Affinity Asset Advisors, LLC Top Holdings and 13F Report (2025) About Affinity Asset Advisors, LLCInvestment ActivityAffinity Asset Advisors, LLC has $2.21 billion in total holdings as of September 30, 2025.Affinity Asset Advisors, LLC owns shares of 110 different stocks, but just 40 companies or ETFs make up 80% of its holdings.Approximately 20.00% of the portfolio was purchased this quarter.About 24.54% of the portfolio was sold this quarter.This quarter, Affinity Asset Advisors, LLC has purchased 103 new stocks and bought additional shares in 35 stocks.Affinity Asset Advisors, LLC sold shares of 27 stocks and completely divested from 16 stocks this quarter.Largest Holdings Roivant Sciences $132,712,500APOGEE THERAPEUTICS INC $131,004,510SPYRE THERAPEUTICS INC $113,561,517Xenon Pharmaceuticals $96,274,200Erasca $96,180,000 Largest New Holdings this Quarter 337185102 - FIRST TRACKS BIOTHERAPEUTICS $40,884,081 Holding00214Q302 - ARK Genomic Revolution ETF $31,545,000 Holding532457108 - Eli Lilly and Company $23,988,600 Holding45166A102 - IDEAYA Biosciences $14,908,000 Holding67613T104 - ODYSSEY THERAPEUTICS INC $14,338,334 Holding Largest Purchases this Quarter FIRST TRACKS BIOTHERAPEUTICS 2,032,012 shares (about $40.88M)Roivant Sciences 950,000 shares (about $33.62M)ARK Genomic Revolution ETF 750,000 shares (about $31.55M)AVALO THERAPEUTICS INC 1,559,160 shares (about $28.81M)Eli Lilly and Company 20,000 shares (about $23.99M) Largest Sales this Quarter APOGEE THERAPEUTICS INC 297,926 shares (about $39.54M)Teva Pharmaceutical Industries 1,026,000 shares (about $34.76M)Cytokinetics 150,483 shares (about $12.82M)Cogent Biosciences 300,000 shares (about $11.61M)Compass Pathways 807,300 shares (about $11.42M) Sector Allocation Over TimeMap of 500 Largest Holdings ofAffinity Asset Advisors, LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorROIVRoivant Sciences$132,712,500$33,620,500 ▲33.9%3,750,0006.0%HealthcareAPOGEE THERAPEUTICS INC$131,004,510$39,543,718 ▼-23.2%987,0005.9%COMSPYRE THERAPEUTICS INC$113,561,5170.0%1,279,1345.1%COM NEWXENEXenon Pharmaceuticals$96,274,200$4,828,800 ▼-4.8%1,595,0004.4%HealthcareERASErasca$96,180,000$1,832,000 ▼-1.9%5,250,0004.3%HealthcareALKSAlkermes$72,043,125$1,309,875 ▲1.9%1,375,0003.3%HealthcareINSMInsmed$69,303,000$18,125,400 ▲35.4%650,0003.1%HealthcareMRNAModerna$68,279,250$12,255,250 ▲21.9%975,0003.1%HealthcarePRAXIS PRECISION MEDICINES I$61,936,150$5,021,850 ▲8.8%185,0002.8%COM NEWORUKA THERAPEUTICS INC$56,150,300$8,596,421 ▲18.1%590,0002.5%COMANABAnaptysBio$55,762,358$7,687,643 ▼-12.1%826,1092.5%HealthcareAVALO THERAPEUTICS INC$53,592,000$28,813,277 ▲116.3%2,900,0002.4%COM NEWCYTKCytokinetics$46,854,500$12,819,647 ▼-21.5%550,0002.1%HealthcareRVMDRevolution Medicines$46,820,000$9,364,000 ▲25.0%250,0002.1%HealthcareABIVAX SA$43,975,800$9,994,500 ▼-18.5%330,0002.0%SPONSORED ADSFIRST TRACKS BIOTHERAPEUTICS$40,884,081$40,884,081 ▲New Holding2,032,0121.8%ORD SHSDIANTHUS THERAPEUTICS INC$38,992,0000.0%400,0001.8%COMSUTRO BIOPHARMA INC$38,926,568$3,418,538 ▲9.6%1,172,4871.8%COM SHSNUVLNuvalent$33,962,500$3,087,500 ▼-8.3%275,0001.5%HealthcareTRVITrevi Therapeutics$33,573,208$3,730,000 ▼-10.0%1,800,1721.5%HealthcareARKGARK Genomic Revolution ETF$31,545,000$31,545,000 ▲New Holding750,0001.4%ETFOVIDOvid Therapeutics$27,288,872$1,322,824 ▼-4.6%10,144,5621.2%HealthcareLEXEO THERAPEUTICS INC$27,034,429$3,525,697 ▲15.0%5,807,6111.2%COMCLDXCelldex Therapeutics$26,047,000$7,442,000 ▲40.0%700,0001.2%HealthcareBLTEBelite Bio$25,407,525$15,398,500 ▲153.8%165,0001.1%HealthcareELVNEnliven Therapeutics$25,375,000$4,410,378 ▼-14.8%500,0001.1%HealthcareFORTE BIOSCIENCES INC$24,339,559$2,836,896 ▲13.2%1,145,3911.1%COM NEWLLYEli Lilly and Company$23,988,600$23,988,600 ▲New Holding20,0001.1%HealthcareNRIXNurix Therapeutics$23,474,4610.0%967,6201.1%HealthcareALTO NEUROSCIENCE INC$22,431,500$9,236,500 ▲70.0%850,0001.0%COM SHSMDGLMadrigal Pharmaceuticals$21,478,000$8,054,250 ▼-27.3%40,0001.0%HealthcarePTGXProtagonist Therapeutics$21,099,0830.0%172,1251.0%HealthcareMLYSMineralys Therapeutics$20,235,0000.0%750,0000.9%HealthcareRLAYRelay Therapeutics$19,645,500$12,161,500 ▲162.5%1,050,0000.9%HealthcareSAGIMET BIOSCIENCES INC$19,308,489$12,598,694 ▲187.8%2,497,8640.9%COM SER AJADE BIOSCIENCES INC$18,672,577$4,452,755 ▲31.3%840,3500.8%COM NEWCOGTCogent Biosciences$17,415,000$11,610,000 ▼-40.0%450,0000.8%HealthcareQUREuniQure$17,272,500$3,454,500 ▲25.0%375,0000.8%HealthcareTVTXTravere Therapeutics$17,043,0000.0%300,0000.8%HealthcareCGEMCullinan Therapeutics$15,947,590$1,720,845 ▲12.1%875,7600.7%HealthcareSVRASavara$15,474,8620.0%2,512,1530.7%HealthcareIDYAIDEAYA Biosciences$14,908,000$14,908,000 ▲New Holding400,0000.7%HealthcarePERSPECTIVE THERAPEUTICS INC$14,371,725$3,580,500 ▲33.2%4,214,5820.6%COM NEWODYSSEY THERAPEUTICS INC$14,338,334$14,338,334 ▲New Holding766,3460.6%COMMON STOCKCOGENT BIOSCIENCES INC$13,653,740$4,964,996 ▲57.1%11,000,0000.6%NOTE 1.625%11/1OMEROmeros$13,421,463$13,421,463 ▲New Holding1,411,3000.6%HealthcareHELIX ACQUISITION CORP III$13,300,0000.0%1,250,0000.6%USD CL A ORD SHSEQEquillium$13,120,000$9,195,808 ▲234.3%4,100,0000.6%HealthcareESTAEstablishment Labs$12,700,996$4,119,996 ▲48.0%148,0130.6%HealthcareELYMEliem Therapeutics$12,674,880$3,546,880 ▲38.9%972,0000.6%HealthcareTEVATeva Pharmaceutical Industries$12,671,120$34,760,880 ▼-73.3%374,0000.6%HealthcareVERADERMICS INC$12,294,000$3,688,200 ▲42.9%100,0000.6%COMMON STOCKARWRArrowhead Pharmaceuticals$12,226,500$4,075,500 ▼-25.0%150,0000.6%HealthcareOMEROS CORP$12,182,3720.0%6,525,0000.6%NOTE 9.500% 6/1TSHATaysha Gene Therapies$11,917,500$5,107,500 ▲75.0%1,750,0000.5%HealthcareDAMORA THERAPEUTICS INC$11,054,250$650,250 ▼-5.6%425,0000.5%COM NEWEUPRAXIA PHARMACEUTICALS INC$10,906,500$403,177 ▲3.8%1,650,0000.5%COMVERAVera Therapeutics$10,727,5000.0%250,0000.5%HealthcarePRQRProQR Therapeutics$10,311,721$5,746,764 ▲125.9%5,543,9360.5%HealthcareNAMSNewAmsterdam Pharma$9,319,7500.0%275,0000.4%HealthcareKORRO BIO INC$9,316,9950.0%706,9040.4%COMANTERIS TECHNOLOGIES GLOBAL$8,987,1100.0%912,3970.4%COMZURAZura Bio$8,639,388$6,490,000 ▼-42.9%1,464,3030.4%HealthcareASCENDIS PHARMA A/S$8,001,600$8,001,600 ▲New Holding30,0000.4%ORD SHSIBIO INC$7,013,792$1,576,192 ▲29.0%4,007,8810.3%COM NEWGENERATE BIOMEDICINES INC$6,748,000$843,500 ▲14.3%400,0000.3%COM SHSEVOMMUNE INC$6,646,329$6,646,329 ▲New Holding500,1000.3%COM SHSTYRATyra Biosciences$6,388,383$1,836,550 ▼-22.3%200,0120.3%HealthcareSOL-GEL TECHNOLOGIES LTD$6,294,486$3,699,586 ▲142.6%84,9000.3%SHS NEWSAB BIOTHERAPEUTICS INC$5,947,500$3,705,000 ▲165.2%1,525,0000.3%COM NEWMGNXMacroGenics$5,620,720$3,310,720 ▲143.3%1,216,6060.3%HealthcareCRSPCRISPR Therapeutics$5,454,000$2,727,000 ▼-33.3%100,0000.2%HealthcareNAMSWNewAmsterdam Pharma$5,343,4500.0%245,0000.2%HealthcareASSEMBLY BIOSCIENCES INC$5,221,200$5,221,200 ▲New Holding190,0000.2%COM NEWRZLTRezolute$5,200,000$2,847,733 ▼-35.4%1,000,0000.2%HealthcarePRECISION BIOSCIENCES INC$5,082,087$382,232 ▲8.1%646,5760.2%COM NEWHEMAB THERAPEUTICS HLDGS INC$5,069,842$5,069,842 ▲New Holding138,0300.2%COM SHSVRDNViridian Therapeutics$4,592,5000.0%250,0000.2%HealthcareARRIVENT BIOPHARMA INC$4,342,500$1,737,000 ▼-28.6%125,0000.2%COMVERRICA PHARMACEUTICALS INC$4,328,9090.0%707,3380.2%COM SHSCMPSCompass Pathways$4,261,739$11,423,294 ▼-72.8%301,1830.2%HealthcareMBX BIOSCIENCES INC$4,140,000$4,140,000 ▼-50.0%75,0000.2%COMRESEARCH ALLIANCE CORP III$3,959,000$3,959,000 ▲New Holding370,0000.2%ORD SHS CL AIMVTImmunovant$3,853,0000.0%100,0000.2%HealthcareAMANAT ACQUISITION CORP$3,810,000$3,810,000 ▲New Holding375,0000.2%CL A ORDBHVNBiohaven$3,720,000$3,720,000 ▲New Holding250,0000.2%HealthcareFAETH THERAPEUTICS INC$3,610,100$3,610,100 ▲New Holding144,4040.2%COM NEWKARYOPHARM THERAPEUTICS INC$3,053,125$1,831,875 ▼-37.5%312,5000.1%COM NEWALECAlector$3,035,100$2,030,100 ▲202.0%1,510,0000.1%HealthcareSPYGLASS PHARMA INC$2,929,104$2,635,895 ▼-47.4%131,5860.1%COM SHSCRNXCrinetics Pharmaceuticals$2,806,5000.0%75,0000.1%HealthcareOAKTREE ACQUISITION CORP III$2,750,0000.0%250,0000.1%UNIT 10/04/2029CELCUITY INC$2,282,800$2,282,800 ▲New Holding2,000,0000.1%NOTE 0.250% 8/0JATT II ACQUISITION CORP$2,272,000$2,272,000 ▲New Holding200,0000.1%ORD SHSNEUMORA THERAPEUTICS INC.$1,820,107$1,820,107 ▲New Holding1,070,6510.1%COMAMLXAmylyx Pharmaceuticals$1,778,022$1,778,022 ▲New Holding98,9990.1%HealthcareADLAI NORTYE LTD$1,769,241$125,362 ▼-6.6%153,8470.1%SPONSORED ADSSPRUCE BIOSCIENCES INC$1,620,000$1,620,000 ▲New Holding30,0000.1%COM NEWSMMTSummit Therapeutics$1,457,000$1,457,000 ▲New Holding100,0000.1%HealthcareEIKON THERAPEUTICS INC$1,278,913$1,278,913 ▲New Holding98,0010.1%COMShowing largest 100 holdings. 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