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Protagonist Therapeutics (PTGX) Competitors

Protagonist Therapeutics logo
$136.64 0.00 (0.00%)
Closing price 07/31/2026 04:00 PM Eastern
Extended Trading
$136.73 +0.09 (+0.07%)
As of 07/31/2026 07:34 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

PTGX vs. BIIB, ALNY, INCY, ROIV, and BNTX

Should you buy Protagonist Therapeutics stock or one of its competitors? MarketBeat compares Protagonist Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Protagonist Therapeutics include Biogen (BIIB), Alnylam Pharmaceuticals (ALNY), Incyte (INCY), Roivant Sciences (ROIV), and BioNTech (BNTX). These companies are all part of the "biotechnology" industry.

How does Protagonist Therapeutics compare to Biogen?

Protagonist Therapeutics (NASDAQ:PTGX) and Biogen (NASDAQ:BIIB) are both healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their risk, institutional ownership, analyst recommendations, media sentiment, earnings, profitability, valuation and dividends.

98.6% of Protagonist Therapeutics shares are held by institutional investors. Comparatively, 87.9% of Biogen shares are held by institutional investors. 5.2% of Protagonist Therapeutics shares are held by company insiders. Comparatively, 0.3% of Biogen shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Protagonist Therapeutics presently has a consensus target price of $123.00, suggesting a potential downside of 9.98%. Biogen has a consensus target price of $223.36, suggesting a potential upside of 10.06%. Given Biogen's higher probable upside, analysts clearly believe Biogen is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94
Biogen
1 Sell rating(s)
13 Hold rating(s)
17 Buy rating(s)
1 Strong Buy rating(s)
2.56

Biogen has higher revenue and earnings than Protagonist Therapeutics. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than Biogen, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$74.06M118.65-$130.15M-$1.81N/A
Biogen$9.89B3.03$1.29B$5.6535.92

In the previous week, Biogen had 53 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 66 mentions for Biogen and 13 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 1.58 beat Biogen's score of 0.91 indicating that Protagonist Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Protagonist Therapeutics
12 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
Biogen
34 Very Positive mention(s)
5 Positive mention(s)
19 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Biogen has a net margin of 8.32% compared to Protagonist Therapeutics' net margin of -154.88%. Biogen's return on equity of 11.18% beat Protagonist Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics-154.88% -17.76% -16.47%
Biogen 8.32%11.18%6.88%

Protagonist Therapeutics has a beta of 1.79, suggesting that its stock price is 79% more volatile than the broader market. Comparatively, Biogen has a beta of 0.17, suggesting that its stock price is 83% less volatile than the broader market.

Summary

Biogen beats Protagonist Therapeutics on 10 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Alnylam Pharmaceuticals?

Alnylam Pharmaceuticals (NASDAQ:ALNY) and Protagonist Therapeutics (NASDAQ:PTGX) are both healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their media sentiment, earnings, institutional ownership, profitability, valuation, analyst recommendations, risk and dividends.

Alnylam Pharmaceuticals presently has a consensus target price of $410.72, suggesting a potential upside of 99.84%. Protagonist Therapeutics has a consensus target price of $123.00, suggesting a potential downside of 9.98%. Given Alnylam Pharmaceuticals' higher possible upside, equities analysts clearly believe Alnylam Pharmaceuticals is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alnylam Pharmaceuticals
0 Sell rating(s)
6 Hold rating(s)
16 Buy rating(s)
2 Strong Buy rating(s)
2.83
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94

Alnylam Pharmaceuticals has a beta of 0.3, indicating that its stock price is 70% less volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.79, indicating that its stock price is 79% more volatile than the broader market.

Alnylam Pharmaceuticals has a net margin of 15.26% compared to Protagonist Therapeutics' net margin of -154.88%. Alnylam Pharmaceuticals' return on equity of 104.81% beat Protagonist Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Alnylam Pharmaceuticals15.26% 104.81% 14.71%
Protagonist Therapeutics -154.88%-17.76%-16.47%

93.0% of Alnylam Pharmaceuticals shares are held by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are held by institutional investors. 0.9% of Alnylam Pharmaceuticals shares are held by company insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

In the previous week, Alnylam Pharmaceuticals had 37 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 50 mentions for Alnylam Pharmaceuticals and 13 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 1.58 beat Alnylam Pharmaceuticals' score of 0.06 indicating that Protagonist Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alnylam Pharmaceuticals
9 Very Positive mention(s)
3 Positive mention(s)
13 Neutral mention(s)
13 Negative mention(s)
2 Very Negative mention(s)
Neutral
Protagonist Therapeutics
12 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

Alnylam Pharmaceuticals has higher revenue and earnings than Protagonist Therapeutics. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alnylam Pharmaceuticals$3.71B7.40$313.75M$5.3838.20
Protagonist Therapeutics$74.06M118.65-$130.15M-$1.81N/A

Summary

Alnylam Pharmaceuticals beats Protagonist Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Incyte?

Incyte (NASDAQ:INCY) and Protagonist Therapeutics (NASDAQ:PTGX) are both healthcare companies, but which is the better business? We will compare the two businesses based on the strength of their institutional ownership, analyst recommendations, valuation, profitability, risk, dividends, media sentiment and earnings.

Incyte has a net margin of 27.71% compared to Protagonist Therapeutics' net margin of -154.88%. Incyte's return on equity of 29.93% beat Protagonist Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Incyte27.71% 29.93% 22.88%
Protagonist Therapeutics -154.88%-17.76%-16.47%

Incyte has a beta of 0.76, suggesting that its stock price is 24% less volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.79, suggesting that its stock price is 79% more volatile than the broader market.

In the previous week, Incyte had 32 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 45 mentions for Incyte and 13 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 1.58 beat Incyte's score of 0.76 indicating that Protagonist Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Incyte
20 Very Positive mention(s)
3 Positive mention(s)
14 Neutral mention(s)
4 Negative mention(s)
0 Very Negative mention(s)
Positive
Protagonist Therapeutics
12 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

97.0% of Incyte shares are owned by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are owned by institutional investors. 16.2% of Incyte shares are owned by insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Incyte has higher revenue and earnings than Protagonist Therapeutics. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than Incyte, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Incyte$5.82B4.16$1.29B$7.8515.23
Protagonist Therapeutics$74.06M118.65-$130.15M-$1.81N/A

Incyte currently has a consensus target price of $117.74, indicating a potential downside of 1.49%. Protagonist Therapeutics has a consensus target price of $123.00, indicating a potential downside of 9.98%. Given Incyte's higher probable upside, equities research analysts plainly believe Incyte is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Incyte
0 Sell rating(s)
14 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.36
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94

Summary

Incyte beats Protagonist Therapeutics on 10 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Roivant Sciences?

Protagonist Therapeutics (NASDAQ:PTGX) and Roivant Sciences (NASDAQ:ROIV) are both healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their earnings, valuation, analyst recommendations, media sentiment, risk, dividends, profitability and institutional ownership.

98.6% of Protagonist Therapeutics shares are held by institutional investors. Comparatively, 64.8% of Roivant Sciences shares are held by institutional investors. 5.2% of Protagonist Therapeutics shares are held by insiders. Comparatively, 8.8% of Roivant Sciences shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Protagonist Therapeutics has higher revenue and earnings than Roivant Sciences. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than Roivant Sciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$74.06M118.65-$130.15M-$1.81N/A
Roivant Sciences$8.26M2,952.84-$299.77M-$0.60N/A

Protagonist Therapeutics has a beta of 1.79, suggesting that its share price is 79% more volatile than the broader market. Comparatively, Roivant Sciences has a beta of 1.12, suggesting that its share price is 12% more volatile than the broader market.

Protagonist Therapeutics has a net margin of -154.88% compared to Roivant Sciences' net margin of -3,629.19%. Protagonist Therapeutics' return on equity of -17.76% beat Roivant Sciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics-154.88% -17.76% -16.47%
Roivant Sciences -3,629.19%-20.54%-19.43%

Protagonist Therapeutics currently has a consensus price target of $123.00, indicating a potential downside of 9.98%. Roivant Sciences has a consensus price target of $33.59, indicating a potential downside of 0.94%. Given Roivant Sciences' higher probable upside, analysts clearly believe Roivant Sciences is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75

In the previous week, Roivant Sciences had 4 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 17 mentions for Roivant Sciences and 13 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 1.58 beat Roivant Sciences' score of 1.16 indicating that Protagonist Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Protagonist Therapeutics
12 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
Roivant Sciences
14 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Protagonist Therapeutics beats Roivant Sciences on 11 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to BioNTech?

Protagonist Therapeutics (NASDAQ:PTGX) and BioNTech (NASDAQ:BNTX) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their media sentiment, institutional ownership, profitability, analyst recommendations, dividends, valuation, earnings and risk.

Protagonist Therapeutics presently has a consensus target price of $123.00, indicating a potential downside of 9.98%. BioNTech has a consensus target price of $129.13, indicating a potential upside of 42.55%. Given BioNTech's higher possible upside, analysts plainly believe BioNTech is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94
BioNTech
1 Sell rating(s)
4 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.74

In the previous week, Protagonist Therapeutics had 7 more articles in the media than BioNTech. MarketBeat recorded 13 mentions for Protagonist Therapeutics and 6 mentions for BioNTech. Protagonist Therapeutics' average media sentiment score of 1.58 beat BioNTech's score of 0.86 indicating that Protagonist Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Protagonist Therapeutics
12 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
BioNTech
2 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

98.6% of Protagonist Therapeutics shares are owned by institutional investors. Comparatively, 15.5% of BioNTech shares are owned by institutional investors. 5.2% of Protagonist Therapeutics shares are owned by insiders. Comparatively, 19.2% of BioNTech shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Protagonist Therapeutics has higher earnings, but lower revenue than BioNTech. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than BioNTech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$74.06M118.65-$130.15M-$1.81N/A
BioNTech$3.25B7.06-$1.29B-$5.88N/A

Protagonist Therapeutics has a beta of 1.79, meaning that its stock price is 79% more volatile than the broader market. Comparatively, BioNTech has a beta of 1.27, meaning that its stock price is 27% more volatile than the broader market.

BioNTech has a net margin of -44.39% compared to Protagonist Therapeutics' net margin of -154.88%. BioNTech's return on equity of -5.30% beat Protagonist Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics-154.88% -17.76% -16.47%
BioNTech -44.39%-5.30%-4.62%

Summary

Protagonist Therapeutics beats BioNTech on 9 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PTGX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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PTGX vs. The Competition

MetricProtagonist TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$8.79B$3.54B$6.86B$12.42B
Dividend YieldN/A3.78%2.59%10.03%
P/E Ratio-75.497.38282.2724.66
Price / Sales118.651,250.98581.5286.64
Price / CashN/A44.8028.6046.71
Price / Book13.9016.7810.936.07
Net Income-$130.15M-$12.56M$3.49B$347.99M
7 Day Performance0.80%-1.82%-0.64%-0.42%
1 Month Performance3.81%-8.45%-3.78%-4.80%
1 Year Performance153.84%48.33%61.99%18.61%

Protagonist Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PTGX
Protagonist Therapeutics
1.5455 of 5 stars
$136.64
flat
$123.00
-10.0%
+153.8%$8.79B$74.06MN/A120
BIIB
Biogen
3.9504 of 5 stars
$202.95
-2.4%
$223.36
+10.1%
+53.8%$30.72B$9.89B35.927,500
ALNY
Alnylam Pharmaceuticals
4.791 of 5 stars
$205.52
+0.0%
$410.72
+99.8%
-48.9%$27.43B$3.71B38.202,770
INCY
Incyte
2.8563 of 5 stars
$119.52
-2.8%
$117.74
-1.5%
+58.1%$24.93B$5.14B15.232,844
ROIV
Roivant Sciences
1.5764 of 5 stars
$33.91
-1.8%
$33.59
-0.9%
+199.8%$24.83B$8.26MN/A860

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This page (NASDAQ:PTGX) was last updated on 8/3/2026 by MarketBeat.com Staff.
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