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Krystal Biotech (KRYS) Competitors

Krystal Biotech logo
$331.59 +5.14 (+1.57%)
Closing price 08/10/2026 04:00 PM Eastern
Extended Trading
$333.25 +1.66 (+0.50%)
As of 04:17 AM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

KRYS vs. RVMD, NTRA, BIIB, ALNY, and ROIV

Should you buy Krystal Biotech stock or one of its competitors? Krystal Biotech's main competitors and comparable companies include Revolution Medicines (RVMD), Natera (NTRA), Biogen (BIIB), Alnylam Pharmaceuticals (ALNY), and Roivant Sciences (ROIV). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Krystal Biotech compare to Revolution Medicines?

Krystal Biotech (NASDAQ:KRYS) and Revolution Medicines (NASDAQ:RVMD) are both healthcare companies, but which is the better stock? We will compare the two businesses based on the strength of their dividends, institutional ownership, risk, analyst recommendations, profitability, earnings, valuation and media sentiment.

In the previous week, Revolution Medicines had 6 more articles in the media than Krystal Biotech. MarketBeat recorded 22 mentions for Revolution Medicines and 16 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 0.88 beat Revolution Medicines' score of 0.29 indicating that Krystal Biotech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Krystal Biotech
5 Very Positive mention(s)
3 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Revolution Medicines
9 Very Positive mention(s)
0 Positive mention(s)
8 Neutral mention(s)
2 Negative mention(s)
1 Very Negative mention(s)
Neutral

Krystal Biotech has a beta of 0.53, indicating that its stock price is 47% less volatile than the broader market. Comparatively, Revolution Medicines has a beta of 1.39, indicating that its stock price is 39% more volatile than the broader market.

Krystal Biotech has higher revenue and earnings than Revolution Medicines. Revolution Medicines is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Krystal Biotech$389.13M25.22$204.83M$7.9841.55
Revolution Medicines$11.58M3,830.91-$1.13B-$8.82N/A

86.3% of Krystal Biotech shares are owned by institutional investors. Comparatively, 94.3% of Revolution Medicines shares are owned by institutional investors. 13.1% of Krystal Biotech shares are owned by insiders. Comparatively, 7.6% of Revolution Medicines shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Krystal Biotech currently has a consensus target price of $361.56, indicating a potential upside of 9.04%. Revolution Medicines has a consensus target price of $160.68, indicating a potential downside of 22.36%. Given Krystal Biotech's stronger consensus rating and higher probable upside, analysts clearly believe Krystal Biotech is more favorable than Revolution Medicines.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.92
Revolution Medicines
1 Sell rating(s)
1 Hold rating(s)
19 Buy rating(s)
1 Strong Buy rating(s)
2.91

Krystal Biotech has a net margin of 54.82% compared to Revolution Medicines' net margin of 0.00%. Krystal Biotech's return on equity of 19.34% beat Revolution Medicines' return on equity.

Company Net Margins Return on Equity Return on Assets
Krystal Biotech54.82% 19.34% 17.65%
Revolution Medicines N/A -88.20%-57.85%

Summary

Krystal Biotech beats Revolution Medicines on 11 of the 16 factors compared between the two stocks.

How does Krystal Biotech compare to Natera?

Krystal Biotech (NASDAQ:KRYS) and Natera (NASDAQ:NTRA) are both healthcare companies, but which is the better business? We will compare the two businesses based on the strength of their analyst recommendations, valuation, profitability, media sentiment, risk, dividends, earnings and institutional ownership.

Krystal Biotech has higher earnings, but lower revenue than Natera. Natera is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Krystal Biotech$389.13M25.22$204.83M$7.9841.55
Natera$2.31B19.77-$208.16M-$1.36N/A

86.3% of Krystal Biotech shares are held by institutional investors. Comparatively, 99.9% of Natera shares are held by institutional investors. 13.1% of Krystal Biotech shares are held by insiders. Comparatively, 5.1% of Natera shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Krystal Biotech has a net margin of 54.82% compared to Natera's net margin of -7.11%. Krystal Biotech's return on equity of 19.34% beat Natera's return on equity.

Company Net Margins Return on Equity Return on Assets
Krystal Biotech54.82% 19.34% 17.65%
Natera -7.11%-11.82%-8.19%

In the previous week, Natera had 20 more articles in the media than Krystal Biotech. MarketBeat recorded 36 mentions for Natera and 16 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 0.88 beat Natera's score of 0.58 indicating that Krystal Biotech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Krystal Biotech
5 Very Positive mention(s)
3 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Natera
15 Very Positive mention(s)
4 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Positive

Krystal Biotech has a beta of 0.53, indicating that its share price is 47% less volatile than the broader market. Comparatively, Natera has a beta of 1.51, indicating that its share price is 51% more volatile than the broader market.

Krystal Biotech presently has a consensus target price of $361.56, indicating a potential upside of 9.04%. Natera has a consensus target price of $301.90, indicating a potential downside of 5.17%. Given Krystal Biotech's stronger consensus rating and higher probable upside, equities research analysts clearly believe Krystal Biotech is more favorable than Natera.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.92
Natera
2 Sell rating(s)
3 Hold rating(s)
15 Buy rating(s)
2 Strong Buy rating(s)
2.77

Summary

Krystal Biotech beats Natera on 11 of the 17 factors compared between the two stocks.

How does Krystal Biotech compare to Biogen?

Biogen (NASDAQ:BIIB) and Krystal Biotech (NASDAQ:KRYS) are both healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their risk, institutional ownership, valuation, profitability, media sentiment, analyst recommendations, earnings and dividends.

Biogen presently has a consensus price target of $224.61, suggesting a potential upside of 8.44%. Krystal Biotech has a consensus price target of $361.56, suggesting a potential upside of 9.04%. Given Krystal Biotech's stronger consensus rating and higher probable upside, analysts plainly believe Krystal Biotech is more favorable than Biogen.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Biogen
1 Sell rating(s)
13 Hold rating(s)
17 Buy rating(s)
1 Strong Buy rating(s)
2.56
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.92

87.9% of Biogen shares are owned by institutional investors. Comparatively, 86.3% of Krystal Biotech shares are owned by institutional investors. 0.3% of Biogen shares are owned by insiders. Comparatively, 13.1% of Krystal Biotech shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Krystal Biotech has a net margin of 54.82% compared to Biogen's net margin of 8.32%. Krystal Biotech's return on equity of 19.34% beat Biogen's return on equity.

Company Net Margins Return on Equity Return on Assets
Biogen8.32% 11.18% 6.88%
Krystal Biotech 54.82%19.34%17.65%

In the previous week, Krystal Biotech had 2 more articles in the media than Biogen. MarketBeat recorded 16 mentions for Krystal Biotech and 14 mentions for Biogen. Krystal Biotech's average media sentiment score of 0.88 beat Biogen's score of 0.80 indicating that Krystal Biotech is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Biogen
6 Very Positive mention(s)
4 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Krystal Biotech
5 Very Positive mention(s)
3 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Biogen has higher revenue and earnings than Krystal Biotech. Biogen is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Biogen$10.03B3.05$1.29B$5.6536.66
Krystal Biotech$389.13M25.22$204.83M$7.9841.55

Biogen has a beta of 0.17, indicating that its stock price is 83% less volatile than the broader market. Comparatively, Krystal Biotech has a beta of 0.53, indicating that its stock price is 47% less volatile than the broader market.

Summary

Krystal Biotech beats Biogen on 12 of the 16 factors compared between the two stocks.

How does Krystal Biotech compare to Alnylam Pharmaceuticals?

Krystal Biotech (NASDAQ:KRYS) and Alnylam Pharmaceuticals (NASDAQ:ALNY) are both healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their earnings, profitability, media sentiment, valuation, risk, dividends, analyst recommendations and institutional ownership.

86.3% of Krystal Biotech shares are held by institutional investors. Comparatively, 93.0% of Alnylam Pharmaceuticals shares are held by institutional investors. 13.1% of Krystal Biotech shares are held by company insiders. Comparatively, 0.9% of Alnylam Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Krystal Biotech has a beta of 0.53, suggesting that its share price is 47% less volatile than the broader market. Comparatively, Alnylam Pharmaceuticals has a beta of 0.3, suggesting that its share price is 70% less volatile than the broader market.

Krystal Biotech has a net margin of 54.82% compared to Alnylam Pharmaceuticals' net margin of 15.26%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Krystal Biotech's return on equity.

Company Net Margins Return on Equity Return on Assets
Krystal Biotech54.82% 19.34% 17.65%
Alnylam Pharmaceuticals 15.26%84.93%14.30%

In the previous week, Alnylam Pharmaceuticals had 8 more articles in the media than Krystal Biotech. MarketBeat recorded 24 mentions for Alnylam Pharmaceuticals and 16 mentions for Krystal Biotech. Krystal Biotech's average media sentiment score of 0.88 beat Alnylam Pharmaceuticals' score of 0.04 indicating that Krystal Biotech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Krystal Biotech
5 Very Positive mention(s)
3 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Alnylam Pharmaceuticals
6 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
5 Negative mention(s)
0 Very Negative mention(s)
Neutral

Alnylam Pharmaceuticals has higher revenue and earnings than Krystal Biotech. Alnylam Pharmaceuticals is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Krystal Biotech$389.13M25.22$204.83M$7.9841.55
Alnylam Pharmaceuticals$4.80B6.04$313.75M$5.3840.33

Krystal Biotech currently has a consensus price target of $361.56, suggesting a potential upside of 9.04%. Alnylam Pharmaceuticals has a consensus price target of $396.72, suggesting a potential upside of 82.84%. Given Alnylam Pharmaceuticals' higher probable upside, analysts clearly believe Alnylam Pharmaceuticals is more favorable than Krystal Biotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.92
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
16 Buy rating(s)
3 Strong Buy rating(s)
2.92

Summary

Krystal Biotech and Alnylam Pharmaceuticals tied by winning 8 of the 16 factors compared between the two stocks.

How does Krystal Biotech compare to Roivant Sciences?

Roivant Sciences (NASDAQ:ROIV) and Krystal Biotech (NASDAQ:KRYS) are both healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their dividends, earnings, analyst recommendations, institutional ownership, risk, media sentiment, profitability and valuation.

Krystal Biotech has a net margin of 54.82% compared to Roivant Sciences' net margin of -3,534.96%. Krystal Biotech's return on equity of 19.34% beat Roivant Sciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Roivant Sciences-3,534.96% -22.94% -21.53%
Krystal Biotech 54.82%19.34%17.65%

In the previous week, Krystal Biotech had 2 more articles in the media than Roivant Sciences. MarketBeat recorded 16 mentions for Krystal Biotech and 14 mentions for Roivant Sciences. Roivant Sciences' average media sentiment score of 0.90 beat Krystal Biotech's score of 0.88 indicating that Roivant Sciences is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Roivant Sciences
5 Very Positive mention(s)
0 Positive mention(s)
7 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Krystal Biotech
5 Very Positive mention(s)
3 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Roivant Sciences has a beta of 1.12, meaning that its stock price is 12% more volatile than the broader market. Comparatively, Krystal Biotech has a beta of 0.53, meaning that its stock price is 47% less volatile than the broader market.

Roivant Sciences currently has a consensus price target of $35.14, indicating a potential downside of 1.80%. Krystal Biotech has a consensus price target of $361.56, indicating a potential upside of 9.04%. Given Krystal Biotech's stronger consensus rating and higher probable upside, analysts clearly believe Krystal Biotech is more favorable than Roivant Sciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.83
Krystal Biotech
0 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.92

64.8% of Roivant Sciences shares are owned by institutional investors. Comparatively, 86.3% of Krystal Biotech shares are owned by institutional investors. 8.8% of Roivant Sciences shares are owned by company insiders. Comparatively, 13.1% of Krystal Biotech shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Krystal Biotech has higher revenue and earnings than Roivant Sciences. Roivant Sciences is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Roivant Sciences$8.26M3,115.68-$299.77M-$0.53N/A
Krystal Biotech$389.13M25.22$204.83M$7.9841.55

Summary

Krystal Biotech beats Roivant Sciences on 12 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding KRYS and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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KRYS vs. The Competition

MetricKrystal BiotechBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$9.66B$3.70B$7.01B$12.98B
Dividend YieldN/A3.76%2.58%10.07%
P/E Ratio41.559.09269.2024.72
Price / Sales25.221,265.42592.8398.22
Price / Cash44.7844.9528.8937.42
Price / Book7.8818.0011.396.42
Net Income$204.83M-$13.25M$3.45B$347.03M
7 Day Performance2.10%3.10%1.92%0.69%
1 Month Performance-9.35%-1.68%-0.57%-0.90%
1 Year Performance141.09%61.75%75.49%21.87%

Krystal Biotech Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
KRYS
Krystal Biotech
3.5236 of 5 stars
$331.59
+1.6%
$361.56
+9.0%
+139.1%$9.66B$389.13M41.55210
RVMD
Revolution Medicines
1.5572 of 5 stars
$182.45
-2.7%
$144.67
-20.7%
+491.3%$39.87B$11.58MN/A250
NTRA
Natera
2.9105 of 5 stars
$270.36
+1.0%
$267.83
-0.9%
+109.5%$38.35B$2.50BN/A6,140
BIIB
Biogen
3.8869 of 5 stars
$201.82
-0.6%
$223.89
+10.9%
+58.5%$29.99B$9.89B35.727,500
ALNY
Alnylam Pharmaceuticals
4.7165 of 5 stars
$220.33
+7.2%
$402.67
+82.8%
-50.6%$27.50B$3.71B40.952,770

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This page (NASDAQ:KRYS) was last updated on 8/11/2026 by MarketBeat.com Staff.
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