Janux Therapeutics, Inc. is a clinical-stage immuno-oncology company headquartered in Cambridge, Massachusetts. Founded in 2021 by Flagship Pioneering, the company focuses on developing novel T-cell receptor (TCR) therapies to treat solid tumors. Janux has built an integrated research and development infrastructure that spans early discovery through clinical evaluation, emphasizing precision targeting of cancer antigens with engineered cell-therapy products.
At the core of Janux’s approach is its proprietary RAMP (Receptor Activation through Membrane Proximal signaling) platform, which aims to enhance TCR signaling strength, specificity, and safety. Leveraging advanced protein engineering, cell-culture technologies, and in vivo modeling, the company advances a pipeline of TCR-T candidates directed against well-characterized tumor antigens such as MAGEA4 and MAGEA10. Preclinical studies conducted at its Cambridge facility have demonstrated promising anti-tumor activity, supporting the initiation of early-phase clinical trials in multiple solid tumor indications.
Janux conducts its clinical programs across the United States and Europe through collaborations with leading cancer research centers and academic institutions. The company is led by President and Chief Executive Officer Christina Vernon, Ph.D., who brings more than 20 years of experience in oncology drug development. Janux’s executive team includes seasoned experts in cell therapy, translational research, and regulatory affairs, positioning the company to advance its TCR-T platform toward broader patient access and future combination strategies.
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