Zentalis Pharmaceuticals (ZNTL) Stock Price, News & Analysis

Company Overview

Zentalis Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing small molecule therapeutics for the treatment of various cancers. Its products candidatures include the ZN-c3, an inhibitor of WEE1, a protein tyrosine kinase for the treatment of inhibitor for advanced solid tumors and hematological malignancies; in Phase 2 clinical trial as a monotherapy for the treatment of uterine serous carcinoma indications; Phase 2 clinical trial in Cyclin E1 driven high-grade serous ovarian cancer, fallopian tube, or primary peritoneal cancer; Phase 1/2 clinical trial in combination with PARPi for platinum-resistant ovarian cancer; Phase 1b clinical trial in combination with chemotherapy in platinum-resistant ovarian, and peritoneal or fallopian tube cancer; Phase 1/2 clinical trial in combination with chemotherapy in relapsed or refractory osteosarcoma; Phase 1/2 clinical trial with encorafenib and cetuximab for mutant metastatic colorectal cancer; and Phase 1/2 clinical trial in combination with chemotherapy in pancreatic cancer. The company's products pipeline also includes ZN-d5, an oral small molecule inhibitor of B-cell lymphoma 2, for hematological malignancies and related disorders; and BCL-xL heterobifunctional degrader, a member of the anti-apoptotic BCL-2 proteins, for solid tumors and hematological malignancies. Zentalis Pharmaceuticals, Inc. has licensing agreements and strategic collaborations with Recurium IP Holdings, LLC; Pfizer, Inc.; Zentera Therapeutics; Dana-Farber; and GlaxoSmithKline plc. The company was incorporated in 2014 and is headquartered in New York, New York.

Key Stats

• Today's Range: $1.39 to $1.46
• 50-Day Range: $1.16 to $1.63
• 52-Week Range: $1.01 to $5.44
• Volume: 349,684 shs
• Average Volume: 1.25 million shs
• Market Capitalization: $101.09 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $8.20
• Consensus Rating: Moderate Buy

Zentalis Pharmaceuticals Stock Analysis - MarketRank™

Zentalis Pharmaceuticals scored higher than 49% of companies evaluated by MarketBeat, and ranked 542nd out of 925 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.3 / 5
• Analyst Rating: Moderate Buy

Consensus Rating

Zentalis Pharmaceuticals has received a consensus rating of Moderate Buy. The company's average rating score is 2.67, and is based on 2 buy ratings, 3 hold ratings, and no sell ratings.

Amount of Analyst Coverage

Zentalis Pharmaceuticals has only been the subject of 3 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Zentalis Pharmaceuticals are expected to decrease in the coming year, from ($2.42) to ($2.60) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Zentalis Pharmaceuticals is -0.62, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Zentalis Pharmaceuticals is -0.62, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Zentalis Pharmaceuticals has a P/B Ratio of 0.29. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.

Short Interest

• Score: 3.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

6.63% of the outstanding shares of Zentalis Pharmaceuticals have been sold short.

Short Interest Ratio / Days to Cover

Zentalis Pharmaceuticals has a short interest ratio ("days to cover") of 4.9.

Change versus previous month

Short interest in Zentalis Pharmaceuticals has recently decreased by 36.32%, indicating that investor sentiment is improving significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Zentalis Pharmaceuticals does not currently pay a dividend.

Dividend Growth

Zentalis Pharmaceuticals does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

6.63% of the outstanding shares of Zentalis Pharmaceuticals have been sold short.

Short Interest Ratio / Days to Cover

Zentalis Pharmaceuticals has a short interest ratio ("days to cover") of 4.9.

Change versus previous month

Short interest in Zentalis Pharmaceuticals has recently decreased by 36.32%, indicating that investor sentiment is improving significantly.

News and Social Media

• Score: 3.8 / 5
• News Sentiment: 0.77

News Sentiment

Zentalis Pharmaceuticals has a news sentiment score of 0.77. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.48 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 19 news articles for Zentalis Pharmaceuticals this week, compared to 3 articles on an average week.

Search Interest

3 people have searched for ZNTL on MarketBeat in the last 30 days. This is an increase of 200% compared to the previous 30 days.

MarketBeat Follows

2 people have added Zentalis Pharmaceuticals to their MarketBeat watchlist in the last 30 days.

Company Ownership

• Score: 0.0 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Zentalis Pharmaceuticals insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 1.90% of the stock of Zentalis Pharmaceuticals is held by insiders.

ZNTL Stock Analysis - Frequently Asked Questions

How have ZNTL shares performed this year?

Zentalis Pharmaceuticals' stock was trading at $3.03 at the beginning of 2025. Since then, ZNTL shares have decreased by 54.0% and is now trading at $1.3950.

How were Zentalis Pharmaceuticals' earnings last quarter?

Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL) announced its earnings results on Wednesday, August, 6th. The company reported ($0.37) EPS for the quarter, topping the consensus estimate of ($0.56) by $0.19.

When did Zentalis Pharmaceuticals IPO?

Zentalis Pharmaceuticals (ZNTL) raised $131 million in an initial public offering (IPO) on Friday, April 3rd 2020. The company issued 7,700,000 shares at a price of $16.00-$18.00 per share. Morgan Stanley, Jefferies, SVB Leerink and Guggenheim Securities served as the underwriters for the IPO.

Who are Zentalis Pharmaceuticals' major shareholders?

Zentalis Pharmaceuticals' top institutional investors include Acadian Asset Management LLC (3.89%), Tybourne Capital Management HK Ltd. (2.05%), Geode Capital Management LLC (0.86%) and Connor Clark & Lunn Investment Management Ltd. (0.44%). Insiders that own company stock include Matrix Capital Management Comp, Cam Gallagher, Melissa B Epperly, Diana Hausman, Scott Dunseth Myers, Kimberly Blackwell, Mark Lackner, Vincent Vultaggio, Jan Skvarka, David Michael Johnson, Carrie Brownstein, Ingmar Bruns and Kevin D Bunker.
View institutional ownership trends.

How do I buy shares of Zentalis Pharmaceuticals?

Shares of ZNTL stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Zentalis Pharmaceuticals own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Zentalis Pharmaceuticals investors own include Meta Platforms (META), Tesla (TSLA), Advanced Micro Devices (AMD), NVIDIA (NVDA), Home Depot (HD), Chevron (CVX) and JPMorgan Chase & Co. (JPM).

Company Calendar

• Last Earnings: 8/06/2025
• Today: 8/11/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:ZNTL
• CIK: 1725160
• Web: www.zentalis.com
• Phone: 212-433-3791
• Fax: N/A
• Employees: 160
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Zentalis Pharmaceuticals: $8.20
• High Price Target: $20.00
• Low Price Target: $2.20
• Potential Upside/Downside: +479.5%
• Consensus Rating: Moderate Buy
• Rating Score (0-4): 2.67
• Research Coverage: 6 Analysts

Profitability

• EPS (Trailing Twelve Months): ($2.26)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$165.84 million
• Net Margins: N/A
• Pretax Margin: -245.74%
• Return on Equity: -51.62%
• Return on Assets: -40.28%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 7.99
• Quick Ratio: 7.99

Sales & Book Value

• Annual Sales: $26.87 million
• Price / Sales: 3.79
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $4.73 per share
• Price / Book: 0.30

Miscellaneous

• Outstanding Shares: 71,952,000
• Free Float: 70,764,000
• Market Cap: $101.81 million
• Optionable: Optionable
• Beta: 1.71