Free Trial

Spyre Therapeutics (SYRE) Competitors

Spyre Therapeutics logo
$93.19 +3.26 (+3.63%)
Closing price 10/2/2026 04:00 PM Eastern
Extended Trading
$93.19 0.00 (0.00%)
As of 10/2/2026 07:30 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

SYRE vs. ROIV, INSM, INCY, BNTX, and GMAB

Should you buy Spyre Therapeutics stock or one of its competitors? Spyre Therapeutics's main competitors and comparable companies include Roivant Sciences (ROIV), Insmed (INSM), Incyte (INCY), BioNTech (BNTX), and Genmab A/S (GMAB). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Spyre Therapeutics compare to Roivant Sciences?

Roivant Sciences (NASDAQ:ROIV) and Spyre Therapeutics (NASDAQ:SYRE) are both healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their dividends, institutional ownership, risk, earnings, profitability, media sentiment, valuation and analyst recommendations.

Spyre Therapeutics has a net margin of 0.00% compared to Roivant Sciences' net margin of -3,534.96%. Roivant Sciences' return on equity of -22.94% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Roivant Sciences-3,534.96% -22.94% -21.53%
Spyre Therapeutics N/A -30.74%-22.23%

Roivant Sciences currently has a consensus price target of $45.64, indicating a potential upside of 27.76%. Spyre Therapeutics has a consensus price target of $109.71, indicating a potential upside of 17.73%. Given Roivant Sciences' higher possible upside, research analysts clearly believe Roivant Sciences is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.85
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.88

Spyre Therapeutics has lower revenue, but higher earnings than Roivant Sciences. Roivant Sciences is trading at a lower price-to-earnings ratio than Spyre Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Roivant Sciences$8.26M3,123.64-$299.77M-$0.53N/A
Spyre Therapeutics$890K9,208.01-$155.20M-$1.95N/A

In the previous week, Spyre Therapeutics had 17 more articles in the media than Roivant Sciences. MarketBeat recorded 24 mentions for Spyre Therapeutics and 7 mentions for Roivant Sciences. Spyre Therapeutics' average media sentiment score of 0.27 beat Roivant Sciences' score of 0.12 indicating that Spyre Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Roivant Sciences
2 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
2 Negative mention(s)
0 Very Negative mention(s)
Neutral
Spyre Therapeutics
6 Very Positive mention(s)
5 Positive mention(s)
6 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

64.8% of Roivant Sciences shares are owned by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are owned by institutional investors. 8.8% of Roivant Sciences shares are owned by insiders. Comparatively, 15.7% of Spyre Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Roivant Sciences has a beta of 1.1, meaning that its stock price is 10% more volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.1, meaning that its stock price is 210% more volatile than the broader market.

Summary

Spyre Therapeutics beats Roivant Sciences on 11 of the 16 factors compared between the two stocks.

How does Spyre Therapeutics compare to Insmed?

Insmed (NASDAQ:INSM) and Spyre Therapeutics (NASDAQ:SYRE) are both healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their institutional ownership, analyst recommendations, earnings, valuation, profitability, risk, dividends and media sentiment.

Spyre Therapeutics has lower revenue, but higher earnings than Insmed. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Insmed, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Insmed$606.42M40.02-$1.28B-$4.11N/A
Spyre Therapeutics$890K9,208.01-$155.20M-$1.95N/A

Insmed currently has a consensus target price of $200.57, indicating a potential upside of 80.49%. Spyre Therapeutics has a consensus target price of $109.71, indicating a potential upside of 17.73%. Given Insmed's stronger consensus rating and higher probable upside, equities analysts plainly believe Insmed is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.88

Spyre Therapeutics has a net margin of 0.00% compared to Insmed's net margin of -76.94%. Spyre Therapeutics' return on equity of -30.74% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Insmed-76.94% -123.94% -44.30%
Spyre Therapeutics N/A -30.74%-22.23%

80.4% of Spyre Therapeutics shares are held by institutional investors. 2.1% of Insmed shares are held by insiders. Comparatively, 15.7% of Spyre Therapeutics shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

In the previous week, Spyre Therapeutics had 19 more articles in the media than Insmed. MarketBeat recorded 24 mentions for Spyre Therapeutics and 5 mentions for Insmed. Insmed's average media sentiment score of 0.53 beat Spyre Therapeutics' score of 0.27 indicating that Insmed is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Insmed
1 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Spyre Therapeutics
6 Very Positive mention(s)
5 Positive mention(s)
6 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

Insmed has a beta of 0.83, meaning that its stock price is 17% less volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.1, meaning that its stock price is 210% more volatile than the broader market.

Summary

Spyre Therapeutics beats Insmed on 10 of the 17 factors compared between the two stocks.

How does Spyre Therapeutics compare to Incyte?

Spyre Therapeutics (NASDAQ:SYRE) and Incyte (NASDAQ:INCY) are both healthcare companies, but which is the superior business? We will contrast the two companies based on the strength of their institutional ownership, media sentiment, risk, dividends, profitability, analyst recommendations, earnings and valuation.

In the previous week, Spyre Therapeutics and Spyre Therapeutics both had 24 articles in the media. Incyte's average media sentiment score of 0.65 beat Spyre Therapeutics' score of 0.27 indicating that Incyte is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
6 Very Positive mention(s)
5 Positive mention(s)
6 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Incyte
8 Very Positive mention(s)
4 Positive mention(s)
9 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Incyte has a net margin of 27.71% compared to Spyre Therapeutics' net margin of 0.00%. Incyte's return on equity of 29.93% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -30.74% -22.23%
Incyte 27.71%29.93%22.88%

Spyre Therapeutics has a beta of 3.1, meaning that its share price is 210% more volatile than the broader market. Comparatively, Incyte has a beta of 0.74, meaning that its share price is 26% less volatile than the broader market.

Spyre Therapeutics presently has a consensus price target of $109.71, suggesting a potential upside of 17.73%. Incyte has a consensus price target of $126.15, suggesting a potential upside of 9.41%. Given Spyre Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Spyre Therapeutics is more favorable than Incyte.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.88
Incyte
0 Sell rating(s)
12 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.56

80.4% of Spyre Therapeutics shares are owned by institutional investors. Comparatively, 97.0% of Incyte shares are owned by institutional investors. 15.7% of Spyre Therapeutics shares are owned by company insiders. Comparatively, 16.2% of Incyte shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Incyte has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Incyte, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre Therapeutics$890K9,208.01-$155.20M-$1.95N/A
Incyte$5.14B4.55$1.29B$7.8514.69

Summary

Incyte beats Spyre Therapeutics on 10 of the 15 factors compared between the two stocks.

How does Spyre Therapeutics compare to BioNTech?

Spyre Therapeutics (NASDAQ:SYRE) and BioNTech (NASDAQ:BNTX) are both healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their earnings, analyst recommendations, institutional ownership, profitability, valuation, media sentiment, dividends and risk.

In the previous week, Spyre Therapeutics had 1 more articles in the media than BioNTech. MarketBeat recorded 24 mentions for Spyre Therapeutics and 23 mentions for BioNTech. Spyre Therapeutics' average media sentiment score of 0.27 beat BioNTech's score of 0.16 indicating that Spyre Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
6 Very Positive mention(s)
5 Positive mention(s)
6 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
BioNTech
8 Very Positive mention(s)
1 Positive mention(s)
7 Neutral mention(s)
2 Negative mention(s)
1 Very Negative mention(s)
Neutral

Spyre Therapeutics has a beta of 3.1, meaning that its share price is 210% more volatile than the broader market. Comparatively, BioNTech has a beta of 1.25, meaning that its share price is 25% more volatile than the broader market.

Spyre Therapeutics has a net margin of 0.00% compared to BioNTech's net margin of -63.54%. BioNTech's return on equity of -6.86% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -30.74% -22.23%
BioNTech -63.54%-6.86%-6.00%

Spyre Therapeutics presently has a consensus price target of $109.71, suggesting a potential upside of 17.73%. BioNTech has a consensus price target of $126.00, suggesting a potential upside of 30.03%. Given BioNTech's higher probable upside, analysts plainly believe BioNTech is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.88
BioNTech
1 Sell rating(s)
5 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.68

Spyre Therapeutics has higher earnings, but lower revenue than BioNTech. Spyre Therapeutics is trading at a lower price-to-earnings ratio than BioNTech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre Therapeutics$890K9,208.01-$155.20M-$1.95N/A
BioNTech$3.25B7.55-$1.29B-$7.83N/A

80.4% of Spyre Therapeutics shares are owned by institutional investors. Comparatively, 15.5% of BioNTech shares are owned by institutional investors. 15.7% of Spyre Therapeutics shares are owned by insiders. Comparatively, 19.2% of BioNTech shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Summary

Spyre Therapeutics beats BioNTech on 10 of the 16 factors compared between the two stocks.

How does Spyre Therapeutics compare to Genmab A/S?

Genmab A/S (NASDAQ:GMAB) and Spyre Therapeutics (NASDAQ:SYRE) are both healthcare companies, but which is the better stock? We will compare the two businesses based on the strength of their institutional ownership, risk, media sentiment, valuation, earnings, analyst recommendations, profitability and dividends.

In the previous week, Spyre Therapeutics had 17 more articles in the media than Genmab A/S. MarketBeat recorded 24 mentions for Spyre Therapeutics and 7 mentions for Genmab A/S. Genmab A/S's average media sentiment score of 0.36 beat Spyre Therapeutics' score of 0.27 indicating that Genmab A/S is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Genmab A/S
2 Very Positive mention(s)
1 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Spyre Therapeutics
6 Very Positive mention(s)
5 Positive mention(s)
6 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

Genmab A/S has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Genmab A/S, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Genmab A/S$3.72B5.83$963M$1.2727.36
Spyre Therapeutics$890K9,208.01-$155.20M-$1.95N/A

Genmab A/S has a net margin of 19.08% compared to Spyre Therapeutics' net margin of 0.00%. Genmab A/S's return on equity of 14.89% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Genmab A/S19.08% 14.89% 7.73%
Spyre Therapeutics N/A -30.74%-22.23%

7.1% of Genmab A/S shares are owned by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are owned by institutional investors. 1.5% of Genmab A/S shares are owned by insiders. Comparatively, 15.7% of Spyre Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Genmab A/S has a beta of 0.81, suggesting that its share price is 19% less volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.1, suggesting that its share price is 210% more volatile than the broader market.

Genmab A/S currently has a consensus price target of $39.50, suggesting a potential upside of 13.67%. Spyre Therapeutics has a consensus price target of $109.71, suggesting a potential upside of 17.73%. Given Spyre Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Spyre Therapeutics is more favorable than Genmab A/S.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Genmab A/S
0 Sell rating(s)
3 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.85
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.88

Summary

Genmab A/S and Spyre Therapeutics tied by winning 8 of the 16 factors compared between the two stocks.

Get Spyre Therapeutics News Delivered to You Automatically

Sign up to receive the latest news and ratings for SYRE and its competitors with MarketBeat's FREE daily newsletter.

Subscribe Now
SMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy.

New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SYRE and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
Skip Chart

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
Skip Chart

SYRE vs. The Competition

MetricSpyre TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$8.19B$3.85B$7.15B$13.28B
Dividend YieldN/A3.65%2.54%17.33%
P/E Ratio-47.7913.00274.7126.04
Price / Sales9,208.011,288.64656.46105.16
Price / CashN/A123.3978.8752.62
Price / Book12.9316.5710.936.31
Net Income-$155.20M-$22.66M$3.51B$362.16M
7 Day Performance8.75%-2.97%-2.00%-1.66%
1 Month Performance4.73%-10.82%-6.19%-4.68%
1 Year Performance486.47%19.00%8.03%1.57%

Spyre Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SYRE
Spyre Therapeutics
2.0639 of 5 stars
$93.19
+3.6%
$109.71
+17.7%
+486.5%$8.19B$890KN/A112
ROIV
Roivant Sciences
2.9735 of 5 stars
$36.50
-1.3%
$45.64
+25.0%
+120.9%$26.36B$8.26MN/A721
INSM
Insmed
3.4308 of 5 stars
$115.63
-1.7%
$201.87
+74.6%
-29.3%$25.25B$606.42MN/A1,664
INCY
Incyte
3.8831 of 5 stars
$123.20
-1.3%
$124.80
+1.3%
+32.8%$24.97B$5.14B15.692,844
BNTX
BioNTech
3.6368 of 5 stars
$98.57
-0.5%
$126.00
+27.8%
-8.1%$24.93B$3.25BN/A7,807

Related Companies and Tools


This page (NASDAQ:SYRE) was last updated on 10/4/2026 by MarketBeat.com Staff.
From Our Partners