Spyre Therapeutics (SYRE) Institutional Ownership

$78.48 +4.96 (+6.75%)

Closing price 04:00 PM Eastern

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$82.00 +3.52 (+4.49%)

As of 07:09 PM Eastern

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Current Institutional Ownership Percentage: 80.39%
Number of Institutional Buyers (last 12 months): 103
Total Institutional Inflows (last 12 months): $654.93M

Number of Institutional Sellers (last 12 months): 51
Total Institutional Outflows (last 12 months): $212.42M

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SYRE Institutional Buying and Selling by Quarter

Spyre Therapeutics Major Shareholders & Ownership History

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Reporting Date	Major Shareholder Name	Shares Held	Market Value	% of Portfolio	Quarterly Change in Shares	Ownership in Company
5/29/2026	Perceptive Advisors LLC	3,783,225	$190.83M	3.7%	+23.3%	4.357%
5/19/2026	Bank of America Corp DE	1,228,093	$61.95M	0.0%	+192.6%	1.414%
5/19/2026	Stempoint Capital LP	167,606	$8.45M	1.6%	+417.7%	0.193%
5/19/2026	Janus Henderson Group PLC	1,656,164	$83.59M	0.0%	-9.5%	1.907%
5/18/2026	ADAR1 Capital Management LLC	338,323	$17.07M	1.0%	+893.6%	0.390%
5/18/2026	California State Teachers Retirement System	59,242	$2.99M	0.0%	+23.3%	0.068%
5/18/2026	Royal Bank of Canada	3,250	$164K	0.0%	+63.5%	0.004%
5/16/2026	The Manufacturers Life Insurance Company	112,841	$5.69M	0.0%	-12.5%	0.130%
5/16/2026	Quantinno Capital Management LP	4,561	$230K	0.0%	N/A	0.005%
5/16/2026	ABS Direct Equity Fund LLC	2,800	$141K	0.1%	N/A	0.003%
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5/15/2026	Commodore Capital LP	1,912,380	$96.46M	5.6%	-19.9%	2.202%
5/15/2026	Affinity Asset Advisors LLC	1,279,134	$64.52M	3.3%	-10.7%	1.473%
5/14/2026	Sei Investments Co.	8,975	$453K	0.0%	+46.7%	0.010%
5/13/2026	First Trust Advisors LP	178,389	$9.00M	0.0%	N/A	0.205%
5/7/2026	Dimensional Fund Advisors LP	47,697	$2.41M	0.0%	-38.3%	0.061%
5/7/2026	AlphaCentric Advisors LLC	6,634	$335K	0.3%	N/A	0.008%
5/7/2026	KBC Group NV	1,372	$69K	0.0%	N/A	0.002%
5/5/2026	Bank of New York Mellon Corp	191,395	$9.65M	0.0%	-0.7%	0.243%
5/4/2026	Emerald Mutual Fund Advisers Trust	408,113	$20.59M	1.0%	-1.0%	0.518%
5/4/2026	Emerald Advisers LLC	613,365	$30.94M	1.0%	-3.6%	0.779%
5/4/2026	Principal Financial Group Inc.	4,299	$217K	0.0%	N/A	0.005%
5/1/2026	Candriam S.C.A.	610,282	$30.78M	0.2%	+43.4%	0.775%
4/30/2026	Summit Securities Group LLC	562	$28K	0.0%	N/A	0.001%
4/25/2026	Strs Ohio	4,500	$227K	0.0%	N/A	0.006%
4/22/2026	Pictet Asset Management Holding SA	491,649	$24.80M	0.0%	-46.2%	0.624%
4/22/2026	Union Bancaire Privee UBP SA	3,880	$196K	0.0%	N/A	0.005%
4/22/2026	Sterling Capital Management LLC	1,051	$53K	0.0%	-34.7%	0.001%
4/20/2026	Assenagon Asset Management S.A.	18,647	$941K	0.0%	-15.8%	0.024%
4/17/2026	High Net Worth Advisory Group LLC	6,000	$303K	0.1%	N/A	0.008%
4/16/2026	SG Americas Securities LLC	13,396	$676K	0.0%	-42.6%	0.017%
2/19/2026	Invesco Ltd.	150,934	$4.95M	0.0%	+197.7%	0.195%
2/18/2026	Mercer Global Advisors Inc. ADV	106,316	$3.48M	0.0%	-0.3%	0.137%
2/18/2026	VARCOV Co.	8,008	$262K	0.1%	N/A	0.010%
2/18/2026	Virtus Investment Advisers LLC	7,913	$259K	0.1%	+23.2%	0.010%
2/18/2026	Wellington Management Group LLP	1,549,284	$50.76M	0.0%	-5.5%	1.997%
2/18/2026	Susquehanna Portfolio Strategies LLC	53,101	$1.74M	0.0%	+144.3%	0.068%
2/18/2026	Tang Capital Management LLC	1,892,200	$61.99M	3.1%	-40.9%	2.439%
2/18/2026	Tudor Investment Corp ET AL	10,127	$332K	0.0%	N/A	0.013%
2/18/2026	RTW Investments LP	4,171,996	$136.68M	1.4%	+15.2%	5.377%
2/18/2026	Perceptive Advisors LLC	3,069,225	$100.55M	1.8%	+149.6%	3.956%
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2/18/2026	Millennium Management LLC	76,194	$2.50M	0.0%	-81.3%	0.098%
2/18/2026	Janus Henderson Group PLC	1,829,009	$59.92M	0.0%	+13,969.3%	2.357%
2/18/2026	Cinctive Capital Management LP	35,935	$1.18M	0.1%	N/A	0.046%
2/18/2026	Commodore Capital LP	2,388,245	$78.24M	5.2%	+20.1%	3.078%
2/18/2026	Balyasny Asset Management L.P.	73,465	$2.41M	0.0%	N/A	0.095%
2/18/2026	Armistice Capital LLC	196,426	$6.44M	0.1%	+25.9%	0.253%
2/17/2026	AQR Capital Management LLC	17,820	$584K	0.0%	+4.5%	0.023%
2/17/2026	Braidwell LP	1,634,615	$53.55M	1.7%	-36.6%	2.107%
2/17/2026	RA Capital Management L.P.	1,621,620	$53.12M	0.5%	N/A	2.090%
2/17/2026	Price T Rowe Associates Inc. MD	1,601,882	$52.48M	0.0%	+158.1%	2.065%
2/17/2026	California State Teachers Retirement System	48,038	$1.57M	0.0%	+44.7%	0.062%
2/17/2026	Russell Investments Group Ltd.	5,554	$182K	0.0%	+31.2%	0.007%
2/17/2026	State of Wisconsin Investment Board	27,252	$893K	0.0%	-18.8%	0.035%
2/17/2026	ExodusPoint Capital Management LP	37,871	$1.24M	0.0%	-44.8%	0.049%
2/17/2026	Royal Bank of Canada	1,988	$65K	0.0%	-74.8%	0.003%
2/17/2026	Persistent Asset Partners Ltd	2,246	$74K	0.0%	N/A	0.003%
2/17/2026	Polar Capital Holdings Plc	740,326	$24.25M	0.1%	-6.1%	0.954%
2/16/2026	Barclays PLC	182,524	$5.98M	0.0%	+8.4%	0.235%
2/13/2026	The Manufacturers Life Insurance Company	129,013	$4.14M	0.0%	+79.3%	0.166%
2/13/2026	Carlyle Group Inc.	9,620	$315K	0.0%	N/A	0.012%
2/13/2026	Affinity Asset Advisors LLC	1,432,591	$46.93M	2.7%	+0.9%	1.846%
2/13/2026	Schroder Investment Management Group	61,574	$1.96M	0.0%	-42.8%	0.079%
2/13/2026	Rafferty Asset Management LLC	53,410	$1.75M	0.0%	-10.5%	0.069%
2/13/2026	Siren L.L.C.	818,598	$26.82M	0.8%	+122.1%	1.055%
2/13/2026	Charles Schwab Investment Management Inc.	574,622	$18.83M	0.0%	+35.1%	0.741%
2/13/2026	Police & Firemen s Retirement System of New Jersey	18,360	$601K	0.0%	+33.0%	0.024%
2/13/2026	State Street Corp	2,262,839	$74.13M	0.0%	+26.8%	2.916%
2/13/2026	Martingale Asset Management L P	6,930	$227K	0.0%	N/A	0.009%
2/13/2026	UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	62,216	$2.04M	0.0%	+57.5%	0.080%
2/13/2026	Wells Fargo & Company MN	82,416	$2.70M	0.0%	+109.6%	0.106%
2/12/2026	Remedium Capital Partners LLC	1,456,231	$47.71M	28.0%	N/A	1.877%
2/12/2026	MetLife Investment Management LLC	38,011	$1.25M	0.0%	+27.1%	0.049%
2/12/2026	State Board of Administration of Florida Retirement System	9,030	$296K	0.0%	N/A	0.012%
2/12/2026	Dimensional Fund Advisors LP	77,290	$2.53M	0.0%	-8.2%	0.100%
2/12/2026	Patient Square Capital LP	150,000	$4.91M	1.1%	N/A	0.193%
2/12/2026	New York State Common Retirement Fund	19,165	$628K	0.0%	+15.7%	0.025%
2/12/2026	Alps Advisors Inc.	63,708	$2.09M	0.0%	N/A	0.082%
2/12/2026	Swiss National Bank	96,500	$3.16M	0.0%	+37.5%	0.124%
2/12/2026	Nuveen LLC	150,980	$4.95M	0.0%	+57.0%	0.195%
2/11/2026	Deutsche Bank AG	121,941	$4.00M	0.0%	+216.4%	0.157%
2/11/2026	Franklin Resources Inc.	1,109,274	$36.34M	0.0%	+39.5%	1.430%
2/11/2026	Capital International Investors	3,492,541	$114.42M	0.0%	+46.0%	4.501%
2/11/2026	Los Angeles Capital Management LLC	12,882	$422K	0.0%	-29.1%	0.017%
2/11/2026	Arrowpoint Investment Partners Singapore Pte. Ltd.	13,724	$450K	0.1%	N/A	0.018%
2/10/2026	TD Asset Management Inc	149,822	$4.91M	0.0%	+107.0%	0.193%
2/10/2026	Goldman Sachs Group Inc.	275,065	$9.01M	0.0%	-16.5%	0.355%
2/10/2026	Intech Investment Management LLC	18,274	$599K	0.0%	-10.2%	0.024%
2/10/2026	Seven Grand Managers LLC	100,000	$3.28M	0.2%	N/A	0.129%
2/9/2026	Geode Capital Management LLC	1,659,140	$54.36M	0.0%	+35.4%	2.138%
2/9/2026	Optimize Financial Inc	25,331	$830K	0.4%	+1.5%	0.033%
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2/6/2026	PSP Research LLC	15,840	$519K	0.5%	N/A	0.020%
2/6/2026	Profund Advisors LLC	20,593	$675K	0.0%	+55.7%	0.027%
2/6/2026	ProShare Advisors LLC	15,989	$524K	0.0%	+49.7%	0.021%
2/4/2026	VIRGINIA RETIREMENT SYSTEMS ET Al	24,950	$817K	0.0%	+34.9%	0.032%
2/3/2026	F m Investments LLC	103,718	$3.40M	0.1%	+88.9%	0.134%
1/30/2026	State of New Jersey Common Pension Fund D	16,698	$547K	0.0%	N/A	0.022%
1/29/2026	Pictet Asset Management Holding SA	913,960	$29.94M	0.0%	-11.8%	1.178%
1/29/2026	UBS Group AG	680,566	$22.30M	0.0%	+76.5%	0.877%
1/29/2026	Vanguard Group Inc.	4,035,074	$132.19M	0.0%	+32.3%	5.201%
1/29/2026	China Universal Asset Management Co. Ltd.	12,644	$414K	0.0%	+19.4%	0.016%

SYRE Institutional Ownership - Frequently Asked Questions

During the previous two years, 160 institutional investors and hedge funds held shares of Spyre Therapeutics. The most heavily invested institutionals were FMR LLC ($204.89M), Perceptive Advisors LLC ($190.83M), RTW Investments LP ($136.68M), Vanguard Group Inc. ($132.19M), Capital International Investors ($114.42M), Commodore Capital LP ($96.46M), and Janus Henderson Group PLC ($83.59M).Learn more on Spyre Therapeutics' institutional investors.

80.39% of Spyre Therapeutics' stock is owned by institutional investors. Learn more on SYRE's institutional investor holdings.

Of the 147 institutional investors that purchased Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Perceptive Advisors LLC ($3.03M), Driehaus Capital Management LLC ($2.80M), Janus Henderson Group PLC ($2.60M), Avoro Capital Advisors LLC ($1.84M), RA Capital Management L.P. ($1.62M), Remedium Capital Partners LLC ($1.46M), and Vanguard Group Inc. ($1.37M).

Institutional investors have bought a total of 20,906,250 shares in the last 24 months. This purchase volume represents approximately $654.93M in transactions.

Of the 51 institutional investors that sold Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Tang Capital Management LLC ($1.31M), Braidwell LP ($943.79K), Perceptive Advisors LLC ($783.83K), Goldman Sachs Group Inc. ($604.95K), Pictet Asset Management Holding SA ($544.57K), Commodore Capital LP ($475.87K), and Paradigm Biocapital Advisors LP ($403.18K).

Institutional investors have sold a total of 7,304,663 shares in the last 24 months. This volume of shares sold represents approximately $212.42M in transactions.

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This page (NASDAQ:SYRE) was last updated on 6/4/2026 by MarketBeat.com Staff.

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Spyre Therapeutics (SYRE) Institutional Ownership

SYRE Institutional Buying and Selling by Quarter

Spyre Therapeutics Major Shareholders & Ownership History

SYRE Institutional Ownership - Frequently Asked Questions

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Spyre Therapeutics (SYRE) Institutional Ownership

Institutional Ownership Changes (13F Filings) for Spyre Therapeutics (NASDAQ:SYRE)

SYRE Institutional Buying and Selling by Quarter

Spyre Therapeutics Major Shareholders & Ownership History

SYRE Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of SYRE shares?

What percentage of Spyre Therapeutics' stock is owned by institutional investors?

Which institutional investors have been buying Spyre Therapeutics' stock?

How much institutional buying is happening at Spyre Therapeutics?

Which of Spyre Therapeutics' major shareholders have been selling company stock?

How much institutional selling is happening at Spyre Therapeutics?

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