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Protagonist Therapeutics (PTGX) Competitors

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$129.89 -1.53 (-1.16%)
Closing price 07/13/2026 04:00 PM Eastern
Extended Trading
$129.88 -0.01 (-0.01%)
As of 07/13/2026 07:32 PM Eastern
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PTGX vs. ONC, MRNA, ROIV, INSM, and BNTX

Should you buy Protagonist Therapeutics stock or one of its competitors? MarketBeat compares Protagonist Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Protagonist Therapeutics include BeOne Medicines (ONC), Moderna (MRNA), Roivant Sciences (ROIV), Insmed (INSM), and BioNTech (BNTX). These companies are all part of the "pharmaceutical products" industry.

How does Protagonist Therapeutics compare to BeOne Medicines?

Protagonist Therapeutics (NASDAQ:PTGX) and BeOne Medicines (NASDAQ:ONC) are both medical companies, but which is the better business? We will contrast the two companies based on the strength of their institutional ownership, earnings, media sentiment, valuation, profitability, dividends, risk and analyst recommendations.

Protagonist Therapeutics has a beta of 1.79, meaning that its share price is 79% more volatile than the broader market. Comparatively, BeOne Medicines has a beta of 0.49, meaning that its share price is 51% less volatile than the broader market.

98.6% of Protagonist Therapeutics shares are held by institutional investors. Comparatively, 48.6% of BeOne Medicines shares are held by institutional investors. 5.2% of Protagonist Therapeutics shares are held by company insiders. Comparatively, 6.2% of BeOne Medicines shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

BeOne Medicines has higher revenue and earnings than Protagonist Therapeutics. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than BeOne Medicines, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$46.02M181.51-$130.15M-$1.81N/A
BeOne Medicines$5.34B6.24$286.93M$4.4768.00

Protagonist Therapeutics currently has a consensus price target of $116.93, indicating a potential downside of 9.98%. BeOne Medicines has a consensus price target of $391.38, indicating a potential upside of 28.76%. Given BeOne Medicines' higher possible upside, analysts plainly believe BeOne Medicines is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94
BeOne Medicines
1 Sell rating(s)
2 Hold rating(s)
11 Buy rating(s)
1 Strong Buy rating(s)
2.80

In the previous week, Protagonist Therapeutics had 2 more articles in the media than BeOne Medicines. MarketBeat recorded 10 mentions for Protagonist Therapeutics and 8 mentions for BeOne Medicines. BeOne Medicines' average media sentiment score of 0.77 beat Protagonist Therapeutics' score of 0.67 indicating that BeOne Medicines is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Protagonist Therapeutics
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
BeOne Medicines
3 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

BeOne Medicines has a net margin of 8.94% compared to Protagonist Therapeutics' net margin of -154.88%. BeOne Medicines' return on equity of 12.06% beat Protagonist Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics-154.88% -17.76% -16.47%
BeOne Medicines 8.94%12.06%6.69%

Summary

BeOne Medicines beats Protagonist Therapeutics on 10 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Moderna?

Moderna (NASDAQ:MRNA) and Protagonist Therapeutics (NASDAQ:PTGX) are both medical companies, but which is the superior stock? We will compare the two businesses based on the strength of their analyst recommendations, institutional ownership, dividends, profitability, media sentiment, valuation, risk and earnings.

Protagonist Therapeutics has lower revenue, but higher earnings than Moderna. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than Moderna, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Moderna$1.94B13.68-$2.82B-$8.15N/A
Protagonist Therapeutics$46.02M181.51-$130.15M-$1.81N/A

Moderna has a net margin of -143.55% compared to Protagonist Therapeutics' net margin of -154.88%. Protagonist Therapeutics' return on equity of -17.76% beat Moderna's return on equity.

Company Net Margins Return on Equity Return on Assets
Moderna-143.55% -26.64% -19.32%
Protagonist Therapeutics -154.88%-17.76%-16.47%

Moderna currently has a consensus target price of $38.27, suggesting a potential downside of 42.89%. Protagonist Therapeutics has a consensus target price of $116.93, suggesting a potential downside of 9.98%. Given Protagonist Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Protagonist Therapeutics is more favorable than Moderna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Moderna
5 Sell rating(s)
10 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
1.82
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94

Moderna has a beta of 0.94, meaning that its stock price is 6% less volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.79, meaning that its stock price is 79% more volatile than the broader market.

75.3% of Moderna shares are held by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are held by institutional investors. 10.8% of Moderna shares are held by company insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

In the previous week, Moderna had 14 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 24 mentions for Moderna and 10 mentions for Protagonist Therapeutics. Moderna's average media sentiment score of 0.82 beat Protagonist Therapeutics' score of 0.67 indicating that Moderna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Moderna
11 Very Positive mention(s)
6 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Protagonist Therapeutics
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Protagonist Therapeutics beats Moderna on 11 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Roivant Sciences?

Protagonist Therapeutics (NASDAQ:PTGX) and Roivant Sciences (NASDAQ:ROIV) are both medical companies, but which is the superior stock? We will compare the two businesses based on the strength of their dividends, valuation, profitability, earnings, institutional ownership, analyst recommendations, risk and media sentiment.

Protagonist Therapeutics presently has a consensus price target of $116.93, indicating a potential downside of 9.98%. Roivant Sciences has a consensus price target of $33.59, indicating a potential downside of 2.66%. Given Roivant Sciences' higher possible upside, analysts plainly believe Roivant Sciences is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75

Protagonist Therapeutics has a beta of 1.79, suggesting that its share price is 79% more volatile than the broader market. Comparatively, Roivant Sciences has a beta of 1.11, suggesting that its share price is 11% more volatile than the broader market.

Protagonist Therapeutics has a net margin of -154.88% compared to Roivant Sciences' net margin of -3,629.19%. Protagonist Therapeutics' return on equity of -17.76% beat Roivant Sciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Protagonist Therapeutics-154.88% -17.76% -16.47%
Roivant Sciences -3,629.19%-20.54%-19.43%

98.6% of Protagonist Therapeutics shares are owned by institutional investors. Comparatively, 64.8% of Roivant Sciences shares are owned by institutional investors. 5.2% of Protagonist Therapeutics shares are owned by company insiders. Comparatively, 10.8% of Roivant Sciences shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Protagonist Therapeutics has higher revenue and earnings than Roivant Sciences. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than Roivant Sciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protagonist Therapeutics$46.02M181.51-$130.15M-$1.81N/A
Roivant Sciences$8.26M3,005.09-$299.77M-$0.60N/A

In the previous week, Protagonist Therapeutics had 5 more articles in the media than Roivant Sciences. MarketBeat recorded 10 mentions for Protagonist Therapeutics and 5 mentions for Roivant Sciences. Roivant Sciences' average media sentiment score of 0.70 beat Protagonist Therapeutics' score of 0.67 indicating that Roivant Sciences is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Protagonist Therapeutics
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Roivant Sciences
1 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Protagonist Therapeutics beats Roivant Sciences on 11 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to Insmed?

Insmed (NASDAQ:INSM) and Protagonist Therapeutics (NASDAQ:PTGX) are both medical companies, but which is the better investment? We will compare the two businesses based on the strength of their dividends, risk, valuation, media sentiment, analyst recommendations, earnings, institutional ownership and profitability.

98.6% of Protagonist Therapeutics shares are held by institutional investors. 2.1% of Insmed shares are held by company insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Insmed has a net margin of -144.44% compared to Protagonist Therapeutics' net margin of -154.88%. Protagonist Therapeutics' return on equity of -17.76% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Insmed-144.44% -130.11% -51.57%
Protagonist Therapeutics -154.88%-17.76%-16.47%

Protagonist Therapeutics has lower revenue, but higher earnings than Insmed. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than Insmed, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Insmed$606.42M39.01-$1.28B-$5.75N/A
Protagonist Therapeutics$46.02M181.51-$130.15M-$1.81N/A

Insmed currently has a consensus target price of $211.00, indicating a potential upside of 93.33%. Protagonist Therapeutics has a consensus target price of $116.93, indicating a potential downside of 9.98%. Given Insmed's stronger consensus rating and higher probable upside, equities analysts plainly believe Insmed is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Insmed
1 Sell rating(s)
0 Hold rating(s)
23 Buy rating(s)
1 Strong Buy rating(s)
2.96
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94

Insmed has a beta of 0.78, indicating that its share price is 22% less volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.79, indicating that its share price is 79% more volatile than the broader market.

In the previous week, Insmed had 3 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 13 mentions for Insmed and 10 mentions for Protagonist Therapeutics. Insmed's average media sentiment score of 0.94 beat Protagonist Therapeutics' score of 0.67 indicating that Insmed is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Insmed
7 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Protagonist Therapeutics
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Protagonist Therapeutics beats Insmed on 9 of the 17 factors compared between the two stocks.

How does Protagonist Therapeutics compare to BioNTech?

BioNTech (NASDAQ:BNTX) and Protagonist Therapeutics (NASDAQ:PTGX) are both medical companies, but which is the superior stock? We will compare the two companies based on the strength of their earnings, media sentiment, profitability, analyst recommendations, valuation, risk, dividends and institutional ownership.

Protagonist Therapeutics has lower revenue, but higher earnings than BioNTech. Protagonist Therapeutics is trading at a lower price-to-earnings ratio than BioNTech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioNTech$3.25B7.02-$1.29B-$5.88N/A
Protagonist Therapeutics$46.02M181.51-$130.15M-$1.81N/A

BioNTech presently has a consensus target price of $129.13, suggesting a potential upside of 43.36%. Protagonist Therapeutics has a consensus target price of $116.93, suggesting a potential downside of 9.98%. Given BioNTech's higher possible upside, equities research analysts clearly believe BioNTech is more favorable than Protagonist Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioNTech
1 Sell rating(s)
4 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.74
Protagonist Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
2 Strong Buy rating(s)
2.94

In the previous week, Protagonist Therapeutics had 4 more articles in the media than BioNTech. MarketBeat recorded 10 mentions for Protagonist Therapeutics and 6 mentions for BioNTech. BioNTech's average media sentiment score of 1.06 beat Protagonist Therapeutics' score of 0.67 indicating that BioNTech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioNTech
2 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Protagonist Therapeutics
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

15.5% of BioNTech shares are held by institutional investors. Comparatively, 98.6% of Protagonist Therapeutics shares are held by institutional investors. 19.2% of BioNTech shares are held by company insiders. Comparatively, 5.2% of Protagonist Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

BioNTech has a beta of 1.32, suggesting that its share price is 32% more volatile than the broader market. Comparatively, Protagonist Therapeutics has a beta of 1.79, suggesting that its share price is 79% more volatile than the broader market.

BioNTech has a net margin of -44.39% compared to Protagonist Therapeutics' net margin of -154.88%. BioNTech's return on equity of -5.30% beat Protagonist Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
BioNTech-44.39% -5.30% -4.62%
Protagonist Therapeutics -154.88%-17.76%-16.47%

Summary

BioNTech and Protagonist Therapeutics tied by winning 8 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PTGX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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PTGX vs. The Competition

MetricProtagonist TherapeuticsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$8.45B$3.71B$7.05B$12.61B
Dividend YieldN/A2.20%2.68%8.00%
P/E Ratio-71.7620.8527.1524.26
Price / Sales181.51314.01587.92117.88
Price / CashN/A61.9829.2249.36
Price / Book13.218.4910.756.29
Net Income-$130.15M$23.83M$3.58B$330.66M
7 Day Performance-7.78%-3.56%-2.07%-1.32%
1 Month Performance18.32%6.31%3.31%-0.64%
1 Year Performance135.18%48.30%26.35%19.08%

Protagonist Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PTGX
Protagonist Therapeutics
1.5561 of 5 stars
$129.89
-1.2%
$116.93
-10.0%
+145.1%$8.45B$46.02MN/A120
ONC
BeOne Medicines
4.6744 of 5 stars
$298.70
-1.4%
$391.38
+31.0%
+21.4%$33.23B$5.34B66.8212,000
MRNA
Moderna
1.8577 of 5 stars
$68.27
-10.8%
$38.27
-43.9%
+99.2%$30.38B$1.94BN/A4,700
ROIV
Roivant Sciences
1.544 of 5 stars
$35.97
-2.3%
$33.59
-6.6%
+203.8%$26.48B$8.26MN/A860
INSM
Insmed
4.0914 of 5 stars
$115.61
-2.2%
$211.00
+82.5%
+11.2%$25.63B$606.42MN/A1,664

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This page (NASDAQ:PTGX) was last updated on 7/14/2026 by MarketBeat.com Staff.
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