NASDAQ:SYRE Spyre Therapeutics Q4 2025 Earnings Results & Report $80.45 -5.45 (-6.34%) Closing price 10/13/2026 04:00 PM EasternExtended Trading$82.72 +2.27 (+2.83%) As of 10/13/2026 07:30 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Spyre Therapeutics missed analyst earnings expectations in its Q4 2025 results, released February 19, 2026. The company reported EPS of -$0.70 versus the -$0.66 consensus estimate. Research:ProfileEarnings HistoryForecast Earnings Announcement Details QuarterQ4 2025Report DateFebruary 19, 2026TimeBefore Market OpensConference Call7:00 AM ET Spyre Therapeutics EPS ResultsActual EPS-$0.70Consensus EPS -$0.66Beat/MissMissed by -$0.04One Year Ago EPSN/AEPS Beat Rate5 of last 8 quartersSpyre Therapeutics Revenue ResultsActual RevenueN/AExpected RevenueN/ABeat/MissN/AYoY Revenue GrowthN/AUpcoming EarningsSpyre Therapeutics' Q3 2026 earnings is estimated for Tuesday, November 3, 2026, based on past reporting schedules, with a conference call scheduled on Friday, November 6, 2026 at 4:00 PM ET. Check back for transcripts, audio, and key financial metrics as they become available.Conference Call ResourcesPress Release (8-K)Annual Report (10-K)Earnings HistoryCompany ProfilePowered by Earnings DocumentsPress Release(8-K)Annual report(10-K) Spyre Therapeutics Q4 2025 Earnings FAQ Did Spyre Therapeutics beat earnings estimates for Q4 2025? Spyre Therapeutics (NASDAQ:SYRE) reported earnings of -$0.70 per share for Q4 2025, missing the consensus estimate of -$0.66. The report was announced on Thursday, February 19, 2026. When is Spyre Therapeutics' next earnings date? Spyre Therapeutics' next earnings date is estimated for Tuesday, November 3, 2026. MarketBeat tracks confirmed and estimated earnings dates for Spyre Therapeutics on the company's earnings history page. Spyre Therapeutics Earnings HeadlinesSpyre Therapeutics (SYRE) Completed A $350 Million Public Stock OfferingOctober 8, 2026 | finance.yahoo.comSpyre Therapeutics Sinks 14% on Upsized $350 Million Stock Offering Priced Below MarketOctober 6, 2026 | finance.yahoo.comA Simple Guide to Options Trading While It's Still FreeA free copy of Options Trading Made Simple is available now but wont stay that way for long. Chris Rowe calls it The 10-Minute Guide to Start Trading Options Today, built to help you open your first options trade with less capital than buying shares outright. | True Market Insiders (Ad)Spyre Therapeutics Prices $350 Million Common Stock Offering; Shares Down Pre-BellOctober 6, 2026 | finance.yahoo.comSpyre Therapeutics Prices $350 Mln Public Offering Of SharesOctober 6, 2026 | rttnews.comSpyre Therapeutics prices $350M public offering at $85 per shareOctober 6, 2026 | msn.comSee More Spyre Therapeutics Headlines Get Earnings Announcements in your inboxWant to stay updated on the latest earnings announcements and upcoming reports for companies like Spyre Therapeutics? Sign up for Earnings360's daily newsletter to receive timely earnings updates on Spyre Therapeutics and other key companies, straight to your email. Email Address About Spyre TherapeuticsSpyre Therapeutics (NASDAQ:SYRE) is a clinical-stage biotechnology company focused on developing antibody therapeutics for inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease. The company is working to create next-generation biologic medicines intended to address significant treatment needs in these chronic gastrointestinal conditions. Spyre’s pipeline includes programs directed at validated inflammatory pathways, including interleukin-23 (IL-23) and tumor necrosis factor-like ligand 1A (TL1A). Its research approach emphasizes antibody engineering, with the goal of developing therapies that may offer durable activity, convenient dosing, and potential use in combination treatment regimens. The company’s programs remain in clinical development and are subject to ongoing evaluation for safety and effectiveness. The company was formed through a transaction involving Aeglea BioTherapeutics and Spyre Therapeutics and began trading under the name Spyre Therapeutics and the Nasdaq symbol SYRE in 2023. Spyre is headquartered in the United States and conducts its drug discovery and development activities through research, clinical, and corporate operations. Its leadership includes Chief Executive Officer and President Cameron Turtle, Ph.D.View Spyre Therapeutics ProfileRead more More Earnings Resources from MarketBeat Earnings Tools Today's Earnings Tomorrow's Earnings Next Week's Earnings Upcoming Earnings Calls Earnings Newsletter Earnings Call Transcripts Earnings Beats & Misses Corporate Guidance Earnings Screener Latest Articles A Chinese Rival Just Spooked Memory Stocks—How Worried Should Micron Investors Be?Surgical Precision, Sustainable Returns: Johnson & Johnson Secures Its Cash Flow RunwayJPMorgan Earnings Miss Estimates But Reveal Broad-Based StrengthAmazon's $220 Billion AI Bet Is Getting Bigger—Can Earnings Justify the Spending?A Silent Winner: Texas Instruments Anchors the AI SupercycleDelta's Guidance Cut Could Spell Trouble for the Airline Industry5 Retail Picks to Watch as the Holiday Shopping Season Nears Upcoming Earnings Bank of America (10/14/2026)BlackRock (10/14/2026)Morgan Stanley (10/14/2026)Progressive (10/14/2026)Fastenal (10/14/2026)ASML (10/14/2026)Interactive Brokers Group (10/15/2026)Marsh & McLennan Companies (10/15/2026)The PNC Financial Services Group (10/15/2026)Charles Schwab (10/15/2026) Unlock superior investment research and tools. 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