Free Trial
→ Nobody Understands Why Trump Is Invading Iran (here’s the answer) (From Banyan Hill Publishing) (Ad)tc pixel Free SYRE Stock Alerts

Spyre Therapeutics (SYRE) Institutional Ownership

Spyre Therapeutics logo
$74.14 -1.51 (-1.99%)
As of 03:17 PM Eastern
This is a fair market value price provided by Massive. Learn more.
Compare

Institutional Ownership Changes (13F Filings) for Spyre Therapeutics (NASDAQ:SYRE)

Current
Institutional Ownership
Percentage
80.39%
Number of
Institutional Buyers
(last 12 months)
100
Total
Institutional Inflows
(last 12 months)
$557.09M
Number of
Institutional Sellers
(last 12 months)
50
Total
Institutional Outflows
(last 12 months)
$191.54M
Get SYRE Insider Trade Alerts

Want to know when executives and insiders are buying or selling Spyre Therapeutics stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily.

Subscribe Now
SMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy.
Skip Chart & View Institutional Buying and Selling Data

SYRE Institutional Buying and Selling by Quarter

Spyre Therapeutics Major Shareholders & Ownership History

Export
Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
5/15/2026Affinity Asset Advisors LLC1,279,134$64.52M3.3%-10.7%1.473%
5/14/2026 Sei Investments Co.8,975$453K0.0%+46.7%0.010%
5/13/2026 First Trust Advisors LP178,389$9.00M0.0%N/A0.205%
5/7/2026 Dimensional Fund Advisors LP47,697$2.41M0.0%-38.3%0.061%
5/7/2026 AlphaCentric Advisors LLC6,634$335K0.3%N/A0.008%
5/7/2026 KBC Group NV1,372$69K0.0%N/A0.002%
5/5/2026 Bank of New York Mellon Corp191,395$9.65M0.0%-0.7%0.243%
5/4/2026 Emerald Mutual Fund Advisers Trust408,113$20.59M1.0%-1.0%0.518%
5/4/2026 Emerald Advisers LLC613,365$30.94M1.0%-3.6%0.779%
5/4/2026 Principal Financial Group Inc.4,299$217K0.0%N/A0.005%
5/1/2026 Candriam S.C.A.610,282$30.78M0.2%+43.4%0.775%
4/30/2026 Summit Securities Group LLC562$28K0.0%N/A0.001%
4/25/2026 Strs Ohio4,500$227K0.0%N/A0.006%
4/22/2026 Pictet Asset Management Holding SA491,649$24.80M0.0%-46.2%0.624%
4/22/2026 Union Bancaire Privee UBP SA3,880$196K0.0%N/A0.005%
4/22/2026 Sterling Capital Management LLC1,051$53K0.0%-34.7%0.001%
4/20/2026 Assenagon Asset Management S.A.18,647$941K0.0%-15.8%0.024%
4/17/2026 High Net Worth Advisory Group LLC6,000$303K0.1%N/A0.008%
4/16/2026 SG Americas Securities LLC13,396$676K0.0%-42.6%0.017%
2/19/2026 Invesco Ltd.150,934$4.95M0.0%+197.7%0.195%
2/18/2026Mercer Global Advisors Inc. ADV106,316$3.48M0.0%-0.3%0.137%
2/18/2026VARCOV Co.8,008$262K0.1%N/A0.010%
2/18/2026Virtus Investment Advisers LLC7,913$259K0.1%+23.2%0.010%
2/18/2026Wellington Management Group LLP1,549,284$50.76M0.0%-5.5%1.997%
2/18/2026Susquehanna Portfolio Strategies LLC53,101$1.74M0.0%+144.3%0.068%
2/18/2026Tang Capital Management LLC1,892,200$61.99M3.1%-40.9%2.439%
2/18/2026Tudor Investment Corp ET AL10,127$332K0.0%N/A0.013%
2/18/2026RTW Investments LP4,171,996$136.68M1.4%+15.2%5.377%
2/18/2026Perceptive Advisors LLC3,069,225$100.55M1.8%+149.6%3.956%
2/18/2026Millennium Management LLC76,194$2.50M0.0%-81.3%0.098%
2/18/2026Janus Henderson Group PLC1,829,009$59.92M0.0%+13,969.3%2.357%
2/18/2026Cinctive Capital Management LP35,935$1.18M0.1%N/A0.046%
2/18/2026Commodore Capital LP2,388,245$78.24M5.2%+20.1%3.078%
2/18/2026Balyasny Asset Management L.P.73,465$2.41M0.0%N/A0.095%
2/18/2026Armistice Capital LLC196,426$6.44M0.1%+25.9%0.253%
2/17/2026AQR Capital Management LLC17,820$584K0.0%+4.5%0.023%
2/17/2026Braidwell LP1,634,615$53.55M1.7%-36.6%2.107%
2/17/2026RA Capital Management L.P.1,621,620$53.12M0.5%N/A2.090%
2/17/2026Price T Rowe Associates Inc. MD1,601,882$52.48M0.0%+158.1%2.065%
2/17/2026California State Teachers Retirement System48,038$1.57M0.0%+44.7%0.062%
The REAL Reason Trump is Invading Iran (Ad)

For a moment… Forget about Trump’s ties to Israel. Forget about reports of Iran’s nuclear program. Because my research has led me to believe we’re risking World War 3 with Iran for a completely different reason.tc pixel

Click here to find out what it is.
2/17/2026 Russell Investments Group Ltd.5,554$182K0.0%+31.2%0.007%
2/17/2026State of Wisconsin Investment Board27,252$893K0.0%-18.8%0.035%
2/17/2026ExodusPoint Capital Management LP37,871$1.24M0.0%-44.8%0.049%
2/17/2026Royal Bank of Canada1,988$65K0.0%-74.8%0.003%
2/17/2026 Persistent Asset Partners Ltd2,246$74K0.0%N/A0.003%
2/17/2026Polar Capital Holdings Plc740,326$24.25M0.1%-6.1%0.954%
2/16/2026Barclays PLC182,524$5.98M0.0%+8.4%0.235%
2/13/2026The Manufacturers Life Insurance Company 129,013$4.14M0.0%+79.3%0.166%
2/13/2026 Carlyle Group Inc.9,620$315K0.0%N/A0.012%
2/13/2026Affinity Asset Advisors LLC1,432,591$46.93M2.7%+0.9%1.846%
2/13/2026Schroder Investment Management Group61,574$1.96M0.0%-42.8%0.079%
2/13/2026Rafferty Asset Management LLC53,410$1.75M0.0%-10.5%0.069%
2/13/2026Siren L.L.C.818,598$26.82M0.8%+122.1%1.055%
2/13/2026Charles Schwab Investment Management Inc.574,622$18.83M0.0%+35.1%0.741%
2/13/2026 Police & Firemen s Retirement System of New Jersey18,360$601K0.0%+33.0%0.024%
2/13/2026State Street Corp2,262,839$74.13M0.0%+26.8%2.916%
2/13/2026 Martingale Asset Management L P6,930$227K0.0%N/A0.009%
2/13/2026 UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC62,216$2.04M0.0%+57.5%0.080%
2/13/2026 Wells Fargo & Company MN82,416$2.70M0.0%+109.6%0.106%
2/12/2026 Remedium Capital Partners LLC1,456,231$47.71M28.0%N/A1.877%
2/12/2026MetLife Investment Management LLC38,011$1.25M0.0%+27.1%0.049%
2/12/2026 State Board of Administration of Florida Retirement System9,030$296K0.0%N/A0.012%
2/12/2026 Dimensional Fund Advisors LP77,290$2.53M0.0%-8.2%0.100%
2/12/2026Patient Square Capital LP150,000$4.91M1.1%N/A0.193%
2/12/2026 New York State Common Retirement Fund19,165$628K0.0%+15.7%0.025%
2/12/2026 Alps Advisors Inc.63,708$2.09M0.0%N/A0.082%
2/12/2026 Swiss National Bank96,500$3.16M0.0%+37.5%0.124%
2/12/2026 Nuveen LLC150,980$4.95M0.0%+57.0%0.195%
2/11/2026 Deutsche Bank AG121,941$4.00M0.0%+216.4%0.157%
2/11/2026 Franklin Resources Inc.1,109,274$36.34M0.0%+39.5%1.430%
2/11/2026 Capital International Investors3,492,541$114.42M0.0%+46.0%4.501%
2/11/2026 Los Angeles Capital Management LLC12,882$422K0.0%-29.1%0.017%
2/11/2026Arrowpoint Investment Partners Singapore Pte. Ltd.13,724$450K0.1%N/A0.018%
2/10/2026 TD Asset Management Inc149,822$4.91M0.0%+107.0%0.193%
2/10/2026Goldman Sachs Group Inc.275,065$9.01M0.0%-16.5%0.355%
2/10/2026 Intech Investment Management LLC18,274$599K0.0%-10.2%0.024%
2/10/2026 Seven Grand Managers LLC100,000$3.28M0.2%N/A0.129%
2/9/2026Geode Capital Management LLC1,659,140$54.36M0.0%+35.4%2.138%
2/9/2026 Optimize Financial Inc25,331$830K0.4%+1.5%0.033%
2/6/2026 PSP Research LLC15,840$519K0.5%N/A0.020%
2/6/2026 Profund Advisors LLC20,593$675K0.0%+55.7%0.027%
2/6/2026 ProShare Advisors LLC15,989$524K0.0%+49.7%0.021%
2/4/2026VIRGINIA RETIREMENT SYSTEMS ET Al24,950$817K0.0%+34.9%0.032%
2/3/2026 F m Investments LLC103,718$3.40M0.1%+88.9%0.134%
1/30/2026 State of New Jersey Common Pension Fund D16,698$547K0.0%N/A0.022%
1/29/2026 Pictet Asset Management Holding SA913,960$29.94M0.0%-11.8%1.178%
1/29/2026 UBS Group AG680,566$22.30M0.0%+76.5%0.877%
1/29/2026Vanguard Group Inc.4,035,074$132.19M0.0%+32.3%5.201%
1/29/2026 China Universal Asset Management Co. Ltd.12,644$414K0.0%+19.4%0.016%
1/28/2026 Arizona State Retirement System13,797$452K0.0%+29.0%0.018%
Before you buy SpaceX shares, consider this alternative approach (Ad)

SpaceX has confidentially filed for an IPO with the SEC, targeting a June 2026 listing at a valuation exceeding $1.75 trillion - potentially the largest IPO in history. But one expert says buying shares directly may not be the smartest move. There is a lesser-known way to tap into this windfall that most investors haven't considered.tc pixel

Discover the overlooked SpaceX IPO strategy before the June listing
1/28/2026 Universal Beteiligungs und Servicegesellschaft mbH171,211$5.61M0.0%+55.0%0.221%
1/26/2026 Mirae Asset Global Investments Co. Ltd.3,770$124K0.0%+61.5%0.005%
1/9/2026 SG Americas Securities LLC23,343$765K0.0%N/A0.030%
1/1/2026 JPMorgan Chase & Co.275,984$4.63M0.0%+483.7%0.356%
11/17/2025Armistice Capital LLC156,000$2.62M0.0%-9.3%0.201%
11/17/2025Woodline Partners LP131,876$2.21M0.0%-71.6%0.170%
11/17/2025TCG Crossover Management LLC1,100,582$18.45M0.9%N/A1.418%
11/17/2025Dark Forest Capital Management LP14,733$247K0.0%N/A0.019%
11/17/2025Verition Fund Management LLC48,496$813K0.0%-25.4%0.063%
11/17/2025Polar Capital Holdings Plc788,788$13.22M0.1%+5.9%1.017%


SYRE Institutional Ownership - Frequently Asked Questions

During the previous two years, 157 institutional investors and hedge funds held shares of Spyre Therapeutics. The most heavily invested institutionals were FMR LLC ($204.89M), RTW Investments LP ($136.68M), Vanguard Group Inc. ($132.19M), Capital International Investors ($114.42M), Perceptive Advisors LLC ($100.55M), Commodore Capital LP ($78.24M), and State Street Corp ($74.13M).Learn more on Spyre Therapeutics' institutional investors.

80.39% of Spyre Therapeutics' stock is owned by institutional investors. Learn more on SYRE's institutional investor holdings.

Of the 142 institutional investors that purchased Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Driehaus Capital Management LLC ($2.80M), Janus Henderson Group PLC ($2.60M), Perceptive Advisors LLC ($2.31M), Avoro Capital Advisors LLC ($1.84M), RA Capital Management L.P. ($1.62M), Remedium Capital Partners LLC ($1.46M), and Vanguard Group Inc. ($1.37M).

Institutional investors have bought a total of 19,055,994 shares in the last 24 months. This purchase volume represents approximately $557.09M in transactions.

Of the 49 institutional investors that sold Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Tang Capital Management LLC ($1.31M), Goldman Sachs Group Inc. ($1.16M), Braidwell LP ($943.79K), Perceptive Advisors LLC ($783.83K), Pictet Asset Management Holding SA ($544.57K), Adage Capital Partners GP L.L.C. ($419.80K), and Paradigm Biocapital Advisors LP ($403.18K).

Institutional investors have sold a total of 7,424,101 shares in the last 24 months. This volume of shares sold represents approximately $191.54M in transactions.


Related Companies

This page (NASDAQ:SYRE) was last updated on 5/15/2026 by MarketBeat.com Staff.
From Our Partners
SpaceX eyes a 1.75 trillion valuation - here's what to know
Elon Musk's team has quietly filed confidential paperwork with the SEC for what Bloomberg estimates could be a...
Brownstone Research | Sponsoredtc pixel
Iran's New Leader Just Said Something That Should Terrify Every American
Iran's Supreme Leader has declared the Strait of Hormuz closed as leverage against the U.S. - and with 40% of ...
American Alternative | Sponsoredtc pixel
$30 stock to buy before Starlink goes public (WATCH NOW!)
In the next 3 minutes… James Altucher – legendary investor and venture capitalist… And someone who’s kno...
Paradigm Press | Sponsoredtc pixel
Your book attached
Your Download Link (Expiring) If you still haven't downloaded the free Simple Options Trading For Beginners...
Profits Run | Sponsoredtc pixel
My feud with Zohran Mamdani
Emmy-winning analyst releases his next big story Whitney Tilson shocked the nation on 60 Minutes when he ac...
Stansberry Research | Sponsoredtc pixel
Iran War Shock: What I Was Told In That Private Meeting
You’re Being LIED To About The Iran War Forget EVERYTHING you’ve heard about the Iran war. Especially th...
Banyan Hill Publishing | Sponsoredtc pixel
Trump's gold order: the announcement they won't put on the front page
On August 15, 1971, Nixon interrupted prime-time television and ended the gold standard in 15 minutes - no deb...
Reagan Gold Group | Sponsoredtc pixel
Why this tiny stock may move before the SpaceX IPO drops
The projected SpaceX and xAI S-1 filing hits the SEC on June 1st - and analyst Dylan Jovine says $1.75 trillio...
Behind the Markets | Sponsoredtc pixel