Affinity Asset Advisors, LLC Top Holdings and 13F Report (2025) About Affinity Asset Advisors, LLCInvestment ActivityAffinity Asset Advisors, LLC has $1.94 billion in total holdings as of September 30, 2025.Affinity Asset Advisors, LLC owns shares of 103 different stocks, but just 37 companies or ETFs make up 80% of its holdings.Approximately 34.19% of the portfolio was purchased this quarter.About 30.61% of the portfolio was sold this quarter.This quarter, Affinity Asset Advisors, LLC has purchased 92 new stocks and bought additional shares in 31 stocks.Affinity Asset Advisors, LLC sold shares of 25 stocks and completely divested from 15 stocks this quarter.Largest Holdings SPDR S&P 500 ETF Trust $130,068,000APOGEE THERAPEUTICS INC $108,152,221Xenon Pharmaceuticals $97,401,250Erasca $86,563,000Insmed $78,489,600 Largest New Holdings this Quarter 78462F103 - SPDR S&P 500 ETF Trust $130,068,000 Holding60770K107 - Moderna $40,640,000 Holding29337E102 - Enliven Therapeutics $23,006,637 Holding110122108 - Bristol Myers Squibb $18,195,000 HoldingG4444S107 - HELIX ACQUISITION CORP III $12,700,000 Holding Largest Purchases this Quarter SPDR S&P 500 ETF Trust 200,000 shares (about $130.07M)Moderna 800,000 shares (about $40.64M)Centessa Pharmaceuticals 799,448 shares (about $31.75M)Roivant Sciences 1,100,000 shares (about $30.47M)AnaptysBio 495,308 shares (about $27.47M) Largest Sales this Quarter Arcellx 160,961 shares (about $18.48M)Cullinan Therapeutics 1,150,846 shares (about $16.35M)ORUKA THERAPEUTICS INC 302,669 shares (about $14.85M)BridgeBio Pharma 170,000 shares (about $12.62M)ABIVAX SA 100,000 shares (about $11.14M) Sector Allocation Over TimeMap of 500 Largest Holdings ofAffinity Asset Advisors, LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorSPYSPDR S&P 500 ETF Trust$130,068,000$130,068,000 â–²New Holding200,0006.7%FinanceAPOGEE THERAPEUTICS INC$108,152,221$4,208,500 â–²4.0%1,284,9265.6%COMXENEXenon Pharmaceuticals$97,401,250$24,713,750 â–²34.0%1,675,0005.0%MedicalERASErasca$86,563,000$23,461,000 â–²37.2%5,350,0004.5%MedicalINSMInsmed$78,489,600$4,905,600 â–²6.7%480,0004.1%MedicalROIVRoivant Sciences$77,560,000$30,470,000 â–²64.7%2,800,0004.0%MedicalSPYRE THERAPEUTICS INC$64,519,519$7,740,371 â–¼-10.7%1,279,1343.3%COM NEWCNTACentessa Pharmaceuticals$55,608,000$31,754,075 â–²133.1%1,400,0002.9%MedicalPRAXIS PRECISION MEDICINES I$54,772,300$4,832,850 â–¼-8.1%170,0002.8%COM NEWANABAnaptysBio$52,132,400$27,469,782 â–²111.4%940,0002.7%MedicalALKSAlkermes$47,736,000$12,376,000 â–²35.0%1,350,0002.5%MedicalCYTKCytokinetics$46,168,835$6,559,166 â–¼-12.4%700,4832.4%MedicalABIVAX SA$45,096,750$11,135,000 â–¼-19.8%405,0002.3%SPONSORED ADSTEVATeva Pharmaceutical Industries$42,168,0000.0%1,400,0002.2%MedicalACLXArcellx$41,652,562$18,481,542 â–¼-30.7%362,7642.2%MedicalMRNAModerna$40,640,000$40,640,000 â–²New Holding800,0002.1%MedicalDIANTHUS THERAPEUTICS INC$33,568,000$23,917,200 â–²247.8%400,0001.7%COMNUVLNuvalent$30,735,000$2,318,751 â–¼-7.0%300,0001.6%MedicalTERNTerns Pharmaceuticals$29,661,906$665,906 â–²2.3%562,6311.5%MedicalLEXEO THERAPEUTICS INC$28,988,211$10,620,211 â–²57.8%5,050,2111.5%COMCOGTCogent Biosciences$28,867,500$15,396,000 â–²114.3%750,0001.5%MedicalMDGLMadrigal Pharmaceuticals$28,790,850$12,494,705 â–²76.7%55,0001.5%MedicalSUTRO BIOPHARMA INC$26,641,718$7,999,523 â–²42.9%1,069,5191.4%COM SHSFORTE BIOSCIENCES INC$26,207,9510.0%1,011,8901.4%COM NEWORUKA THERAPEUTICS INC$24,508,961$14,845,915 â–¼-37.7%499,6731.3%COMTRVITrevi Therapeutics$23,862,052$1,789,500 â–¼-7.0%2,000,1721.2%MedicalOVIDOvid Therapeutics$23,612,626$7,739,626 â–²48.8%10,636,3181.2%MedicalELVNEnliven Therapeutics$23,006,637$23,006,637 â–²New Holding586,9041.2%MedicalASNDAscendis Pharma A/S$21,729,350$14,867,450 â–²216.7%95,0001.1%MedicalMLYSMineralys Therapeutics$20,317,500$541,800 â–²2.7%750,0001.0%MedicalAVALO THERAPEUTICS INC$20,018,741$4,326,505 â–²27.6%1,340,8401.0%COM NEWRVMDRevolution Medicines$19,450,000$9,725,000 â–²100.0%200,0001.0%MedicalBMYBristol Myers Squibb$18,195,000$18,195,000 â–²New Holding300,0000.9%MedicalPTGXProtagonist Therapeutics$18,141,9750.0%172,1250.9%MedicalCLDXCelldex Therapeutics$15,860,000$4,758,000 â–²42.9%500,0000.8%MedicalZURAZura Bio$15,257,603$4,466,260 â–²41.4%2,564,3030.8%MedicalNRIXNurix Therapeutics$14,998,1100.0%967,6200.8%MedicalSVRASavara$13,716,355$1,556,100 â–¼-10.2%2,512,1530.7%MedicalOMEROS CORP$13,219,2260.0%6,525,0000.7%NOTE 9.500% 6/1PERSPECTIVE THERAPEUTICS INC$13,196,307$11,945,307 â–²954.9%3,164,5820.7%COM NEWHELIX ACQUISITION CORP III$12,700,000$12,700,000 â–²New Holding1,250,0000.7%USD CL A ORD SHSARWRArrowhead Pharmaceuticals$12,540,000$8,151,000 â–²185.7%200,0000.6%MedicalDAMORA THERAPEUTICS INC$11,655,000$11,655,000 â–²New Holding450,0000.6%COM NEWEUPRAXIA PHARMACEUTICALS INC$11,504,396$9,332,396 â–²429.7%1,589,0050.6%COMALTO NEUROSCIENCE INC$11,240,000$11,240,000 â–²New Holding500,0000.6%COM SHSBBIOBridgeBio Pharma$11,139,000$12,624,200 â–¼-53.1%150,0000.6%MedicalCGEMCullinan Therapeutics$11,101,705$16,353,522 â–¼-59.6%781,2600.6%MedicalBLTEBelite Bio$10,363,600$7,174,800 â–²225.0%65,0000.5%MedicalWVEWAVE Life Sciences$10,162,521$9,412,479 â–¼-48.1%1,401,7270.5%MedicalVERAVera Therapeutics$10,057,5000.0%250,0000.5%MedicalTYRATyra Biosciences$9,862,710$9,862,710 â–²New Holding257,5120.5%MedicalIBRXImmunityBio$9,587,500$9,587,500 â–²New Holding1,250,0000.5%MedicalJADE BIOSCIENCES INC$8,991,382$1,053,750 â–¼-10.5%639,9560.5%COM NEWTVTXTravere Therapeutics$8,913,0000.0%300,0000.5%MedicalNAMSNewAmsterdam Pharma$8,802,7500.0%275,0000.5%MedicalCOGENT BIOSCIENCES INC$8,585,500$7,359,000 â–²600.0%7,000,0000.4%NOTE 1.625%11/1KORRO BIO INC$8,002,153$8,002,153 â–²New Holding706,9040.4%COMCELCUITY INC$7,314,0000.0%3,000,0000.4%NOTE 2.750% 8/0CRSPCRISPR Therapeutics$7,135,500$7,135,500 â–²New Holding150,0000.4%MedicalSPYGLASS PHARMA INC$6,477,500$6,477,500 â–²New Holding250,0000.3%COM SHSNVONovo Nordisk A/S$6,431,250$6,431,250 â–²New Holding175,0000.3%MedicalCMPSCompass Pathways$6,129,911$5,023,911 â–²454.2%1,108,4830.3%MedicalIBIO INC$5,903,680$1,995,000 â–²51.0%3,107,2000.3%COM NEWESTAEstablishment Labs$5,678,000$5,678,000 â–¼-50.0%100,0000.3%MedicalANTERIS TECHNOLOGIES GLOBAL$5,063,803$2,362,707 â–²87.5%912,3970.3%COMNAMSWNewAmsterdam Pharma$4,909,8000.0%245,0000.3%MedicalQUREuniQure$4,905,000$8,992,500 â–¼-64.7%300,0000.3%MedicalVRDNViridian Therapeutics$4,890,0000.0%250,0000.3%MedicalELYMEliem Therapeutics$4,795,000$4,110,000 â–¼-46.2%700,0000.2%MedicalRZLTRezolute$4,720,305$2,450,684 â–¼-34.2%1,547,6410.2%MedicalSAGIMET BIOSCIENCES INC$4,535,405$1,464,176 â–¼-24.4%868,0200.2%COM SER AMBX BIOSCIENCES INC$4,477,500$2,985,000 â–¼-40.0%150,0000.2%COMTSHATaysha Gene Therapies$4,470,000$10,281,000 â–¼-69.7%1,000,0000.2%MedicalVERADERMICS INC$4,420,500$4,420,500 â–²New Holding70,0000.2%COMMON STOCKGENERATE BIOMEDICINES INC$4,375,000$4,375,000 â–²New Holding350,0000.2%COM SHSENGENE HOLDINGS INC$4,156,620$224,730 â–¼-5.1%610,3700.2%COMCG ONCOLOGY INC$4,060,800$4,060,800 â–²New Holding60,0000.2%COMARRIVENT BIOPHARMA INC$4,037,250$576,750 â–²16.7%175,0000.2%COMRLAYRelay Therapeutics$3,980,000$3,980,000 â–²New Holding400,0000.2%MedicalPRQRProQR Therapeutics$3,975,9300.0%2,454,2780.2%MedicalVERRICA PHARMACEUTICALS INC$3,741,8180.0%707,3380.2%COM SHSCELCCelcuity$3,424,200$3,424,200 â–²New Holding30,0000.2%MedicalPRECISION BIOSCIENCES INC$3,288,703$3,288,703 â–²New Holding597,9460.2%COM NEWKARYOPHARM THERAPEUTICS INC$2,785,000$2,169,933 â–¼-43.8%500,0000.1%COM NEWSOL-GEL TECHNOLOGIES LTD$2,772,700$2,772,700 â–²New Holding35,0000.1%SHS NEWCRNXCrinetics Pharmaceuticals$2,724,0000.0%75,0000.1%MedicalOAKTREE ACQUISITION CORP III$2,662,5000.0%250,0000.1%UNIT 10/04/2029NEXTCURE INC$2,582,702$58,398 â–¼-2.2%241,8260.1%COM NEWIMVTImmunovant$2,484,000$2,484,000 â–¼-50.0%100,0000.1%MedicalEQEquillium$2,452,620$2,452,620 â–²New Holding1,226,3100.1%MedicalSAB BIOTHERAPEUTICS INC$2,202,250$2,202,250 â–²New Holding575,0000.1%COM NEWCORTCorcept Therapeutics$2,015,500$2,015,500 â–²New Holding50,0000.1%MedicalOBIOOrchestra BioMed$1,710,838$723,580 â–¼-29.7%402,5500.1%MedicalKEZAR LIFE SCIENCES INC$1,699,7440.0%229,0760.1%COM NEWMGNXMacroGenics$1,445,000$45,350 â–²3.2%500,0000.1%MedicalADLAI NORTYE LTD$1,140,056$1,140,056 â–²New Holding164,7480.1%SPONSORED ADSALECAlector$1,075,000$1,075,000 â–²New Holding500,0000.1%MedicalONKURE THERAPEUTICS INC$997,587$997,587 â–²New Holding240,9630.1%COM CL ALENZ THERAPEUTICS INC$915,0000.0%100,0000.0%COMX4 PHARMACEUTICALS INC$598,8500.0%145,0000.0%COM NEWShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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