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Amylyx Pharmaceuticals (AMLX) Competitors

Amylyx Pharmaceuticals logo
$38.66 -1.00 (-2.52%)
As of 08/21/2026 04:00 PM Eastern

AMLX vs. IONS, CYTK, SYRE, PCVX, and IMVT

Should you buy Amylyx Pharmaceuticals stock or one of its competitors? Amylyx Pharmaceuticals's main competitors and comparable companies include Ionis Pharmaceuticals (IONS), Cytokinetics (CYTK), Spyre Therapeutics (SYRE), Vaxcyte (PCVX), and Immunovant (IMVT). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Amylyx Pharmaceuticals compare to Ionis Pharmaceuticals?

Amylyx Pharmaceuticals (NASDAQ:AMLX) and Ionis Pharmaceuticals (NASDAQ:IONS) are both mid-cap healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their dividends, valuation, risk, institutional ownership, analyst recommendations, media sentiment, earnings and profitability.

Amylyx Pharmaceuticals currently has a consensus target price of $36.25, indicating a potential downside of 6.23%. Ionis Pharmaceuticals has a consensus target price of $94.15, indicating a potential upside of 57.60%. Given Ionis Pharmaceuticals' higher possible upside, analysts plainly believe Ionis Pharmaceuticals is more favorable than Amylyx Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amylyx Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
8 Buy rating(s)
2 Strong Buy rating(s)
3.00
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73

Amylyx Pharmaceuticals has higher earnings, but lower revenue than Ionis Pharmaceuticals. Amylyx Pharmaceuticals is trading at a lower price-to-earnings ratio than Ionis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amylyx Pharmaceuticals$87.37M49.30-$144.74M-$1.43N/A
Ionis Pharmaceuticals$944M10.52-$381.39M-$3.46N/A

Amylyx Pharmaceuticals has a net margin of 0.00% compared to Ionis Pharmaceuticals' net margin of -64.76%. Amylyx Pharmaceuticals' return on equity of -52.92% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Amylyx PharmaceuticalsN/A -52.92% -48.53%
Ionis Pharmaceuticals -64.76%-111.08%-17.41%

95.8% of Amylyx Pharmaceuticals shares are held by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are held by institutional investors. 10.9% of Amylyx Pharmaceuticals shares are held by company insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

In the previous week, Amylyx Pharmaceuticals had 24 more articles in the media than Ionis Pharmaceuticals. MarketBeat recorded 42 mentions for Amylyx Pharmaceuticals and 18 mentions for Ionis Pharmaceuticals. Ionis Pharmaceuticals' average media sentiment score of 1.08 beat Amylyx Pharmaceuticals' score of 0.71 indicating that Ionis Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amylyx Pharmaceuticals
14 Very Positive mention(s)
7 Positive mention(s)
12 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Ionis Pharmaceuticals
9 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Amylyx Pharmaceuticals has a beta of -0.21, indicating that its stock price is 121% less volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.41, indicating that its stock price is 59% less volatile than the broader market.

Summary

Amylyx Pharmaceuticals beats Ionis Pharmaceuticals on 10 of the 17 factors compared between the two stocks.

How does Amylyx Pharmaceuticals compare to Cytokinetics?

Amylyx Pharmaceuticals (NASDAQ:AMLX) and Cytokinetics (NASDAQ:CYTK) are both mid-cap healthcare companies, but which is the better investment? We will compare the two companies based on the strength of their institutional ownership, earnings, media sentiment, valuation, dividends, profitability, risk and analyst recommendations.

95.8% of Amylyx Pharmaceuticals shares are held by institutional investors. 10.9% of Amylyx Pharmaceuticals shares are held by company insiders. Comparatively, 2.6% of Cytokinetics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Amylyx Pharmaceuticals has a net margin of 0.00% compared to Cytokinetics' net margin of -1,321.12%. Cytokinetics' return on equity of 0.00% beat Amylyx Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Amylyx PharmaceuticalsN/A -52.92% -48.53%
Cytokinetics -1,321.12%N/A -51.01%

Amylyx Pharmaceuticals currently has a consensus target price of $36.25, suggesting a potential downside of 6.23%. Cytokinetics has a consensus target price of $102.20, suggesting a potential upside of 33.00%. Given Cytokinetics' higher probable upside, analysts plainly believe Cytokinetics is more favorable than Amylyx Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amylyx Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
8 Buy rating(s)
2 Strong Buy rating(s)
3.00
Cytokinetics
1 Sell rating(s)
1 Hold rating(s)
19 Buy rating(s)
0 Strong Buy rating(s)
2.86

Amylyx Pharmaceuticals has a beta of -0.21, indicating that its share price is 121% less volatile than the broader market. Comparatively, Cytokinetics has a beta of 0.38, indicating that its share price is 62% less volatile than the broader market.

Amylyx Pharmaceuticals has higher earnings, but lower revenue than Cytokinetics. Amylyx Pharmaceuticals is trading at a lower price-to-earnings ratio than Cytokinetics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amylyx Pharmaceuticals$87.37M49.30-$144.74M-$1.43N/A
Cytokinetics$88.04M108.60-$784.96M-$7.22N/A

In the previous week, Amylyx Pharmaceuticals had 34 more articles in the media than Cytokinetics. MarketBeat recorded 42 mentions for Amylyx Pharmaceuticals and 8 mentions for Cytokinetics. Amylyx Pharmaceuticals' average media sentiment score of 0.71 beat Cytokinetics' score of 0.65 indicating that Amylyx Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amylyx Pharmaceuticals
14 Very Positive mention(s)
7 Positive mention(s)
12 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Cytokinetics
4 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Amylyx Pharmaceuticals beats Cytokinetics on 10 of the 17 factors compared between the two stocks.

How does Amylyx Pharmaceuticals compare to Spyre Therapeutics?

Spyre Therapeutics (NASDAQ:SYRE) and Amylyx Pharmaceuticals (NASDAQ:AMLX) are both mid-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their dividends, institutional ownership, valuation, media sentiment, earnings, analyst recommendations, profitability and risk.

Spyre Therapeutics has a beta of 3.03, meaning that its stock price is 203% more volatile than the broader market. Comparatively, Amylyx Pharmaceuticals has a beta of -0.21, meaning that its stock price is 121% less volatile than the broader market.

Amylyx Pharmaceuticals has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Amylyx Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre Therapeutics$890K10,522.17-$155.20M-$1.95N/A
Amylyx Pharmaceuticals$87.37M49.30-$144.74M-$1.43N/A

In the previous week, Amylyx Pharmaceuticals had 37 more articles in the media than Spyre Therapeutics. MarketBeat recorded 42 mentions for Amylyx Pharmaceuticals and 5 mentions for Spyre Therapeutics. Amylyx Pharmaceuticals' average media sentiment score of 0.71 beat Spyre Therapeutics' score of 0.43 indicating that Amylyx Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Amylyx Pharmaceuticals
14 Very Positive mention(s)
7 Positive mention(s)
12 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

80.4% of Spyre Therapeutics shares are held by institutional investors. Comparatively, 95.8% of Amylyx Pharmaceuticals shares are held by institutional investors. 15.7% of Spyre Therapeutics shares are held by insiders. Comparatively, 10.9% of Amylyx Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Spyre Therapeutics' return on equity of -30.74% beat Amylyx Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -30.74% -22.23%
Amylyx Pharmaceuticals N/A -52.92%-48.53%

Spyre Therapeutics presently has a consensus price target of $111.69, indicating a potential upside of 4.89%. Amylyx Pharmaceuticals has a consensus price target of $36.25, indicating a potential downside of 6.23%. Given Spyre Therapeutics' higher possible upside, analysts clearly believe Spyre Therapeutics is more favorable than Amylyx Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87
Amylyx Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
8 Buy rating(s)
2 Strong Buy rating(s)
3.00

Summary

Amylyx Pharmaceuticals beats Spyre Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Amylyx Pharmaceuticals compare to Vaxcyte?

Vaxcyte (NASDAQ:PCVX) and Amylyx Pharmaceuticals (NASDAQ:AMLX) are both mid-cap healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their institutional ownership, analyst recommendations, earnings, valuation, profitability, risk, dividends and media sentiment.

96.8% of Vaxcyte shares are held by institutional investors. Comparatively, 95.8% of Amylyx Pharmaceuticals shares are held by institutional investors. 3.3% of Vaxcyte shares are held by insiders. Comparatively, 10.9% of Amylyx Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Vaxcyte has a beta of 1.23, meaning that its stock price is 23% more volatile than the broader market. Comparatively, Amylyx Pharmaceuticals has a beta of -0.21, meaning that its stock price is 121% less volatile than the broader market.

In the previous week, Amylyx Pharmaceuticals had 38 more articles in the media than Vaxcyte. MarketBeat recorded 42 mentions for Amylyx Pharmaceuticals and 4 mentions for Vaxcyte. Vaxcyte's average media sentiment score of 1.07 beat Amylyx Pharmaceuticals' score of 0.71 indicating that Vaxcyte is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vaxcyte
2 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Amylyx Pharmaceuticals
14 Very Positive mention(s)
7 Positive mention(s)
12 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Vaxcyte currently has a consensus target price of $86.00, indicating a potential upside of 37.34%. Amylyx Pharmaceuticals has a consensus target price of $36.25, indicating a potential downside of 6.23%. Given Vaxcyte's higher probable upside, equities analysts plainly believe Vaxcyte is more favorable than Amylyx Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vaxcyte
1 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.50
Amylyx Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
8 Buy rating(s)
2 Strong Buy rating(s)
3.00

Vaxcyte's return on equity of -37.56% beat Amylyx Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
VaxcyteN/A -37.56% -33.62%
Amylyx Pharmaceuticals N/A -52.92%-48.53%

Amylyx Pharmaceuticals has higher revenue and earnings than Vaxcyte. Amylyx Pharmaceuticals is trading at a lower price-to-earnings ratio than Vaxcyte, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
VaxcyteN/AN/A-$766.63M-$7.63N/A
Amylyx Pharmaceuticals$87.37M49.30-$144.74M-$1.43N/A

Summary

Amylyx Pharmaceuticals beats Vaxcyte on 8 of the 15 factors compared between the two stocks.

How does Amylyx Pharmaceuticals compare to Immunovant?

Immunovant (NASDAQ:IMVT) and Amylyx Pharmaceuticals (NASDAQ:AMLX) are both mid-cap healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their earnings, profitability, media sentiment, analyst recommendations, institutional ownership, risk, valuation and dividends.

Amylyx Pharmaceuticals' return on equity of -52.92% beat Immunovant's return on equity.

Company Net Margins Return on Equity Return on Assets
ImmunovantN/A -69.59% -62.49%
Amylyx Pharmaceuticals N/A -52.92%-48.53%

Amylyx Pharmaceuticals has higher revenue and earnings than Immunovant. Amylyx Pharmaceuticals is trading at a lower price-to-earnings ratio than Immunovant, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
ImmunovantN/AN/A-$505.61M-$2.82N/A
Amylyx Pharmaceuticals$87.37M49.30-$144.74M-$1.43N/A

In the previous week, Amylyx Pharmaceuticals had 34 more articles in the media than Immunovant. MarketBeat recorded 42 mentions for Amylyx Pharmaceuticals and 8 mentions for Immunovant. Immunovant's average media sentiment score of 0.97 beat Amylyx Pharmaceuticals' score of 0.71 indicating that Immunovant is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Immunovant
4 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Amylyx Pharmaceuticals
14 Very Positive mention(s)
7 Positive mention(s)
12 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

47.1% of Immunovant shares are held by institutional investors. Comparatively, 95.8% of Amylyx Pharmaceuticals shares are held by institutional investors. 1.9% of Immunovant shares are held by insiders. Comparatively, 10.9% of Amylyx Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Immunovant has a beta of 0.77, indicating that its share price is 23% less volatile than the broader market. Comparatively, Amylyx Pharmaceuticals has a beta of -0.21, indicating that its share price is 121% less volatile than the broader market.

Immunovant currently has a consensus price target of $44.00, indicating a potential downside of 0.83%. Amylyx Pharmaceuticals has a consensus price target of $36.25, indicating a potential downside of 6.23%. Given Immunovant's higher probable upside, equities analysts plainly believe Immunovant is more favorable than Amylyx Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Immunovant
1 Sell rating(s)
3 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.50
Amylyx Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
8 Buy rating(s)
2 Strong Buy rating(s)
3.00

Summary

Amylyx Pharmaceuticals beats Immunovant on 11 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding AMLX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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AMLX vs. The Competition

MetricAmylyx PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$4.31B$4.01B$7.37B$12.85B
Dividend YieldN/A3.64%2.53%11.08%
P/E Ratio-27.0311.62272.6024.25
Price / Sales49.301,338.15618.9699.05
Price / CashN/A105.1478.6253.99
Price / Book17.9816.8013.056.20
Net Income-$144.74M-$12.50M$3.47B$348.59M
7 Day Performance78.73%3.29%2.09%0.08%
1 Month Performance119.78%8.23%6.64%3.88%
1 Year Performance315.70%55.05%25.02%16.98%

Amylyx Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
AMLX
Amylyx Pharmaceuticals
1.7938 of 5 stars
$38.66
-2.5%
$36.25
-6.2%
+315.7%$4.31B$87.37MN/A200
IONS
Ionis Pharmaceuticals
3.5655 of 5 stars
$58.63
+2.4%
$94.65
+61.4%
+39.9%$9.51B$944MN/A1,402
CYTK
Cytokinetics
3.3778 of 5 stars
$75.87
+2.3%
$102.20
+34.7%
+100.4%$9.22B$88.04MN/A250
SYRE
Spyre Therapeutics
1.4993 of 5 stars
$104.60
+0.9%
$111.69
+6.8%
+512.7%$9.11B$890KN/A73
PCVX
Vaxcyte
1.9709 of 5 stars
$60.22
+3.7%
$86.00
+42.8%
+93.9%$8.64BN/AN/A160

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This page (NASDAQ:AMLX) was last updated on 8/23/2026 by MarketBeat.com Staff.
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