OTCMKTS:OPHLF Ono Pharmaceutical (OPHLF) Stock Price, News & Analysis $14.15 -0.85 (-5.67%) As of 09:30 AM Eastern Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartEarningsNews and TrendsShort Interest About Ono Pharmaceutical Stock (OTCMKTS:OPHLF) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Ono Pharmaceutical alerts:Sign Up Key Stats Today's Range$14.15▼$14.1550-Day Range$13.38▼$16.5052-Week Range$10.35▼$18.67Volume200 shsAverage Volume775 shsMarket Capitalization$6.65 billionP/E Ratio13.48Dividend YieldN/APrice TargetN/AConsensus RatingHold Company Overview Ono Pharmaceutical Co., Ltd. is a Japanese research-driven pharmaceutical company headquartered in Osaka. The company discovers, develops, manufactures and markets prescription medicines, with a focus on oncology, immunology, neurology and other specialty-care areas. Its activities include both internally developed products and collaborations with pharmaceutical and biotechnology companies worldwide. Ono is best known internationally for Opdivo (nivolumab), an immune checkpoint inhibitor developed in collaboration with Bristol Myers Squibb and used to treat multiple types of cancer. The company’s portfolio also includes medicines for other therapeutic areas, such as diabetes, Parkinson’s disease and gastrointestinal conditions. Product availability and commercial rights vary by country and may be managed through licensing or co-development arrangements. Ono traces its origins to 1717, when it began as a pharmaceutical wholesaler in Osaka, and later transitioned toward pharmaceutical manufacturing and research. Today, it conducts research and development in Japan and works with partners to serve patients in markets around the world. The company is listed in Japan, and its shares also trade in the United States over the counter under the symbol OPHLF.AI Generated. May Contain Errors. Read More Receive OPHLF Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Ono Pharmaceutical and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. 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Because my research has led me to believe we’re risking World War 3 with Iran for a completely different reason.September 21 at 1:00 AM | Banyan Hill Publishing (Ad)Ono Pharma’s New Cancer Trial Adds Early-Stage Upside—and Risk—for OPHLF InvestorsAugust 26, 2026 | tipranks.comOno Pharma Halts Early Lymphoma Trial, Raising Fresh Questions for InvestorsJuly 29, 2026 | tipranks.comOno’s New GIST Study Puts Early‑Stage Oncology Back in Focus for OPHLF InvestorsJuly 20, 2026 | tipranks.comOno Pharmaceutical Co. (OPHLF) moves 10.4% higher: Will this strength last?July 7, 2026 | msn.comOno Pharma Announces Oral Presentation of New Data from the Phase 2 Clinical Study of ONO-4578 (EP4 antagonist) in Certain Gastric Cancers at the ASCO 2026 Annual MeetingJune 1, 2026 | businesswire.comSee More Headlines OPHLF Stock Analysis - Frequently Asked Questions How have OPHLF shares performed this year? Ono Pharmaceutical's stock was trading at $12.8696 at the beginning of 2026. Since then, OPHLF shares have increased by 16.6% and is now trading at $15.00. How were Ono Pharmaceutical's earnings last quarter? Ono Pharmaceutical Co. (OTCMKTS:OPHLF) posted its quarterly earnings data on Monday, February, 2nd. The company reported $0.40 earnings per share (EPS) for the quarter, beating the consensus estimate of $0.29 by $0.11. The firm earned $892.70 million during the quarter, compared to analyst estimates of $727.58 million. Ono Pharmaceutical had a net margin of 15.02% and a trailing twelve-month return on equity of 9.77%. How do I buy shares of Ono Pharmaceutical? Shares of OPHLF stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. Company Calendar Last Earnings2/02/2026Today9/21/2026Next Earnings (Estimated)10/29/2026Fiscal Year End3/31/2027Get Stock AlertsIndustry, Sector and Symbol Stock ExchangeOTCMKTS SectorHealthcare Industry Pharmaceuticals Sub-IndustryPharmaceuticals Current SymbolOTCMKTS:OPHLF CIK940821 Webwww.ono.co.jp Phone(166) 263-5670Fax816-6263-2950Employees4,206Year Founded1717Profitability EPS (Trailing Twelve Months)$1.05 Trailing P/E Ratio13.48 Forward P/E Ratio14.15 P/E GrowthN/ANet Income$436.04 million Net Margins15.02% Pretax Margin17.96% Return on Equity9.77% Return on Assets7.63% Debt Debt-to-Equity Ratio0.08 Current Ratio3.28 Quick Ratio2.86 Sales & Book Value Annual Sales$3.43 billion Price / Sales1.94 Cash Flow$1.40 per share Price / Cash Flow10.08 Book Value$11.39 per share Price / Book1.24Miscellaneous Outstanding Shares469,910,000Free FloatN/AMarket Cap$6.65 billion OptionableNot Optionable Beta0.33 Social Links (Almost) Everything You Need To Know About The EV MarketLooking to profit from the electric vehicle mega-trend? 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