Go Pro

Spyre Therapeutics (SYRE) Competitors

Spyre Therapeutics logo
$106.65 +0.16 (+0.15%)
Closing price 04:00 PM Eastern
Extended Trading
$107.51 +0.86 (+0.81%)
As of 04:34 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

SYRE vs. BIIB, ALNY, INSM, ROIV, and MRNA

Should you buy Spyre Therapeutics stock or one of its competitors? Spyre Therapeutics's main competitors and comparable companies include Biogen (BIIB), Alnylam Pharmaceuticals (ALNY), Insmed (INSM), Roivant Sciences (ROIV), and Moderna (MRNA). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Spyre Therapeutics compare to Biogen?

Spyre Therapeutics (NASDAQ:SYRE) and Biogen (NASDAQ:BIIB) are both healthcare companies, but which is the superior stock? We will compare the two companies based on the strength of their dividends, analyst recommendations, risk, profitability, institutional ownership, media sentiment, valuation and earnings.

Biogen has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Biogen, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre TherapeuticsN/AN/A-$155.20M-$1.95N/A
Biogen$9.89B3.26$1.29B$5.6538.61

Spyre Therapeutics presently has a consensus price target of $111.69, suggesting a potential upside of 4.73%. Biogen has a consensus price target of $227.07, suggesting a potential upside of 4.10%. Given Spyre Therapeutics' stronger consensus rating and higher probable upside, research analysts clearly believe Spyre Therapeutics is more favorable than Biogen.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58

In the previous week, Biogen had 33 more articles in the media than Spyre Therapeutics. MarketBeat recorded 36 mentions for Biogen and 3 mentions for Spyre Therapeutics. Biogen's average media sentiment score of 1.31 beat Spyre Therapeutics' score of 0.66 indicating that Biogen is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Biogen
25 Very Positive mention(s)
3 Positive mention(s)
6 Neutral mention(s)
2 Negative mention(s)
0 Very Negative mention(s)
Positive

Spyre Therapeutics has a beta of 3.03, indicating that its stock price is 203% more volatile than the broader market. Comparatively, Biogen has a beta of 0.17, indicating that its stock price is 83% less volatile than the broader market.

Biogen has a net margin of 8.32% compared to Spyre Therapeutics' net margin of 0.00%. Biogen's return on equity of 11.18% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -30.74% -22.23%
Biogen 8.32%11.18%6.88%

80.4% of Spyre Therapeutics shares are owned by institutional investors. Comparatively, 87.9% of Biogen shares are owned by institutional investors. 15.7% of Spyre Therapeutics shares are owned by company insiders. Comparatively, 0.3% of Biogen shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Summary

Biogen beats Spyre Therapeutics on 11 of the 15 factors compared between the two stocks.

How does Spyre Therapeutics compare to Alnylam Pharmaceuticals?

Spyre Therapeutics (NASDAQ:SYRE) and Alnylam Pharmaceuticals (NASDAQ:ALNY) are both healthcare companies, but which is the better investment? We will contrast the two businesses based on the strength of their analyst recommendations, dividends, earnings, profitability, institutional ownership, media sentiment, valuation and risk.

Alnylam Pharmaceuticals has a net margin of 15.26% compared to Spyre Therapeutics' net margin of 0.00%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -30.74% -22.23%
Alnylam Pharmaceuticals 15.26%84.93%14.30%

Spyre Therapeutics has a beta of 3.03, suggesting that its share price is 203% more volatile than the broader market. Comparatively, Alnylam Pharmaceuticals has a beta of 0.3, suggesting that its share price is 70% less volatile than the broader market.

Spyre Therapeutics presently has a consensus target price of $111.69, suggesting a potential upside of 4.73%. Alnylam Pharmaceuticals has a consensus target price of $386.62, suggesting a potential upside of 63.82%. Given Alnylam Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Alnylam Pharmaceuticals is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
15 Buy rating(s)
4 Strong Buy rating(s)
2.96

80.4% of Spyre Therapeutics shares are held by institutional investors. Comparatively, 93.0% of Alnylam Pharmaceuticals shares are held by institutional investors. 15.7% of Spyre Therapeutics shares are held by insiders. Comparatively, 0.9% of Alnylam Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Alnylam Pharmaceuticals has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre TherapeuticsN/AN/A-$155.20M-$1.95N/A
Alnylam Pharmaceuticals$3.71B8.50$313.75M$5.3843.87

In the previous week, Alnylam Pharmaceuticals had 25 more articles in the media than Spyre Therapeutics. MarketBeat recorded 28 mentions for Alnylam Pharmaceuticals and 3 mentions for Spyre Therapeutics. Alnylam Pharmaceuticals' average media sentiment score of 0.98 beat Spyre Therapeutics' score of 0.66 indicating that Alnylam Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Alnylam Pharmaceuticals
16 Very Positive mention(s)
1 Positive mention(s)
9 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Alnylam Pharmaceuticals beats Spyre Therapeutics on 14 of the 16 factors compared between the two stocks.

How does Spyre Therapeutics compare to Insmed?

Spyre Therapeutics (NASDAQ:SYRE) and Insmed (NASDAQ:INSM) are both healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their media sentiment, profitability, institutional ownership, valuation, earnings, dividends, analyst recommendations and risk.

Spyre Therapeutics has a beta of 3.03, meaning that its stock price is 203% more volatile than the broader market. Comparatively, Insmed has a beta of 0.81, meaning that its stock price is 19% less volatile than the broader market.

Spyre Therapeutics has higher earnings, but lower revenue than Insmed. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Insmed, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre TherapeuticsN/AN/A-$155.20M-$1.95N/A
Insmed$606.42M44.65-$1.28B-$4.11N/A

80.4% of Spyre Therapeutics shares are held by institutional investors. 15.7% of Spyre Therapeutics shares are held by company insiders. Comparatively, 2.1% of Insmed shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

In the previous week, Spyre Therapeutics had 1 more articles in the media than Insmed. MarketBeat recorded 3 mentions for Spyre Therapeutics and 2 mentions for Insmed. Insmed's average media sentiment score of 0.84 beat Spyre Therapeutics' score of 0.66 indicating that Insmed is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Insmed
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Spyre Therapeutics currently has a consensus price target of $111.69, indicating a potential upside of 4.73%. Insmed has a consensus price target of $205.52, indicating a potential upside of 65.77%. Given Insmed's stronger consensus rating and higher possible upside, analysts clearly believe Insmed is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00

Spyre Therapeutics has a net margin of 0.00% compared to Insmed's net margin of -76.94%. Spyre Therapeutics' return on equity of -30.74% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -30.74% -22.23%
Insmed -76.94%-123.94%-44.30%

Summary

Spyre Therapeutics beats Insmed on 9 of the 16 factors compared between the two stocks.

How does Spyre Therapeutics compare to Roivant Sciences?

Roivant Sciences (NASDAQ:ROIV) and Spyre Therapeutics (NASDAQ:SYRE) are both healthcare companies, but which is the superior business? We will compare the two businesses based on the strength of their dividends, valuation, risk, analyst recommendations, institutional ownership, earnings, profitability and media sentiment.

In the previous week, Roivant Sciences had 17 more articles in the media than Spyre Therapeutics. MarketBeat recorded 20 mentions for Roivant Sciences and 3 mentions for Spyre Therapeutics. Spyre Therapeutics' average media sentiment score of 0.66 beat Roivant Sciences' score of 0.25 indicating that Spyre Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Roivant Sciences
10 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Spyre Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Roivant Sciences currently has a consensus price target of $35.14, suggesting a potential downside of 3.37%. Spyre Therapeutics has a consensus price target of $111.69, suggesting a potential upside of 4.73%. Given Spyre Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Spyre Therapeutics is more favorable than Roivant Sciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.83
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87

Roivant Sciences has a beta of 1.12, indicating that its stock price is 12% more volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.03, indicating that its stock price is 203% more volatile than the broader market.

64.8% of Roivant Sciences shares are held by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are held by institutional investors. 8.8% of Roivant Sciences shares are held by insiders. Comparatively, 15.7% of Spyre Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Spyre Therapeutics has a net margin of 0.00% compared to Roivant Sciences' net margin of -3,534.96%. Roivant Sciences' return on equity of -22.94% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Roivant Sciences-3,534.96% -22.94% -21.53%
Spyre Therapeutics N/A -30.74%-22.23%

Spyre Therapeutics has lower revenue, but higher earnings than Roivant Sciences. Roivant Sciences is trading at a lower price-to-earnings ratio than Spyre Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Roivant Sciences$8.26M3,179.61-$299.77M-$0.53N/A
Spyre TherapeuticsN/AN/A-$155.20M-$1.95N/A

Summary

Spyre Therapeutics beats Roivant Sciences on 10 of the 15 factors compared between the two stocks.

How does Spyre Therapeutics compare to Moderna?

Spyre Therapeutics (NASDAQ:SYRE) and Moderna (NASDAQ:MRNA) are both healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their dividends, analyst recommendations, institutional ownership, valuation, earnings, profitability, risk and media sentiment.

Spyre Therapeutics has a net margin of 0.00% compared to Moderna's net margin of -141.43%. Moderna's return on equity of -28.30% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -30.74% -22.23%
Moderna -141.43%-28.30%-19.39%

Spyre Therapeutics has a beta of 3.03, indicating that its share price is 203% more volatile than the broader market. Comparatively, Moderna has a beta of 0.91, indicating that its share price is 9% less volatile than the broader market.

80.4% of Spyre Therapeutics shares are held by institutional investors. Comparatively, 75.3% of Moderna shares are held by institutional investors. 15.7% of Spyre Therapeutics shares are held by insiders. Comparatively, 10.8% of Moderna shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

Spyre Therapeutics has higher earnings, but lower revenue than Moderna. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Moderna, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre TherapeuticsN/AN/A-$155.20M-$1.95N/A
Moderna$2.21B25.09-$2.82B-$7.99N/A

In the previous week, Moderna had 120 more articles in the media than Spyre Therapeutics. MarketBeat recorded 123 mentions for Moderna and 3 mentions for Spyre Therapeutics. Spyre Therapeutics' average media sentiment score of 0.66 beat Moderna's score of 0.37 indicating that Spyre Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Moderna
48 Very Positive mention(s)
20 Positive mention(s)
14 Neutral mention(s)
20 Negative mention(s)
16 Very Negative mention(s)
Neutral

Spyre Therapeutics currently has a consensus price target of $111.69, indicating a potential upside of 4.73%. Moderna has a consensus price target of $74.31, indicating a potential downside of 46.50%. Given Spyre Therapeutics' stronger consensus rating and higher probable upside, equities analysts plainly believe Spyre Therapeutics is more favorable than Moderna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87
Moderna
4 Sell rating(s)
11 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.00

Summary

Spyre Therapeutics beats Moderna on 11 of the 16 factors compared between the two stocks.

Get Spyre Therapeutics News Delivered to You Automatically

Sign up to receive the latest news and ratings for SYRE and its competitors with MarketBeat's FREE daily newsletter.

Subscribe Now
SMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy.

New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SYRE and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
Skip Chart

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
Skip Chart

SYRE vs. The Competition

MetricSpyre TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$9.38B$3.99B$7.30B$12.71B
Dividend YieldN/A3.64%2.54%10.79%
P/E Ratio-54.6911.76271.3924.11
Price / SalesN/A1,296.80604.5677.78
Price / CashN/A44.9429.0336.90
Price / Book14.7917.2711.186.40
Net Income-$155.20M-$22.72M$3.46B$348.28M
7 Day Performance1.96%2.83%1.97%0.95%
1 Month Performance4.43%9.67%7.30%5.15%
1 Year Performance513.64%54.74%24.74%16.18%

Spyre Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SYRE
Spyre Therapeutics
1.4685 of 5 stars
$106.65
+0.2%
$111.69
+4.7%
+512.7%$9.38BN/AN/A73
BIIB
Biogen
3.9116 of 5 stars
$212.59
+1.6%
$227.07
+6.8%
+55.6%$31.41B$9.89B37.637,500
ALNY
Alnylam Pharmaceuticals
4.8669 of 5 stars
$228.61
+1.8%
$393.86
+72.3%
-48.0%$30.59B$3.71B42.492,770
INSM
Insmed
3.3497 of 5 stars
$128.49
+0.1%
$205.52
+60.0%
-4.6%$28.06B$606.42MN/A1,664
ROIV
Roivant Sciences
1.4965 of 5 stars
$37.37
+3.1%
$35.14
-6.0%
+204.5%$26.99B$8.26MN/A860

Related Companies and Tools


This page (NASDAQ:SYRE) was last updated on 8/24/2026 by MarketBeat.com Staff.
From Our Partners