASDAQ:HALO) and Denali Therapeutics (NASDAQ:DNLI) are both healthcare companies, but which is the superior business? We will compare the two businesses based on the strength of their analyst recommendations, media sentiment, earnings, dividends, risk, institutional ownership, profitability and valuation.

97.8% of Halozyme Therapeutics shares are owned by institutional investors. Comparatively, 92.9% of Denali Therapeutics shares are owned by institutional investors. 2.5% of Halozyme Therapeutics shares are owned by insiders. Comparatively, 9.7% of Denali Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Halozyme Therapeutics has higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than Halozyme Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Halozyme Therapeutics$1.40B8.71$316.89M$3.3532.00
Denali Therapeutics$330.53M10.20-$512.54M-$2.84N/A

Halozyme Therapeutics presently has a consensus price target of $91.20, indicating a potential downside of 14.93%. Denali Therapeutics has a consensus price target of $35.85, indicating a potential upside of 69.97%. Given Denali Therapeutics' stronger consensus rating and higher probable upside, analysts plainly believe Denali Therapeutics is more favorable than Halozyme Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Halozyme Therapeutics
1 Sell rating(s)
3 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.62
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75

Halozyme Therapeutics has a net margin of 24.86% compared to Denali Therapeutics' net margin of 0.00%. Halozyme Therapeutics' return on equity of 260.98% beat Denali Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Halozyme Therapeutics24.86% 260.98% 23.91%
Denali Therapeutics N/A -55.27%-44.24%

In the previous week, Halozyme Therapeutics had 11 more articles in the media than Denali Therapeutics. MarketBeat recorded 13 mentions for Halozyme Therapeutics and 2 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 1.46 beat Halozyme Therapeutics' score of 1.20 indicating that Denali Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Halozyme Therapeutics
9 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Halozyme Therapeutics has a beta of 0.88, indicating that its stock price is 12% less volatile than the broader market. Comparatively, Denali Therapeutics has a beta of 1.01, indicating that its stock price is 1% more volatile than the broader market.

Summary

Halozyme Therapeutics beats Denali Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Denali Therapeutics compare to Madrigal Pharmaceuticals?

Denali Therapeutics (NASDAQ:DNLI) and Madrigal Pharmaceuticals (NASDAQ:MDGL) are both healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their dividends, risk, earnings, analyst recommendations, valuation, media sentiment, institutional ownership and profitability.

In the previous week, Madrigal Pharmaceuticals had 8 more articles in the media than Denali Therapeutics. MarketBeat recorded 10 mentions for Madrigal Pharmaceuticals and 2 mentions for Denali Therapeutics. Denali Therapeutics' average media sentiment score of 1.46 beat Madrigal Pharmaceuticals' score of 0.82 indicating that Denali Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Denali Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Madrigal Pharmaceuticals
6 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Denali Therapeutics presently has a consensus price target of $35.85, suggesting a potential upside of 69.97%. Madrigal Pharmaceuticals has a consensus price target of $699.64, suggesting a potential upside of 30.90%. Given Denali Therapeutics' higher probable upside, equities research analysts clearly believe Denali Therapeutics is more favorable than Madrigal Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics
1 Sell rating(s)
2 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.75
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78

Madrigal Pharmaceuticals has higher revenue and earnings than Denali Therapeutics. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Denali Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Denali Therapeutics$330.53M10.20-$512.54M-$2.84N/A
Madrigal Pharmaceuticals$958.40M12.88-$288.28M-$12.89N/A

Denali Therapeutics has a beta of 1.01, indicating that its share price is 1% more volatile than the broader market. Comparatively, Madrigal Pharmaceuticals has a beta of -0.98, indicating that its share price is 198% less volatile than the broader market.

92.9% of Denali Therapeutics shares are held by institutional investors. Comparatively, 98.5% of Madrigal Pharmaceuticals shares are held by institutional investors. 9.7% of Denali Therapeutics shares are held by insiders. Comparatively, 17.6% of Madrigal Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Denali Therapeutics has a net margin of 0.00% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Denali Therapeutics' return on equity of -55.27% beat Madrigal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Denali TherapeuticsN/A -55.27% -44.24%
Madrigal Pharmaceuticals -25.32%-56.65%-25.53%

Summary

Madrigal Pharmaceuticals beats Denali Therapeutics on 9 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding DNLI and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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DNLI vs. The Competition

MetricDenali TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$3.42B$3.85B$7.15B$12.72B
Dividend YieldN/A3.63%2.56%11.15%
P/E Ratio-7.4314.18274.9525.29
Price / Sales10.201,477.55656.5698.96
Price / CashN/A106.6877.0451.44
Price / Book3.0515.1210.336.20
Net Income-$512.54M-$22.86M$3.50B$358.50M
7 Day Performance-5.34%-4.34%-3.32%-2.35%
1 Month Performance-16.54%-0.02%-0.41%-2.77%
1 Year Performance48.63%40.64%19.21%7.63%

Denali Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
DNLI
Denali Therapeutics
3.7574 of 5 stars
$21.09
-1.4%
$35.85
+70.0%
+42.3%$3.42B$330.53MN/A507
BEAM
Beam Therapeutics
2.3477 of 5 stars
$29.66
flat
$49.00
+65.2%
+11.3%$3.06B$139.74MN/A510
SMMT
Summit Therapeutics
3.6748 of 5 stars
$17.60
flat
$24.07
+36.8%
-5.6%$14.04BN/AN/A110
BMRN
BioMarin Pharmaceutical
4.6226 of 5 stars
$66.53
flat
$89.17
+34.0%
+17.5%$12.88B$3.22B179.813,221
HALO
Halozyme Therapeutics
3.1798 of 5 stars
$110.19
flat
$91.20
-17.2%
+38.3%$12.51B$1.40B32.89390

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This page (NASDAQ:DNLI) was last updated on 9/12/2026 by MarketBeat.com Staff.
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