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Spyre Therapeutics (SYRE) Institutional Ownership

Spyre Therapeutics logo
$93.19 +3.26 (+3.63%)
Closing price 10/2/2026 04:00 PM Eastern
Extended Trading
$93.19 0.00 (0.00%)
As of 10/2/2026 07:30 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.
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Institutional Ownership Changes (13F Filings) for Spyre Therapeutics (NASDAQ:SYRE)

Current
Institutional Ownership
Percentage
80.39%
Number of
Institutional Buyers
(last 12 months)
102
Total
Institutional Inflows
(last 12 months)
$687.84M
Number of
Institutional Sellers
(last 12 months)
47
Total
Institutional Outflows
(last 12 months)
$213.51M
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SYRE Institutional Buying and Selling by Quarter

Spyre Therapeutics Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
9/9/2026Engineers Gate Manager LP38,474$3.42M0.0%N/A0.044%
9/9/2026Integrated Wealth Concepts LLC353$31K0.0%N/A0.000%
9/9/2026Maven Securities LTD40,000$3.55M0.1%N/A0.045%
9/9/2026Squarepoint Ops LLC139,605$12.39M0.0%N/A0.159%
9/8/2026Arizona State Retirement System15,471$1.37M0.0%+15.1%0.018%
9/8/2026Waverly Advisors LLC25,512$2.27M0.0%-1.7%0.029%
9/8/2026Nykredit A S1,953$173K0.0%N/A0.002%
9/2/2026Allianz Asset Management GmbH14,100$1.25M0.0%N/A0.016%
8/25/2026VIRGINIA RETIREMENT SYSTEMS ET Al11,250$999K0.0%N/A0.013%
8/22/2026Seven Fleet Capital Management LP13,300$1.18M0.2%-32.5%0.015%
8/21/2026Braidwell LP879,467$78.08M2.9%-5.7%1.000%
8/21/2026Nykredit A S1,953$173K0.0%N/A0.002%
8/19/2026Wellington Management Group LLP1,581,505$140.41M0.0%-13.3%1.798%
8/6/2026Bank of New York Mellon Corp245,193$21.77M0.0%N/A0.279%
7/10/2026Handelsbanken Fonder AB26,000$2.31M0.0%N/A0.030%
7/7/2026GAMMA Investing LLC663$59K0.0%+26.8%0.001%
6/4/2026Seven Fleet Capital Management LP19,690$993K0.3%N/A0.023%
5/29/2026Perceptive Advisors LLC3,783,225$190.83M3.7%+23.3%4.357%
5/19/2026Bank of America Corp DE1,228,093$61.95M0.0%+192.6%1.414%
5/19/2026Stempoint Capital LP167,606$8.45M1.6%+417.7%0.193%
5/19/2026Janus Henderson Group PLC1,656,164$83.59M0.0%-9.5%1.907%
5/18/2026ADAR1 Capital Management LLC338,323$17.07M1.0%+893.6%0.390%
5/18/2026California State Teachers Retirement System59,242$2.99M0.0%+23.3%0.068%
5/18/2026Royal Bank of Canada3,250$164K0.0%+63.5%0.004%
5/16/2026The Manufacturers Life Insurance Company112,841$5.69M0.0%-12.5%0.130%
5/16/2026Quantinno Capital Management LP4,561$230K0.0%N/A0.005%
5/16/2026ABS Direct Equity Fund LLC2,800$141K0.1%N/A0.003%
5/15/2026Commodore Capital LP1,912,380$96.46M5.6%-19.9%2.202%
5/15/2026Affinity Asset Advisors LLC1,279,134$64.52M3.3%-10.7%1.473%
5/14/2026Sei Investments Co.8,975$453K0.0%+46.7%0.010%
5/13/2026First Trust Advisors LP178,389$9.00M0.0%N/A0.205%
5/7/2026Dimensional Fund Advisors LP47,697$2.41M0.0%-38.3%0.061%
5/7/2026AlphaCentric Advisors LLC6,634$335K0.3%N/A0.008%
5/7/2026KBC Group NV1,372$69K0.0%N/A0.002%
5/5/2026Bank of New York Mellon Corp191,395$9.65M0.0%-0.7%0.243%
5/4/2026Emerald Mutual Fund Advisers Trust408,113$20.59M1.0%-1.0%0.518%
5/4/2026Emerald Advisers LLC613,365$30.94M1.0%-3.6%0.779%
5/4/2026Principal Financial Group Inc.4,299$217K0.0%N/A0.005%
5/1/2026Candriam S.C.A.610,282$30.78M0.2%+43.4%0.775%
4/30/2026Summit Securities Group LLC562$28K0.0%N/A0.001%
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4/25/2026Strs Ohio4,500$227K0.0%N/A0.006%
4/22/2026Pictet Asset Management Holding SA491,649$24.80M0.0%-46.2%0.624%
4/22/2026Union Bancaire Privee UBP SA3,880$196K0.0%N/A0.005%
4/22/2026Sterling Capital Management LLC1,051$53K0.0%-34.7%0.001%
4/20/2026Assenagon Asset Management S.A.18,647$941K0.0%-15.8%0.024%
4/17/2026High Net Worth Advisory Group LLC6,000$303K0.1%N/A0.008%
4/16/2026SG Americas Securities LLC13,396$676K0.0%-42.6%0.017%
2/19/2026Invesco Ltd.150,934$4.95M0.0%+197.7%0.195%
2/18/2026Mercer Global Advisors Inc. ADV106,316$3.48M0.0%-0.3%0.137%
2/18/2026VARCOV Co.8,008$262K0.1%N/A0.010%
2/18/2026Virtus Investment Advisers LLC7,913$259K0.1%+23.2%0.010%
2/18/2026Wellington Management Group LLP1,549,284$50.76M0.0%-5.5%1.997%
2/18/2026Susquehanna Portfolio Strategies LLC53,101$1.74M0.0%+144.3%0.068%
2/18/2026Tang Capital Management LLC1,892,200$61.99M3.1%-40.9%2.439%
2/18/2026Tudor Investment Corp ET AL10,127$332K0.0%N/A0.013%
2/18/2026RTW Investments LP4,171,996$136.68M1.4%+15.2%5.377%
2/18/2026Perceptive Advisors LLC3,069,225$100.55M1.8%+149.6%3.956%
2/18/2026Millennium Management LLC76,194$2.50M0.0%-81.3%0.098%
2/18/2026Janus Henderson Group PLC1,829,009$59.92M0.0%+13,969.3%2.357%
2/18/2026Cinctive Capital Management LP35,935$1.18M0.1%N/A0.046%
2/18/2026Commodore Capital LP2,388,245$78.24M5.2%+20.1%3.078%
2/18/2026Balyasny Asset Management L.P.73,465$2.41M0.0%N/A0.095%
2/18/2026Armistice Capital LLC196,426$6.44M0.1%+25.9%0.253%
2/17/2026AQR Capital Management LLC17,820$584K0.0%+4.5%0.023%
2/17/2026Braidwell LP1,634,615$53.55M1.7%-36.6%2.107%
2/17/2026RA Capital Management L.P.1,621,620$53.12M0.5%N/A2.090%
2/17/2026Price T Rowe Associates Inc. MD1,601,882$52.48M0.0%+158.1%2.065%
2/17/2026California State Teachers Retirement System48,038$1.57M0.0%+44.7%0.062%
2/17/2026Russell Investments Group Ltd.5,554$182K0.0%+31.2%0.007%
2/17/2026State of Wisconsin Investment Board27,252$893K0.0%-18.8%0.035%
2/17/2026ExodusPoint Capital Management LP37,871$1.24M0.0%-44.8%0.049%
2/17/2026Royal Bank of Canada1,988$65K0.0%-74.8%0.003%
2/17/2026Persistent Asset Partners Ltd2,246$74K0.0%N/A0.003%
2/17/2026Polar Capital Holdings Plc740,326$24.25M0.1%-6.1%0.954%
2/16/2026Barclays PLC182,524$5.98M0.0%+8.4%0.235%
2/13/2026The Manufacturers Life Insurance Company 129,013$4.14M0.0%+79.3%0.166%
2/13/2026Carlyle Group Inc.9,620$315K0.0%N/A0.012%
2/13/2026Affinity Asset Advisors LLC1,432,591$46.93M2.7%+0.9%1.846%
2/13/2026Schroder Investment Management Group61,574$1.96M0.0%-42.8%0.079%
2/13/2026Rafferty Asset Management LLC53,410$1.75M0.0%-10.5%0.069%
2/13/2026Siren L.L.C.818,598$26.82M0.8%+122.1%1.055%
2/13/2026Charles Schwab Investment Management Inc.574,622$18.83M0.0%+35.1%0.741%
2/13/2026Police & Firemen s Retirement System of New Jersey18,360$601K0.0%+33.0%0.024%
2/13/2026State Street Corp2,262,839$74.13M0.0%+26.8%2.916%
2/13/2026Martingale Asset Management L P6,930$227K0.0%N/A0.009%
2/13/2026UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC62,216$2.04M0.0%+57.5%0.080%
2/13/2026Wells Fargo & Company MN82,416$2.70M0.0%+109.6%0.106%
2/12/2026Remedium Capital Partners LLC1,456,231$47.71M28.0%N/A1.877%
2/12/2026MetLife Investment Management LLC38,011$1.25M0.0%+27.1%0.049%
2/12/2026State Board of Administration of Florida Retirement System9,030$296K0.0%N/A0.012%
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2/12/2026Dimensional Fund Advisors LP77,290$2.53M0.0%-8.2%0.100%
2/12/2026Patient Square Capital LP150,000$4.91M1.1%N/A0.193%
2/12/2026New York State Common Retirement Fund19,165$628K0.0%+15.7%0.025%
2/12/2026Alps Advisors Inc.63,708$2.09M0.0%N/A0.082%
2/12/2026Swiss National Bank96,500$3.16M0.0%+37.5%0.124%
2/12/2026Nuveen LLC150,980$4.95M0.0%+57.0%0.195%
2/11/2026Deutsche Bank AG121,941$4.00M0.0%+216.4%0.157%
2/11/2026Franklin Resources Inc.1,109,274$36.34M0.0%+39.5%1.430%
2/11/2026Capital International Investors3,492,541$114.42M0.0%+46.0%4.501%
2/11/2026Los Angeles Capital Management LLC12,882$422K0.0%-29.1%0.017%


SYRE Institutional Ownership - Frequently Asked Questions

During the previous two years, 159 institutional investors and hedge funds held shares of Spyre Therapeutics. The most heavily invested institutionals were FMR LLC ($204.89M), Perceptive Advisors LLC ($190.83M), Wellington Management Group LLP ($140.41M), RTW Investments LP ($136.68M), Vanguard Group Inc. ($132.19M), Capital International Investors ($114.42M), and Commodore Capital LP ($96.46M).Learn more on Spyre Therapeutics' institutional investors.

80.39% of Spyre Therapeutics' stock is owned by institutional investors. Learn more on SYRE's institutional investor holdings.

Of the 145 institutional investors that purchased Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Janus Henderson Group PLC ($2.60M), Perceptive Advisors LLC ($2.55M), Driehaus Capital Management LLC ($2.12M), RA Capital Management L.P. ($1.62M), Remedium Capital Partners LLC ($1.46M), Vanguard Group Inc. ($1.37M), and FMR LLC ($1.29M).

Institutional investors have bought a total of 20,488,810 shares in the last 24 months. This purchase volume represents approximately $687.84M in transactions.

Of the 47 institutional investors that sold Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Tang Capital Management LLC ($1.31M), Braidwell LP ($997.15K), Pictet Asset Management Holding SA ($544.57K), Commodore Capital LP ($475.87K), Paradigm Biocapital Advisors LP ($403.18K), Wellington Management Group LLP ($334.33K), and Woodline Partners LP ($333.28K).

Institutional investors have sold a total of 5,923,694 shares in the last 24 months. This volume of shares sold represents approximately $213.51M in transactions.


Related Companies

Institutional ownership data for NASDAQ:SYRE is compiled from quarterly 13F filings submitted to the U.S. Securities and Exchange Commission (SEC), with the most recent received on 9/9/2026. New 13F filings are added each quarter as they're published.
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