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Spyre Therapeutics (SYRE) Competitors

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$78.48 +4.96 (+6.75%)
Closing price 04:00 PM Eastern
Extended Trading
$82.00 +3.52 (+4.48%)
As of 07:04 PM Eastern
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SYRE vs. INSM, BNTX, ROIV, VTRS, and MRNA

Should you buy Spyre Therapeutics stock or one of its competitors? MarketBeat compares Spyre Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Spyre Therapeutics include Insmed (INSM), BioNTech (BNTX), Roivant Sciences (ROIV), Viatris (VTRS), and Moderna (MRNA). These companies are all part of the "pharmaceutical products" industry.

How does Spyre Therapeutics compare to Insmed?

Spyre Therapeutics (NASDAQ:SYRE) and Insmed (NASDAQ:INSM) are both medical companies, but which is the superior business? We will compare the two businesses based on the strength of their valuation, profitability, earnings, dividends, institutional ownership, media sentiment, analyst recommendations and risk.

In the previous week, Insmed had 7 more articles in the media than Spyre Therapeutics. MarketBeat recorded 13 mentions for Insmed and 6 mentions for Spyre Therapeutics. Insmed's average media sentiment score of 1.50 beat Spyre Therapeutics' score of 0.07 indicating that Insmed is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Insmed
11 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Very Positive

80.4% of Spyre Therapeutics shares are owned by institutional investors. 15.7% of Spyre Therapeutics shares are owned by insiders. Comparatively, 2.1% of Insmed shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

Spyre Therapeutics has higher earnings, but lower revenue than Insmed. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Insmed, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre Therapeutics$890K7,657.53-$155.20M-$2.08N/A
Insmed$606.42M37.50-$1.28B-$5.75N/A

Spyre Therapeutics has a beta of 3.05, meaning that its share price is 205% more volatile than the broader market. Comparatively, Insmed has a beta of 0.79, meaning that its share price is 21% less volatile than the broader market.

Spyre Therapeutics presently has a consensus price target of $91.33, suggesting a potential upside of 16.38%. Insmed has a consensus price target of $210.95, suggesting a potential upside of 101.06%. Given Insmed's higher possible upside, analysts plainly believe Insmed is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00
Insmed
1 Sell rating(s)
0 Hold rating(s)
23 Buy rating(s)
1 Strong Buy rating(s)
2.96

Spyre Therapeutics has a net margin of 0.00% compared to Insmed's net margin of -144.44%. Spyre Therapeutics' return on equity of -42.88% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -42.88% -27.76%
Insmed -144.44%-130.11%-51.57%

Summary

Spyre Therapeutics beats Insmed on 11 of the 17 factors compared between the two stocks.

How does Spyre Therapeutics compare to BioNTech?

BioNTech (NASDAQ:BNTX) and Spyre Therapeutics (NASDAQ:SYRE) are both medical companies, but which is the superior business? We will contrast the two companies based on the strength of their earnings, dividends, analyst recommendations, media sentiment, profitability, risk, institutional ownership and valuation.

BioNTech has a beta of 1.32, suggesting that its share price is 32% more volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.05, suggesting that its share price is 205% more volatile than the broader market.

BioNTech presently has a consensus price target of $129.56, suggesting a potential upside of 44.62%. Spyre Therapeutics has a consensus price target of $91.33, suggesting a potential upside of 16.38%. Given BioNTech's higher probable upside, equities analysts plainly believe BioNTech is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioNTech
1 Sell rating(s)
4 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.74
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00

15.5% of BioNTech shares are owned by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are owned by institutional investors. 19.2% of BioNTech shares are owned by insiders. Comparatively, 15.7% of Spyre Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

In the previous week, BioNTech had 2 more articles in the media than Spyre Therapeutics. MarketBeat recorded 8 mentions for BioNTech and 6 mentions for Spyre Therapeutics. BioNTech's average media sentiment score of 0.66 beat Spyre Therapeutics' score of 0.07 indicating that BioNTech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioNTech
3 Very Positive mention(s)
1 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Spyre Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Spyre Therapeutics has a net margin of 0.00% compared to BioNTech's net margin of -44.39%. BioNTech's return on equity of -5.30% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
BioNTech-44.39% -5.30% -4.62%
Spyre Therapeutics N/A -42.88%-27.76%

Spyre Therapeutics has lower revenue, but higher earnings than BioNTech. Spyre Therapeutics is trading at a lower price-to-earnings ratio than BioNTech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioNTech$3.25B6.98-$1.29B-$5.88N/A
Spyre Therapeutics$890K7,657.53-$155.20M-$2.08N/A

Summary

BioNTech beats Spyre Therapeutics on 9 of the 17 factors compared between the two stocks.

How does Spyre Therapeutics compare to Roivant Sciences?

Spyre Therapeutics (NASDAQ:SYRE) and Roivant Sciences (NASDAQ:ROIV) are both medical companies, but which is the better business? We will compare the two companies based on the strength of their valuation, media sentiment, risk, analyst recommendations, profitability, institutional ownership, dividends and earnings.

Spyre Therapeutics currently has a consensus target price of $91.33, suggesting a potential upside of 16.38%. Roivant Sciences has a consensus target price of $33.59, suggesting a potential upside of 13.75%. Given Spyre Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Spyre Therapeutics is more favorable than Roivant Sciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75

Spyre Therapeutics has a net margin of 0.00% compared to Roivant Sciences' net margin of -3,629.19%. Roivant Sciences' return on equity of -20.54% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -42.88% -27.76%
Roivant Sciences -3,629.19%-20.54%-19.43%

Spyre Therapeutics has a beta of 3.05, suggesting that its share price is 205% more volatile than the broader market. Comparatively, Roivant Sciences has a beta of 1.13, suggesting that its share price is 13% more volatile than the broader market.

80.4% of Spyre Therapeutics shares are owned by institutional investors. Comparatively, 64.8% of Roivant Sciences shares are owned by institutional investors. 15.7% of Spyre Therapeutics shares are owned by insiders. Comparatively, 10.8% of Roivant Sciences shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Spyre Therapeutics has higher earnings, but lower revenue than Roivant Sciences. Roivant Sciences is trading at a lower price-to-earnings ratio than Spyre Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre Therapeutics$890K7,657.53-$155.20M-$2.08N/A
Roivant Sciences$8.26M2,571.43-$299.77M-$0.60N/A

In the previous week, Roivant Sciences had 3 more articles in the media than Spyre Therapeutics. MarketBeat recorded 9 mentions for Roivant Sciences and 6 mentions for Spyre Therapeutics. Roivant Sciences' average media sentiment score of 0.99 beat Spyre Therapeutics' score of 0.07 indicating that Roivant Sciences is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Roivant Sciences
5 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Spyre Therapeutics beats Roivant Sciences on 10 of the 16 factors compared between the two stocks.

How does Spyre Therapeutics compare to Viatris?

Spyre Therapeutics (NASDAQ:SYRE) and Viatris (NASDAQ:VTRS) are both medical companies, but which is the superior investment? We will contrast the two companies based on the strength of their risk, earnings, media sentiment, analyst recommendations, dividends, valuation, profitability and institutional ownership.

80.4% of Spyre Therapeutics shares are held by institutional investors. Comparatively, 79.9% of Viatris shares are held by institutional investors. 15.7% of Spyre Therapeutics shares are held by company insiders. Comparatively, 0.3% of Viatris shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

In the previous week, Spyre Therapeutics had 6 more articles in the media than Viatris. MarketBeat recorded 6 mentions for Spyre Therapeutics and 0 mentions for Viatris. Viatris' average media sentiment score of 1.44 beat Spyre Therapeutics' score of 0.07 indicating that Viatris is being referred to more favorably in the news media.

Company Overall Sentiment
Spyre Therapeutics Neutral
Viatris Positive

Spyre Therapeutics has a net margin of 0.00% compared to Viatris' net margin of -2.04%. Viatris' return on equity of 19.04% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -42.88% -27.76%
Viatris -2.04%19.04%7.62%

Spyre Therapeutics has higher earnings, but lower revenue than Viatris. Viatris is trading at a lower price-to-earnings ratio than Spyre Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre Therapeutics$890K7,657.53-$155.20M-$2.08N/A
Viatris$14.30B1.29-$3.51B-$0.26N/A

Spyre Therapeutics has a beta of 3.05, indicating that its share price is 205% more volatile than the broader market. Comparatively, Viatris has a beta of 0.9, indicating that its share price is 10% less volatile than the broader market.

Spyre Therapeutics currently has a consensus price target of $91.33, suggesting a potential upside of 16.38%. Viatris has a consensus price target of $16.43, suggesting a potential upside of 3.32%. Given Spyre Therapeutics' stronger consensus rating and higher probable upside, research analysts plainly believe Spyre Therapeutics is more favorable than Viatris.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00
Viatris
1 Sell rating(s)
3 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.38

Summary

Spyre Therapeutics beats Viatris on 12 of the 17 factors compared between the two stocks.

How does Spyre Therapeutics compare to Moderna?

Moderna (NASDAQ:MRNA) and Spyre Therapeutics (NASDAQ:SYRE) are both medical companies, but which is the superior business? We will compare the two companies based on the strength of their dividends, risk, analyst recommendations, media sentiment, earnings, valuation, profitability and institutional ownership.

75.3% of Moderna shares are held by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are held by institutional investors. 10.8% of Moderna shares are held by insiders. Comparatively, 15.7% of Spyre Therapeutics shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

In the previous week, Moderna had 23 more articles in the media than Spyre Therapeutics. MarketBeat recorded 29 mentions for Moderna and 6 mentions for Spyre Therapeutics. Moderna's average media sentiment score of 0.50 beat Spyre Therapeutics' score of 0.07 indicating that Moderna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Moderna
11 Very Positive mention(s)
3 Positive mention(s)
11 Neutral mention(s)
0 Negative mention(s)
4 Very Negative mention(s)
Positive
Spyre Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Moderna presently has a consensus price target of $35.73, suggesting a potential downside of 30.74%. Spyre Therapeutics has a consensus price target of $91.33, suggesting a potential upside of 16.38%. Given Spyre Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Spyre Therapeutics is more favorable than Moderna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Moderna
5 Sell rating(s)
11 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
1.83
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00

Moderna has a beta of 1.05, suggesting that its share price is 5% more volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.05, suggesting that its share price is 205% more volatile than the broader market.

Spyre Therapeutics has lower revenue, but higher earnings than Moderna. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Moderna, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Moderna$1.94B10.53-$2.82B-$8.15N/A
Spyre Therapeutics$890K7,657.53-$155.20M-$2.08N/A

Spyre Therapeutics has a net margin of 0.00% compared to Moderna's net margin of -143.55%. Moderna's return on equity of -26.64% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Moderna-143.55% -26.64% -19.32%
Spyre Therapeutics N/A -42.88%-27.76%

Summary

Spyre Therapeutics beats Moderna on 11 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SYRE and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SYRE vs. The Competition

MetricSpyre TherapeuticsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$6.82B$3.34B$6.44B$12.46B
Dividend YieldN/A2.37%2.69%5.22%
P/E Ratio-37.7318.7823.8724.36
Price / Sales7,657.53320.80521.52117.06
Price / CashN/A110.4041.2757.13
Price / Book10.886.809.996.73
Net Income-$155.20M$24.09M$3.56B$337.03M
7 Day Performance8.83%-2.56%-0.89%0.09%
1 Month PerformanceN/AN/AN/A-1.78%
1 Year Performance375.06%48.90%28.76%33.98%

Spyre Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SYRE
Spyre Therapeutics
1.9131 of 5 stars
$78.48
+6.7%
$91.33
+16.4%
+343.7%$6.82B$890KN/A73
INSM
Insmed
3.8095 of 5 stars
$108.89
+2.5%
$210.95
+93.7%
+42.1%$23.60B$606.42MN/A1,664
BNTX
BioNTech
3.7439 of 5 stars
$92.38
+0.3%
$128.44
+39.0%
-23.5%$23.36B$3.25BN/A7,807
ROIV
Roivant Sciences
2.881 of 5 stars
$29.64
-1.1%
$33.59
+13.3%
+155.3%$21.21B$8.26MN/A860
VTRS
Viatris
3.0441 of 5 stars
$16.24
-2.5%
$16.43
+1.2%
+78.3%$18.91B$14.30BN/A30,000

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This page (NASDAQ:SYRE) was last updated on 6/4/2026 by MarketBeat.com Staff.
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