Vigil Neuroscience (VIGL) Stock Price, News & Analysis

Company Overview

Vigil Neuroscience, Inc., a clinical-stage biotechnology company, focuses on developing treatments for rare and common neurodegenerative diseases by restoring the vigilance of microglia, the sentinel immune cells of the brain. Its lead candidate is VGL101(Iluzanebart), a human monoclonal antibody agonist targeting human triggering receptor expressed on myeloid cells 2 and is in a Phase 2 trial in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare and fatal neurodegenerative disease. The company is also developing VG-3927, an orally-available small molecule TREM2 agonist to treat common neurodegenerative diseases associated with microglial dysfunction, with an initial focus on Alzheimer's disease in genetically defined subpopulations, which is being evaluated in a Phase 1 clinical trial. It has license agreement with Amgen Inc. to commercially develop, manufacture, use, distribute, and sell therapeutic products containing compounds that bind to TREM2. The company was incorporated in 2020 and is headquartered in Watertown, Massachusetts.

Key Stats

• Today's Range: $8.05 to $8.05
• 50-Day Range: $7.92 to $8.08
• 52-Week Range: $1.31 to $8.10
• Volume: N/A
• Average Volume: 1.09 million shs
• Market Capitalization: $383.90 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $10.80
• Consensus Rating: Hold

Vigil Neuroscience Stock Analysis - MarketRank™

Vigil Neuroscience scored higher than 36% of companies evaluated by MarketBeat, and ranked 759th out of 949 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.0 / 5
• Analyst Rating: Hold

Consensus Rating

Vigil Neuroscience has received a consensus rating of Hold. The company's average rating score is 2.00, and is based on no buy ratings, 10 hold ratings, and no sell ratings.

Amount of Analyst Coverage

Vigil Neuroscience has received no research coverage in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for Vigil Neuroscience are expected to grow in the coming year, from ($2.07) to ($2.03) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Vigil Neuroscience is -3.93, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Vigil Neuroscience is -3.93, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Vigil Neuroscience has a P/B Ratio of 4.60. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.

Short Interest

• Score: 3.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

1.40% of the float of Vigil Neuroscience has been sold short.

Short Interest Ratio / Days to Cover

Vigil Neuroscience has a short interest ratio ("days to cover") of 0.3, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Vigil Neuroscience has recently increased by 314.26%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Vigil Neuroscience does not currently pay a dividend.

Dividend Growth

Vigil Neuroscience does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

1.40% of the float of Vigil Neuroscience has been sold short.

Short Interest Ratio / Days to Cover

Vigil Neuroscience has a short interest ratio ("days to cover") of 0.3, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Vigil Neuroscience has recently increased by 314.26%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 0.0 / 5
• News Sentiment: N/A

Search Interest

Only 4 people have searched for VIGL on MarketBeat in the last 30 days. This is a decrease of 0% compared to the previous 30 days.

Company Ownership

• Score: 2.5 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Vigil Neuroscience insiders have not sold or bought any company stock.

Percentage Held by Insiders

18.01% of the stock of Vigil Neuroscience is held by insiders. A high percentage of insider ownership can be a sign of company health.

Percentage Held by Institutions

83.64% of the stock of Vigil Neuroscience is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

VIGL Stock Analysis - Frequently Asked Questions

How have VIGL shares performed this year?

Vigil Neuroscience's stock was trading at $1.70 at the start of the year. Since then, VIGL stock has increased by 373.5% and is now trading at $8.05.

How were Vigil Neuroscience's earnings last quarter?

Vigil Neuroscience, Inc. (NASDAQ:VIGL) released its quarterly earnings results on Wednesday, May, 7th. The company reported ($0.49) earnings per share (EPS) for the quarter, topping the consensus estimate of ($0.53) by $0.04.

When did Vigil Neuroscience IPO?

Vigil Neuroscience (VIGL) raised $112 million in an IPO on Friday, January 7th 2022. The company issued 7,000,000 shares at a price of $15.00-$17.00 per share.

Who are Vigil Neuroscience's major shareholders?

Top institutional shareholders of Vigil Neuroscience include Beryl Capital Management LLC (9.66%), 683 Capital Management LLC (2.65%), Gabelli Funds LLC (2.49%) and Alpine Associates Management Inc. (2.30%). Insiders that own company stock include Ivana Magovcevic-Liebisch, Haeberlein Samantha L Budd and Spyros Papapetropoulos.
View institutional ownership trends.

How do I buy shares of Vigil Neuroscience?

Shares of VIGL stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Vigil Neuroscience own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Vigil Neuroscience investors own include NVIDIA (NVDA), Meta Platforms (META), Exxon Mobil (XOM), JPMorgan Chase & Co. (JPM), Netflix (NFLX), Tesla (TSLA) and Home Depot (HD).

Company Calendar

• Last Earnings: 5/07/2025
• Today: 8/29/2025
• Next Earnings (Estimated): 11/06/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:VIGL
• CIK: 1827087
• Web: vigilneuro.com
• Phone: 857-254-4445
• Fax: N/A
• Employees: 40
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Vigil Neuroscience: $10.80
• High Price Target: $22.00
• Low Price Target: $8.00
• Potential Upside/Downside: +34.2%
• Consensus Rating: Hold
• Rating Score (0-4): 2.00
• Research Coverage: 10 Analysts

Profitability

• EPS (Trailing Twelve Months): ($2.05)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$84.26 million
• Net Margins: N/A
• Pretax Margin: N/A
• Return on Equity: -111.70%
• Return on Assets: -74.67%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 2.97
• Quick Ratio: 2.97

Sales & Book Value

• Annual Sales: N/A
• Price / Sales: N/A
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $1.75 per share
• Price / Book: 4.60

Miscellaneous

• Outstanding Shares: 47,690,000
• Free Float: 39,099,000
• Market Cap: $383.90 million
• Optionable: Not Optionable
• Beta: 3.33