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Protagonist Therapeutics (PTGX) Competitors

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$148.18 +3.02 (+2.08%)
Closing price 09/11/2026 04:00 PM Eastern
Extended Trading
$151.44 +3.26 (+2.20%)
As of 09/11/2026 07:30 PM Eastern
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PTGX vs. ALNY, BIIB, INSM, BNTX, and INCY

Should you buy Protagonist Therapeutics stock or one of its competitors? Protagonist Therapeutics's main competitors and comparable companies include Alnylam Pharmaceuticals (ALNY), Biogen (BIIB), Insmed (INSM), BioNTech (BNTX), and Incyte (INCY). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Protagonist Therapeutics compare to Alnylam Pharmaceuticals?

Alnylam Pharmaceuticals (NASDAQ:ALNY) and Protagonist Therapeutics (NASDAQ:PTGX) are both healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their risk, institutional ownership, media sentiment, earnings, dividends, analyst recommendations, valuation and profitability.

Alnylam Pharmaceuticals has higher revenue and earnings than Protagonist Therapeutics. Alnylam Pharmaceuticals is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alnylam Pharmaceuticals$3.71B8.96$313.75M$5.3846.22
Protagonist Therapeutics$46.02M208.36-$130.15M$1.03143.86

Protagonist Therapeutics has a net margin of 29.40% compared to Alnylam Pharmaceuticals' net margin of 15.26%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Protagonist Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Alnylam Pharmaceuticals15.26% 84.93% 14.30%
Protagonist Therapeutics 29.40%12.03%11.23%

Alnylam Pharmaceuticals has a beta of 0.31, suggesting that its share price is 69% less volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.8, suggesting that its share price is 80% more volatile than the broader market.

Alnylam Pharmaceuticals currently has a consensus price target of $376.67, suggesting a potential upside of 51.47%. Protagonist Therapeutics has a consensus price target of $147.13, suggesting a potential downside of 0.71%. Given Alnylam Pharmaceuticals' higher probable upside, equities analysts plainly believe Alnylam Pharmaceuticals is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
17 Buy rating(s)
2 Strong Buy rating(s)
2.88
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
16 Buy rating(s)
0 Strong Buy rating(s)
2.89

In the previous week, Alnylam Pharmaceuticals had 2 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 14 mentions for Alnylam Pharmaceuticals and 12 mentions for Protagonist Therapeutics. Alnylam Pharmaceuticals' average media sentiment score of 1.12 beat Protagonist Therapeutics' score of 0.61 indicating that Alnylam Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alnylam Pharmaceuticals
8 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Protagonist Therapeutics
6 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

93.0% of Alnylam Pharmaceuticals shares are held by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are held by institutional investors. 0.9% of Alnylam Pharmaceuticals shares are held by insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock is poised for long-term growth.

Summary

Alnylam Pharmaceuticals beats Protagonist Therapeutics on 10 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Biogen?

Biogen (NASDAQ:BIIB) and Protagonist Therapeutics (NASDAQ:PTGX) are both healthcare companies, but which is the better business? We will contrast the two businesses based on the strength of their institutional ownership, valuation, dividends, media sentiment, earnings, analyst recommendations, profitability and risk.

In the previous week, Protagonist Therapeutics had 1 more articles in the media than Biogen. MarketBeat recorded 12 mentions for Protagonist Therapeutics and 11 mentions for Biogen. Biogen's average media sentiment score of 1.10 beat Protagonist Therapeutics' score of 0.61 indicating that Biogen is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Biogen
7 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Protagonist Therapeutics
6 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Biogen has a beta of 0.17, suggesting that its share price is 83% less volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.8, suggesting that its share price is 80% more volatile than the broader market.

Biogen has higher revenue and earnings than Protagonist Therapeutics. Biogen is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Biogen$9.89B3.24$1.29B$5.6538.43
Protagonist Therapeutics$46.02M208.36-$130.15M$1.03143.86

87.9% of Biogen shares are held by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are held by institutional investors. 0.3% of Biogen shares are held by company insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Biogen presently has a consensus target price of $230.14, suggesting a potential upside of 5.98%. Protagonist Therapeutics has a consensus target price of $147.13, suggesting a potential downside of 0.71%. Given Biogen's higher possible upside, equities research analysts plainly believe Biogen is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
16 Buy rating(s)
0 Strong Buy rating(s)
2.89

Protagonist Therapeutics has a net margin of 29.40% compared to Biogen's net margin of 8.32%. Protagonist Therapeutics' return on equity of 12.03% beat Biogen's return on equity.

Company Net Margins Return on Equity Return on Assets
Biogen8.32% 11.18% 6.88%
Protagonist Therapeutics 29.40%12.03%11.23%

Summary

Protagonist Therapeutics beats Biogen on 10 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Insmed?

Protagonist Therapeutics (NASDAQ:PTGX) and Insmed (NASDAQ:INSM) are both healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their risk, earnings, media sentiment, dividends, analyst recommendations, institutional ownership, valuation and profitability.

Protagonist Therapeutics has a beta of 1.8, suggesting that its share price is 80% more volatile than the broader market. Comparatively, Insmed has a beta of 0.82, suggesting that its share price is 18% less volatile than the broader market.

Protagonist Therapeutics has a net margin of 29.40% compared to Insmed's net margin of -76.94%. Protagonist Therapeutics' return on equity of 12.03% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics29.40% 12.03% 11.23%
Insmed -76.94%-123.94%-44.30%

In the previous week, Protagonist Therapeutics had 1 more articles in the media than Insmed. MarketBeat recorded 12 mentions for Protagonist Therapeutics and 11 mentions for Insmed. Insmed's average media sentiment score of 1.15 beat Protagonist Therapeutics' score of 0.61 indicating that Insmed is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Protagonist Therapeutics
6 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Insmed
8 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Protagonist Therapeutics has higher earnings, but lower revenue than Insmed. Insmed is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$46.02M208.36-$130.15M$1.03143.86
Insmed$1.14B24.84-$1.28B-$4.11N/A

98.6% of Protagonist Therapeutics shares are held by institutional investors. 5.2% of Protagonist Therapeutics shares are held by company insiders. Comparatively, 2.1% of Insmed shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

Protagonist Therapeutics presently has a consensus price target of $147.13, indicating a potential downside of 0.71%. Insmed has a consensus price target of $205.52, indicating a potential upside of 58.81%. Given Insmed's stronger consensus rating and higher possible upside, analysts clearly believe Insmed is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
16 Buy rating(s)
0 Strong Buy rating(s)
2.89
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00

Summary

Protagonist Therapeutics beats Insmed on 11 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to BioNTech?

Protagonist Therapeutics (NASDAQ:PTGX) and BioNTech (NASDAQ:BNTX) are both healthcare companies, but which is the better business? We will compare the two businesses based on the strength of their analyst recommendations, valuation, profitability, media sentiment, risk, dividends, earnings and institutional ownership.

Protagonist Therapeutics presently has a consensus target price of $147.13, indicating a potential downside of 0.71%. BioNTech has a consensus target price of $126.00, indicating a potential upside of 30.26%. Given BioNTech's higher probable upside, analysts clearly believe BioNTech is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
16 Buy rating(s)
0 Strong Buy rating(s)
2.89
BioNTech
1 Sell rating(s)
5 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.68

In the previous week, BioNTech had 9 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 21 mentions for BioNTech and 12 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 0.61 beat BioNTech's score of 0.44 indicating that Protagonist Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Protagonist Therapeutics
6 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
BioNTech
10 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

Protagonist Therapeutics has higher earnings, but lower revenue than BioNTech. BioNTech is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$46.02M208.36-$130.15M$1.03143.86
BioNTech$2.65B9.23-$1.29B-$7.83N/A

Protagonist Therapeutics has a beta of 1.8, indicating that its share price is 80% more volatile than the broader market. Comparatively, BioNTech has a beta of 1.29, indicating that its share price is 29% more volatile than the broader market.

Protagonist Therapeutics has a net margin of 29.40% compared to BioNTech's net margin of -63.54%. Protagonist Therapeutics' return on equity of 12.03% beat BioNTech's return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics29.40% 12.03% 11.23%
BioNTech -63.54%-6.86%-6.00%

98.6% of Protagonist Therapeutics shares are held by institutional investors. Comparatively, 15.5% of BioNTech shares are held by institutional investors. 5.2% of Protagonist Therapeutics shares are held by insiders. Comparatively, 19.2% of BioNTech shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Summary

Protagonist Therapeutics beats BioNTech on 12 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Incyte?

Incyte (NASDAQ:INCY) and Protagonist Therapeutics (NASDAQ:PTGX) are both healthcare companies, but which is the better investment? We will contrast the two businesses based on the strength of their analyst recommendations, earnings, risk, dividends, media sentiment, profitability, institutional ownership and valuation.

Incyte has higher revenue and earnings than Protagonist Therapeutics. Incyte is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Incyte$5.82B4.23$1.29B$7.8515.47
Protagonist Therapeutics$46.02M208.36-$130.15M$1.03143.86

Incyte currently has a consensus target price of $124.05, indicating a potential upside of 2.12%. Protagonist Therapeutics has a consensus target price of $147.13, indicating a potential downside of 0.71%. Given Incyte's higher probable upside, analysts plainly believe Incyte is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Incyte
0 Sell rating(s)
13 Hold rating(s)
11 Buy rating(s)
1 Strong Buy rating(s)
2.52
Protagonist Therapeutics
0 Sell rating(s)
2 Hold rating(s)
16 Buy rating(s)
0 Strong Buy rating(s)
2.89

Protagonist Therapeutics has a net margin of 29.40% compared to Incyte's net margin of 27.71%. Incyte's return on equity of 29.93% beat Protagonist Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Incyte27.71% 29.93% 22.88%
Protagonist Therapeutics 29.40%12.03%11.23%

97.0% of Incyte shares are owned by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are owned by institutional investors. 16.2% of Incyte shares are owned by company insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

In the previous week, Incyte had 7 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 19 mentions for Incyte and 12 mentions for Protagonist Therapeutics. Incyte's average media sentiment score of 0.98 beat Protagonist Therapeutics' score of 0.61 indicating that Incyte is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Incyte
9 Very Positive mention(s)
1 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Protagonist Therapeutics
6 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Incyte has a beta of 0.77, indicating that its stock price is 23% less volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.8, indicating that its stock price is 80% more volatile than the broader market.

Summary

Incyte beats Protagonist Therapeutics on 10 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PTGX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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PTGX vs. The Competition

MetricProtagonist TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$9.39B$3.86B$7.16B$12.73B
Dividend YieldN/A3.63%2.56%11.15%
P/E Ratio143.8714.18274.1025.29
Price / Sales208.361,482.03656.0099.06
Price / CashN/A106.6877.0451.44
Price / Book15.0715.1210.336.20
Net Income-$130.15M-$22.86M$3.50B$358.50M
7 Day Performance1.69%-4.35%-3.35%-2.35%
1 Month Performance-2.52%-0.04%-0.43%-2.77%
1 Year Performance151.75%40.63%19.21%7.63%

Protagonist Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PTGX
Protagonist Therapeutics
1.5511 of 5 stars
$148.18
+2.1%
$147.13
-0.7%
+148.3%$9.39B$46.02M143.87141
ALNY
Alnylam Pharmaceuticals
4.4566 of 5 stars
$266.11
+0.6%
$386.14
+45.1%
-46.9%$35.39B$3.71B49.462,770
BIIB
Biogen
3.2673 of 5 stars
$220.83
-1.6%
$228.50
+3.5%
+45.9%$33.17B$9.89B39.087,500
INSM
Insmed
3.4202 of 5 stars
$126.29
-0.3%
$205.52
+62.7%
-11.2%$27.66B$606.42MN/A1,664
BNTX
BioNTech
4.2591 of 5 stars
$103.76
+0.9%
$127.44
+22.8%
-7.3%$26.02B$3.25BN/A7,807

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This page (NASDAQ:PTGX) was last updated on 9/12/2026 by MarketBeat.com Staff.
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