Paradigm Biocapital Advisors Lp Top Holdings and 13F Report (2026) About Paradigm Biocapital Advisors LpInvestment ActivityParadigm Biocapital Advisors Lp has $5.34 billion in total holdings as of June 30, 2026.Paradigm Biocapital Advisors Lp owns shares of 28 different stocks, but just 12 companies or ETFs make up 80% of its holdings.Approximately 22.15% of the portfolio was purchased this quarter.About 31.67% of the portfolio was sold this quarter.This quarter, Paradigm Biocapital Advisors Lp has purchased 35 new stocks and bought additional shares in 12 stocks.Paradigm Biocapital Advisors Lp sold shares of 7 stocks and completely divested from 14 stocks this quarter.Largest Holdings Revolution Medicines $1,191,348,571Nuvalent $731,667,476Edgewise Therapeutics $415,053,937Genmab A/S $360,767,109SPYRE THERAPEUTICS INC $340,984,271 Largest New Holdings this Quarter 02043Q107 - Alnylam Pharmaceuticals $144,494,400 Holding55287L101 - MBX BIOSCIENCES INC $138,442,428 Holding008064206 - JADE BIOSCIENCES INC $63,491,539 Holding004468500 - Achieve Life Sciences $32,335,620 Holding56565P103 - MAPLIGHT THERAPEUTICS INC $24,580,936 Holding Largest Purchases this Quarter SPYRE THERAPEUTICS INC 1,883,512 shares (about $167.22M)Alnylam Pharmaceuticals 480,000 shares (about $144.49M)Genmab A/S 5,165,295 shares (about $141.89M)MBX BIOSCIENCES INC 2,508,015 shares (about $138.44M)Edgewise Therapeutics 2,850,417 shares (about $115.81M) Largest Sales this Quarter Vaxcyte 2,665,168 shares (about $154.93M)Revolution Medicines 294,380 shares (about $55.13M)ORUKA THERAPEUTICS INC 175,790 shares (about $16.73M)Erasca 842,702 shares (about $15.44M)LEXEO THERAPEUTICS INC 2,008,752 shares (about $9.35M) Sector Allocation Over TimeMap of 500 Largest Holdings ofParadigm Biocapital Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorRVMDRevolution Medicines$1,191,348,571$55,131,486 â–¼-4.4%6,361,32322.3%HealthcareNUVLNuvalent$731,667,476$74,100,000 â–²11.3%5,924,43313.7%HealthcareEWTXEdgewise Therapeutics$415,053,937$115,812,443 â–²38.7%10,215,4557.8%HealthcareGMABGenmab A/S$360,767,109$141,890,654 â–²64.8%13,133,1316.8%HealthcareSPYRE THERAPEUTICS INC$340,984,271$167,218,195 â–²96.2%3,840,7786.4%COM NEWAPOGEE THERAPEUTICS INC$209,233,581$30,281,288 â–²16.9%1,576,3853.9%COMORUKA THERAPEUTICS INC$204,094,539$16,729,934 â–¼-7.6%2,144,5263.8%COMTNGXTango Therapeutics$198,736,169$73,393,603 â–²58.6%6,357,5233.7%HealthcareBLTEBelite Bio$189,844,565$18,184,551 â–²10.6%1,232,8773.6%HealthcareERASErasca$174,956,000$15,438,301 â–¼-8.1%9,550,0003.3%HealthcareTARSTarsus Pharmaceuticals$174,699,348$13,437,375 â–²8.3%2,775,6493.3%HealthcareALNYAlnylam Pharmaceuticals$144,494,400$144,494,400 â–²New Holding480,0002.7%HealthcareINSMInsmed$141,375,668$7,622,157 â–²5.7%1,325,9772.6%HealthcareMBX BIOSCIENCES INC$138,442,428$138,442,428 â–²New Holding2,508,0152.6%COMPCVXVaxcyte$123,692,037$154,926,216 â–¼-55.6%2,127,8522.3%HealthcareVRDNViridian Therapeutics$123,515,986$65,670,821 â–²113.5%6,723,7882.3%HealthcareOLMAOlema Pharmaceuticals$108,468,906$8,131,500 â–²8.1%8,670,5762.0%HealthcareJADE BIOSCIENCES INC$63,491,539$63,491,539 â–²New Holding2,857,4051.2%COM NEWTYRATyra Biosciences$58,405,708$7,230,705 â–¼-11.0%1,828,6071.1%HealthcareASSEMBLY BIOSCIENCES INC$42,696,995$24,415,898 â–²133.6%1,553,7480.8%COM NEWEYPTEyepoint Pharmaceuticals$41,332,677$3,604,172 â–¼-8.0%2,890,3970.8%HealthcareACHVAchieve Life Sciences$32,335,620$32,335,620 â–²New Holding4,951,8560.6%HealthcareVOR BIOPHARMA INC$32,217,5000.0%1,750,0000.6%COM NEWMAPLIGHT THERAPEUTICS INC$24,580,936$24,580,936 â–²New Holding685,8520.5%COMKARDIGAN INC$21,465,000$21,465,000 â–²New Holding900,0000.4%COMLEXEO THERAPEUTICS INC$19,436,403$9,350,740 â–¼-32.5%4,175,3820.4%COMEDITEditas Medicine$18,100,665$18,100,665 â–²New Holding5,586,6250.3%HealthcareIVAInventiva$15,120,0000.0%4,000,0000.3%HealthcareACLXArcellx$0$662,972,517 â–¼-100.0%00.0%HealthcareCNTACentessa Pharmaceuticals$0$141,961,187 â–¼-100.0%00.0%HealthcareTERNTerns Pharmaceuticals$0$116,853,827 â–¼-100.0%00.0%HealthcareCYTKCytokinetics$0$97,603,285 â–¼-100.0%00.0%HealthcareABIVAX SA$0$86,014,869 â–¼-100.0%00.0%SPONSORED ADSMAZE THERAPEUTICS INC$0$81,920,310 â–¼-100.0%00.0%COMSRRKScholar Rock$0$60,274,093 â–¼-100.0%00.0%HealthcareMIRMMirum Pharmaceuticals$0$57,737,500 â–¼-100.0%00.0%HealthcareVERADERMICS INC$0$33,153,750 â–¼-100.0%00.0%COMMON STOCKURGNUrogen Pharma$0$30,637,003 â–¼-100.0%00.0%HealthcareGPCRStructure Therapeutics$0$26,282,833 â–¼-100.0%00.0%HealthcareORICOric Pharmaceuticals$0$21,554,419 â–¼-100.0%00.0%HealthcareBRIDGEBIO ONCOLOGY THERAPEUT$0$7,770,506 â–¼-100.0%00.0%COM NEWKALARIS THERAPEUTICS INC$0$4,039,000 â–¼-100.0%00.0%COMShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Unlock superior investment research and tools. Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools and reports. Get MarketBeat All Access MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. Real-time analyst ratings, insider transactions, earnings data, and more. Our daily ratings and market update email newsletter. Sign in to your free account to enjoy all that MarketBeat has to offer. Sign In Create Account Your Email Address: Email Address Required Your Password: Password Required Log In Email Me a Login Link or Sign in with Facebook Sign in with Google Forgot your password? Your Email Address: Please enter your email address. Please enter a valid email address Choose a Password: Please enter your password. Your password must be at least 8 characters long and contain at least 1 number, 1 letter, and 1 special character. Create My Account (Free) or Sign in with Facebook Sign in with Google By creating a free account, you agree to our terms of service. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
