Eledon Pharmaceuticals is a clinical‐stage biotechnology company focused on developing novel cell‐based therapies for rare hematological disorders. The company’s lead candidate, BIVV003, is an investigational, mesenchymal‐like placental cell therapy designed to address the underlying pathology of sickle cell disease (SCD) and transfusion‐dependent beta‐thalassemia (TDT). By harnessing the immunomodulatory and tissue‐supportive properties of placental cells, Eledon aims to reduce vaso‐occlusive events, chronic hemolysis and transfusion requirements in affected patients.
In preclinical studies, BIVV003 demonstrated an ability to modulate inflammatory cascades and promote reparative processes in the bone marrow and vasculature. The company is advancing its ongoing Phase 1/2 program to assess safety, tolerability and preliminary efficacy in individuals living with SCD and TDT. Eledon’s pipeline also includes additional indications for rare blood disorders, leveraging its proprietary cell culture and expansion platform to support scalable manufacturing and consistent product quality.
Founded in 2016, Eledon Pharmaceuticals is headquartered in San Carlos, California, and maintains research collaborations and clinical trial sites across North America and Europe. The executive team combines deep expertise in cell therapy, hematology and regulatory affairs, drawing on leadership experience from both large pharmaceutical companies and successful biotech start‐ups. Eledon’s board and scientific advisory group include specialists in stem cell biology, clinical development and rare disease advocacy.
Looking ahead, Eledon plans to expand its clinical development network, engage with key opinion leaders and explore strategic partnerships to broaden access for patients with life‐threatening blood disorders. Through its cell therapy platform, the company seeks to deliver transformative treatments that address unmet medical needs and improve long‐term outcomes for individuals worldwide.
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