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Spyre Therapeutics (SYRE) Institutional Ownership

Spyre Therapeutics logo
$106.65 +0.16 (+0.15%)
Closing price 04:00 PM Eastern
Extended Trading
$107.51 +0.86 (+0.81%)
As of 04:34 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.
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Institutional Ownership Changes (13F Filings) for Spyre Therapeutics (NASDAQ:SYRE)

Current
Institutional Ownership
Percentage
80.39%
Number of
Institutional Buyers
(last 12 months)
97
Total
Institutional Inflows
(last 12 months)
$1.17B
Number of
Institutional Sellers
(last 12 months)
46
Total
Institutional Outflows
(last 12 months)
$213.47M
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SYRE Institutional Buying and Selling by Quarter

Spyre Therapeutics Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
8/24/2026California State Teachers Retirement System5,742,912$509.86M0.0%+9,594.0%6.531%
8/22/2026 Seven Fleet Capital Management LP13,300$1.18M0.2%-32.5%0.015%
8/21/2026 Braidwell LP879,467$78.08M2.9%-5.7%1.000%
8/21/2026 Nykredit A S1,953$173K0.0%N/A0.002%
8/19/2026 Wellington Management Group LLP1,581,505$140.41M0.0%-13.3%1.798%
8/6/2026 Bank of New York Mellon Corp245,193$21.77M0.0%N/A0.279%
7/10/2026 Handelsbanken Fonder AB26,000$2.31M0.0%N/A0.030%
7/7/2026 GAMMA Investing LLC663$59K0.0%+26.8%0.001%
6/4/2026 Seven Fleet Capital Management LP19,690$993K0.3%N/A0.023%
5/29/2026 Perceptive Advisors LLC3,783,225$190.83M3.7%+23.3%4.357%
5/19/2026 Bank of America Corp DE1,228,093$61.95M0.0%+192.6%1.414%
5/19/2026 Stempoint Capital LP167,606$8.45M1.6%+417.7%0.193%
5/19/2026Janus Henderson Group PLC1,656,164$83.59M0.0%-9.5%1.907%
5/18/2026 ADAR1 Capital Management LLC338,323$17.07M1.0%+893.6%0.390%
5/18/2026California State Teachers Retirement System59,242$2.99M0.0%+23.3%0.068%
5/18/2026 Royal Bank of Canada3,250$164K0.0%+63.5%0.004%
5/16/2026 The Manufacturers Life Insurance Company112,841$5.69M0.0%-12.5%0.130%
5/16/2026 Quantinno Capital Management LP4,561$230K0.0%N/A0.005%
5/16/2026 ABS Direct Equity Fund LLC2,800$141K0.1%N/A0.003%
5/15/2026 Commodore Capital LP1,912,380$96.46M5.6%-19.9%2.202%
5/15/2026 Affinity Asset Advisors LLC1,279,134$64.52M3.3%-10.7%1.473%
5/14/2026 Sei Investments Co.8,975$453K0.0%+46.7%0.010%
5/13/2026 First Trust Advisors LP178,389$9.00M0.0%N/A0.205%
5/7/2026 Dimensional Fund Advisors LP47,697$2.41M0.0%-38.3%0.061%
5/7/2026 AlphaCentric Advisors LLC6,634$335K0.3%N/A0.008%
5/7/2026 KBC Group NV1,372$69K0.0%N/A0.002%
5/5/2026 Bank of New York Mellon Corp191,395$9.65M0.0%-0.7%0.243%
5/4/2026 Emerald Mutual Fund Advisers Trust408,113$20.59M1.0%-1.0%0.518%
5/4/2026 Emerald Advisers LLC613,365$30.94M1.0%-3.6%0.779%
5/4/2026 Principal Financial Group Inc.4,299$217K0.0%N/A0.005%
5/1/2026 Candriam S.C.A.610,282$30.78M0.2%+43.4%0.775%
4/30/2026 Summit Securities Group LLC562$28K0.0%N/A0.001%
4/25/2026 Strs Ohio4,500$227K0.0%N/A0.006%
4/22/2026 Pictet Asset Management Holding SA491,649$24.80M0.0%-46.2%0.624%
4/22/2026 Union Bancaire Privee UBP SA3,880$196K0.0%N/A0.005%
4/22/2026 Sterling Capital Management LLC1,051$53K0.0%-34.7%0.001%
4/20/2026 Assenagon Asset Management S.A.18,647$941K0.0%-15.8%0.024%
4/17/2026 High Net Worth Advisory Group LLC6,000$303K0.1%N/A0.008%
4/16/2026 SG Americas Securities LLC13,396$676K0.0%-42.6%0.017%
2/19/2026 Invesco Ltd.150,934$4.95M0.0%+197.7%0.195%
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2/18/2026 Mercer Global Advisors Inc. ADV106,316$3.48M0.0%-0.3%0.137%
2/18/2026 VARCOV Co.8,008$262K0.1%N/A0.010%
2/18/2026 Virtus Investment Advisers LLC7,913$259K0.1%+23.2%0.010%
2/18/2026 Wellington Management Group LLP1,549,284$50.76M0.0%-5.5%1.997%
2/18/2026 Susquehanna Portfolio Strategies LLC53,101$1.74M0.0%+144.3%0.068%
2/18/2026 Tang Capital Management LLC1,892,200$61.99M3.1%-40.9%2.439%
2/18/2026 Tudor Investment Corp ET AL10,127$332K0.0%N/A0.013%
2/18/2026 RTW Investments LP4,171,996$136.68M1.4%+15.2%5.377%
2/18/2026 Perceptive Advisors LLC3,069,225$100.55M1.8%+149.6%3.956%
2/18/2026 Millennium Management LLC76,194$2.50M0.0%-81.3%0.098%
2/18/2026Janus Henderson Group PLC1,829,009$59.92M0.0%+13,969.3%2.357%
2/18/2026 Cinctive Capital Management LP35,935$1.18M0.1%N/A0.046%
2/18/2026 Commodore Capital LP2,388,245$78.24M5.2%+20.1%3.078%
2/18/2026 Balyasny Asset Management L.P.73,465$2.41M0.0%N/A0.095%
2/18/2026 Armistice Capital LLC196,426$6.44M0.1%+25.9%0.253%
2/17/2026 AQR Capital Management LLC17,820$584K0.0%+4.5%0.023%
2/17/2026 Braidwell LP1,634,615$53.55M1.7%-36.6%2.107%
2/17/2026 RA Capital Management L.P.1,621,620$53.12M0.5%N/A2.090%
2/17/2026 Price T Rowe Associates Inc. MD1,601,882$52.48M0.0%+158.1%2.065%
2/17/2026California State Teachers Retirement System48,038$1.57M0.0%+44.7%0.062%
2/17/2026 Russell Investments Group Ltd.5,554$182K0.0%+31.2%0.007%
2/17/2026 State of Wisconsin Investment Board27,252$893K0.0%-18.8%0.035%
2/17/2026 ExodusPoint Capital Management LP37,871$1.24M0.0%-44.8%0.049%
2/17/2026 Royal Bank of Canada1,988$65K0.0%-74.8%0.003%
2/17/2026 Persistent Asset Partners Ltd2,246$74K0.0%N/A0.003%
2/17/2026 Polar Capital Holdings Plc740,326$24.25M0.1%-6.1%0.954%
2/16/2026 Barclays PLC182,524$5.98M0.0%+8.4%0.235%
2/13/2026 The Manufacturers Life Insurance Company 129,013$4.14M0.0%+79.3%0.166%
2/13/2026 Carlyle Group Inc.9,620$315K0.0%N/A0.012%
2/13/2026 Affinity Asset Advisors LLC1,432,591$46.93M2.7%+0.9%1.846%
2/13/2026 Schroder Investment Management Group61,574$1.96M0.0%-42.8%0.079%
2/13/2026 Rafferty Asset Management LLC53,410$1.75M0.0%-10.5%0.069%
2/13/2026 Siren L.L.C.818,598$26.82M0.8%+122.1%1.055%
2/13/2026 Charles Schwab Investment Management Inc.574,622$18.83M0.0%+35.1%0.741%
2/13/2026 Police & Firemen s Retirement System of New Jersey18,360$601K0.0%+33.0%0.024%
2/13/2026 State Street Corp2,262,839$74.13M0.0%+26.8%2.916%
2/13/2026 Martingale Asset Management L P6,930$227K0.0%N/A0.009%
2/13/2026 UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC62,216$2.04M0.0%+57.5%0.080%
2/13/2026 Wells Fargo & Company MN82,416$2.70M0.0%+109.6%0.106%
2/12/2026 Remedium Capital Partners LLC1,456,231$47.71M28.0%N/A1.877%
2/12/2026 MetLife Investment Management LLC38,011$1.25M0.0%+27.1%0.049%
2/12/2026 State Board of Administration of Florida Retirement System9,030$296K0.0%N/A0.012%
2/12/2026 Dimensional Fund Advisors LP77,290$2.53M0.0%-8.2%0.100%
2/12/2026 Patient Square Capital LP150,000$4.91M1.1%N/A0.193%
2/12/2026 New York State Common Retirement Fund19,165$628K0.0%+15.7%0.025%
2/12/2026 Alps Advisors Inc.63,708$2.09M0.0%N/A0.082%
2/12/2026 Swiss National Bank96,500$3.16M0.0%+37.5%0.124%
2/12/2026 Nuveen LLC150,980$4.95M0.0%+57.0%0.195%
2/11/2026 Deutsche Bank AG121,941$4.00M0.0%+216.4%0.157%
2/11/2026 Franklin Resources Inc.1,109,274$36.34M0.0%+39.5%1.430%
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2/11/2026 Capital International Investors3,492,541$114.42M0.0%+46.0%4.501%
2/11/2026 Los Angeles Capital Management LLC12,882$422K0.0%-29.1%0.017%
2/11/2026 Arrowpoint Investment Partners Singapore Pte. Ltd.13,724$450K0.1%N/A0.018%
2/10/2026 TD Asset Management Inc149,822$4.91M0.0%+107.0%0.193%
2/10/2026 Goldman Sachs Group Inc.275,065$9.01M0.0%-16.5%0.355%
2/10/2026 Intech Investment Management LLC18,274$599K0.0%-10.2%0.024%
2/10/2026 Seven Grand Managers LLC100,000$3.28M0.2%N/A0.129%
2/9/2026 Geode Capital Management LLC1,659,140$54.36M0.0%+35.4%2.138%
2/9/2026Optimize Financial Inc25,331$830K0.4%+1.5%0.033%
2/6/2026 PSP Research LLC15,840$519K0.5%N/A0.020%


SYRE Institutional Ownership - Frequently Asked Questions

During the previous two years, 154 institutional investors and hedge funds held shares of Spyre Therapeutics. The most heavily invested institutionals were California State Teachers Retirement System ($509.86M), FMR LLC ($204.89M), Perceptive Advisors LLC ($190.83M), Wellington Management Group LLP ($140.41M), RTW Investments LP ($136.68M), Vanguard Group Inc. ($132.19M), and Capital International Investors ($114.42M).Learn more on Spyre Therapeutics' institutional investors.

80.39% of Spyre Therapeutics' stock is owned by institutional investors. Learn more on SYRE's institutional investor holdings.

Of the 141 institutional investors that purchased Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: California State Teachers Retirement System ($5.72M), Janus Henderson Group PLC ($2.60M), Perceptive Advisors LLC ($2.55M), Driehaus Capital Management LLC ($2.12M), RA Capital Management L.P. ($1.62M), Remedium Capital Partners LLC ($1.46M), and Vanguard Group Inc. ($1.37M).

Institutional investors have bought a total of 25,924,712 shares in the last 24 months. This purchase volume represents approximately $1.17B in transactions.

Of the 46 institutional investors that sold Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Tang Capital Management LLC ($1.31M), Braidwell LP ($997.15K), Pictet Asset Management Holding SA ($544.57K), Commodore Capital LP ($475.87K), Paradigm Biocapital Advisors LP ($403.18K), Wellington Management Group LLP ($334.33K), and Woodline Partners LP ($333.28K).

Institutional investors have sold a total of 5,923,240 shares in the last 24 months. This volume of shares sold represents approximately $213.47M in transactions.


Related Companies

Institutional ownership data for NASDAQ:SYRE is compiled from quarterly 13F filings submitted to the U.S. Securities and Exchange Commission (SEC), with the most recent received on 8/24/2026. New 13F filings are added each quarter as they're published.
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