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Krystal Biotech (KRYS) Competitors

Krystal Biotech logo
$346.58 +9.56 (+2.84%)
As of 08/21/2026 04:00 PM Eastern

KRYS vs. BIIB, ALNY, INSM, ROIV, and MRNA

Should you buy Krystal Biotech stock or one of its competitors? Krystal Biotech's main competitors and comparable companies include Biogen (BIIB), Alnylam Pharmaceuticals (ALNY), Insmed (INSM), Roivant Sciences (ROIV), and Moderna (MRNA). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Krystal Biotech compare to Biogen?

Biogen (NASDAQ:BIIB) and Krystal Biotech (NASDAQ:KRYS) are both large-cap healthcare companies, but which is the better investment? We will contrast the two businesses based on the strength of their risk, profitability, media sentiment, valuation, dividends, earnings, institutional ownership and analyst recommendations.

87.9% of Biogen shares are owned by institutional investors. Comparatively, 86.3% of Krystal Biotech shares are owned by institutional investors. 0.3% of Biogen shares are owned by company insiders. Comparatively, 13.1% of Krystal Biotech shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock is poised for long-term growth.

Biogen has higher revenue and earnings than Krystal Biotech. Biogen is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Biogen$10.03B3.19$1.29B$5.6538.37
Krystal Biotech$389.13M26.36$204.83M$7.9843.43

Krystal Biotech has a net margin of 54.82% compared to Biogen's net margin of 8.32%. Krystal Biotech's return on equity of 19.34% beat Biogen's return on equity.

Company Net Margins Return on Equity Return on Assets
Biogen8.32% 11.18% 6.88%
Krystal Biotech 54.82%19.34%17.65%

Biogen presently has a consensus target price of $227.07, indicating a potential upside of 4.75%. Krystal Biotech has a consensus target price of $365.40, indicating a potential upside of 5.43%. Given Krystal Biotech's stronger consensus rating and higher probable upside, analysts clearly believe Krystal Biotech is more favorable than Biogen.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92

Biogen has a beta of 0.17, indicating that its stock price is 83% less volatile than the broader market. Comparatively, Krystal Biotech has a beta of 0.53, indicating that its stock price is 47% less volatile than the broader market.

In the previous week, Biogen had 20 more articles in the media than Krystal Biotech. MarketBeat recorded 28 mentions for Biogen and 8 mentions for Krystal Biotech. Biogen's average media sentiment score of 1.33 beat Krystal Biotech's score of 1.20 indicating that Biogen is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Biogen
22 Very Positive mention(s)
3 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Krystal Biotech
6 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Krystal Biotech beats Biogen on 10 of the 16 factors compared between the two stocks.

How does Krystal Biotech compare to Alnylam Pharmaceuticals?

Krystal Biotech (NASDAQ:KRYS) and Alnylam Pharmaceuticals (NASDAQ:ALNY) are both large-cap healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their earnings, analyst recommendations, dividends, institutional ownership, valuation, risk, media sentiment and profitability.

Alnylam Pharmaceuticals has higher revenue and earnings than Krystal Biotech. Krystal Biotech is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Krystal Biotech$389.13M26.36$204.83M$7.9843.43
Alnylam Pharmaceuticals$4.80B6.58$313.75M$5.3843.91

In the previous week, Alnylam Pharmaceuticals had 19 more articles in the media than Krystal Biotech. MarketBeat recorded 27 mentions for Alnylam Pharmaceuticals and 8 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 1.20 beat Alnylam Pharmaceuticals' score of 0.78 indicating that Krystal Biotech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Krystal Biotech
6 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Alnylam Pharmaceuticals
13 Very Positive mention(s)
1 Positive mention(s)
10 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

86.3% of Krystal Biotech shares are held by institutional investors. Comparatively, 93.0% of Alnylam Pharmaceuticals shares are held by institutional investors. 13.1% of Krystal Biotech shares are held by insiders. Comparatively, 0.9% of Alnylam Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Krystal Biotech has a beta of 0.53, meaning that its share price is 47% less volatile than the broader market. Comparatively, Alnylam Pharmaceuticals has a beta of 0.3, meaning that its share price is 70% less volatile than the broader market.

Krystal Biotech currently has a consensus price target of $365.40, suggesting a potential upside of 5.43%. Alnylam Pharmaceuticals has a consensus price target of $386.62, suggesting a potential upside of 63.67%. Given Alnylam Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Alnylam Pharmaceuticals is more favorable than Krystal Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
15 Buy rating(s)
4 Strong Buy rating(s)
2.96

Krystal Biotech has a net margin of 54.82% compared to Alnylam Pharmaceuticals' net margin of 15.26%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Krystal Biotech's return on equity.

Company Net Margins Return on Equity Return on Assets
Krystal Biotech54.82% 19.34% 17.65%
Alnylam Pharmaceuticals 15.26%84.93%14.30%

Summary

Alnylam Pharmaceuticals beats Krystal Biotech on 10 of the 17 factors compared between the two stocks.

How does Krystal Biotech compare to Insmed?

Krystal Biotech (NASDAQ:KRYS) and Insmed (NASDAQ:INSM) are both large-cap healthcare companies, but which is the better business? We will contrast the two businesses based on the strength of their dividends, media sentiment, risk, earnings, institutional ownership, analyst recommendations, valuation and profitability.

86.3% of Krystal Biotech shares are held by institutional investors. 13.1% of Krystal Biotech shares are held by insiders. Comparatively, 2.1% of Insmed shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Krystal Biotech has a beta of 0.53, suggesting that its share price is 47% less volatile than the broader market. Comparatively, Insmed has a beta of 0.81, suggesting that its share price is 19% less volatile than the broader market.

Krystal Biotech has higher earnings, but lower revenue than Insmed. Insmed is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Krystal Biotech$389.13M26.36$204.83M$7.9843.43
Insmed$606.42M45.29-$1.28B-$4.11N/A

Krystal Biotech has a net margin of 54.82% compared to Insmed's net margin of -76.94%. Krystal Biotech's return on equity of 19.34% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Krystal Biotech54.82% 19.34% 17.65%
Insmed -76.94%-123.94%-44.30%

In the previous week, Krystal Biotech had 7 more articles in the media than Insmed. MarketBeat recorded 8 mentions for Krystal Biotech and 1 mentions for Insmed. Insmed's average media sentiment score of 1.44 beat Krystal Biotech's score of 1.20 indicating that Insmed is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Krystal Biotech
6 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Insmed
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Krystal Biotech presently has a consensus price target of $365.40, suggesting a potential upside of 5.43%. Insmed has a consensus price target of $205.52, suggesting a potential upside of 63.41%. Given Insmed's stronger consensus rating and higher probable upside, analysts clearly believe Insmed is more favorable than Krystal Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00

Summary

Krystal Biotech beats Insmed on 9 of the 17 factors compared between the two stocks.

How does Krystal Biotech compare to Roivant Sciences?

Roivant Sciences (NASDAQ:ROIV) and Krystal Biotech (NASDAQ:KRYS) are both large-cap healthcare companies, but which is the superior business? We will contrast the two companies based on the strength of their profitability, valuation, earnings, analyst recommendations, risk, institutional ownership, media sentiment and dividends.

Krystal Biotech has a net margin of 54.82% compared to Roivant Sciences' net margin of -3,534.96%. Krystal Biotech's return on equity of 19.34% beat Roivant Sciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Roivant Sciences-3,534.96% -22.94% -21.53%
Krystal Biotech 54.82%19.34%17.65%

Roivant Sciences presently has a consensus price target of $35.14, suggesting a potential downside of 3.21%. Krystal Biotech has a consensus price target of $365.40, suggesting a potential upside of 5.43%. Given Krystal Biotech's stronger consensus rating and higher possible upside, analysts clearly believe Krystal Biotech is more favorable than Roivant Sciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.83
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92

64.8% of Roivant Sciences shares are held by institutional investors. Comparatively, 86.3% of Krystal Biotech shares are held by institutional investors. 8.8% of Roivant Sciences shares are held by company insiders. Comparatively, 13.1% of Krystal Biotech shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

Krystal Biotech has higher revenue and earnings than Roivant Sciences. Roivant Sciences is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Roivant Sciences$8.26M3,174.36-$299.77M-$0.53N/A
Krystal Biotech$389.13M26.36$204.83M$7.9843.43

In the previous week, Roivant Sciences had 11 more articles in the media than Krystal Biotech. MarketBeat recorded 19 mentions for Roivant Sciences and 8 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 1.20 beat Roivant Sciences' score of 0.48 indicating that Krystal Biotech is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Roivant Sciences
10 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Krystal Biotech
6 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Roivant Sciences has a beta of 1.12, indicating that its share price is 12% more volatile than the broader market. Comparatively, Krystal Biotech has a beta of 0.53, indicating that its share price is 47% less volatile than the broader market.

Summary

Krystal Biotech beats Roivant Sciences on 13 of the 16 factors compared between the two stocks.

How does Krystal Biotech compare to Moderna?

Krystal Biotech (NASDAQ:KRYS) and Moderna (NASDAQ:MRNA) are both large-cap healthcare companies, but which is the better investment? We will contrast the two businesses based on the strength of their risk, earnings, analyst recommendations, dividends, profitability, media sentiment, institutional ownership and valuation.

86.3% of Krystal Biotech shares are held by institutional investors. Comparatively, 75.3% of Moderna shares are held by institutional investors. 13.1% of Krystal Biotech shares are held by company insiders. Comparatively, 10.8% of Moderna shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Krystal Biotech has a net margin of 54.82% compared to Moderna's net margin of -141.43%. Krystal Biotech's return on equity of 19.34% beat Moderna's return on equity.

Company Net Margins Return on Equity Return on Assets
Krystal Biotech54.82% 19.34% 17.65%
Moderna -141.43%-28.30%-19.39%

In the previous week, Moderna had 105 more articles in the media than Krystal Biotech. MarketBeat recorded 113 mentions for Moderna and 8 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 1.20 beat Moderna's score of 0.40 indicating that Krystal Biotech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Krystal Biotech
6 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Moderna
46 Very Positive mention(s)
16 Positive mention(s)
14 Neutral mention(s)
18 Negative mention(s)
14 Very Negative mention(s)
Neutral

Krystal Biotech has higher earnings, but lower revenue than Moderna. Moderna is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Krystal Biotech$389.13M26.36$204.83M$7.9843.43
Moderna$1.94B29.79-$2.82B-$7.99N/A

Krystal Biotech presently has a consensus price target of $365.40, indicating a potential upside of 5.43%. Moderna has a consensus price target of $69.50, indicating a potential downside of 52.09%. Given Krystal Biotech's stronger consensus rating and higher probable upside, research analysts clearly believe Krystal Biotech is more favorable than Moderna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92
Moderna
4 Sell rating(s)
11 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.00

Krystal Biotech has a beta of 0.53, suggesting that its stock price is 47% less volatile than the broader market. Comparatively, Moderna has a beta of 0.91, suggesting that its stock price is 9% less volatile than the broader market.

Summary

Krystal Biotech beats Moderna on 13 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding KRYS and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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KRYS vs. The Competition

MetricKrystal BiotechBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$10.26B$4.01B$7.38B$12.85B
Dividend YieldN/A3.64%2.53%11.08%
P/E Ratio43.4311.62272.6024.25
Price / Sales26.361,334.62623.33101.53
Price / Cash47.54105.1478.6253.99
Price / Book7.5516.8013.056.20
Net Income$204.83M-$12.50M$3.47B$348.59M
7 Day Performance4.31%3.29%2.09%0.08%
1 Month Performance5.83%8.23%6.64%3.88%
1 Year Performance130.30%55.05%25.02%16.98%

Krystal Biotech Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
KRYS
Krystal Biotech
4.1152 of 5 stars
$346.58
+2.8%
$365.40
+5.4%
+130.3%$10.26B$389.13M43.43210
BIIB
Biogen
3.9575 of 5 stars
$209.15
-0.3%
$227.07
+8.6%
+55.6%$31.00B$9.89B37.027,500
ALNY
Alnylam Pharmaceuticals
4.9356 of 5 stars
$224.60
-1.8%
$393.86
+75.4%
-48.0%$30.60B$3.71B41.752,770
INSM
Insmed
3.4485 of 5 stars
$128.32
+3.7%
$205.52
+60.2%
-4.6%$27.02B$606.42MN/A1,664
ROIV
Roivant Sciences
1.5306 of 5 stars
$36.24
+0.1%
$35.14
-3.0%
+204.5%$26.15B$8.26MN/A860

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This page (NASDAQ:KRYS) was last updated on 8/23/2026 by MarketBeat.com Staff.
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