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Spyre Therapeutics (SYRE) Short Interest Ratio & Short Volume

Spyre Therapeutics logo
$74.86 -0.79 (-1.04%)
As of 03:55 PM Eastern
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Spyre Therapeutics Short Interest Overview

As of April 30, 2026, Spyre Therapeutics (SYRE) had a short interest of 12.22 million shares sold short, representing 16.69% of the public float. This marks a 4.70% increase in short interest since the prior report. The short interest ratio (days to cover) is 10.0, meaning it would take 10.0 days of the average trading volume of 934,865 shares to cover all short positions.

Current Short Interest
12,221,682 shares
Previous Short Interest
11,672,747 shares
Change Vs. Previous Month
4.70%
Dollar Volume Sold Short
$909.90 million
Short Interest Ratio
10.0 Days to Cover
Last Record Date
April 30, 2026
Outstanding Shares
86,840,000 shares
Short Percent of Float
16.69%
Today's Trading Volume
608,669 shares
Average Trading Volume
934,865 shares
Today's Volume Vs. Average
65%
Short Selling Spyre Therapeutics?
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Short Interest ChartDays to Cover ChartShort Percent of Float Chart

SYRE Short Interest Over Time

SYRE Days to Cover Over Time

SYRE Percentage of Float Shorted Over Time

Spyre Therapeutics Tesla Short Interest History & Recent Changes

Export
Report DateTotal Shares Sold ShortDollar Volume Sold ShortChange from Previous ReportPercentage of Float ShortedDays to CoverPrice on Report Date
4/30/202612,221,682 shares $909.90 million +4.7%16.7%10.04 $74.45
4/15/202611,672,747 shares $805.30 million +11.9%17.6%7.35 $68.99
3/31/202610,435,737 shares $526.38 million +4.4%15.7%11.48 $50.44
3/13/20269,997,086 shares $398.78 million +0.1%13.6%13.99 $39.89
2/27/20269,985,198 shares $429.46 million +1.2%13.6%12.42 $43.01
2/13/20269,862,924 shares $361.28 million -1.2%13.4%14.87 $36.63
1/30/20269,980,496 shares $319.18 million -0.9%13.7%20.29 $31.98
1/15/202610,069,741 shares $333.21 million -13.5%13.8%13.89 $33.09
12/31/202511,636,998 shares $381.23 million -1.5%16.0%14.06 $32.76
12/15/202511,818,159 shares $394.02 million +5.9%16.2%13.87 $33.34
11/28/202511,157,711 shares $335.23 million -10.5%15.3%18.26 $30.05
11/14/202512,464,842 shares $292.92 million +0.5%24.4%20.15 $23.50
10/31/202512,407,305 shares $303.48 million -7.3%24.3%11.89 $24.46
10/15/202513,390,000 shares $297.12 million -7.4%19.6%16.9 $22.19
9/30/202514,460,000 shares $242.35 million +4.9%28.3%24.4 $16.76
9/15/202513,780,000 shares $204.50 million -2.2%27.0%24.7 $14.84
8/31/202514,090,000 shares $232.34 million +6.8%27.6%25.8 $16.49
8/15/202513,190,000 shares $223.57 million +2.4%25.8%23.8 $16.95
7/31/202512,880,000 shares $218.57 million -5.3%25.1%22.9 $16.97
7/15/202513,600,000 shares $208.22 million +0.8%26.5%24.6 $15.31
6/30/202513,490,000 shares $201.95 million +7.2%26.3%21.9 $14.97
6/15/202512,590,000 shares $217.68 million +4.1%24.5%19.9 $17.29
5/31/202512,090,000 shares $184.37 million -1.7%23.5%19.5 $15.25
5/15/202512,300,000 shares $178.84 million -2.0%23.9%18.2 $14.54
4/30/202512,550,000 shares $191.14 million +6.8%24.5%18.2 $15.23
4/15/202511,750,000 shares $149.34 million +3.4%23.0%16.7 $12.71
3/31/202511,360,000 shares $183.35 million +5.5%22.2%16.4 $16.14
3/15/202510,770,000 shares $194.29 million +7.5%21.1%18 $18.04
2/28/202510,020,000 shares $197.39 million +1.0%19.6%16.9 $19.70
2/15/20259,920,000 shares $227.37 million -3.1%19.9%17.2 $22.92
1/31/202510,240,000 shares $235.42 million +2.4%20.5%16.5 $22.99
1/15/202510,000,000 shares $216.60 million +0.6%20.0%17.5 $21.66
12/31/20249,940,000 shares $231.40 million +3.3%19.9%18.1 $23.28
12/15/20249,620,000 shares $232.03 million +8.6%19.2%17.2 $24.12
11/30/20248,860,000 shares $251.89 million +10.2%18.2%15.3 $28.43
11/15/20248,040,000 shares $234.77 million -2.6%16.5%14 $29.20
10/31/20248,250,000 shares $268.37 million -1.9%19.3%17.3 $32.53
10/15/20248,410,000 shares $264.75 million -2.7%18.5%17.6 $31.48
9/30/20248,640,000 shares $254.10 million -0.9%19.0%17.4 $29.41
9/15/20248,720,000 shares $256.02 million +3.1%19.2%14.4 $29.36
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8/31/20248,460,000 shares $243.23 million +5.2%18.7%12.8 $28.75
8/15/20248,040,000 shares $213.46 million +2.9%17.8%12.5 $26.55
7/31/20247,810,000 shares $214.78 million -13.7%16.9%12.5 $27.50
7/15/20249,050,000 shares $260.64 million +16.2%19.6%15 $28.80
6/30/20247,790,000 shares $183.14 million +61.0%16.9%13.6 $23.51
6/15/20244,840,000 shares $152.51 million +5.7%10.8%10.5 $31.51
5/31/20244,580,000 shares $160.07 million +1.3%10.3%11.9 $34.95
5/15/20244,520,000 shares $168.96 million +3.2%12.9%9.5 $37.38
4/30/20244,380,000 shares $144.67 million +23.0%12.8%8.9 $33.03
4/15/20243,560,000 shares $132.43 million +18.3%10.6%7.3 $37.20
3/31/20243,010,000 shares $114.17 million +4.5%9.4%6 $37.93
3/15/20242,880,000 shares $130.67 million +34.0%9.0%6.4 $45.37
2/29/20242,150,000 shares $59.00 million +35.2%6.7%5.5 $27.44
2/15/20241,590,000 shares $35.87 million +123.6%5.0%5.8 $22.56
1/31/2024711,000 shares $18.42 million No Change2.1%3.8 $25.91

SYRE Short Interest - Frequently Asked Questions

Short interest is the volume of Spyre Therapeutics shares that have been sold short but have not yet been covered or closed out. As of April 30th, traders have sold 12,221,682 shares of SYRE short. 16.69% of Spyre Therapeutics' shares are currently sold short. Learn More on Spyre Therapeutics' current short interest.

The short interest ratio, also known as the "days to cover ratio", is calculated by dividing the number of shares of a stock sold short divided by its average trading volume. A short interest ratio ranging between 1 and 4 generally indicates strong positive sentiment about a stock and a lack of short sellers. A short interest ratio of 10 or greater indicates strong pessimism about a stock. SYRE shares currently have a short interest ratio of 10.0. Learn More on Spyre Therapeutics's short interest ratio.

Companies that have a short interest as a percentage of float below 10% indicates positive investor sentiment and few short sellers. Stocks with a short interest percentage above 10% is considered high, suggesting some investors are pessimistic about the stock. Companies with a short interest percentage of 20% or more indicates widespread negative sentiment. 16.69% of Spyre Therapeutics' floating shares are currently sold short.

Spyre Therapeutics saw a increase in short interest in April. As of April 30th, there was short interest totaling 12,221,682 shares, an increase of 4.7% from the previous total of 11,672,747 shares. Changes in short volume can be used to identify positive and negative investor sentiment. Investors that short sell a stock are betting that its price will decline in the future. An increase in short sale volume suggests bearish (negative) sentiment among investors. A decrease on short sale volume suggests bullish (positive) sentiment.

16.69% of Spyre Therapeutics' shares are currently sold short. Here is how the short interest of companies in the industry of "pharmaceutical products" compare to Spyre Therapeutics: Roivant Sciences Ltd. (4.24%), Moderna, Inc. (16.47%), Viatris Inc. (3.25%), Genmab A/S Sponsored ADR (1.38%), Ascendis Pharma A/S (7.57%), Summit Therapeutics PLC (22.80%), Regencell Bioscience Holdings Limited (0.16%), BridgeBio Pharma, Inc. (14.30%), Axsome Therapeutics, Inc. (6.73%), Elanco Animal Health Incorporated (4.93%),

As of the most recent reporting period, the following stocks had the largest short interest positions: SPDR S&P 500 ETF Trust ($86.09 billion), Invesco QQQ ($39.89 billion), iShares Russell 2000 ETF ($26.13 billion), Western Digital Corporation ($12.66 billion), Salesforce Inc. ($12.29 billion), Sandisk Corporation ($11.87 billion), SPDR S&P Biotech ETF ($9.82 billion), Lumentum Holdings Inc. ($8.51 billion), iShares 20+ Year Treasury Bond ETF ($7.76 billion), and Bloom Energy Corporation ($7.40 billion). View all of the most shorted stocks.

Short selling SYRE is an investing strategy that aims to generate trading profit from Spyre Therapeutics as its price is falling. SYRE shares are trading down $1.72 today. To short a stock, an investor borrows shares, sells them and buys the shares back on the public market later to return it to the lender. Short sellers are betting that a stock will decline in price. If the stock does drop after selling, the short seller buys it back at a lower price and returns it to the lender. The difference between the sell price and the buy price is the trader's profit.

A short squeeze for Spyre Therapeutics occurs when it has a large amount of short interest and its stock appreciates in price. This forces short sellers to cover their short interest positions by buying actual shares of SYRE, which in turn drives the price of the stock up even further.

Short interest is typically published by a stock exchange once per month. However, NASDAQ publishes a report for U.S. stocks, including SYRE, twice per month. The most recent reporting period available is April, 30 2026.

Understanding short interest metrics can help you assess how traders are positioning around a stock like SYRE:

  • Shares Sold Short: The total number of shares that have been sold by short sellers but have not yet been covered or closed out. A high number may indicate bearish sentiment.
  • Short Float: The percentage of a company’s publicly available shares (or "float") that are sold short. A higher short float suggests a greater portion of the stock is being bet against.
  • Days to Cover (Short Interest Ratio): This estimates how many days it would take short sellers to cover their positions, based on average daily trading volume. Higher values can signal potential for a short squeeze if buying pressure increases.

These metrics are often used by traders to gauge sentiment, volatility risk, and the potential for price movements based on short covering activity.


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This page (NASDAQ:SYRE) was last updated on 5/15/2026 by MarketBeat.com Staff.
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