| 9/9/2026 | Opaleye Management Inc. | 338,374 | $14.38M | 1.3% | +12.8% | 2.698% | |
| 8/20/2026 | Newtyn Management LLC | 709,247 | $30.14M | 3.8% | N/A | 5.655% | |
| 8/6/2026 | Bank of New York Mellon Corp | 75,348 | $3.20M | 0.0% | N/A | 0.601% | |
| 5/19/2026 | Bank of America Corp DE | 11,018 | $346K | 0.0% | -7.7% | 0.088% | |
| 5/18/2026 | Royal Bank of Canada | 1,002 | $31K | 0.0% | -19.4% | 0.008% | |
| 5/7/2026 | Dimensional Fund Advisors LP | 133,360 | $4.18M | 0.0% | +207.7% | 1.119% | |
| 5/5/2026 | Bank of New York Mellon Corp | 74,984 | $2.35M | 0.0% | +9.7% | 0.629% | |
| 2/18/2026 | Opaleye Management Inc. | 292,590 | $7.78M | 1.0% | +14.7% | 2.363% | |
| 2/18/2026 | Bridgeway Capital Management LLC | 17,580 | $467K | 0.0% | -29.6% | 0.142% | |
| 2/17/2026 | RBF Capital LLC | 30,000 | $798K | 0.0% | -2.0% | 0.242% | |
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| 2/16/2026 | Squarepoint Ops LLC | 8,901 | $237K | 0.0% | N/A | 0.072% | |
| 2/16/2026 | Panagora Asset Management Inc. | 21,229 | $564K | 0.0% | +24.2% | 0.171% | |
| 2/16/2026 | Barclays PLC | 14,822 | $394K | 0.0% | +12.1% | 0.120% | |
| 2/13/2026 | State Street Corp | 174,908 | $4.65M | 0.0% | +4.7% | 1.413% | |
| 2/13/2026 | Wells Fargo & Company MN | 10,755 | $286K | 0.0% | +66.0% | 0.087% | |
| 2/12/2026 | Renaissance Technologies LLC | 39,017 | $1.04M | 0.0% | +35.0% | 0.315% | |
| 2/12/2026 | Dimensional Fund Advisors LP | 43,335 | $1.15M | 0.0% | +48.5% | 0.350% | |
| 2/11/2026 | Los Angeles Capital Management LLC | 19,332 | $514K | 0.0% | +31.7% | 0.156% | |
| 2/10/2026 | Goldman Sachs Group Inc. | 16,097 | $428K | 0.0% | +99.4% | 0.130% | |
| 2/9/2026 | Geode Capital Management LLC | 221,566 | $5.89M | 0.0% | +4.5% | 1.790% | |
| 2/6/2026 | Nano Cap New Millennium Growth Fund L P | 15,000 | $399K | 0.3% | N/A | 0.121% | |
| 2/2/2026 | CM Management LLC | 40,000 | $1.06M | 0.9% | -16.7% | 0.323% | |
| 1/26/2026 | Diversified Management Inc. | 10,000 | $266K | 0.1% | N/A | 0.081% | |
| 1/23/2026 | State of Alaska Department of Revenue | 1,050 | $27K | 0.0% | N/A | 0.008% | |
| 1/9/2026 | SG Americas Securities LLC | 6,356 | $169K | 0.0% | N/A | 0.051% | |
| 1/1/2026 | JPMorgan Chase & Co. | 3,796 | $146K | 0.0% | -14.5% | 0.031% | |
| 11/17/2025 | Woodline Partners LP | 209,945 | $8.09M | 0.0% | +16.5% | 1.695% | |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,312 | $166K | 0.0% | -16.1% | 0.035% | |
| 11/17/2025 | HighVista Strategies LLC | 105,714 | $4.07M | 1.0% | -7.7% | 0.854% | |
| 11/17/2025 | Citadel Advisors LLC | 7,581 | $292K | 0.0% | N/A | 0.061% | |
| 11/14/2025 | Man Group plc | 6,397 | $247K | 0.0% | N/A | 0.053% | |
| 11/14/2025 | Bridgeway Capital Management LLC | 24,980 | $963K | 0.0% | -4.7% | 0.207% | |
| 11/13/2025 | BNP Paribas Financial Markets | 3,226 | $124K | 0.0% | +266.6% | 0.027% | |
| 11/13/2025 | Russell Investments Group Ltd. | 778 | $30K | 0.0% | +3,436.4% | 0.006% | |
| 11/13/2025 | CM Management LLC | 48,000 | $1.85M | 1.5% | -25.0% | 0.397% | |
| 11/12/2025 | Dimensional Fund Advisors LP | 29,190 | $1.12M | 0.0% | +4.5% | 0.241% | |
| 11/7/2025 | Vanguard Group Inc. | 668,111 | $25.75M | 0.0% | +4.6% | 5.527% | |
| 11/7/2025 | JPMorgan Chase & Co. | 3,796 | $146K | 0.0% | -14.5% | 0.031% | |
| 8/15/2025 | Tower Research Capital LLC TRC | 2,273 | $57K | 0.0% | +203.1% | 0.019% | |
| 8/15/2025 | Opaleye Management Inc. | 255,087 | $6.43M | 1.3% | +0.8% | 2.131% | |
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| 8/15/2025 | BVF Inc. IL | 2,590,303 | $65.28M | 2.3% | -13.2% | 21.640% | |
| 8/15/2025 | Bank of America Corp DE | 4,200 | $106K | 0.0% | -15.3% | 0.035% | |
| 8/14/2025 | Raymond James Financial Inc. | 4,600 | $116K | 0.0% | N/A | 0.038% | |
| 8/14/2025 | Occudo Quantitative Strategies LP | 20,925 | $527K | 0.1% | N/A | 0.175% | |
| 8/13/2025 | Marshall Wace LLP | 16,308 | $411K | 0.0% | +12.2% | 0.136% | |
| 8/13/2025 | Stonepine Capital Management LLC | 152,143 | $3.83M | 3.8% | +17.2% | 1.271% | |
| 8/13/2025 | Panagora Asset Management Inc. | 18,379 | $463K | 0.0% | N/A | 0.154% | |
| 8/12/2025 | Rhumbline Advisers | 13,249 | $334K | 0.0% | +18.0% | 0.111% | |
| 8/12/2025 | JPMorgan Chase & Co. | 4,440 | $112K | 0.0% | +13.9% | 0.037% | |
| 8/8/2025 | Geode Capital Management LLC | 203,601 | $5.13M | 0.0% | +9.1% | 1.701% | |
| 8/7/2025 | Los Angeles Capital Management LLC | 14,676 | $370K | 0.0% | N/A | 0.123% | |
| 6/27/2025 | Goldman Sachs Group Inc. | 11,523 | $230K | 0.0% | -45.1% | 0.096% | |
| 5/16/2025 | Woodline Partners LP | 168,550 | $3.36M | 0.0% | +7.9% | 1.410% | |
| 5/16/2025 | Goldman Sachs Group Inc. | 11,523 | $230K | 0.0% | -45.1% | 0.096% | |
| 5/16/2025 | BVF Inc. IL | 2,983,026 | $59.45M | 2.4% | -17.9% | 24.956% | |
| 5/14/2025 | Stonepine Capital Management LLC | 129,813 | $2.59M | 2.5% | +3.3% | 1.086% | |
| 5/12/2025 | Nuveen LLC | 14,363 | $286K | 0.0% | N/A | 0.120% | |
| 5/9/2025 | Deutsche Bank AG | 6,433 | $128K | 0.0% | +5,087.9% | 0.054% | |
| 5/9/2025 | CM Management LLC | 64,000 | $1.28M | 1.3% | +16.4% | 0.535% | |
| 4/28/2025 | Acuitas Investments LLC | 5,674 | $113K | 0.1% | -90.7% | 0.047% | |
| 4/7/2025 | GAMMA Investing LLC | 1,734 | $35K | 0.0% | +1,063.8% | 0.014% | |
| 2/17/2025 | Woodline Partners LP | 156,266 | $4.11M | 0.0% | +63.9% | 1.326% | |
| 2/17/2025 | Squarepoint Ops LLC | 9,484 | $249K | 0.0% | -28.9% | 0.080% | |
| 2/17/2025 | Stonepine Capital Management LLC | 125,700 | $3.30M | 2.7% | -35.6% | 1.067% | |
| 2/17/2025 | Nuveen Asset Management LLC | 14,363 | $377K | 0.0% | +3.8% | 0.122% | |
| 2/17/2025 | Bridgeway Capital Management LLC | 25,500 | $670K | 0.0% | -3.4% | 0.216% | |
| 2/17/2025 | Bank of America Corp DE | 7,796 | $205K | 0.0% | +34.7% | 0.066% | |
| 2/17/2025 | BNP Paribas Financial Markets | 1,109 | $29K | 0.0% | -32.0% | 0.009% | |
| 2/14/2025 | Northern Trust Corp | 91,181 | $2.40M | 0.0% | +1.5% | 0.774% | |
| 2/14/2025 | Eversept Partners LP | 95,417 | $2.51M | 0.2% | +1.2% | 0.810% | |
| 2/13/2025 | Barclays PLC | 12,784 | $336K | 0.0% | +13.6% | 0.109% | |
| 2/13/2025 | Renaissance Technologies LLC | 16,100 | $423K | 0.0% | +89.8% | 0.137% | |
| 2/13/2025 | Wells Fargo & Company MN | 4,300 | $113K | 0.0% | +38.0% | 0.037% | |
| 2/12/2025 | Geode Capital Management LLC | 182,190 | $4.79M | 0.0% | -0.3% | 1.547% | |
| 2/12/2025 | TLS Advisors LLC | 118,844 | $3.12M | 7.1% | -0.8% | 1.009% | |
| 2/12/2025 | JPMorgan Chase & Co. | 12,089 | $318K | 0.0% | +238.9% | 0.103% | |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 23,113 | $607K | 0.0% | +5.8% | 0.196% | |
| 2/4/2025 | Los Angeles Capital Management LLC | 7,852 | $206K | 0.0% | N/A | 0.067% | |
| 1/31/2025 | New York State Common Retirement Fund | 2,362 | $62K | 0.0% | +51.2% | 0.020% | |
| 1/31/2025 | Acuitas Investments LLC | 60,704 | $1.60M | 1.3% | -31.1% | 0.515% | |
| 1/30/2025 | Rhumbline Advisers | 11,065 | $291K | 0.0% | +18.1% | 0.094% | |
| 11/19/2024 | Barclays PLC | 11,256 | $298K | 0.0% | +300.7% | 0.096% | |
| 11/16/2024 | Geode Capital Management LLC | 182,741 | $4.84M | 0.0% | +0.6% | 1.551% | |
| 11/15/2024 | Barclays PLC | 11,256 | $298K | 0.0% | +300.7% | 0.096% | |
| 11/15/2024 | State Street Corp | 142,857 | $3.78M | 0.0% | +1.2% | 1.213% | |
| 11/15/2024 | HighVista Strategies LLC | 114,548 | $3.03M | 1.0% | -3.7% | 0.972% | |
| 11/14/2024 | Stonepine Capital Management LLC | 195,096 | $5.17M | 3.3% | -22.0% | 1.656% | |
| 11/13/2024 | BNP Paribas Financial Markets | 1,632 | $43K | 0.0% | +95.0% | 0.014% | |
| 11/13/2024 | FMR LLC | 1,102,401 | $29.19M | 0.0% | -4.4% | 9.358% | |
| 10/17/2024 | Ellsworth Advisors LLC | 19,475 | $516K | 0.1% | N/A | 0.166% | |
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| 8/21/2024 | Stonepine Capital Management LLC | 250,129 | $5.93M | 5.4% | -1.4% | 2.138% | |
| 8/9/2024 | Dimensional Fund Advisors LP | 22,414 | $531K | 0.0% | -12.2% | 0.193% | |
| 8/1/2024 | Rhumbline Advisers | 9,695 | $230K | 0.0% | +16.0% | 0.083% | |
| 7/26/2024 | Bank of New York Mellon Corp | 62,656 | $1.48M | 0.0% | +3.2% | 0.538% | |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 8,778 | $212K | 0.0% | N/A | 0.075% | |
| 5/10/2024 | Vanguard Group Inc. | 405,533 | $9.75M | 0.0% | -3.8% | 3.484% | |
| 5/1/2024 | BNP Paribas Financial Markets | 3,543 | $85K | 0.0% | +55.6% | 0.030% | |
| 2/15/2024 | Opaleye Management Inc. | 250,000 | $4.63M | 1.2% | -8.9% | 2.176% | |
| 2/13/2024 | Stonepine Capital Management LLC | 250,000 | $4.63M | 2.0% | -42.7% | 2.176% | |
| 11/14/2023 | Stonepine Capital Management LLC | 436,602 | $6.15M | 2.0% | +25.0% | 3.800% | |