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Krystal Biotech (KRYS) Competitors

Krystal Biotech logo
$347.00 +1.45 (+0.42%)
Closing price 09/11/2026 04:00 PM Eastern
Extended Trading
$348.84 +1.83 (+0.53%)
As of 09/11/2026 07:30 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

KRYS vs. ALNY, BIIB, INSM, BNTX, and INCY

Should you buy Krystal Biotech stock or one of its competitors? Krystal Biotech's main competitors and comparable companies include Alnylam Pharmaceuticals (ALNY), Biogen (BIIB), Insmed (INSM), BioNTech (BNTX), and Incyte (INCY). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Krystal Biotech compare to Alnylam Pharmaceuticals?

Krystal Biotech (NASDAQ:KRYS) and Alnylam Pharmaceuticals (NASDAQ:ALNY) are both large-cap healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their media sentiment, analyst recommendations, profitability, risk, valuation, earnings, institutional ownership and dividends.

Krystal Biotech has a net margin of 54.82% compared to Alnylam Pharmaceuticals' net margin of 15.26%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Krystal Biotech's return on equity.

Company Net Margins Return on Equity Return on Assets
Krystal Biotech54.82% 19.34% 17.65%
Alnylam Pharmaceuticals 15.26%84.93%14.30%

86.3% of Krystal Biotech shares are owned by institutional investors. Comparatively, 93.0% of Alnylam Pharmaceuticals shares are owned by institutional investors. 13.1% of Krystal Biotech shares are owned by company insiders. Comparatively, 0.9% of Alnylam Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Krystal Biotech has a beta of 0.54, indicating that its share price is 46% less volatile than the broader market. Comparatively, Alnylam Pharmaceuticals has a beta of 0.31, indicating that its share price is 69% less volatile than the broader market.

Alnylam Pharmaceuticals has higher revenue and earnings than Krystal Biotech. Krystal Biotech is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Krystal Biotech$389.13M26.40$204.83M$7.9843.48
Alnylam Pharmaceuticals$3.71B8.96$313.75M$5.3846.22

In the previous week, Alnylam Pharmaceuticals had 8 more articles in the media than Krystal Biotech. MarketBeat recorded 14 mentions for Alnylam Pharmaceuticals and 6 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 1.32 beat Alnylam Pharmaceuticals' score of 1.12 indicating that Krystal Biotech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Krystal Biotech
5 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Alnylam Pharmaceuticals
8 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Krystal Biotech presently has a consensus target price of $365.40, indicating a potential upside of 5.30%. Alnylam Pharmaceuticals has a consensus target price of $376.67, indicating a potential upside of 51.47%. Given Alnylam Pharmaceuticals' higher possible upside, analysts plainly believe Alnylam Pharmaceuticals is more favorable than Krystal Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
17 Buy rating(s)
2 Strong Buy rating(s)
2.88

Summary

Alnylam Pharmaceuticals beats Krystal Biotech on 9 of the 17 factors compared between the two stocks.

How does Krystal Biotech compare to Biogen?

Biogen (NASDAQ:BIIB) and Krystal Biotech (NASDAQ:KRYS) are both large-cap healthcare companies, but which is the superior stock? We will compare the two companies based on the strength of their earnings, valuation, media sentiment, analyst recommendations, risk, dividends, institutional ownership and profitability.

Biogen has a beta of 0.17, indicating that its share price is 83% less volatile than the broader market. Comparatively, Krystal Biotech has a beta of 0.54, indicating that its share price is 46% less volatile than the broader market.

Biogen has higher revenue and earnings than Krystal Biotech. Biogen is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Biogen$9.89B3.24$1.29B$5.6538.43
Krystal Biotech$389.13M26.40$204.83M$7.9843.48

Krystal Biotech has a net margin of 54.82% compared to Biogen's net margin of 8.32%. Krystal Biotech's return on equity of 19.34% beat Biogen's return on equity.

Company Net Margins Return on Equity Return on Assets
Biogen8.32% 11.18% 6.88%
Krystal Biotech 54.82%19.34%17.65%

In the previous week, Biogen had 5 more articles in the media than Krystal Biotech. MarketBeat recorded 11 mentions for Biogen and 6 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 1.32 beat Biogen's score of 1.10 indicating that Krystal Biotech is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Biogen
7 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Krystal Biotech
5 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

87.9% of Biogen shares are held by institutional investors. Comparatively, 86.3% of Krystal Biotech shares are held by institutional investors. 0.3% of Biogen shares are held by insiders. Comparatively, 13.1% of Krystal Biotech shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

Biogen currently has a consensus target price of $230.14, suggesting a potential upside of 5.98%. Krystal Biotech has a consensus target price of $365.40, suggesting a potential upside of 5.30%. Given Biogen's higher probable upside, equities analysts plainly believe Biogen is more favorable than Krystal Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92

Summary

Krystal Biotech beats Biogen on 10 of the 16 factors compared between the two stocks.

How does Krystal Biotech compare to Insmed?

Insmed (NASDAQ:INSM) and Krystal Biotech (NASDAQ:KRYS) are both large-cap healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their analyst recommendations, institutional ownership, earnings, risk, profitability, media sentiment, valuation and dividends.

Insmed presently has a consensus target price of $205.52, indicating a potential upside of 58.81%. Krystal Biotech has a consensus target price of $365.40, indicating a potential upside of 5.30%. Given Insmed's stronger consensus rating and higher probable upside, equities research analysts plainly believe Insmed is more favorable than Krystal Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92

Insmed has a beta of 0.82, indicating that its stock price is 18% less volatile than the broader market. Comparatively, Krystal Biotech has a beta of 0.54, indicating that its stock price is 46% less volatile than the broader market.

Krystal Biotech has a net margin of 54.82% compared to Insmed's net margin of -76.94%. Krystal Biotech's return on equity of 19.34% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Insmed-76.94% -123.94% -44.30%
Krystal Biotech 54.82%19.34%17.65%

In the previous week, Insmed had 5 more articles in the media than Krystal Biotech. MarketBeat recorded 11 mentions for Insmed and 6 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 1.32 beat Insmed's score of 1.15 indicating that Krystal Biotech is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Insmed
8 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Krystal Biotech
5 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

86.3% of Krystal Biotech shares are owned by institutional investors. 2.1% of Insmed shares are owned by insiders. Comparatively, 13.1% of Krystal Biotech shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Krystal Biotech has lower revenue, but higher earnings than Insmed. Insmed is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Insmed$606.42M46.60-$1.28B-$4.11N/A
Krystal Biotech$389.13M26.40$204.83M$7.9843.48

Summary

Krystal Biotech beats Insmed on 9 of the 17 factors compared between the two stocks.

How does Krystal Biotech compare to BioNTech?

BioNTech (NASDAQ:BNTX) and Krystal Biotech (NASDAQ:KRYS) are both large-cap healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their profitability, earnings, institutional ownership, dividends, valuation, media sentiment, analyst recommendations and risk.

Krystal Biotech has a net margin of 54.82% compared to BioNTech's net margin of -63.54%. Krystal Biotech's return on equity of 19.34% beat BioNTech's return on equity.

Company Net Margins Return on Equity Return on Assets
BioNTech-63.54% -6.86% -6.00%
Krystal Biotech 54.82%19.34%17.65%

In the previous week, BioNTech had 15 more articles in the media than Krystal Biotech. MarketBeat recorded 21 mentions for BioNTech and 6 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 1.32 beat BioNTech's score of 0.44 indicating that Krystal Biotech is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioNTech
10 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Krystal Biotech
5 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Krystal Biotech has lower revenue, but higher earnings than BioNTech. BioNTech is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioNTech$2.65B9.23-$1.29B-$7.83N/A
Krystal Biotech$389.13M26.40$204.83M$7.9843.48

BioNTech presently has a consensus price target of $126.00, suggesting a potential upside of 30.26%. Krystal Biotech has a consensus price target of $365.40, suggesting a potential upside of 5.30%. Given BioNTech's higher probable upside, equities analysts plainly believe BioNTech is more favorable than Krystal Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioNTech
1 Sell rating(s)
5 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.68
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92

BioNTech has a beta of 1.29, meaning that its stock price is 29% more volatile than the broader market. Comparatively, Krystal Biotech has a beta of 0.54, meaning that its stock price is 46% less volatile than the broader market.

15.5% of BioNTech shares are held by institutional investors. Comparatively, 86.3% of Krystal Biotech shares are held by institutional investors. 19.2% of BioNTech shares are held by insiders. Comparatively, 13.1% of Krystal Biotech shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Summary

Krystal Biotech beats BioNTech on 10 of the 16 factors compared between the two stocks.

How does Krystal Biotech compare to Incyte?

Incyte (NASDAQ:INCY) and Krystal Biotech (NASDAQ:KRYS) are both large-cap healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their dividends, institutional ownership, valuation, profitability, earnings, risk, analyst recommendations and media sentiment.

Incyte has higher revenue and earnings than Krystal Biotech. Incyte is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Incyte$5.82B4.23$1.29B$7.8515.47
Krystal Biotech$389.13M26.40$204.83M$7.9843.48

97.0% of Incyte shares are held by institutional investors. Comparatively, 86.3% of Krystal Biotech shares are held by institutional investors. 16.2% of Incyte shares are held by company insiders. Comparatively, 13.1% of Krystal Biotech shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

Krystal Biotech has a net margin of 54.82% compared to Incyte's net margin of 27.71%. Incyte's return on equity of 29.93% beat Krystal Biotech's return on equity.

Company Net Margins Return on Equity Return on Assets
Incyte27.71% 29.93% 22.88%
Krystal Biotech 54.82%19.34%17.65%

In the previous week, Incyte had 13 more articles in the media than Krystal Biotech. MarketBeat recorded 19 mentions for Incyte and 6 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 1.32 beat Incyte's score of 0.98 indicating that Krystal Biotech is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Incyte
9 Very Positive mention(s)
1 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Krystal Biotech
5 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Incyte currently has a consensus price target of $124.05, indicating a potential upside of 2.12%. Krystal Biotech has a consensus price target of $365.40, indicating a potential upside of 5.30%. Given Krystal Biotech's stronger consensus rating and higher probable upside, analysts plainly believe Krystal Biotech is more favorable than Incyte.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Incyte
0 Sell rating(s)
13 Hold rating(s)
11 Buy rating(s)
1 Strong Buy rating(s)
2.52
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.92

Incyte has a beta of 0.77, suggesting that its stock price is 23% less volatile than the broader market. Comparatively, Krystal Biotech has a beta of 0.54, suggesting that its stock price is 46% less volatile than the broader market.

Summary

Incyte beats Krystal Biotech on 9 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding KRYS and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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KRYS vs. The Competition

MetricKrystal BiotechBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$10.23B$3.86B$7.15B$12.71B
Dividend YieldN/A3.63%2.56%11.15%
P/E Ratio43.4814.11272.9825.27
Price / Sales26.401,449.22646.2090.55
Price / Cash47.40106.6877.0451.44
Price / Book8.2515.1310.336.20
Net Income$204.83M-$22.82M$3.49B$358.27M
7 Day Performance-3.14%-4.31%-3.33%-2.36%
1 Month Performance4.25%0.00%-0.42%-2.77%
1 Year Performance141.51%40.67%19.22%7.64%

Krystal Biotech Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
KRYS
Krystal Biotech
3.1536 of 5 stars
$347.00
+0.4%
$365.40
+5.3%
+140.4%$10.23B$389.13M43.48295
ALNY
Alnylam Pharmaceuticals
4.4564 of 5 stars
$266.11
flat
$386.14
+45.1%
-46.9%$35.61B$3.71B49.462,770
BIIB
Biogen
3.2646 of 5 stars
$220.83
flat
$228.50
+3.5%
+45.9%$32.63B$9.89B39.087,500
INSM
Insmed
3.42 of 5 stars
$126.29
flat
$205.52
+62.7%
-11.2%$27.58B$606.42MN/A1,664
BNTX
BioNTech
4.2576 of 5 stars
$103.76
flat
$126.00
+21.4%
-7.3%$26.24B$3.25BN/A7,807

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This page (NASDAQ:KRYS) was last updated on 9/12/2026 by MarketBeat.com Staff.
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