| 5/16/2019 | FMR LLC | 4,692,707 | $552.33M | 0.1% | +9.4% | 11.137% |  |
| 5/16/2019 | Sio Capital Management LLC | 90,325 | $10.63M | 2.9% | +50.0% | 0.214% | |
| 5/15/2019 | Opaleye Management Inc. | 95,000 | $11.18M | 3.1% | +50.0% | 0.225% | |
| 5/15/2019 | Schonfeld Strategic Advisors LLC | 184,400 | $21.71M | 0.8% | +50.0% | 0.438% | |
| 5/15/2019 | Morgan Stanley | 3,975 | $0.47M | 0.0% | +117.6% | 0.009% | |
| 5/15/2019 | SEI Investments Co | 25,100 | $2.95M | 0.0% | +50.0% | 0.060% | |
| 5/15/2019 | Goldman Sachs Group Inc. | 21,166 | $2.49M | 0.0% | -157.1% | 0.050% | |
| 5/15/2019 | ExodusPoint Capital Management LP | 42,954 | $5.06M | 0.4% | +50.0% | 0.102% | |
| 5/15/2019 | Wellington Management Group LLP | 109,577 | $12.90M | 0.0% | +35.7% | 0.260% | |
| 5/15/2019 | Loomis Sayles & Co. L P | 107,344 | $12.64M | 0.0% | -0.3% | 0.255% | |
| 5/15/2019 | Marshall Wace LLP | 28,948 | $3.41M | 0.0% | +27.4% | 0.069% | |
| 5/14/2019 | Geode Capital Management LLC | 31,073 | $3.66M | 0.0% | +1.1% | 0.074% | |
| 5/14/2019 | Blueshift Asset Management LLC | 2,408 | $0.28M | 0.0% | +50.0% | 0.006% | |
| 5/14/2019 | Renaissance Technologies LLC | 88,799 | $10.45M | 0.0% | +50.0% | 0.211% | |
| 5/14/2019 | Marshall Wace North America L.P. | 1,161,476 | $136.71M | 1.0% | +26.5% | 2.757% | |
| 5/14/2019 | Westfield Capital Management Co. LP | 686,545 | $80.81M | 0.6% | +17.7% | 1.629% | |
| 5/14/2019 | Vivo Capital LLC | 2,046,832 | $240.91M | 24.0% | -6.2% | 4.858% | |
| 5/13/2019 | Atika Capital Management LLC | 46,000 | $5.41M | 1.1% | +50.0% | 0.109% | |
| 5/13/2019 | Citigroup Inc. | 593 | $70K | 0.0% | +50.0% | 0.001% | |
| 5/13/2019 | FIL Ltd | 248,699 | $29.27M | 0.0% | +32.9% | 0.590% | |
| 5/13/2019 | OppenheimerFunds Inc. | 426,318 | $50.18M | 0.1% | -0.2% | 1.012% | |
| 5/10/2019 | EAM Global Investors LLC | 25,455 | $3M | 1.3% | +50.0% | 0.060% | |
| 5/10/2019 | NumerixS Investment Technologies Inc | 820 | $94K | 0.0% | +50.0% | 0.002% | |
| 5/10/2019 | DekaBank Deutsche Girozentrale | 27,100 | $1.92M | 0.0% | +15.4% | 0.064% | |
| 5/10/2019 | Wells Fargo & Company MN | 25,917 | $3.05M | 0.0% | +39.4% | 0.062% | |
| 5/10/2019 | Financial Counselors Inc. | 2,320 | $0.27M | 0.0% | +50.0% | 0.006% | |
| 5/10/2019 | Fosun International Ltd | 67,426 | $7.77M | 0.5% | +17.3% | 0.160% | |
| 5/10/2019 | Artisan Partners Limited Partnership | 1,131,107 | $133.13M | 0.3% | +40.3% | 2.684% | |
| 5/10/2019 | PNC Financial Services Group Inc. | 3,620 | $0.43M | 0.0% | -352.5% | 0.009% | |
| 5/9/2019 | BlackRock Inc. | 423,405 | $49.84M | 0.0% | -5.7% | 1.005% | |
| 5/9/2019 | Emory University | 32,477 | $3.82M | 2.7% | -26.2% | 0.077% | |
| 5/9/2019 | Parametric Portfolio Associates LLC | 2,403 | $0.28M | 0.0% | -71.2% | 0.006% | |
| 5/8/2019 | TD Asset Management Inc. | 87,368 | $10.28M | 0.0% | +10.9% | 0.207% | |
| 5/6/2019 | Raymond James & Associates | 2,895 | $0.34M | 0.0% | +50.0% | 0.007% | |
| 5/6/2019 | Private Ocean LLC | 961 | $0.11M | 0.0% | +50.0% | 0.002% | |
| 5/3/2019 | California Public Employees Retirement System | 27,175 | $3.20M | 0.0% | -143.5% | 0.064% | |
| 5/3/2019 | Victory Capital Management Inc. | 322,718 | $37.98M | 0.1% | +48.1% | 0.766% | |
| 5/2/2019 | Comerica Bank | 2,281 | $0.28M | 0.0% | +50.0% | 0.005% | |
| 5/2/2019 | Telemus Capital LLC | 2,000 | $0.24M | 0.0% | +50.0% | 0.005% | |
| 5/1/2019 | Alps Advisors Inc. | 70,468 | $8.29M | 0.1% | -60.9% | 0.167% | |
| 4/29/2019 | SG Americas Securities LLC | 2,088 | $0.25M | 0.0% | +10.1% | 0.005% | |
| 4/24/2019 | Matisse Capital | 10,130 | $1.19M | 1.4% | +25.1% | 0.024% | |
| 4/23/2019 | Lindbrook Capital LLC | 665 | $78K | 0.0% | -43.0% | 0.002% | |
| 4/22/2019 | Henry James International Management Inc. | 3,507 | $0.41M | 0.2% | +50.0% | 0.008% | |
| 4/19/2019 | Financial Gravity Wealth Inc. | 1,133 | $0.13M | 0.1% | +50.0% | 0.003% | |
| 4/15/2019 | Quantitative Systematic Strategies LLC | 2,198 | $0.26M | 0.1% | +786.9% | 0.005% | |
| 4/12/2019 | Virtu Financial LLC | 1,964 | $0.23M | 0.0% | +50.0% | 0.005% | |
| 4/12/2019 | First Manhattan Co. | 75,000 | $8.83M | 0.1% | +180.4% | 0.178% | |
| 4/11/2019 | Chartwell Investment Partners LLC | 20,637 | $2.43M | 0.1% | +50.0% | 0.049% | |
| 4/1/2019 | Deutsche Bank AG | 120,287 | $7.54M | 0.0% | +17.7% | 0.286% | |
| 3/6/2019 | Geode Capital Management LLC | 30,743 | $1.93M | 0.0% | +10.1% | 0.073% | |
| 2/26/2019 | FMR LLC | 4,203,246 | $263.33M | 0.0% | +1.2% | 10.001% | |
| 2/22/2019 | Sofinnova Investments Inc. | 1,498,538 | $93.88M | 11.7% | -189.5% | 3.565% | |
| 2/15/2019 | Millennium Management LLC | 183,675 | $11.51M | 0.0% | -21.4% | 0.437% | |
| 2/14/2019 | Squarepoint Ops LLC | 3,260 | $0.20M | 0.0% | +50.0% | 0.008% | |
| 2/14/2019 | Orbimed Advisors LLC | 4,087,373 | $256.07M | 4.7% | -1.7% | 9.724% | |
| 2/14/2019 | Perceptive Advisors LLC | 1,052,647 | $63.04M | 2.4% | -1.9% | 2.504% | |
| 2/14/2019 | D. E. Shaw & Co. Inc. | 46,181 | $2.89M | 0.0% | +11.3% | 0.110% | |
| 2/14/2019 | Partner Fund Management L.P. | 27,519 | $1.72M | 0.0% | +50.0% | 0.065% | |
| 2/14/2019 | Bank of America Corp DE | 14,498 | $0.91M | 0.0% | +157.7% | 0.034% | |
| 2/14/2019 | venBio Select Advisor LLC | 1,980,000 | $124.05M | 7.4% | +0.8% | 4.711% | |
| 2/14/2019 | Sphera Funds Management LTD. | 58,273 | $3.65M | 0.4% | -144.1% | 0.139% | |
| 2/13/2019 | Geode Capital Management LLC | 30,743 | $1.93M | 0.0% | +10.1% | 0.073% | |
| 2/13/2019 | Eversept Partners LP | 15,254 | $0.96M | 0.5% | -33.2% | 0.036% | |
| 2/13/2019 | Tekla Capital Management LLC | 42,399 | $2.66M | 0.1% | -122.2% | 0.101% | |
| 2/13/2019 | Foresite Capital Management III LLC | 204,088 | $12.79M | 4.2% | +5.8% | 0.486% | |
| 2/13/2019 | Flinton Capital Management LLC | 3,008 | $0.19M | 0.0% | -276.0% | 0.007% | |
| 2/12/2019 | Emory University | 39,217 | $2.46M | 1.9% | +1.8% | 0.093% | |
| 2/11/2019 | Mirae Asset Global Investments Co. Ltd. | 11,294 | $0.71M | 0.0% | +20.1% | 0.027% | |
| 2/11/2019 | Bank of New York Mellon Corp | 123,415 | $7.73M | 0.0% | +50.0% | 0.294% | |
| 2/8/2019 | BlackRock Inc. | 446,311 | $27.96M | 0.0% | -3.4% | 1.062% | |
| 2/8/2019 | Westfield Capital Management Co. LP | 539,120 | $33.78M | 0.3% | -8.6% | 1.283% | |
| 2/8/2019 | New York State Common Retirement Fund | 233,049 | $14.60M | 0.0% | +23.5% | 0.554% | |
| 2/8/2019 | California Public Employees Retirement System | 43,192 | $2.71M | 0.0% | -5.1% | 0.103% | |
| 2/8/2019 | PNC Financial Services Group Inc. | 6,440 | $0.40M | 0.0% | -5.2% | 0.015% | |
| 2/7/2019 | Lindbrook Capital LLC | 865 | $54K | 0.0% | +50.0% | 0.002% | |
| 2/7/2019 | Westpac Banking Corp | 87,160 | $5.46M | 0.1% | +50.0% | 0.207% | |
| 2/5/2019 | Victory Capital Management Inc. | 23,318 | $1.46M | 0.0% | -1.8% | 0.055% | |
| 2/5/2019 | Virtus ETF Advisers LLC | 4,789 | $0.30M | 0.1% | +50.0% | 0.011% | |
| 2/4/2019 | Alps Advisors Inc. | 97,135 | $6.09M | 0.0% | +24.6% | 0.231% | |
| 2/1/2019 | TD Asset Management Inc. | 76,672 | $4.80M | 0.0% | +12.0% | 0.182% | |
| 2/1/2019 | SG Americas Securities LLC | 1,854 | $0.12M | 0.0% | +50.0% | 0.004% | |
| 1/30/2019 | First Manhattan Co. | 243,306 | $15.24M | 0.1% | -14.0% | 0.579% | |
| 1/28/2019 | Quantamental Technologies LLC | 400 | $25K | 0.0% | +50.0% | 0.001% | |
| 1/18/2019 | Matisse Capital | 6,730 | $0.42M | 0.5% | -216.0% | 0.016% | |
| 12/6/2018 | Marshall Wace North America L.P. | 703,087 | $49.82M | 0.3% | +8.3% | 1.673% | |
| 12/6/2018 | Marshall Wace LLP | 6,238 | $0.44M | 0.0% | -768.8% | 0.015% | |
| 11/20/2018 | Morgan Stanley | 47,100 | $3.34M | 0.0% | +25.9% | 0.112% | |
| 11/15/2018 | Putnam Investments LLC | 164,463 | $11.65M | 0.0% | +50.0% | 0.391% | |
| 11/14/2018 | Sphera Funds Management LTD. | 92,673 | $6.57M | 0.8% | +13.6% | 0.220% | |
| 11/13/2018 | Renaissance Technologies LLC | 41,900 | $2.97M | 0.0% | -53.5% | 0.100% | |
| 11/13/2018 | University of Notre Dame DU Lac | 40,871 | $2.90M | 0.5% | -3.3% | 0.097% | |
| 11/13/2018 | Tekla Capital Management LLC | 65,714 | $4.66M | 0.2% | +24.9% | 0.156% | |
| 11/13/2018 | Foresite Capital Management IV LLC | 245,424 | $17.39M | 5.7% | -11.3% | 0.584% | |
| 11/13/2018 | Loomis Sayles & Co. L P | 88,055 | $6.24M | 0.0% | +50.0% | 0.210% | |
| 11/13/2018 | Allianz Asset Management GmbH | 78,120 | $5.54M | 0.0% | -789.7% | 0.186% | |
| 11/13/2018 | Mirae Asset Global Investments Co. Ltd. | 8,444 | $0.60M | 0.0% | +37.7% | 0.020% | |
| 11/13/2018 | Advisory Research Inc. | 11,833 | $0.84M | 0.0% | +50.0% | 0.028% | |
| 11/13/2018 | Franklin Resources Inc. | 591,898 | $41.94M | 0.0% | +6.7% | 1.408% | |
| 11/9/2018 | DekaBank Deutsche Girozentrale | 27,100 | $1.92M | 0.0% | +45.1% | 0.064% | |
