Spyre Therapeutics (SYRE) Competitors

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$86.24 -10.81 (-11.14%)
Closing price 04:00 PM Eastern
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$84.36 -1.88 (-2.18%)
As of 07:57 PM Eastern
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SYRE vs. ONC, MRNA, ROIV, BNTX, and INSM

Should you buy Spyre Therapeutics stock or one of its competitors? MarketBeat compares Spyre Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Spyre Therapeutics include BeOne Medicines (ONC), Moderna (MRNA), Roivant Sciences (ROIV), BioNTech (BNTX), and Insmed (INSM). These companies are all part of the "pharmaceutical products" industry.

How does Spyre Therapeutics compare to BeOne Medicines?

BeOne Medicines (NASDAQ:ONC) and Spyre Therapeutics (NASDAQ:SYRE) are both medical companies, but which is the superior investment? We will contrast the two companies based on the strength of their valuation, analyst recommendations, risk, media sentiment, profitability, earnings, institutional ownership and dividends.

BeOne Medicines has a beta of 0.49, meaning that its share price is 51% less volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.05, meaning that its share price is 205% more volatile than the broader market.

BeOne Medicines has a net margin of 8.94% compared to Spyre Therapeutics' net margin of 0.00%. BeOne Medicines' return on equity of 12.06% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
BeOne Medicines8.94% 12.06% 6.69%
Spyre Therapeutics N/A -42.88%-27.76%

BeOne Medicines has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than BeOne Medicines, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BeOne Medicines$5.34B5.69$286.93M$4.4762.00
Spyre Therapeutics$890K8,414.70-$155.20M-$2.08N/A

In the previous week, BeOne Medicines had 2 more articles in the media than Spyre Therapeutics. MarketBeat recorded 12 mentions for BeOne Medicines and 10 mentions for Spyre Therapeutics. Spyre Therapeutics' average media sentiment score of 0.32 beat BeOne Medicines' score of -0.46 indicating that Spyre Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BeOne Medicines
1 Very Positive mention(s)
1 Positive mention(s)
5 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Spyre Therapeutics
3 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

BeOne Medicines currently has a consensus price target of $390.00, suggesting a potential upside of 40.73%. Spyre Therapeutics has a consensus price target of $95.83, suggesting a potential upside of 11.12%. Given BeOne Medicines' higher possible upside, research analysts clearly believe BeOne Medicines is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BeOne Medicines
1 Sell rating(s)
1 Hold rating(s)
11 Buy rating(s)
2 Strong Buy rating(s)
2.93
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00

48.6% of BeOne Medicines shares are owned by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are owned by institutional investors. 6.2% of BeOne Medicines shares are owned by insiders. Comparatively, 15.7% of Spyre Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Summary

BeOne Medicines beats Spyre Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Spyre Therapeutics compare to Moderna?

Spyre Therapeutics (NASDAQ:SYRE) and Moderna (NASDAQ:MRNA) are both medical companies, but which is the superior business? We will contrast the two companies based on the strength of their valuation, analyst recommendations, risk, media sentiment, profitability, earnings, institutional ownership and dividends.

Spyre Therapeutics has higher earnings, but lower revenue than Moderna. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Moderna, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre Therapeutics$890K8,414.70-$155.20M-$2.08N/A
Moderna$1.94B12.33-$2.82B-$8.15N/A

80.4% of Spyre Therapeutics shares are owned by institutional investors. Comparatively, 75.3% of Moderna shares are owned by institutional investors. 15.7% of Spyre Therapeutics shares are owned by company insiders. Comparatively, 10.8% of Moderna shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Spyre Therapeutics has a net margin of 0.00% compared to Moderna's net margin of -143.55%. Moderna's return on equity of -26.64% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -42.88% -27.76%
Moderna -143.55%-26.64%-19.32%

Spyre Therapeutics presently has a consensus target price of $95.83, indicating a potential upside of 11.12%. Moderna has a consensus target price of $36.60, indicating a potential downside of 39.42%. Given Spyre Therapeutics' stronger consensus rating and higher possible upside, research analysts clearly believe Spyre Therapeutics is more favorable than Moderna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00
Moderna
5 Sell rating(s)
11 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
1.83

Spyre Therapeutics has a beta of 3.05, suggesting that its share price is 205% more volatile than the broader market. Comparatively, Moderna has a beta of 1.05, suggesting that its share price is 5% more volatile than the broader market.

In the previous week, Moderna had 24 more articles in the media than Spyre Therapeutics. MarketBeat recorded 34 mentions for Moderna and 10 mentions for Spyre Therapeutics. Moderna's average media sentiment score of 0.37 beat Spyre Therapeutics' score of 0.32 indicating that Moderna is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
3 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Moderna
13 Very Positive mention(s)
4 Positive mention(s)
7 Neutral mention(s)
9 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

Spyre Therapeutics beats Moderna on 11 of the 17 factors compared between the two stocks.

How does Spyre Therapeutics compare to Roivant Sciences?

Roivant Sciences (NASDAQ:ROIV) and Spyre Therapeutics (NASDAQ:SYRE) are both medical companies, but which is the better investment? We will compare the two companies based on the strength of their analyst recommendations, risk, dividends, valuation, earnings, media sentiment, institutional ownership and profitability.

In the previous week, Spyre Therapeutics had 4 more articles in the media than Roivant Sciences. MarketBeat recorded 10 mentions for Spyre Therapeutics and 6 mentions for Roivant Sciences. Roivant Sciences' average media sentiment score of 1.35 beat Spyre Therapeutics' score of 0.32 indicating that Roivant Sciences is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Roivant Sciences
5 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Spyre Therapeutics
3 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Roivant Sciences has a beta of 1.13, indicating that its stock price is 13% more volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.05, indicating that its stock price is 205% more volatile than the broader market.

Roivant Sciences currently has a consensus price target of $33.59, indicating a potential downside of 1.23%. Spyre Therapeutics has a consensus price target of $95.83, indicating a potential upside of 11.12%. Given Spyre Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Spyre Therapeutics is more favorable than Roivant Sciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00

64.8% of Roivant Sciences shares are held by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are held by institutional investors. 10.8% of Roivant Sciences shares are held by company insiders. Comparatively, 15.7% of Spyre Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Spyre Therapeutics has lower revenue, but higher earnings than Roivant Sciences. Roivant Sciences is trading at a lower price-to-earnings ratio than Spyre Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Roivant Sciences$8.26M2,961.55-$299.77M-$0.60N/A
Spyre Therapeutics$890K8,414.70-$155.20M-$2.08N/A

Spyre Therapeutics has a net margin of 0.00% compared to Roivant Sciences' net margin of -3,629.19%. Roivant Sciences' return on equity of -20.54% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Roivant Sciences-3,629.19% -20.54% -19.43%
Spyre Therapeutics N/A -42.88%-27.76%

Summary

Spyre Therapeutics beats Roivant Sciences on 11 of the 16 factors compared between the two stocks.

How does Spyre Therapeutics compare to BioNTech?

BioNTech (NASDAQ:BNTX) and Spyre Therapeutics (NASDAQ:SYRE) are both medical companies, but which is the superior stock? We will compare the two businesses based on the strength of their analyst recommendations, dividends, valuation, institutional ownership, earnings, media sentiment, profitability and risk.

In the previous week, Spyre Therapeutics had 8 more articles in the media than BioNTech. MarketBeat recorded 10 mentions for Spyre Therapeutics and 2 mentions for BioNTech. BioNTech's average media sentiment score of 0.85 beat Spyre Therapeutics' score of 0.32 indicating that BioNTech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioNTech
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Spyre Therapeutics
3 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Spyre Therapeutics has a net margin of 0.00% compared to BioNTech's net margin of -44.39%. BioNTech's return on equity of -5.30% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
BioNTech-44.39% -5.30% -4.62%
Spyre Therapeutics N/A -42.88%-27.76%

Spyre Therapeutics has lower revenue, but higher earnings than BioNTech. Spyre Therapeutics is trading at a lower price-to-earnings ratio than BioNTech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioNTech$3.25B7.03-$1.29B-$5.88N/A
Spyre Therapeutics$890K8,414.70-$155.20M-$2.08N/A

15.5% of BioNTech shares are held by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are held by institutional investors. 19.2% of BioNTech shares are held by insiders. Comparatively, 15.7% of Spyre Therapeutics shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

BioNTech presently has a consensus target price of $129.56, indicating a potential upside of 43.62%. Spyre Therapeutics has a consensus target price of $95.83, indicating a potential upside of 11.12%. Given BioNTech's higher probable upside, equities research analysts clearly believe BioNTech is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioNTech
1 Sell rating(s)
4 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.74
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00

BioNTech has a beta of 1.32, indicating that its stock price is 32% more volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.05, indicating that its stock price is 205% more volatile than the broader market.

Summary

Spyre Therapeutics beats BioNTech on 9 of the 17 factors compared between the two stocks.

How does Spyre Therapeutics compare to Insmed?

Spyre Therapeutics (NASDAQ:SYRE) and Insmed (NASDAQ:INSM) are both medical companies, but which is the better business? We will contrast the two companies based on the strength of their media sentiment, dividends, analyst recommendations, earnings, institutional ownership, profitability, valuation and risk.

In the previous week, Insmed had 2 more articles in the media than Spyre Therapeutics. MarketBeat recorded 12 mentions for Insmed and 10 mentions for Spyre Therapeutics. Insmed's average media sentiment score of 1.17 beat Spyre Therapeutics' score of 0.32 indicating that Insmed is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
3 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Insmed
8 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Spyre Therapeutics has a net margin of 0.00% compared to Insmed's net margin of -144.44%. Spyre Therapeutics' return on equity of -42.88% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -42.88% -27.76%
Insmed -144.44%-130.11%-51.57%

Spyre Therapeutics has higher earnings, but lower revenue than Insmed. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Insmed, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre Therapeutics$890K8,414.70-$155.20M-$2.08N/A
Insmed$606.42M36.97-$1.28B-$5.75N/A

Spyre Therapeutics currently has a consensus target price of $95.83, suggesting a potential upside of 11.12%. Insmed has a consensus target price of $211.86, suggesting a potential upside of 104.81%. Given Insmed's higher probable upside, analysts clearly believe Insmed is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
2 Strong Buy rating(s)
3.00
Insmed
1 Sell rating(s)
0 Hold rating(s)
23 Buy rating(s)
1 Strong Buy rating(s)
2.96

80.4% of Spyre Therapeutics shares are held by institutional investors. 15.7% of Spyre Therapeutics shares are held by insiders. Comparatively, 2.1% of Insmed shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Spyre Therapeutics has a beta of 3.05, indicating that its stock price is 205% more volatile than the broader market. Comparatively, Insmed has a beta of 0.79, indicating that its stock price is 21% less volatile than the broader market.

Summary

Spyre Therapeutics beats Insmed on 11 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SYRE and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SYRE vs. The Competition

MetricSpyre TherapeuticsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$8.43B$3.49B$6.74B$12.32B
Dividend YieldN/A2.28%2.68%5.88%
P/E Ratio-41.4620.5025.3923.96
Price / Sales8,414.70328.65530.17107.90
Price / CashN/A130.9645.2953.76
Price / Book11.968.2610.766.41
Net Income-$155.20M$23.91M$3.56B$337.14M
7 Day Performance-1.43%3.05%1.37%-0.48%
1 Month Performance16.46%2.40%0.81%0.49%
1 Year Performance459.64%56.35%30.53%28.16%

Spyre Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SYRE
Spyre Therapeutics
1.6831 of 5 stars
$86.24
-11.1%
$95.83
+11.1%
+561.1%$8.43B$890KN/A73
ONC
BeOne Medicines
4.1189 of 5 stars
$276.13
+1.6%
$390.00
+41.2%
+7.2%$30.30B$5.34B61.7712,000
MRNA
Moderna
1.2326 of 5 stars
$61.00
+2.8%
$36.60
-40.0%
+137.6%$24.20B$1.94BN/A4,700
ROIV
Roivant Sciences
1.6094 of 5 stars
$32.21
+3.1%
$33.59
+4.3%
+180.1%$23.17B$8.26MN/A860
BNTX
BioNTech
4.5304 of 5 stars
$90.62
+0.5%
$129.56
+43.0%
-12.0%$22.92B$3.25BN/A7,807

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This page (NASDAQ:SYRE) was last updated on 6/24/2026 by MarketBeat.com Staff.
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