Affinity Asset Advisors, LLC Top Holdings and 13F Report (2025) About Affinity Asset Advisors, LLCInvestment ActivityAffinity Asset Advisors, LLC has $1.94 billion in total holdings as of September 30, 2025.Affinity Asset Advisors, LLC owns shares of 103 different stocks, but just 37 companies or ETFs make up 80% of its holdings.Approximately 34.19% of the portfolio was purchased this quarter.About 30.61% of the portfolio was sold this quarter.This quarter, Affinity Asset Advisors, LLC has purchased 92 new stocks and bought additional shares in 31 stocks.Affinity Asset Advisors, LLC sold shares of 25 stocks and completely divested from 15 stocks this quarter.Largest Holdings SPDR S&P 500 ETF Trust $130,068,000APOGEE THERAPEUTICS INC $108,152,221Xenon Pharmaceuticals $97,401,250Erasca $86,563,000Insmed $78,489,600 Largest New Holdings this Quarter 78462F103 - SPDR S&P 500 ETF Trust $130,068,000 Holding60770K107 - Moderna $40,640,000 Holding29337E102 - Enliven Therapeutics $23,006,637 Holding110122108 - Bristol Myers Squibb $18,195,000 HoldingG4444S107 - HELIX ACQUISITION CORP III $12,700,000 Holding Largest Purchases this Quarter SPDR S&P 500 ETF Trust 200,000 shares (about $130.07M)Moderna 800,000 shares (about $40.64M)Centessa Pharmaceuticals 799,448 shares (about $31.75M)Roivant Sciences 1,100,000 shares (about $30.47M)AnaptysBio 495,308 shares (about $27.47M) Largest Sales this Quarter Arcellx 160,961 shares (about $18.48M)Cullinan Therapeutics 1,150,846 shares (about $16.35M)ORUKA THERAPEUTICS INC 302,669 shares (about $14.85M)BridgeBio Pharma 170,000 shares (about $12.62M)ABIVAX SA 100,000 shares (about $11.14M) Sector Allocation Over TimeMap of 500 Largest Holdings ofAffinity Asset Advisors, LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorSPYSPDR S&P 500 ETF Trust$130,068,000$130,068,000 â–²New Holding200,0006.7%ETFAPOGEE THERAPEUTICS INC$108,152,221$4,208,500 â–²4.0%1,284,9265.6%COMXENEXenon Pharmaceuticals$97,401,250$24,713,750 â–²34.0%1,675,0005.0%HealthcareERASErasca$86,563,000$23,461,000 â–²37.2%5,350,0004.5%HealthcareINSMInsmed$78,489,600$4,905,600 â–²6.7%480,0004.1%HealthcareROIVRoivant Sciences$77,560,000$30,470,000 â–²64.7%2,800,0004.0%HealthcareSPYRE THERAPEUTICS INC$64,519,519$7,740,371 â–¼-10.7%1,279,1343.3%COM NEWCNTACentessa Pharmaceuticals$55,608,000$31,754,075 â–²133.1%1,400,0002.9%HealthcarePRAXIS PRECISION MEDICINES I$54,772,300$4,832,850 â–¼-8.1%170,0002.8%COM NEWANABAnaptysBio$52,132,400$27,469,782 â–²111.4%940,0002.7%HealthcareALKSAlkermes$47,736,000$12,376,000 â–²35.0%1,350,0002.5%HealthcareCYTKCytokinetics$46,168,835$6,559,166 â–¼-12.4%700,4832.4%HealthcareABIVAX SA$45,096,750$11,135,000 â–¼-19.8%405,0002.3%SPONSORED ADSTEVATeva Pharmaceutical Industries$42,168,0000.0%1,400,0002.2%HealthcareACLXArcellx$41,652,562$18,481,542 â–¼-30.7%362,7642.2%HealthcareMRNAModerna$40,640,000$40,640,000 â–²New Holding800,0002.1%HealthcareDIANTHUS THERAPEUTICS INC$33,568,000$23,917,200 â–²247.8%400,0001.7%COMNUVLNuvalent$30,735,000$2,318,751 â–¼-7.0%300,0001.6%HealthcareTERNTerns Pharmaceuticals$29,661,906$665,906 â–²2.3%562,6311.5%HealthcareLEXEO THERAPEUTICS INC$28,988,211$10,620,211 â–²57.8%5,050,2111.5%COMCOGTCogent Biosciences$28,867,500$15,396,000 â–²114.3%750,0001.5%HealthcareMDGLMadrigal Pharmaceuticals$28,790,850$12,494,705 â–²76.7%55,0001.5%HealthcareSUTRO BIOPHARMA INC$26,641,718$7,999,523 â–²42.9%1,069,5191.4%COM SHSFORTE BIOSCIENCES INC$26,207,9510.0%1,011,8901.4%COM NEWORUKA THERAPEUTICS INC$24,508,961$14,845,915 â–¼-37.7%499,6731.3%COMTRVITrevi Therapeutics$23,862,052$1,789,500 â–¼-7.0%2,000,1721.2%HealthcareOVIDOvid Therapeutics$23,612,626$7,739,626 â–²48.8%10,636,3181.2%HealthcareELVNEnliven Therapeutics$23,006,637$23,006,637 â–²New Holding586,9041.2%HealthcareASNDAscendis Pharma A/S$21,729,350$14,867,450 â–²216.7%95,0001.1%HealthcareMLYSMineralys Therapeutics$20,317,500$541,800 â–²2.7%750,0001.0%HealthcareAVALO THERAPEUTICS INC$20,018,741$4,326,505 â–²27.6%1,340,8401.0%COM NEWRVMDRevolution Medicines$19,450,000$9,725,000 â–²100.0%200,0001.0%HealthcareBMYBristol Myers Squibb$18,195,000$18,195,000 â–²New Holding300,0000.9%HealthcarePTGXProtagonist Therapeutics$18,141,9750.0%172,1250.9%HealthcareCLDXCelldex Therapeutics$15,860,000$4,758,000 â–²42.9%500,0000.8%HealthcareZURAZura Bio$15,257,603$4,466,260 â–²41.4%2,564,3030.8%HealthcareNRIXNurix Therapeutics$14,998,1100.0%967,6200.8%HealthcareSVRASavara$13,716,355$1,556,100 â–¼-10.2%2,512,1530.7%HealthcareOMEROS CORP$13,219,2260.0%6,525,0000.7%NOTE 9.500% 6/1PERSPECTIVE THERAPEUTICS INC$13,196,307$11,945,307 â–²954.9%3,164,5820.7%COM NEWHELIX ACQUISITION CORP III$12,700,000$12,700,000 â–²New Holding1,250,0000.7%USD CL A ORD SHSARWRArrowhead Pharmaceuticals$12,540,000$8,151,000 â–²185.7%200,0000.6%HealthcareDAMORA THERAPEUTICS INC$11,655,000$11,655,000 â–²New Holding450,0000.6%COM NEWEUPRAXIA PHARMACEUTICALS INC$11,504,396$9,332,396 â–²429.7%1,589,0050.6%COMALTO NEUROSCIENCE INC$11,240,000$11,240,000 â–²New Holding500,0000.6%COM SHSBBIOBridgeBio Pharma$11,139,000$12,624,200 â–¼-53.1%150,0000.6%HealthcareCGEMCullinan Therapeutics$11,101,705$16,353,522 â–¼-59.6%781,2600.6%HealthcareBLTEBelite Bio$10,363,600$7,174,800 â–²225.0%65,0000.5%HealthcareWVEWAVE Life Sciences$10,162,521$9,412,479 â–¼-48.1%1,401,7270.5%HealthcareVERAVera Therapeutics$10,057,5000.0%250,0000.5%HealthcareTYRATyra Biosciences$9,862,710$9,862,710 â–²New Holding257,5120.5%HealthcareIBRXImmunityBio$9,587,500$9,587,500 â–²New Holding1,250,0000.5%HealthcareJADE BIOSCIENCES INC$8,991,382$1,053,750 â–¼-10.5%639,9560.5%COM NEWTVTXTravere Therapeutics$8,913,0000.0%300,0000.5%HealthcareNAMSNewAmsterdam Pharma$8,802,7500.0%275,0000.5%HealthcareCOGENT BIOSCIENCES INC$8,585,500$7,359,000 â–²600.0%7,000,0000.4%NOTE 1.625%11/1KORRO BIO INC$8,002,153$8,002,153 â–²New Holding706,9040.4%COMCELCUITY INC$7,314,0000.0%3,000,0000.4%NOTE 2.750% 8/0CRSPCRISPR Therapeutics$7,135,500$7,135,500 â–²New Holding150,0000.4%HealthcareSPYGLASS PHARMA INC$6,477,500$6,477,500 â–²New Holding250,0000.3%COM SHSNVONovo Nordisk A/S$6,431,250$6,431,250 â–²New Holding175,0000.3%HealthcareCMPSCompass Pathways$6,129,911$5,023,911 â–²454.2%1,108,4830.3%HealthcareIBIO INC$5,903,680$1,995,000 â–²51.0%3,107,2000.3%COM NEWESTAEstablishment Labs$5,678,000$5,678,000 â–¼-50.0%100,0000.3%HealthcareANTERIS TECHNOLOGIES GLOBAL$5,063,803$2,362,707 â–²87.5%912,3970.3%COMNAMSWNewAmsterdam Pharma$4,909,8000.0%245,0000.3%HealthcareQUREuniQure$4,905,000$8,992,500 â–¼-64.7%300,0000.3%HealthcareVRDNViridian Therapeutics$4,890,0000.0%250,0000.3%HealthcareELYMEliem Therapeutics$4,795,000$4,110,000 â–¼-46.2%700,0000.2%HealthcareRZLTRezolute$4,720,305$2,450,684 â–¼-34.2%1,547,6410.2%HealthcareSAGIMET BIOSCIENCES INC$4,535,405$1,464,176 â–¼-24.4%868,0200.2%COM SER AMBX BIOSCIENCES INC$4,477,500$2,985,000 â–¼-40.0%150,0000.2%COMTSHATaysha Gene Therapies$4,470,000$10,281,000 â–¼-69.7%1,000,0000.2%HealthcareVERADERMICS INC$4,420,500$4,420,500 â–²New Holding70,0000.2%COMMON STOCKGENERATE BIOMEDICINES INC$4,375,000$4,375,000 â–²New Holding350,0000.2%COM SHSENGENE HOLDINGS INC$4,156,620$224,730 â–¼-5.1%610,3700.2%COMCG ONCOLOGY INC$4,060,800$4,060,800 â–²New Holding60,0000.2%COMARRIVENT BIOPHARMA INC$4,037,250$576,750 â–²16.7%175,0000.2%COMRLAYRelay Therapeutics$3,980,000$3,980,000 â–²New Holding400,0000.2%HealthcarePRQRProQR Therapeutics$3,975,9300.0%2,454,2780.2%HealthcareVERRICA PHARMACEUTICALS INC$3,741,8180.0%707,3380.2%COM SHSCELCCelcuity$3,424,200$3,424,200 â–²New Holding30,0000.2%HealthcarePRECISION BIOSCIENCES INC$3,288,703$3,288,703 â–²New Holding597,9460.2%COM NEWKARYOPHARM THERAPEUTICS INC$2,785,000$2,169,933 â–¼-43.8%500,0000.1%COM NEWSOL-GEL TECHNOLOGIES LTD$2,772,700$2,772,700 â–²New Holding35,0000.1%SHS NEWCRNXCrinetics Pharmaceuticals$2,724,0000.0%75,0000.1%HealthcareOAKTREE ACQUISITION CORP III$2,662,5000.0%250,0000.1%UNIT 10/04/2029NEXTCURE INC$2,582,702$58,398 â–¼-2.2%241,8260.1%COM NEWIMVTImmunovant$2,484,000$2,484,000 â–¼-50.0%100,0000.1%HealthcareEQEquillium$2,452,620$2,452,620 â–²New Holding1,226,3100.1%HealthcareSAB BIOTHERAPEUTICS INC$2,202,250$2,202,250 â–²New Holding575,0000.1%COM NEWCORTCorcept Therapeutics$2,015,500$2,015,500 â–²New Holding50,0000.1%HealthcareOBIOOrchestra BioMed$1,710,838$723,580 â–¼-29.7%402,5500.1%HealthcareKEZAR LIFE SCIENCES INC$1,699,7440.0%229,0760.1%COM NEWMGNXMacroGenics$1,445,000$45,350 â–²3.2%500,0000.1%HealthcareADLAI NORTYE LTD$1,140,056$1,140,056 â–²New Holding164,7480.1%SPONSORED ADSALECAlector$1,075,000$1,075,000 â–²New Holding500,0000.1%HealthcareONKURE THERAPEUTICS INC$997,587$997,587 â–²New Holding240,9630.1%COM CL ALENZ THERAPEUTICS INC$915,0000.0%100,0000.0%COMX4 PHARMACEUTICALS INC$598,8500.0%145,0000.0%COM NEWShowing largest 100 holdings. 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