Perceptive Advisors LLC Top Holdings and 13F Report (2026) About Perceptive Advisors LLCInvestment ActivityPerceptive Advisors LLC has $6.66 billion in total holdings as of June 30, 2026.Perceptive Advisors LLC owns shares of 108 different stocks, but just 31 companies or ETFs make up 80% of its holdings.Approximately 23.62% of the portfolio was purchased this quarter.About 16.03% of the portfolio was sold this quarter.This quarter, Perceptive Advisors LLC has purchased 94 new stocks and bought additional shares in 30 stocks.Perceptive Advisors LLC sold shares of 26 stocks and completely divested from 14 stocks this quarter.Largest Holdings PRAXIS PRECISION MEDICINES I $681,627,753SPYRE THERAPEUTICS INC $383,484,855Celcuity $334,491,064ASCENDIS PHARMA A/S $310,387,665Rhythm Pharmaceuticals $287,156,334 Largest New Holdings this Quarter K08588103 - ASCENDIS PHARMA A/S $310,387,665 Holding485925101 - KARDIGAN INC $195,585,788 Holding05348Y105 - AVALYN PHARMACEUTICALS INC $88,070,744 Holding09062X103 - Biogen $59,669,938 Holding91324P102 - UnitedHealth Group $48,548,078 Holding Largest Purchases this Quarter ASCENDIS PHARMA A/S 1,163,721 shares (about $310.39M)KARDIGAN INC 8,200,662 shares (about $195.59M)AVALYN PHARMACEUTICALS INC 2,675,296 shares (about $88.07M)Relay Therapeutics 4,355,046 shares (about $81.48M)Tango Therapeutics 2,568,847 shares (about $80.30M) Largest Sales this Quarter DYNE THERAPEUTICS INC 1,979,604 shares (about $43.97M)Guardant Health 258,673 shares (about $38.81M)ABIVAX SA 254,884 shares (about $33.97M)APOGEE THERAPEUTICS INC 232,271 shares (about $30.83M)Protagonist Therapeutics 249,000 shares (about $30.52M) Sector Allocation Over TimeMap of 500 Largest Holdings ofPerceptive Advisors LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorPRAXIS PRECISION MEDICINES I$681,627,7530.0%2,035,98610.2%COM NEWSPYRE THERAPEUTICS INC$383,484,855$47,610,139 â–²14.2%4,319,4965.8%COM NEWCELCCelcuity$334,491,064$7,323,400 â–²2.2%3,197,2005.0%HealthcareASCENDIS PHARMA A/S$310,387,665$310,387,665 â–²New Holding1,163,7214.7%ORD SHSRYTMRhythm Pharmaceuticals$287,156,334$23,593,875 â–²9.0%2,586,2954.3%HealthcareROIVRoivant Sciences$286,144,465$7,078,000 â–¼-2.4%8,085,4614.3%HealthcareRLAYRelay Therapeutics$263,926,759$81,482,911 â–²44.7%14,106,1874.0%HealthcareTVTXTravere Therapeutics$213,183,729$22,154,593 â–¼-9.4%3,752,5743.2%HealthcareKARDIGAN INC$195,585,788$195,585,788 â–²New Holding8,200,6622.9%COMNUVLNuvalent$195,192,3680.0%1,580,5052.9%HealthcareEWTXEdgewise Therapeutics$177,714,564$2,031,500 â–¼-1.1%4,373,9742.7%HealthcareAPOGEE THERAPEUTICS INC$173,625,838$30,829,330 â–¼-15.1%1,308,1132.6%COMAMLXAmylyx Pharmaceuticals$149,694,481$898,000 â–²0.6%8,334,8822.2%HealthcareMGTXMeiraGTx$145,727,749$6,222,098 â–²4.5%10,786,6582.2%HealthcareORUKA THERAPEUTICS INC$128,009,646$4,800,184 â–¼-3.6%1,345,0631.9%COMINHIBRX BIOSCIENCES INC$122,963,044$13,733,444 â–¼-10.0%1,297,7631.8%COMPTGXProtagonist Therapeutics$120,358,728$30,522,420 â–¼-20.2%981,8791.8%HealthcareSLDBSolid Biosciences$118,947,3930.0%11,906,6461.8%HealthcareZYMEWORKS INC$109,342,391$17,588,952 â–²19.2%4,182,9531.6%COMTNGXTango Therapeutics$105,565,020$80,302,157 â–²317.9%3,377,0001.6%HealthcareIMTXImmatics$105,184,4090.0%10,383,4561.6%HealthcareNRIXNurix Therapeutics$104,813,438$14,787,562 â–²16.4%4,320,4221.6%HealthcareBCRXBioCryst Pharmaceuticals$103,088,880$28,748,550 â–²38.7%10,308,8881.5%HealthcareRVMDRevolution Medicines$98,808,928$50,378,320 â–²104.0%527,6001.5%HealthcareAVALYN PHARMACEUTICALS INC$88,070,744$88,070,744 â–²New Holding2,675,2961.3%COM SHSMRNAModerna$70,030,0000.0%1,000,0001.1%HealthcareDYNE THERAPEUTICS INC$59,727,909$43,967,005 â–¼-42.4%2,689,2350.9%COMBIIBBiogen$59,669,938$59,669,938 â–²New Holding276,1730.9%HealthcareIMVTImmunovant$52,299,967$9,247,200 â–¼-15.0%1,357,3830.8%HealthcareUNHUnitedHealth Group$48,548,078$48,548,078 â–²New Holding116,8060.7%HealthcareXBISPDR S&P Biotech ETF$47,475,000$47,475,000 â–²New Holding300,0000.7%ETFIONSIonis Pharmaceuticals$44,878,140$4,915,980 â–²12.3%566,0000.7%HealthcareSUTRO BIOPHARMA INC$43,320,887$19,572,695 â–²82.4%1,304,8460.7%COM SHSALTO NEUROSCIENCE INC$42,485,076$10,556,000 â–¼-19.9%1,609,8930.6%COM SHSJAZZJazz Pharmaceuticals$40,964,9000.0%170,0000.6%HealthcareCRVSCorvus Pharmaceuticals$39,851,569$5,602,500 â–²16.4%2,667,4410.6%HealthcareSIONNA THERAPEUTICS INC$39,810,950$10,846,218 â–²37.4%905,0000.6%COMCTMXCytomX Therapeutics$39,146,944$1,276,354 â–²3.4%10,439,1850.6%HealthcareAORTArtivion$39,036,906$2,247,000 â–²6.1%1,737,2900.6%HealthcareX4 PHARMACEUTICALS INC$37,049,403$5,584,587 â–²17.7%7,933,4910.6%COM NEWCAPRCapricor Therapeutics$36,120,000$36,120,000 â–²New Holding1,500,0000.5%HealthcareCORTCorcept Therapeutics$34,639,576$30,292,076 â–²696.8%398,3850.5%HealthcareRGENRepligen$33,866,045$4,410,969 â–¼-11.5%248,2120.5%HealthcareANTERIS TECHNOLOGIES GLOBAL$33,740,9390.0%3,425,4760.5%COMRAPPORT THERAPEUTICS INC$32,225,161$4,142,790 â–²14.8%773,3420.5%COMDAMORA THERAPEUTICS INC$31,810,2300.0%1,223,0000.5%COM NEWCRLCharles River Laboratories International$31,750,600$31,750,600 â–²New Holding140,0000.5%HealthcareAXSMAxsome Therapeutics$28,993,007$7,710,255 â–¼-21.0%118,4500.4%HealthcareEYPTEyepoint Pharmaceuticals$28,600,000$28,600,000 â–²New Holding2,000,0000.4%HealthcareDBV TECHNOLOGIES S A$27,114,940$11,298,928 â–²71.4%1,653,3500.4%SPONSORED ADSIRTCiRhythm Technologies$26,616,966$14,124,123 â–²113.1%223,7660.4%HealthcareADPTAdaptive Biotechnologies$26,111,621$22,840,496 â–²698.2%1,217,3250.4%HealthcareSAB BIOTHERAPEUTICS INC$25,847,254$763,456 â–²3.0%6,627,5010.4%COM NEWDHRDanaher$24,762,400$24,762,400 â–²New Holding130,0000.4%HealthcareTENAX THERAPEUTICS INC$24,735,000$3,669,772 â–²17.4%1,700,0000.4%COM NEWSLSSELLAS Life Sciences Group$22,140,000$22,140,000 â–²New Holding1,500,0000.3%HealthcareNAUTNautilus Biotechnology$21,755,974$1,795,200 â–¼-7.6%11,634,2110.3%HealthcareOBIOOrchestra BioMed$21,738,5640.0%5,037,9060.3%HealthcareISRGIntuitive Surgical$20,633,229$13,336,199 â–¼-39.3%51,8840.3%HealthcareADLAI NORTYE LTD$20,621,685$20,621,685 â–²New Holding1,793,1900.3%SPONSORED ADSCONTINEUM THERAPEUTICS INC$20,579,1530.0%1,255,5920.3%CL ANVCTNuvectis Pharma$18,390,000$18,390,000 â–²New Holding1,000,0000.3%HealthcarePALISADE BIO INC$17,608,386$1,051,446 â–¼-5.6%8,425,0650.3%COMOMADA HEALTH INC$17,259,9430.0%786,3300.3%COMLEONABIO INC$17,087,1690.0%1,859,3220.3%COMEOLSEvolus$17,067,438$8,136,616 â–²91.1%2,459,2850.3%HealthcareNAMSNewAmsterdam Pharma$16,945,000$16,945,000 â–²New Holding500,0000.3%HealthcareIVVDInvivyd$16,131,231$2,066,425 â–¼-11.4%18,490,6360.2%HealthcareCELCUITY INC$14,629,4420.0%6,500,0000.2%NOTE 2.750% 8/0MIRMMirum Pharmaceuticals$13,508,824$13,508,824 â–²New Holding115,3910.2%HealthcareSURROZEN INC$13,078,411$7,125,663 â–²119.7%503,9850.2%COM NEWBETA BIONICS INC$13,052,232$156,700 â–¼-1.2%832,9440.2%COMAXGNAxoGen$11,423,341$20,785,499 â–¼-64.5%247,3120.2%HealthcareOSCROscar Health$11,408,000$11,408,000 â–²New Holding400,0000.2%HealthcareOCSOculis$11,218,430$4,369,050 â–²63.8%808,8270.2%HealthcareSEAPORT THERAPEUTICS INC$10,860,000$10,860,000 â–²New Holding500,0000.2%COMMON STOCKVRDNViridian Therapeutics$10,690,973$10,817,157 â–¼-50.3%581,9800.2%HealthcareBSXBoston Scientific$10,670,000$10,670,000 â–²New Holding250,0000.2%HealthcareBILLIONTOONE INC$10,415,704$599,900 â–¼-5.4%86,8120.2%CL AABIVAX SA$9,861,240$33,965,842 â–¼-77.5%74,0000.1%SPONSORED ADSNTRANatera$9,416,329$9,416,329 â–²New Holding34,6890.1%HealthcareENGENE THERAPEUTICS INC$8,342,352$8,342,352 â–²New Holding4,822,1690.1%COMRESEARCH ALLIANCE CORP III$8,025,000$8,025,000 â–²New Holding750,0000.1%ORD SHS CL AAGOMAB THERAPEUTICS NV$7,788,0000.0%600,0000.1%SPONSORED ADSCGEMCullinan Therapeutics$7,766,164$7,766,164 â–²New Holding426,4780.1%HealthcareQUREuniQure$7,738,080$7,738,080 â–²New Holding168,0000.1%HealthcareMOBIA MED INC$7,016,963$7,016,963 â–²New Holding523,6540.1%COMMON STOCKADAGIO MED HLDGS INC$6,439,534$7 â–²0.0%9,876,5860.1%COMGHGuardant Health$6,200,290$38,808,711 â–¼-86.2%41,3270.1%HealthcarePHATPhathom Pharmaceuticals$5,772,200$4,264,050 â–¼-42.5%532,0000.1%HealthcareOUTLOOK THERAPEUTICS INC$4,991,353$4,991,353 â–²New Holding3,139,2160.1%COMCOGTCogent Biosciences$4,685,8730.0%121,0820.1%HealthcareEDESA BIOTECH INC$4,579,1330.0%563,2390.1%COM NEWAVALO THERAPEUTICS INC$4,062,144$1,481,098 â–²57.4%219,8130.1%COM NEWTWSTTwist Bioscience$3,787,219$11,644,783 â–¼-75.5%36,8120.1%HealthcareCRESCENT BIOPHARMA INC.$3,724,9560.0%206,9420.1%COMXERSXeris Biopharma$3,698,743$3,698,743 â–²New Holding467,0130.1%HealthcareOUTSET MED INC$3,599,9980.0%833,3330.1%COM NEWBIODESIX INC$2,451,049$2,451,049 â–²New Holding108,6940.0%COMREVOLUTION MEDICINES INC$2,344,9750.0%250,0000.0%*W EXP 12/17/202Showing largest 100 holdings. 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