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Amylyx Pharmaceuticals (AMLX) Competitors

Amylyx Pharmaceuticals logo
$14.58 +0.14 (+0.97%)
Closing price 05/13/2026 04:00 PM Eastern
Extended Trading
$14.34 -0.24 (-1.64%)
As of 06:14 AM Eastern
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AMLX vs. MIRM, SYRE, RYTM, PTGX, and BLTE

Should you buy Amylyx Pharmaceuticals stock or one of its competitors? MarketBeat compares Amylyx Pharmaceuticals with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Amylyx Pharmaceuticals include Mirum Pharmaceuticals (MIRM), Spyre Therapeutics (SYRE), Rhythm Pharmaceuticals (RYTM), Protagonist Therapeutics (PTGX), and Belite Bio (BLTE). These companies are all part of the "pharmaceutical products" industry.

How does Amylyx Pharmaceuticals compare to Mirum Pharmaceuticals?

Amylyx Pharmaceuticals (NASDAQ:AMLX) and Mirum Pharmaceuticals (NASDAQ:MIRM) are both medical companies, but which is the superior business? We will compare the two businesses based on the strength of their earnings, dividends, risk, institutional ownership, profitability, analyst recommendations, valuation and media sentiment.

In the previous week, Mirum Pharmaceuticals had 9 more articles in the media than Amylyx Pharmaceuticals. MarketBeat recorded 25 mentions for Mirum Pharmaceuticals and 16 mentions for Amylyx Pharmaceuticals. Mirum Pharmaceuticals' average media sentiment score of 0.36 beat Amylyx Pharmaceuticals' score of -0.06 indicating that Mirum Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amylyx Pharmaceuticals
0 Very Positive mention(s)
3 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Mirum Pharmaceuticals
6 Very Positive mention(s)
2 Positive mention(s)
4 Neutral mention(s)
2 Negative mention(s)
0 Very Negative mention(s)
Neutral

Amylyx Pharmaceuticals presently has a consensus target price of $23.00, indicating a potential upside of 57.75%. Mirum Pharmaceuticals has a consensus target price of $136.42, indicating a potential upside of 24.97%. Given Amylyx Pharmaceuticals' higher probable upside, equities analysts plainly believe Amylyx Pharmaceuticals is more favorable than Mirum Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amylyx Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.77
Mirum Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.93

Amylyx Pharmaceuticals has a beta of -0.11, indicating that its stock price is 111% less volatile than the broader market. Comparatively, Mirum Pharmaceuticals has a beta of 0.52, indicating that its stock price is 48% less volatile than the broader market.

95.8% of Amylyx Pharmaceuticals shares are owned by institutional investors. 12.3% of Amylyx Pharmaceuticals shares are owned by company insiders. Comparatively, 14.4% of Mirum Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Amylyx Pharmaceuticals has a net margin of 0.00% compared to Mirum Pharmaceuticals' net margin of -140.24%. Mirum Pharmaceuticals' return on equity of -11.28% beat Amylyx Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Amylyx PharmaceuticalsN/A -55.69% -50.73%
Mirum Pharmaceuticals -140.24%-11.28%-3.84%

Mirum Pharmaceuticals has higher revenue and earnings than Amylyx Pharmaceuticals. Amylyx Pharmaceuticals is trading at a lower price-to-earnings ratio than Mirum Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amylyx Pharmaceuticals$87.37M18.55-$144.74M-$1.50N/A
Mirum Pharmaceuticals$521.31M12.77-$23.36M-$13.61N/A

Summary

Mirum Pharmaceuticals beats Amylyx Pharmaceuticals on 11 of the 16 factors compared between the two stocks.

How does Amylyx Pharmaceuticals compare to Spyre Therapeutics?

Amylyx Pharmaceuticals (NASDAQ:AMLX) and Spyre Therapeutics (NASDAQ:SYRE) are both medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their risk, earnings, institutional ownership, profitability, dividends, analyst recommendations, media sentiment and valuation.

Amylyx Pharmaceuticals has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Amylyx Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amylyx Pharmaceuticals$87.37M18.55-$144.74M-$1.50N/A
Spyre Therapeutics$890K7,445.80-$155.20M-$2.08N/A

In the previous week, Amylyx Pharmaceuticals had 6 more articles in the media than Spyre Therapeutics. MarketBeat recorded 16 mentions for Amylyx Pharmaceuticals and 10 mentions for Spyre Therapeutics. Spyre Therapeutics' average media sentiment score of 0.89 beat Amylyx Pharmaceuticals' score of -0.06 indicating that Spyre Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amylyx Pharmaceuticals
0 Very Positive mention(s)
3 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Spyre Therapeutics
6 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Amylyx Pharmaceuticals has a beta of -0.11, indicating that its share price is 111% less volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.12, indicating that its share price is 212% more volatile than the broader market.

Amylyx Pharmaceuticals presently has a consensus target price of $23.00, indicating a potential upside of 57.75%. Spyre Therapeutics has a consensus target price of $90.25, indicating a potential upside of 18.27%. Given Amylyx Pharmaceuticals' higher possible upside, equities research analysts plainly believe Amylyx Pharmaceuticals is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amylyx Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.77
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00

Spyre Therapeutics' return on equity of -42.88% beat Amylyx Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Amylyx PharmaceuticalsN/A -55.69% -50.73%
Spyre Therapeutics N/A -42.88%-27.76%

95.8% of Amylyx Pharmaceuticals shares are owned by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are owned by institutional investors. 12.3% of Amylyx Pharmaceuticals shares are owned by insiders. Comparatively, 15.7% of Spyre Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Summary

Spyre Therapeutics beats Amylyx Pharmaceuticals on 9 of the 16 factors compared between the two stocks.

How does Amylyx Pharmaceuticals compare to Rhythm Pharmaceuticals?

Amylyx Pharmaceuticals (NASDAQ:AMLX) and Rhythm Pharmaceuticals (NASDAQ:RYTM) are both medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their risk, earnings, institutional ownership, profitability, dividends, analyst recommendations, media sentiment and valuation.

Amylyx Pharmaceuticals has higher earnings, but lower revenue than Rhythm Pharmaceuticals. Rhythm Pharmaceuticals is trading at a lower price-to-earnings ratio than Amylyx Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amylyx Pharmaceuticals$87.37M18.55-$144.74M-$1.50N/A
Rhythm Pharmaceuticals$189.76M33.85-$196.54M-$3.13N/A

In the previous week, Rhythm Pharmaceuticals had 3 more articles in the media than Amylyx Pharmaceuticals. MarketBeat recorded 19 mentions for Rhythm Pharmaceuticals and 16 mentions for Amylyx Pharmaceuticals. Amylyx Pharmaceuticals' average media sentiment score of -0.06 beat Rhythm Pharmaceuticals' score of -0.18 indicating that Amylyx Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amylyx Pharmaceuticals
0 Very Positive mention(s)
3 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Rhythm Pharmaceuticals
1 Very Positive mention(s)
1 Positive mention(s)
7 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Amylyx Pharmaceuticals has a beta of -0.11, indicating that its share price is 111% less volatile than the broader market. Comparatively, Rhythm Pharmaceuticals has a beta of 1.94, indicating that its share price is 94% more volatile than the broader market.

Amylyx Pharmaceuticals presently has a consensus target price of $23.00, indicating a potential upside of 57.75%. Rhythm Pharmaceuticals has a consensus target price of $131.81, indicating a potential upside of 40.65%. Given Amylyx Pharmaceuticals' higher possible upside, equities research analysts plainly believe Amylyx Pharmaceuticals is more favorable than Rhythm Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amylyx Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.77
Rhythm Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
1 Strong Buy rating(s)
2.84

Amylyx Pharmaceuticals has a net margin of 0.00% compared to Rhythm Pharmaceuticals' net margin of -93.33%. Amylyx Pharmaceuticals' return on equity of -55.69% beat Rhythm Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Amylyx PharmaceuticalsN/A -55.69% -50.73%
Rhythm Pharmaceuticals -93.33%-203.25%-44.99%

95.8% of Amylyx Pharmaceuticals shares are owned by institutional investors. 12.3% of Amylyx Pharmaceuticals shares are owned by insiders. Comparatively, 5.9% of Rhythm Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Summary

Amylyx Pharmaceuticals beats Rhythm Pharmaceuticals on 9 of the 16 factors compared between the two stocks.

How does Amylyx Pharmaceuticals compare to Protagonist Therapeutics?

Amylyx Pharmaceuticals (NASDAQ:AMLX) and Protagonist Therapeutics (NASDAQ:PTGX) are both medical companies, but which is the better business? We will contrast the two businesses based on the strength of their profitability, media sentiment, valuation, risk, earnings, dividends, analyst recommendations and institutional ownership.

Amylyx Pharmaceuticals has a net margin of 0.00% compared to Protagonist Therapeutics' net margin of -154.88%. Protagonist Therapeutics' return on equity of -17.76% beat Amylyx Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Amylyx PharmaceuticalsN/A -55.69% -50.73%
Protagonist Therapeutics -154.88%-17.76%-16.47%

95.8% of Amylyx Pharmaceuticals shares are held by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are held by institutional investors. 12.3% of Amylyx Pharmaceuticals shares are held by company insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Protagonist Therapeutics has lower revenue, but higher earnings than Amylyx Pharmaceuticals. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than Amylyx Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amylyx Pharmaceuticals$87.37M18.55-$144.74M-$1.50N/A
Protagonist Therapeutics$46.02M145.17-$130.15M-$1.81N/A

In the previous week, Amylyx Pharmaceuticals had 1 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 16 mentions for Amylyx Pharmaceuticals and 15 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 0.10 beat Amylyx Pharmaceuticals' score of -0.06 indicating that Protagonist Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amylyx Pharmaceuticals
0 Very Positive mention(s)
3 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Protagonist Therapeutics
6 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Amylyx Pharmaceuticals presently has a consensus price target of $23.00, suggesting a potential upside of 57.75%. Protagonist Therapeutics has a consensus price target of $113.69, suggesting a potential upside of 9.45%. Given Amylyx Pharmaceuticals' higher possible upside, research analysts plainly believe Amylyx Pharmaceuticals is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amylyx Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.77
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
0 Strong Buy rating(s)
2.80

Amylyx Pharmaceuticals has a beta of -0.11, suggesting that its share price is 111% less volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.89, suggesting that its share price is 89% more volatile than the broader market.

Summary

Protagonist Therapeutics beats Amylyx Pharmaceuticals on 9 of the 17 factors compared between the two stocks.

How does Amylyx Pharmaceuticals compare to Belite Bio?

Amylyx Pharmaceuticals (NASDAQ:AMLX) and Belite Bio (NASDAQ:BLTE) are both medical companies, but which is the superior investment? We will compare the two businesses based on the strength of their risk, earnings, profitability, dividends, analyst recommendations, valuation, media sentiment and institutional ownership.

95.8% of Amylyx Pharmaceuticals shares are owned by institutional investors. Comparatively, 0.5% of Belite Bio shares are owned by institutional investors. 12.3% of Amylyx Pharmaceuticals shares are owned by company insiders. Comparatively, 13.3% of Belite Bio shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

In the previous week, Amylyx Pharmaceuticals had 6 more articles in the media than Belite Bio. MarketBeat recorded 16 mentions for Amylyx Pharmaceuticals and 10 mentions for Belite Bio. Belite Bio's average media sentiment score of 0.71 beat Amylyx Pharmaceuticals' score of -0.06 indicating that Belite Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amylyx Pharmaceuticals
0 Very Positive mention(s)
3 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Belite Bio
4 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Belite Bio has lower revenue, but higher earnings than Amylyx Pharmaceuticals. Belite Bio is trading at a lower price-to-earnings ratio than Amylyx Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amylyx Pharmaceuticals$87.37M18.55-$144.74M-$1.50N/A
Belite BioN/AN/A-$77.61M-$2.30N/A

Amylyx Pharmaceuticals currently has a consensus price target of $23.00, indicating a potential upside of 57.75%. Belite Bio has a consensus price target of $202.33, indicating a potential upside of 31.80%. Given Amylyx Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Amylyx Pharmaceuticals is more favorable than Belite Bio.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amylyx Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.77
Belite Bio
1 Sell rating(s)
1 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.63

Amylyx Pharmaceuticals has a beta of -0.11, meaning that its stock price is 111% less volatile than the broader market. Comparatively, Belite Bio has a beta of -1.19, meaning that its stock price is 219% less volatile than the broader market.

Belite Bio's return on equity of -19.49% beat Amylyx Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Amylyx PharmaceuticalsN/A -55.69% -50.73%
Belite Bio N/A -19.49%-19.05%

Summary

Amylyx Pharmaceuticals beats Belite Bio on 10 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding AMLX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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AMLX vs. The Competition

MetricAmylyx PharmaceuticalsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$1.61B$3.04B$6.30B$12.20B
Dividend YieldN/A1.96%2.79%5.30%
P/E Ratio-9.7218.8621.0325.58
Price / Sales18.55289.31552.9878.84
Price / CashN/A56.5342.9455.34
Price / Book5.934.359.826.66
Net Income-$144.74M$72.19M$3.55B$333.63M
7 Day Performance-4.08%-1.05%-0.53%-0.11%
1 Month Performance-13.88%-0.02%1.20%3.94%
1 Year Performance235.17%46.31%41.23%36.07%

Amylyx Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
AMLX
Amylyx Pharmaceuticals
2.6461 of 5 stars
$14.58
+1.0%
$23.00
+57.8%
+224.7%$1.61B$87.37MN/A200
MIRM
Mirum Pharmaceuticals
2.5226 of 5 stars
$106.17
-0.9%
$136.42
+28.5%
+141.1%$6.53B$521.31MN/A140
SYRE
Spyre Therapeutics
2.4147 of 5 stars
$76.43
+1.9%
$89.08
+16.6%
+417.4%$6.52B$890KN/A73
RYTM
Rhythm Pharmaceuticals
2.4176 of 5 stars
$87.39
-7.2%
$131.81
+50.8%
+65.0%$6.45B$189.76MN/A140
PTGX
Protagonist Therapeutics
1.8044 of 5 stars
$103.50
+4.2%
$113.69
+9.8%
+134.7%$6.39B$46.02MN/A120

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This page (NASDAQ:AMLX) was last updated on 5/14/2026 by MarketBeat.com Staff.
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