Paradigm Biocapital Advisors Lp Top Holdings and 13F Report (2026) About Paradigm Biocapital Advisors LpInvestment ActivityParadigm Biocapital Advisors Lp has $4.89 billion in total holdings as of March 31, 2026.Paradigm Biocapital Advisors Lp owns shares of 35 different stocks, but just 15 companies or ETFs make up 80% of its holdings.Approximately 26.27% of the portfolio was purchased this quarter.About 17.22% of the portfolio was sold this quarter.This quarter, Paradigm Biocapital Advisors Lp has purchased 30 new stocks and bought additional shares in 13 stocks.Paradigm Biocapital Advisors Lp sold shares of 7 stocks and completely divested from 5 stocks this quarter.Largest Holdings Arcellx $662,972,517Revolution Medicines $647,267,117Nuvalent $545,488,161Vaxcyte $278,522,392Edgewise Therapeutics $231,998,697 Largest New Holdings this Quarter 457669307 - Insmed $205,133,878 Holding07782B104 - Belite Bio $177,741,161 Holding152309100 - Centessa Pharmaceuticals $141,961,187 Holding23282W605 - Cytokinetics $97,603,285 Holding87583X109 - Tango Therapeutics $83,882,485 Holding Largest Purchases this Quarter Insmed 1,254,488 shares (about $205.13M)Belite Bio 1,114,784 shares (about $177.74M)Centessa Pharmaceuticals 3,574,048 shares (about $141.96M)Cytokinetics 1,480,857 shares (about $97.60M)Tango Therapeutics 4,009,679 shares (about $83.88M) Largest Sales this Quarter Scholar Rock 1,836,077 shares (about $90.26M)ABIVAX SA 645,000 shares (about $71.82M)Erasca 3,766,393 shares (about $60.94M)Urogen Pharma 2,769,699 shares (about $49.80M)BRIDGEBIO ONCOLOGY THERAPEUT 1,393,536 shares (about $12.47M) Sector Allocation Over TimeMap of 500 Largest Holdings ofParadigm Biocapital Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorACLXArcellx$662,972,517$5,741,000 â–²0.9%5,774,01613.5%MedicalRVMDRevolution Medicines$647,267,117$1,098,925 â–²0.2%6,655,70313.2%MedicalNUVLNuvalent$545,488,161$5,634,750 â–²1.0%5,324,43311.1%MedicalPCVXVaxcyte$278,522,392$42,129,750 â–²17.8%4,793,0205.7%MedicalEWTXEdgewise Therapeutics$231,998,697$25,950,582 â–²12.6%7,365,0384.7%MedicalGMABGenmab A/S$213,777,040$24,898,294 â–²13.2%7,967,8364.4%MedicalINSMInsmed$205,133,878$205,133,878 â–²New Holding1,254,4884.2%MedicalTARSTarsus Pharmaceuticals$179,735,1030.0%2,562,1543.7%MedicalBLTEBelite Bio$177,741,161$177,741,161 â–²New Holding1,114,7843.6%MedicalERASErasca$168,153,918$60,940,239 â–¼-26.6%10,392,7023.4%MedicalCNTACentessa Pharmaceuticals$141,961,187$141,961,187 â–²New Holding3,574,0482.9%MedicalOLMAOlema Pharmaceuticals$119,586,788$7,103,184 â–²6.3%8,020,5762.4%MedicalTERNTerns Pharmaceuticals$116,853,827$74,135,549 â–²173.5%2,216,4992.4%MedicalORUKA THERAPEUTICS INC$113,811,500$29,920,500 â–²35.7%2,320,3162.3%COMAPOGEE THERAPEUTICS INC$113,481,613$18,938,250 â–²20.0%1,348,2432.3%COMSPYRE THERAPEUTICS INC$98,724,497$24,715,600 â–²33.4%1,957,2662.0%COM NEWCYTKCytokinetics$97,603,285$97,603,285 â–²New Holding1,480,8572.0%MedicalABIVAX SA$86,014,869$71,820,750 â–¼-45.5%772,4731.8%SPONSORED ADSTNGXTango Therapeutics$83,882,485$83,882,485 â–²New Holding4,009,6791.7%MedicalMAZE THERAPEUTICS INC$81,920,310$81,920,310 â–²New Holding2,744,3991.7%COMTYRATyra Biosciences$78,706,155$78,706,155 â–²New Holding2,054,9911.6%MedicalVRDNViridian Therapeutics$61,592,347$33,365,272 â–²118.2%3,148,8931.3%MedicalSRRKScholar Rock$60,274,093$90,261,546 â–¼-60.0%1,226,0801.2%MedicalMIRMMirum Pharmaceuticals$57,737,500$57,737,500 â–²New Holding625,0001.2%MedicalEYPTEyepoint Pharmaceuticals$40,506,013$7,077,100 â–¼-14.9%3,142,4370.8%MedicalLEXEO THERAPEUTICS INC$35,496,929$8,156,173 â–²29.8%6,184,1340.7%COMVERADERMICS INC$33,153,750$33,153,750 â–²New Holding525,0000.7%COMMON STOCKVOR BIOPHARMA INC$31,220,0000.0%1,750,0000.6%COM NEWURGNUrogen Pharma$30,637,003$49,799,188 â–¼-61.9%1,703,9490.6%MedicalGPCRStructure Therapeutics$26,282,833$26,282,833 â–²New Holding545,2870.5%MedicalIVAInventiva$22,200,0000.0%4,000,0000.5%MedicalORICOric Pharmaceuticals$21,554,419$8,869,000 â–¼-29.2%1,701,2170.4%MedicalASSEMBLY BIOSCIENCES INC$18,460,7150.0%665,2510.4%COM NEWBRIDGEBIO ONCOLOGY THERAPEUT$7,770,506$12,472,147 â–¼-61.6%868,2130.2%COM NEWKALARIS THERAPEUTICS INC$4,039,0000.0%700,0000.1%COMXBISPDR S&P Biotech ETF$0$182,895,000 â–¼-100.0%00.0%ETFCIDARA THERAPEUTICS INC$0$167,780,313 â–¼-100.0%00.0%COM NEWCRNXCrinetics Pharmaceuticals$0$102,911,530 â–¼-100.0%00.0%MedicalBBIOBridgeBio Pharma$0$52,340,348 â–¼-100.0%00.0%MedicalOCULOcular Therapeutix$0$35,634,348 â–¼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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