Paradigm Biocapital Advisors Lp Top Holdings and 13F Report (2025) About Paradigm Biocapital Advisors LpInvestment ActivityParadigm Biocapital Advisors Lp has $2.34 billion in total holdings as of June 30, 2025.Paradigm Biocapital Advisors Lp owns shares of 28 different stocks, but just 13 companies or ETFs make up 80% of its holdings.Approximately 18.14% of the portfolio was purchased this quarter.About 10.81% of the portfolio was sold this quarter.This quarter, Paradigm Biocapital Advisors Lp has purchased 27 new stocks and bought additional shares in 14 stocks.Paradigm Biocapital Advisors Lp sold shares of 5 stocks and completely divested from 5 stocks this quarter.Largest Holdings Nuvalent $402,057,738Arcellx $306,137,704Merus $225,230,780Revolution Medicines $224,172,176Tarsus Pharmaceuticals $120,561,770 Largest New Holdings this Quarter 80706P103 - Scholar Rock $56,691,623 Holding10806X102 - BridgeBio Pharma $41,701,690 HoldingG01767105 - Alkermes $39,355,029 Holding00847X104 - Agios Pharmaceuticals $37,999,916 HoldingN69605108 - Pharvaris $18,707,234 Holding Largest Purchases this Quarter Scholar Rock 1,600,554 shares (about $56.69M)Vaxcyte 1,676,356 shares (about $54.50M)Merus 912,255 shares (about $47.98M)BridgeBio Pharma 965,764 shares (about $41.70M)Alkermes 1,375,569 shares (about $39.36M) Largest Sales this Quarter BeiGene 318,237 shares (about $77.04M)Janux Therapeutics 409,651 shares (about $9.46M)SPYRE THERAPEUTICS INC 256,760 shares (about $3.84M)Revolution Medicines 84,820 shares (about $3.12M)APOGEE THERAPEUTICS INC 3,077 shares (about $133.63K) Sector Allocation Over TimeMap of 500 Largest Holdings ofParadigm Biocapital Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorNUVLNuvalent$402,057,7380.0%5,269,43317.2%MedicalACLXArcellx$306,137,704$10,337,396 ▲3.5%4,649,01613.1%MedicalMRUSMerus$225,230,780$47,984,613 ▲27.1%4,281,9549.6%MedicalRVMDRevolution Medicines$224,172,176$3,120,528 ▼-1.4%6,093,2919.6%MedicalTARSTarsus Pharmaceuticals$120,561,770$14,822,690 ▲14.0%2,976,0995.1%MedicalPCVXVaxcyte$109,650,931$54,498,334 ▲98.8%3,372,8374.7%MedicalBGNEBeiGene$84,188,799$77,035,631 ▼-47.8%347,7873.6%MedicalEWTXEdgewise Therapeutics$80,526,130$16,358,501 ▲25.5%6,142,3443.4%MedicalCOGTCogent Biosciences$74,330,584$9,971,541 ▲15.5%10,352,4493.2%MedicalJANXJanux Therapeutics$67,457,960$9,462,938 ▼-12.3%2,920,2582.9%MedicalCRNXCrinetics Pharmaceuticals$67,400,584$11,428,793 ▲20.4%2,343,5532.9%MedicalIRONDisc Medicine$64,133,0240.0%1,210,9712.7%MedicalSRRKScholar Rock$56,691,623$56,691,623 ▲New Holding1,600,5542.4%MedicalLENZ THERAPEUTICS INC$50,327,204$6,012,477 ▲13.6%1,717,0662.1%COMBBIOBridgeBio Pharma$41,701,690$41,701,690 ▲New Holding965,7641.8%MedicalAPOGEE THERAPEUTICS INC$41,633,301$133,634 ▼-0.3%958,6301.8%COMMLTXMoonLake Immunotherapeutics$41,456,846$11,842,480 ▲40.0%878,3231.8%MedicalALKSAlkermes$39,355,029$39,355,029 ▲New Holding1,375,5691.7%MedicalVRDNViridian Therapeutics$38,327,232$9,038,028 ▲30.9%2,741,5761.6%MedicalAGIOAgios Pharmaceuticals$37,999,916$37,999,916 ▲New Holding1,142,5111.6%MedicalOCULOcular Therapeutix$31,740,755$19,546,668 ▲160.3%3,420,3401.4%MedicalOLMAOlema Pharmaceuticals$28,815,373$97,980 ▲0.3%6,764,1721.2%MedicalSPYRE THERAPEUTICS INC$28,000,562$3,843,697 ▼-12.1%1,870,4451.2%COM NEWYMABY-mAbs Therapeutics$19,105,9200.0%4,236,3460.8%MedicalPHVSPharvaris$18,707,234$18,707,234 ▲New Holding1,062,9110.8%MedicalIMTXImmatics$16,915,565$6,655,324 ▲64.9%3,144,1570.7%MedicalERASErasca$15,122,121$1,403,132 ▲10.2%11,907,1820.6%MedicalCRESCENT BIOPHARMA INC.$10,373,517$10,373,517 ▲New Holding642,7210.4%COMARGXargenex$0$35,321,911 ▼-100.0%00.0%MedicalCYTKCytokinetics$0$34,509,706 ▼-100.0%00.0%MedicalINSMInsmed$0$34,434,178 ▼-100.0%00.0%MedicalMETSERA INC$0$32,431,596 ▼-100.0%00.0%COMARQTArcutis Biotherapeutics$0$22,917,824 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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