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Madrigal Pharmaceuticals (MDGL) Competitors

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$534.49 +1.37 (+0.26%)
Closing price 09/11/2026 04:00 PM Eastern
Extended Trading
$534.42 -0.07 (-0.01%)
As of 09/11/2026 07:30 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

MDGL vs. NTRA, RVMD, ALNY, BIIB, and INSM

Should you buy Madrigal Pharmaceuticals stock or one of its competitors? Madrigal Pharmaceuticals's main competitors and comparable companies include Natera (NTRA), Revolution Medicines (RVMD), Alnylam Pharmaceuticals (ALNY), Biogen (BIIB), and Insmed (INSM). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Madrigal Pharmaceuticals compare to Natera?

Natera (NASDAQ:NTRA) and Madrigal Pharmaceuticals (NASDAQ:MDGL) are both large-cap healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, dividends, valuation, media sentiment, analyst recommendations, institutional ownership, profitability and earnings.

99.9% of Natera shares are held by institutional investors. Comparatively, 98.5% of Madrigal Pharmaceuticals shares are held by institutional investors. 5.1% of Natera shares are held by insiders. Comparatively, 17.6% of Madrigal Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Natera has higher revenue and earnings than Madrigal Pharmaceuticals. Natera is trading at a lower price-to-earnings ratio than Madrigal Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Natera$2.31B20.56-$208.16M-$1.36N/A
Madrigal Pharmaceuticals$958.40M12.88-$288.28M-$12.89N/A

In the previous week, Natera had 9 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 19 mentions for Natera and 10 mentions for Madrigal Pharmaceuticals. Natera's average media sentiment score of 1.21 beat Madrigal Pharmaceuticals' score of 0.82 indicating that Natera is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Natera
11 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Madrigal Pharmaceuticals
6 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Natera has a net margin of -7.11% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Natera's return on equity of -11.38% beat Madrigal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Natera-7.11% -11.38% -7.87%
Madrigal Pharmaceuticals -25.32%-56.65%-25.53%

Natera presently has a consensus price target of $330.83, suggesting a potential upside of 0.58%. Madrigal Pharmaceuticals has a consensus price target of $699.64, suggesting a potential upside of 30.90%. Given Madrigal Pharmaceuticals' higher probable upside, analysts clearly believe Madrigal Pharmaceuticals is more favorable than Natera.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Natera
1 Sell rating(s)
4 Hold rating(s)
16 Buy rating(s)
2 Strong Buy rating(s)
2.83
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78

Natera has a beta of 1.54, meaning that its stock price is 54% more volatile than the broader market. Comparatively, Madrigal Pharmaceuticals has a beta of -0.98, meaning that its stock price is 198% less volatile than the broader market.

Summary

Natera beats Madrigal Pharmaceuticals on 14 of the 17 factors compared between the two stocks.

How does Madrigal Pharmaceuticals compare to Revolution Medicines?

Revolution Medicines (NASDAQ:RVMD) and Madrigal Pharmaceuticals (NASDAQ:MDGL) are both large-cap healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their institutional ownership, earnings, dividends, profitability, risk, valuation, media sentiment and analyst recommendations.

94.3% of Revolution Medicines shares are owned by institutional investors. Comparatively, 98.5% of Madrigal Pharmaceuticals shares are owned by institutional investors. 7.6% of Revolution Medicines shares are owned by company insiders. Comparatively, 17.6% of Madrigal Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

In the previous week, Revolution Medicines had 3 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 13 mentions for Revolution Medicines and 10 mentions for Madrigal Pharmaceuticals. Revolution Medicines' average media sentiment score of 1.20 beat Madrigal Pharmaceuticals' score of 0.82 indicating that Revolution Medicines is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Revolution Medicines
10 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Positive
Madrigal Pharmaceuticals
6 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Revolution Medicines has a net margin of 0.00% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Madrigal Pharmaceuticals' return on equity of -56.65% beat Revolution Medicines' return on equity.

Company Net Margins Return on Equity Return on Assets
Revolution MedicinesN/A -88.20% -57.85%
Madrigal Pharmaceuticals -25.32%-56.65%-25.53%

Madrigal Pharmaceuticals has higher revenue and earnings than Revolution Medicines. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Revolution Medicines, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Revolution MedicinesN/AN/A-$1.13B-$8.82N/A
Madrigal Pharmaceuticals$958.40M12.88-$288.28M-$12.89N/A

Revolution Medicines has a beta of 1.4, suggesting that its stock price is 40% more volatile than the broader market. Comparatively, Madrigal Pharmaceuticals has a beta of -0.98, suggesting that its stock price is 198% less volatile than the broader market.

Revolution Medicines currently has a consensus target price of $226.17, indicating a potential upside of 10.99%. Madrigal Pharmaceuticals has a consensus target price of $699.64, indicating a potential upside of 30.90%. Given Madrigal Pharmaceuticals' higher probable upside, analysts plainly believe Madrigal Pharmaceuticals is more favorable than Revolution Medicines.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Revolution Medicines
1 Sell rating(s)
1 Hold rating(s)
17 Buy rating(s)
2 Strong Buy rating(s)
2.95
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78

Summary

Revolution Medicines beats Madrigal Pharmaceuticals on 9 of the 16 factors compared between the two stocks.

How does Madrigal Pharmaceuticals compare to Alnylam Pharmaceuticals?

Madrigal Pharmaceuticals (NASDAQ:MDGL) and Alnylam Pharmaceuticals (NASDAQ:ALNY) are both large-cap healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their media sentiment, earnings, profitability, risk, analyst recommendations, dividends, valuation and institutional ownership.

98.5% of Madrigal Pharmaceuticals shares are owned by institutional investors. Comparatively, 93.0% of Alnylam Pharmaceuticals shares are owned by institutional investors. 17.6% of Madrigal Pharmaceuticals shares are owned by insiders. Comparatively, 0.9% of Alnylam Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

In the previous week, Alnylam Pharmaceuticals had 4 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 14 mentions for Alnylam Pharmaceuticals and 10 mentions for Madrigal Pharmaceuticals. Alnylam Pharmaceuticals' average media sentiment score of 1.12 beat Madrigal Pharmaceuticals' score of 0.82 indicating that Alnylam Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Madrigal Pharmaceuticals
6 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Alnylam Pharmaceuticals
8 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Madrigal Pharmaceuticals currently has a consensus target price of $699.64, indicating a potential upside of 30.90%. Alnylam Pharmaceuticals has a consensus target price of $376.67, indicating a potential upside of 51.47%. Given Alnylam Pharmaceuticals' stronger consensus rating and higher possible upside, analysts plainly believe Alnylam Pharmaceuticals is more favorable than Madrigal Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
17 Buy rating(s)
2 Strong Buy rating(s)
2.88

Alnylam Pharmaceuticals has higher revenue and earnings than Madrigal Pharmaceuticals. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Madrigal Pharmaceuticals$958.40M12.88-$288.28M-$12.89N/A
Alnylam Pharmaceuticals$3.71B8.96$313.75M$5.3846.22

Madrigal Pharmaceuticals has a beta of -0.98, indicating that its share price is 198% less volatile than the broader market. Comparatively, Alnylam Pharmaceuticals has a beta of 0.31, indicating that its share price is 69% less volatile than the broader market.

Alnylam Pharmaceuticals has a net margin of 15.26% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Madrigal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Madrigal Pharmaceuticals-25.32% -56.65% -25.53%
Alnylam Pharmaceuticals 15.26%84.93%14.30%

Summary

Alnylam Pharmaceuticals beats Madrigal Pharmaceuticals on 14 of the 17 factors compared between the two stocks.

How does Madrigal Pharmaceuticals compare to Biogen?

Madrigal Pharmaceuticals (NASDAQ:MDGL) and Biogen (NASDAQ:BIIB) are both large-cap healthcare companies, but which is the better business? We will compare the two companies based on the strength of their media sentiment, profitability, valuation, dividends, earnings, analyst recommendations, institutional ownership and risk.

Biogen has a net margin of 8.32% compared to Madrigal Pharmaceuticals' net margin of -25.32%. Biogen's return on equity of 11.18% beat Madrigal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Madrigal Pharmaceuticals-25.32% -56.65% -25.53%
Biogen 8.32%11.18%6.88%

Madrigal Pharmaceuticals has a beta of -0.98, indicating that its stock price is 198% less volatile than the broader market. Comparatively, Biogen has a beta of 0.17, indicating that its stock price is 83% less volatile than the broader market.

Madrigal Pharmaceuticals currently has a consensus target price of $699.64, suggesting a potential upside of 30.90%. Biogen has a consensus target price of $230.14, suggesting a potential upside of 5.98%. Given Madrigal Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Madrigal Pharmaceuticals is more favorable than Biogen.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58

In the previous week, Biogen had 1 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 11 mentions for Biogen and 10 mentions for Madrigal Pharmaceuticals. Biogen's average media sentiment score of 1.10 beat Madrigal Pharmaceuticals' score of 0.82 indicating that Biogen is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Madrigal Pharmaceuticals
6 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Biogen
7 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

98.5% of Madrigal Pharmaceuticals shares are owned by institutional investors. Comparatively, 87.9% of Biogen shares are owned by institutional investors. 17.6% of Madrigal Pharmaceuticals shares are owned by insiders. Comparatively, 0.3% of Biogen shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Biogen has higher revenue and earnings than Madrigal Pharmaceuticals. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Biogen, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Madrigal Pharmaceuticals$958.40M12.88-$288.28M-$12.89N/A
Biogen$9.89B3.24$1.29B$5.6538.43

Summary

Biogen beats Madrigal Pharmaceuticals on 12 of the 17 factors compared between the two stocks.

How does Madrigal Pharmaceuticals compare to Insmed?

Insmed (NASDAQ:INSM) and Madrigal Pharmaceuticals (NASDAQ:MDGL) are both large-cap healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their media sentiment, institutional ownership, valuation, risk, analyst recommendations, earnings, dividends and profitability.

98.5% of Madrigal Pharmaceuticals shares are held by institutional investors. 2.1% of Insmed shares are held by insiders. Comparatively, 17.6% of Madrigal Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Insmed currently has a consensus target price of $205.52, indicating a potential upside of 58.81%. Madrigal Pharmaceuticals has a consensus target price of $699.64, indicating a potential upside of 30.90%. Given Insmed's stronger consensus rating and higher possible upside, research analysts plainly believe Insmed is more favorable than Madrigal Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00
Madrigal Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.78

Insmed has a beta of 0.82, meaning that its stock price is 18% less volatile than the broader market. Comparatively, Madrigal Pharmaceuticals has a beta of -0.98, meaning that its stock price is 198% less volatile than the broader market.

Madrigal Pharmaceuticals has a net margin of -25.32% compared to Insmed's net margin of -76.94%. Madrigal Pharmaceuticals' return on equity of -56.65% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Insmed-76.94% -123.94% -44.30%
Madrigal Pharmaceuticals -25.32%-56.65%-25.53%

Madrigal Pharmaceuticals has lower revenue, but higher earnings than Insmed. Madrigal Pharmaceuticals is trading at a lower price-to-earnings ratio than Insmed, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Insmed$1.14B24.84-$1.28B-$4.11N/A
Madrigal Pharmaceuticals$958.40M12.88-$288.28M-$12.89N/A

In the previous week, Insmed had 1 more articles in the media than Madrigal Pharmaceuticals. MarketBeat recorded 11 mentions for Insmed and 10 mentions for Madrigal Pharmaceuticals. Insmed's average media sentiment score of 1.15 beat Madrigal Pharmaceuticals' score of 0.82 indicating that Insmed is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Insmed
8 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Madrigal Pharmaceuticals
6 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Insmed beats Madrigal Pharmaceuticals on 11 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding MDGL and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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MDGL vs. The Competition

MetricMadrigal PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$12.32B$3.85B$7.15B$12.72B
Dividend YieldN/A3.63%2.56%11.15%
P/E Ratio-41.4714.18274.9525.29
Price / Sales12.881,477.55656.5698.96
Price / CashN/A106.6877.0451.44
Price / Book20.1415.1210.336.20
Net Income-$288.28M-$22.86M$3.50B$358.50M
7 Day Performance-1.22%-4.34%-3.32%-2.35%
1 Month Performance-0.32%-0.02%-0.41%-2.77%
1 Year Performance23.66%40.64%19.21%7.63%

Madrigal Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
MDGL
Madrigal Pharmaceuticals
3.2807 of 5 stars
$534.49
+0.3%
$699.64
+30.9%
+21.6%$12.32B$958.40MN/A915
NTRA
Natera
2.1538 of 5 stars
$328.18
flat
$319.38
-2.7%
+89.2%$47.31B$2.31BN/A6,140
RVMD
Revolution Medicines
2.9753 of 5 stars
$210.02
flat
$200.74
-4.4%
+340.7%$45.01B$11.58MN/A250
ALNY
Alnylam Pharmaceuticals
4.4566 of 5 stars
$266.11
flat
$386.14
+45.1%
-46.9%$35.61B$3.71B49.462,770
BIIB
Biogen
3.2678 of 5 stars
$220.83
flat
$228.50
+3.5%
+45.9%$32.63B$9.89B39.087,500

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This page (NASDAQ:MDGL) was last updated on 9/12/2026 by MarketBeat.com Staff.
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