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Madrigal Pharmaceuticals (MDGL) Competitors

Madrigal Pharmaceuticals logo
$516.74 -2.35 (-0.45%)
As of 08/21/2026 04:00 PM Eastern

MDGL vs. NTRA, RVMD, BIIB, ALNY, and INSM

Should you buy Madrigal Pharmaceuticals stock or one of its competitors? Madrigal Pharmaceuticals's main competitors and comparable companies include Natera (NTRA), Revolution Medicines (RVMD), Biogen (BIIB), Alnylam Pharmaceuticals (ALNY), and Insmed (INSM). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Madrigal Pharmaceuticals compare to Natera?

Madrigal Pharmaceuticals (NASDAQ:MDGL) and Natera (NASDAQ:NTRA) are both large-cap healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their valuation, institutional ownership, earnings, media sentiment, risk, profitability, analyst recommendations and dividends.

Natera has a net margin of -7.11% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Natera's return on equity of -11.38% beat Madrigal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Madrigal Pharmaceuticals-25.32% -56.65% -25.53%
Natera -7.11%-11.38%-7.87%

Natera has higher revenue and earnings than Madrigal Pharmaceuticals. Natera is trading at a lower price-to-earnings ratio than Madrigal Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Madrigal Pharmaceuticals$958.40M12.45-$288.28M-$12.89N/A
Natera$2.31B20.75-$208.16M-$1.36N/A

98.5% of Madrigal Pharmaceuticals shares are owned by institutional investors. Comparatively, 99.9% of Natera shares are owned by institutional investors. 17.6% of Madrigal Pharmaceuticals shares are owned by insiders. Comparatively, 5.1% of Natera shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Madrigal Pharmaceuticals has a beta of -1.01, meaning that its share price is 201% less volatile than the broader market. Comparatively, Natera has a beta of 1.51, meaning that its share price is 51% more volatile than the broader market.

Madrigal Pharmaceuticals currently has a consensus price target of $689.93, indicating a potential upside of 33.52%. Natera has a consensus price target of $319.38, indicating a potential downside of 3.81%. Given Madrigal Pharmaceuticals' higher probable upside, equities research analysts plainly believe Madrigal Pharmaceuticals is more favorable than Natera.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78
Natera
1 Sell rating(s)
4 Hold rating(s)
15 Buy rating(s)
2 Strong Buy rating(s)
2.82

In the previous week, Natera had 23 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 30 mentions for Natera and 7 mentions for Madrigal Pharmaceuticals. Natera's average media sentiment score of 1.34 beat Madrigal Pharmaceuticals' score of 1.08 indicating that Natera is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Madrigal Pharmaceuticals
5 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Natera
25 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Natera beats Madrigal Pharmaceuticals on 13 of the 16 factors compared between the two stocks.

How does Madrigal Pharmaceuticals compare to Revolution Medicines?

Revolution Medicines (NASDAQ:RVMD) and Madrigal Pharmaceuticals (NASDAQ:MDGL) are both large-cap healthcare companies, but which is the better business? We will compare the two businesses based on the strength of their risk, profitability, earnings, dividends, institutional ownership, media sentiment, analyst recommendations and valuation.

Revolution Medicines has a beta of 1.39, suggesting that its stock price is 39% more volatile than the broader market. Comparatively, Madrigal Pharmaceuticals has a beta of -1.01, suggesting that its stock price is 201% less volatile than the broader market.

Madrigal Pharmaceuticals has higher revenue and earnings than Revolution Medicines. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Revolution Medicines, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Revolution Medicines$11.58M3,877.00-$1.13B-$8.82N/A
Madrigal Pharmaceuticals$958.40M12.45-$288.28M-$12.89N/A

In the previous week, Revolution Medicines had 5 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 12 mentions for Revolution Medicines and 7 mentions for Madrigal Pharmaceuticals. Revolution Medicines' average media sentiment score of 1.37 beat Madrigal Pharmaceuticals' score of 1.08 indicating that Revolution Medicines is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Revolution Medicines
10 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Positive
Madrigal Pharmaceuticals
5 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

94.3% of Revolution Medicines shares are owned by institutional investors. Comparatively, 98.5% of Madrigal Pharmaceuticals shares are owned by institutional investors. 7.6% of Revolution Medicines shares are owned by insiders. Comparatively, 17.6% of Madrigal Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Revolution Medicines has a net margin of 0.00% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Madrigal Pharmaceuticals' return on equity of -56.65% beat Revolution Medicines' return on equity.

Company Net Margins Return on Equity Return on Assets
Revolution MedicinesN/A -88.20% -57.85%
Madrigal Pharmaceuticals -25.32%-56.65%-25.53%

Revolution Medicines currently has a consensus target price of $167.89, indicating a potential downside of 19.85%. Madrigal Pharmaceuticals has a consensus target price of $689.93, indicating a potential upside of 33.52%. Given Madrigal Pharmaceuticals' higher probable upside, analysts clearly believe Madrigal Pharmaceuticals is more favorable than Revolution Medicines.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Revolution Medicines
1 Sell rating(s)
1 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.90
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78

Summary

Revolution Medicines beats Madrigal Pharmaceuticals on 10 of the 17 factors compared between the two stocks.

How does Madrigal Pharmaceuticals compare to Biogen?

Madrigal Pharmaceuticals (NASDAQ:MDGL) and Biogen (NASDAQ:BIIB) are both large-cap healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their dividends, valuation, profitability, earnings, institutional ownership, analyst recommendations, risk and media sentiment.

In the previous week, Biogen had 21 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 28 mentions for Biogen and 7 mentions for Madrigal Pharmaceuticals. Biogen's average media sentiment score of 1.35 beat Madrigal Pharmaceuticals' score of 1.08 indicating that Biogen is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Madrigal Pharmaceuticals
5 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Biogen
22 Very Positive mention(s)
3 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

98.5% of Madrigal Pharmaceuticals shares are owned by institutional investors. Comparatively, 87.9% of Biogen shares are owned by institutional investors. 17.6% of Madrigal Pharmaceuticals shares are owned by company insiders. Comparatively, 0.3% of Biogen shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Madrigal Pharmaceuticals has a beta of -1.01, suggesting that its share price is 201% less volatile than the broader market. Comparatively, Biogen has a beta of 0.17, suggesting that its share price is 83% less volatile than the broader market.

Madrigal Pharmaceuticals presently has a consensus price target of $689.93, indicating a potential upside of 33.52%. Biogen has a consensus price target of $227.07, indicating a potential upside of 4.75%. Given Madrigal Pharmaceuticals' stronger consensus rating and higher possible upside, equities analysts plainly believe Madrigal Pharmaceuticals is more favorable than Biogen.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58

Biogen has a net margin of 8.32% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Biogen's return on equity of 11.18% beat Madrigal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Madrigal Pharmaceuticals-25.32% -56.65% -25.53%
Biogen 8.32%11.18%6.88%

Biogen has higher revenue and earnings than Madrigal Pharmaceuticals. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Biogen, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Madrigal Pharmaceuticals$958.40M12.45-$288.28M-$12.89N/A
Biogen$10.03B3.19$1.29B$5.6538.37

Summary

Biogen beats Madrigal Pharmaceuticals on 12 of the 17 factors compared between the two stocks.

How does Madrigal Pharmaceuticals compare to Alnylam Pharmaceuticals?

Alnylam Pharmaceuticals (NASDAQ:ALNY) and Madrigal Pharmaceuticals (NASDAQ:MDGL) are both large-cap healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their media sentiment, risk, institutional ownership, valuation, profitability, earnings, analyst recommendations and dividends.

Alnylam Pharmaceuticals presently has a consensus target price of $386.62, suggesting a potential upside of 63.67%. Madrigal Pharmaceuticals has a consensus target price of $689.93, suggesting a potential upside of 33.52%. Given Alnylam Pharmaceuticals' stronger consensus rating and higher possible upside, equities research analysts plainly believe Alnylam Pharmaceuticals is more favorable than Madrigal Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
15 Buy rating(s)
4 Strong Buy rating(s)
2.96
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78

In the previous week, Alnylam Pharmaceuticals had 18 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 25 mentions for Alnylam Pharmaceuticals and 7 mentions for Madrigal Pharmaceuticals. Madrigal Pharmaceuticals' average media sentiment score of 1.08 beat Alnylam Pharmaceuticals' score of 0.81 indicating that Madrigal Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alnylam Pharmaceuticals
11 Very Positive mention(s)
1 Positive mention(s)
10 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Madrigal Pharmaceuticals
5 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Alnylam Pharmaceuticals has higher revenue and earnings than Madrigal Pharmaceuticals. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alnylam Pharmaceuticals$4.80B6.58$313.75M$5.3843.91
Madrigal Pharmaceuticals$958.40M12.45-$288.28M-$12.89N/A

Alnylam Pharmaceuticals has a beta of 0.3, indicating that its share price is 70% less volatile than the broader market. Comparatively, Madrigal Pharmaceuticals has a beta of -1.01, indicating that its share price is 201% less volatile than the broader market.

Alnylam Pharmaceuticals has a net margin of 15.26% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Madrigal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Alnylam Pharmaceuticals15.26% 84.93% 14.30%
Madrigal Pharmaceuticals -25.32%-56.65%-25.53%

93.0% of Alnylam Pharmaceuticals shares are owned by institutional investors. Comparatively, 98.5% of Madrigal Pharmaceuticals shares are owned by institutional investors. 0.9% of Alnylam Pharmaceuticals shares are owned by insiders. Comparatively, 17.6% of Madrigal Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Summary

Alnylam Pharmaceuticals beats Madrigal Pharmaceuticals on 12 of the 16 factors compared between the two stocks.

How does Madrigal Pharmaceuticals compare to Insmed?

Madrigal Pharmaceuticals (NASDAQ:MDGL) and Insmed (NASDAQ:INSM) are both large-cap healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their profitability, dividends, institutional ownership, risk, valuation, media sentiment, earnings and analyst recommendations.

Madrigal Pharmaceuticals has higher revenue and earnings than Insmed. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Insmed, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Madrigal Pharmaceuticals$958.40M12.45-$288.28M-$12.89N/A
Insmed$606.42M45.29-$1.28B-$4.11N/A

Madrigal Pharmaceuticals presently has a consensus price target of $689.93, suggesting a potential upside of 33.52%. Insmed has a consensus price target of $205.52, suggesting a potential upside of 63.41%. Given Insmed's stronger consensus rating and higher probable upside, analysts clearly believe Insmed is more favorable than Madrigal Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00

Madrigal Pharmaceuticals has a net margin of -25.32% compared to Insmed's net margin of -76.94%. Madrigal Pharmaceuticals' return on equity of -56.65% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Madrigal Pharmaceuticals-25.32% -56.65% -25.53%
Insmed -76.94%-123.94%-44.30%

98.5% of Madrigal Pharmaceuticals shares are held by institutional investors. 17.6% of Madrigal Pharmaceuticals shares are held by company insiders. Comparatively, 2.1% of Insmed shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Madrigal Pharmaceuticals has a beta of -1.01, meaning that its share price is 201% less volatile than the broader market. Comparatively, Insmed has a beta of 0.81, meaning that its share price is 19% less volatile than the broader market.

In the previous week, Madrigal Pharmaceuticals had 7 more articles in the media than Insmed. MarketBeat recorded 7 mentions for Madrigal Pharmaceuticals and 0 mentions for Insmed. Insmed's average media sentiment score of 1.84 beat Madrigal Pharmaceuticals' score of 1.08 indicating that Insmed is being referred to more favorably in the news media.

Company Overall Sentiment
Madrigal Pharmaceuticals Positive
Insmed Very Positive

Summary

Insmed beats Madrigal Pharmaceuticals on 9 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding MDGL and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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MDGL vs. The Competition

MetricMadrigal PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$11.94B$4.01B$7.37B$12.85B
Dividend YieldN/A3.64%2.53%11.08%
P/E Ratio-40.0911.62272.6024.24
Price / Sales12.451,338.17618.9699.78
Price / CashN/A105.1478.6253.99
Price / Book22.7916.8013.056.20
Net Income-$288.28M-$12.50M$3.47B$348.59M
7 Day Performance1.81%3.29%2.09%0.08%
1 Month Performance-4.90%8.23%6.64%3.88%
1 Year Performance24.61%55.05%25.02%16.98%

Madrigal Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
MDGL
Madrigal Pharmaceuticals
3.8051 of 5 stars
$516.74
-0.5%
$689.93
+33.5%
+24.6%$11.94B$958.40MN/A90
NTRA
Natera
2.5905 of 5 stars
$314.18
+1.4%
$319.38
+1.7%
+100.5%$44.67B$2.31BN/A6,140
RVMD
Revolution Medicines
2.5369 of 5 stars
$212.00
+4.1%
$166.33
-21.5%
+466.0%$43.66B$11.58MN/A250
BIIB
Biogen
3.9629 of 5 stars
$209.15
-0.3%
$227.07
+8.6%
+55.6%$31.00B$9.89B37.027,500
ALNY
Alnylam Pharmaceuticals
4.9363 of 5 stars
$224.60
-1.8%
$393.86
+75.4%
-48.0%$30.60B$3.71B41.752,770

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This page (NASDAQ:MDGL) was last updated on 8/23/2026 by MarketBeat.com Staff.
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