Go Pro

Protagonist Therapeutics (PTGX) Competitors

Protagonist Therapeutics logo
$154.32 +3.63 (+2.41%)
As of 08/21/2026 04:00 PM Eastern

PTGX vs. BIIB, ALNY, INSM, ROIV, and MRNA

Should you buy Protagonist Therapeutics stock or one of its competitors? Protagonist Therapeutics's main competitors and comparable companies include Biogen (BIIB), Alnylam Pharmaceuticals (ALNY), Insmed (INSM), Roivant Sciences (ROIV), and Moderna (MRNA). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Protagonist Therapeutics compare to Biogen?

Protagonist Therapeutics (NASDAQ:PTGX) and Biogen (NASDAQ:BIIB) are both healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their media sentiment, institutional ownership, profitability, analyst recommendations, risk, dividends, earnings and valuation.

Biogen has higher revenue and earnings than Protagonist Therapeutics. Biogen is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$46.02M216.99-$130.15M$1.03149.83
Biogen$10.03B3.19$1.29B$5.6538.37

Protagonist Therapeutics has a beta of 1.78, meaning that its share price is 78% more volatile than the broader market. Comparatively, Biogen has a beta of 0.17, meaning that its share price is 83% less volatile than the broader market.

98.6% of Protagonist Therapeutics shares are owned by institutional investors. Comparatively, 87.9% of Biogen shares are owned by institutional investors. 5.2% of Protagonist Therapeutics shares are owned by insiders. Comparatively, 0.3% of Biogen shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Protagonist Therapeutics has a net margin of 29.40% compared to Biogen's net margin of 8.32%. Protagonist Therapeutics' return on equity of 12.03% beat Biogen's return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics29.40% 12.03% 11.23%
Biogen 8.32%11.18%6.88%

Protagonist Therapeutics currently has a consensus price target of $140.53, suggesting a potential downside of 8.93%. Biogen has a consensus price target of $227.07, suggesting a potential upside of 4.75%. Given Biogen's higher possible upside, analysts plainly believe Biogen is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
1 Strong Buy rating(s)
2.94
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58

In the previous week, Biogen had 19 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 28 mentions for Biogen and 9 mentions for Protagonist Therapeutics. Biogen's average media sentiment score of 1.33 beat Protagonist Therapeutics' score of 0.96 indicating that Biogen is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Protagonist Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Biogen
22 Very Positive mention(s)
3 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Protagonist Therapeutics beats Biogen on 9 of the 16 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Alnylam Pharmaceuticals?

Alnylam Pharmaceuticals (NASDAQ:ALNY) and Protagonist Therapeutics (NASDAQ:PTGX) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their earnings, risk, media sentiment, analyst recommendations, institutional ownership, dividends, valuation and profitability.

In the previous week, Alnylam Pharmaceuticals had 16 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 25 mentions for Alnylam Pharmaceuticals and 9 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 0.96 beat Alnylam Pharmaceuticals' score of 0.78 indicating that Protagonist Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alnylam Pharmaceuticals
11 Very Positive mention(s)
1 Positive mention(s)
10 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Protagonist Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Alnylam Pharmaceuticals has a beta of 0.3, indicating that its stock price is 70% less volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.78, indicating that its stock price is 78% more volatile than the broader market.

Alnylam Pharmaceuticals currently has a consensus price target of $386.62, suggesting a potential upside of 63.67%. Protagonist Therapeutics has a consensus price target of $140.53, suggesting a potential downside of 8.93%. Given Alnylam Pharmaceuticals' stronger consensus rating and higher possible upside, research analysts plainly believe Alnylam Pharmaceuticals is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
15 Buy rating(s)
4 Strong Buy rating(s)
2.96
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
1 Strong Buy rating(s)
2.94

Alnylam Pharmaceuticals has higher revenue and earnings than Protagonist Therapeutics. Alnylam Pharmaceuticals is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alnylam Pharmaceuticals$4.80B6.58$313.75M$5.3843.91
Protagonist Therapeutics$46.02M216.99-$130.15M$1.03149.83

93.0% of Alnylam Pharmaceuticals shares are held by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are held by institutional investors. 0.9% of Alnylam Pharmaceuticals shares are held by company insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Protagonist Therapeutics has a net margin of 29.40% compared to Alnylam Pharmaceuticals' net margin of 15.26%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Protagonist Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Alnylam Pharmaceuticals15.26% 84.93% 14.30%
Protagonist Therapeutics 29.40%12.03%11.23%

Summary

Alnylam Pharmaceuticals beats Protagonist Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Insmed?

Protagonist Therapeutics (NASDAQ:PTGX) and Insmed (NASDAQ:INSM) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their media sentiment, valuation, profitability, risk, institutional ownership, analyst recommendations, earnings and dividends.

Protagonist Therapeutics has a beta of 1.78, indicating that its stock price is 78% more volatile than the broader market. Comparatively, Insmed has a beta of 0.81, indicating that its stock price is 19% less volatile than the broader market.

Protagonist Therapeutics has higher earnings, but lower revenue than Insmed. Insmed is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$46.02M216.99-$130.15M$1.03149.83
Insmed$606.42M45.29-$1.28B-$4.11N/A

98.6% of Protagonist Therapeutics shares are owned by institutional investors. 5.2% of Protagonist Therapeutics shares are owned by insiders. Comparatively, 2.1% of Insmed shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Protagonist Therapeutics has a net margin of 29.40% compared to Insmed's net margin of -76.94%. Protagonist Therapeutics' return on equity of 12.03% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics29.40% 12.03% 11.23%
Insmed -76.94%-123.94%-44.30%

In the previous week, Protagonist Therapeutics had 9 more articles in the media than Insmed. MarketBeat recorded 9 mentions for Protagonist Therapeutics and 0 mentions for Insmed. Insmed's average media sentiment score of 1.44 beat Protagonist Therapeutics' score of 0.96 indicating that Insmed is being referred to more favorably in the news media.

Company Overall Sentiment
Protagonist Therapeutics Positive
Insmed Positive

Protagonist Therapeutics currently has a consensus price target of $140.53, suggesting a potential downside of 8.93%. Insmed has a consensus price target of $205.52, suggesting a potential upside of 63.41%. Given Insmed's stronger consensus rating and higher probable upside, analysts clearly believe Insmed is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
1 Strong Buy rating(s)
2.94
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00

Summary

Protagonist Therapeutics beats Insmed on 11 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Roivant Sciences?

Roivant Sciences (NASDAQ:ROIV) and Protagonist Therapeutics (NASDAQ:PTGX) are both healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their analyst recommendations, earnings, profitability, risk, dividends, media sentiment, institutional ownership and valuation.

Protagonist Therapeutics has a net margin of 29.40% compared to Roivant Sciences' net margin of -3,534.96%. Protagonist Therapeutics' return on equity of 12.03% beat Roivant Sciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Roivant Sciences-3,534.96% -22.94% -21.53%
Protagonist Therapeutics 29.40%12.03%11.23%

In the previous week, Roivant Sciences had 10 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 19 mentions for Roivant Sciences and 9 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 0.96 beat Roivant Sciences' score of 0.48 indicating that Protagonist Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Roivant Sciences
10 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Protagonist Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Protagonist Therapeutics has higher revenue and earnings than Roivant Sciences. Roivant Sciences is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Roivant Sciences$8.26M3,174.36-$299.77M-$0.53N/A
Protagonist Therapeutics$46.02M216.99-$130.15M$1.03149.83

64.8% of Roivant Sciences shares are owned by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are owned by institutional investors. 8.8% of Roivant Sciences shares are owned by insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.

Roivant Sciences has a beta of 1.12, meaning that its share price is 12% more volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.78, meaning that its share price is 78% more volatile than the broader market.

Roivant Sciences presently has a consensus price target of $35.14, indicating a potential downside of 3.21%. Protagonist Therapeutics has a consensus price target of $140.53, indicating a potential downside of 8.93%. Given Roivant Sciences' higher probable upside, equities research analysts plainly believe Roivant Sciences is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.83
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
1 Strong Buy rating(s)
2.94

Summary

Protagonist Therapeutics beats Roivant Sciences on 12 of the 16 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Moderna?

Protagonist Therapeutics (NASDAQ:PTGX) and Moderna (NASDAQ:MRNA) are both healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their institutional ownership, media sentiment, valuation, profitability, risk, dividends, earnings and analyst recommendations.

98.6% of Protagonist Therapeutics shares are owned by institutional investors. Comparatively, 75.3% of Moderna shares are owned by institutional investors. 5.2% of Protagonist Therapeutics shares are owned by insiders. Comparatively, 10.8% of Moderna shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Protagonist Therapeutics has a net margin of 29.40% compared to Moderna's net margin of -141.43%. Protagonist Therapeutics' return on equity of 12.03% beat Moderna's return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics29.40% 12.03% 11.23%
Moderna -141.43%-28.30%-19.39%

In the previous week, Moderna had 104 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 113 mentions for Moderna and 9 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 0.96 beat Moderna's score of 0.40 indicating that Protagonist Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Protagonist Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Moderna
46 Very Positive mention(s)
16 Positive mention(s)
14 Neutral mention(s)
18 Negative mention(s)
14 Very Negative mention(s)
Neutral

Protagonist Therapeutics has a beta of 1.78, suggesting that its share price is 78% more volatile than the broader market. Comparatively, Moderna has a beta of 0.91, suggesting that its share price is 9% less volatile than the broader market.

Protagonist Therapeutics presently has a consensus target price of $140.53, indicating a potential downside of 8.93%. Moderna has a consensus target price of $69.50, indicating a potential downside of 52.09%. Given Protagonist Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Protagonist Therapeutics is more favorable than Moderna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
1 Strong Buy rating(s)
2.94
Moderna
4 Sell rating(s)
11 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.00

Protagonist Therapeutics has higher earnings, but lower revenue than Moderna. Moderna is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$46.02M216.99-$130.15M$1.03149.83
Moderna$1.94B29.79-$2.82B-$7.99N/A

Summary

Protagonist Therapeutics beats Moderna on 14 of the 17 factors compared between the two stocks.

Get Protagonist Therapeutics News Delivered to You Automatically

Sign up to receive the latest news and ratings for PTGX and its competitors with MarketBeat's FREE daily newsletter.

Subscribe Now
SMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy.

New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PTGX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
Skip Chart

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
Skip Chart

PTGX vs. The Competition

MetricProtagonist TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$9.99B$4.01B$7.37B$12.85B
Dividend YieldN/A3.64%2.53%11.08%
P/E Ratio149.8311.62272.6024.25
Price / Sales216.991,334.62624.33101.47
Price / CashN/A105.1478.6253.99
Price / Book11.8616.8013.056.20
Net Income-$130.15M-$12.50M$3.47B$348.59M
7 Day Performance-0.50%3.29%2.09%0.08%
1 Month Performance13.95%8.23%6.64%3.88%
1 Year Performance168.48%55.05%25.02%16.98%

Protagonist Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PTGX
Protagonist Therapeutics
2.0026 of 5 stars
$154.32
+2.4%
$140.53
-8.9%
+168.5%$9.99B$46.02M149.83120
BIIB
Biogen
3.9575 of 5 stars
$209.83
-0.4%
$227.07
+8.2%
+55.6%$31.12B$9.89B37.147,500
ALNY
Alnylam Pharmaceuticals
4.9356 of 5 stars
$228.65
+0.7%
$393.86
+72.3%
-48.0%$30.39B$3.71B42.502,770
INSM
Insmed
3.4485 of 5 stars
$123.74
-2.1%
$205.52
+66.1%
-4.6%$27.59B$606.42MN/A1,664
ROIV
Roivant Sciences
1.5285 of 5 stars
$36.20
-0.2%
$35.14
-2.9%
+204.5%$26.10B$8.26MN/A860

Related Companies and Tools


This page (NASDAQ:PTGX) was last updated on 8/23/2026 by MarketBeat.com Staff.
From Our Partners