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Zentalis Pharmaceuticals (ZNTL) Competitors

Zentalis Pharmaceuticals logo
$2.87 -0.21 (-6.82%)
Closing price 09/23/2026 04:00 PM Eastern
Extended Trading
$2.84 -0.04 (-1.22%)
As of 05:07 AM Eastern
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ZNTL vs. HELP, SGP, ARDX, TBPH, and IVA

Should you buy Zentalis Pharmaceuticals stock or one of its competitors? Zentalis Pharmaceuticals's main competitors and comparable companies include Cybin (HELP), Spyglass Pharma (SGP), Ardelyx (ARDX), Theravance Biopharma (TBPH), and Inventiva (IVA). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "pharmaceuticals" industry.

How does Zentalis Pharmaceuticals compare to Cybin?

Zentalis Pharmaceuticals (NASDAQ:ZNTL) and Cybin (NASDAQ:HELP) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their profitability, valuation, dividends, earnings, risk, media sentiment, analyst recommendations and institutional ownership.

Zentalis Pharmaceuticals has a beta of 1.85, suggesting that its stock price is 85% more volatile than the broader market. Comparatively, Cybin has a beta of 0.63, suggesting that its stock price is 37% less volatile than the broader market.

17.9% of Cybin shares are held by institutional investors. 3.8% of Zentalis Pharmaceuticals shares are held by company insiders. Comparatively, 15.0% of Cybin shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Cybin is trading at a lower price-to-earnings ratio than Zentalis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zentalis PharmaceuticalsN/AN/A-$137.06M-$1.95N/A
CybinN/AN/A-$148M-$3.02N/A

Zentalis Pharmaceuticals' return on equity of -70.18% beat Cybin's return on equity.

Company Net Margins Return on Equity Return on Assets
Zentalis PharmaceuticalsN/A -70.18% -51.46%
Cybin N/A -71.78%-64.81%

Zentalis Pharmaceuticals presently has a consensus target price of $6.75, suggesting a potential upside of 135.19%. Cybin has a consensus target price of $46.33, suggesting a potential upside of 255.86%. Given Cybin's stronger consensus rating and higher possible upside, analysts clearly believe Cybin is more favorable than Zentalis Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zentalis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.40
Cybin
0 Sell rating(s)
0 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
3.00

In the previous week, Cybin had 18 more articles in the media than Zentalis Pharmaceuticals. MarketBeat recorded 19 mentions for Cybin and 1 mentions for Zentalis Pharmaceuticals. Cybin's average media sentiment score of 0.46 beat Zentalis Pharmaceuticals' score of 0.31 indicating that Cybin is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zentalis Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Cybin
3 Very Positive mention(s)
5 Positive mention(s)
6 Neutral mention(s)
1 Negative mention(s)
2 Very Negative mention(s)
Neutral

Summary

Cybin beats Zentalis Pharmaceuticals on 7 of the 13 factors compared between the two stocks.

How does Zentalis Pharmaceuticals compare to Spyglass Pharma?

Zentalis Pharmaceuticals (NASDAQ:ZNTL) and Spyglass Pharma (NASDAQ:SGP) are both small-cap healthcare companies, but which is the superior business? We will contrast the two companies based on the strength of their earnings, analyst recommendations, risk, valuation, institutional ownership, media sentiment, profitability and dividends.

In the previous week, Spyglass Pharma had 2 more articles in the media than Zentalis Pharmaceuticals. MarketBeat recorded 3 mentions for Spyglass Pharma and 1 mentions for Zentalis Pharmaceuticals. Spyglass Pharma's average media sentiment score of 0.46 beat Zentalis Pharmaceuticals' score of 0.31 indicating that Spyglass Pharma is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zentalis Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Spyglass Pharma
0 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Spyglass Pharma is trading at a lower price-to-earnings ratio than Zentalis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zentalis PharmaceuticalsN/AN/A-$137.06M-$1.95N/A
Spyglass PharmaN/AN/A-$39.87M-$7.00N/A

Spyglass Pharma's return on equity of -62.40% beat Zentalis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Zentalis PharmaceuticalsN/A -70.18% -51.46%
Spyglass Pharma N/A -62.40%-24.83%

Zentalis Pharmaceuticals currently has a consensus price target of $6.75, suggesting a potential upside of 135.19%. Spyglass Pharma has a consensus price target of $44.00, suggesting a potential upside of 56.25%. Given Zentalis Pharmaceuticals' higher possible upside, research analysts clearly believe Zentalis Pharmaceuticals is more favorable than Spyglass Pharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zentalis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.40
Spyglass Pharma
1 Sell rating(s)
1 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.63

Summary

Spyglass Pharma beats Zentalis Pharmaceuticals on 7 of the 10 factors compared between the two stocks.

How does Zentalis Pharmaceuticals compare to Ardelyx?

Zentalis Pharmaceuticals (NASDAQ:ZNTL) and Ardelyx (NASDAQ:ARDX) are both small-cap healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their institutional ownership, valuation, analyst recommendations, media sentiment, earnings, profitability, risk and dividends.

Ardelyx has higher revenue and earnings than Zentalis Pharmaceuticals. Ardelyx is trading at a lower price-to-earnings ratio than Zentalis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zentalis PharmaceuticalsN/AN/A-$137.06M-$1.95N/A
Ardelyx$407.32M2.13-$61.60M-$0.22N/A

58.9% of Ardelyx shares are owned by institutional investors. 3.8% of Zentalis Pharmaceuticals shares are owned by insiders. Comparatively, 5.3% of Ardelyx shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

Zentalis Pharmaceuticals currently has a consensus price target of $6.75, indicating a potential upside of 135.19%. Ardelyx has a consensus price target of $13.90, indicating a potential upside of 299.43%. Given Ardelyx's stronger consensus rating and higher probable upside, analysts plainly believe Ardelyx is more favorable than Zentalis Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zentalis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.40
Ardelyx
2 Sell rating(s)
0 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.75

Zentalis Pharmaceuticals has a net margin of 0.00% compared to Ardelyx's net margin of -12.35%. Ardelyx's return on equity of -36.00% beat Zentalis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Zentalis PharmaceuticalsN/A -70.18% -51.46%
Ardelyx -12.35%-36.00%-10.77%

In the previous week, Ardelyx had 20 more articles in the media than Zentalis Pharmaceuticals. MarketBeat recorded 21 mentions for Ardelyx and 1 mentions for Zentalis Pharmaceuticals. Zentalis Pharmaceuticals' average media sentiment score of 0.31 beat Ardelyx's score of -0.03 indicating that Zentalis Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zentalis Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Ardelyx
2 Very Positive mention(s)
1 Positive mention(s)
15 Neutral mention(s)
2 Negative mention(s)
1 Very Negative mention(s)
Neutral

Zentalis Pharmaceuticals has a beta of 1.85, indicating that its share price is 85% more volatile than the broader market. Comparatively, Ardelyx has a beta of 0.7, indicating that its share price is 30% less volatile than the broader market.

Summary

Ardelyx beats Zentalis Pharmaceuticals on 12 of the 16 factors compared between the two stocks.

How does Zentalis Pharmaceuticals compare to Theravance Biopharma?

Theravance Biopharma (NASDAQ:TBPH) and Zentalis Pharmaceuticals (NASDAQ:ZNTL) are both small-cap healthcare companies, but which is the better business? We will contrast the two businesses based on the strength of their risk, valuation, analyst recommendations, dividends, institutional ownership, profitability, media sentiment and earnings.

Theravance Biopharma has higher revenue and earnings than Zentalis Pharmaceuticals. Zentalis Pharmaceuticals is trading at a lower price-to-earnings ratio than Theravance Biopharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Theravance Biopharma$107.46M8.23$105.89M$1.0116.86
Zentalis PharmaceuticalsN/AN/A-$137.06M-$1.95N/A

In the previous week, Theravance Biopharma had 9 more articles in the media than Zentalis Pharmaceuticals. MarketBeat recorded 10 mentions for Theravance Biopharma and 1 mentions for Zentalis Pharmaceuticals. Theravance Biopharma's average media sentiment score of 0.39 beat Zentalis Pharmaceuticals' score of 0.31 indicating that Theravance Biopharma is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Theravance Biopharma
3 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Zentalis Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

99.1% of Theravance Biopharma shares are owned by institutional investors. 7.7% of Theravance Biopharma shares are owned by company insiders. Comparatively, 3.8% of Zentalis Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Theravance Biopharma presently has a consensus target price of $19.40, indicating a potential upside of 13.92%. Zentalis Pharmaceuticals has a consensus target price of $6.75, indicating a potential upside of 135.19%. Given Zentalis Pharmaceuticals' stronger consensus rating and higher possible upside, analysts plainly believe Zentalis Pharmaceuticals is more favorable than Theravance Biopharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Theravance Biopharma
0 Sell rating(s)
8 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
2.00
Zentalis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.40

Theravance Biopharma has a beta of 0.25, suggesting that its share price is 75% less volatile than the broader market. Comparatively, Zentalis Pharmaceuticals has a beta of 1.85, suggesting that its share price is 85% more volatile than the broader market.

Theravance Biopharma has a net margin of 51.58% compared to Zentalis Pharmaceuticals' net margin of 0.00%. Theravance Biopharma's return on equity of -0.77% beat Zentalis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Theravance Biopharma51.58% -0.77% -0.46%
Zentalis Pharmaceuticals N/A -70.18%-51.46%

Summary

Theravance Biopharma beats Zentalis Pharmaceuticals on 11 of the 15 factors compared between the two stocks.

How does Zentalis Pharmaceuticals compare to Inventiva?

Zentalis Pharmaceuticals (NASDAQ:ZNTL) and Inventiva (NASDAQ:IVA) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their valuation, profitability, media sentiment, risk, institutional ownership, earnings, dividends and analyst recommendations.

In the previous week, Inventiva had 2 more articles in the media than Zentalis Pharmaceuticals. MarketBeat recorded 3 mentions for Inventiva and 1 mentions for Zentalis Pharmaceuticals. Zentalis Pharmaceuticals' average media sentiment score of 0.31 beat Inventiva's score of 0.24 indicating that Zentalis Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zentalis Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Inventiva
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Zentalis Pharmaceuticals presently has a consensus target price of $6.75, suggesting a potential upside of 135.19%. Inventiva has a consensus target price of $15.75, suggesting a potential upside of 356.52%. Given Inventiva's stronger consensus rating and higher possible upside, analysts clearly believe Inventiva is more favorable than Zentalis Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zentalis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.40
Inventiva
1 Sell rating(s)
0 Hold rating(s)
7 Buy rating(s)
3 Strong Buy rating(s)
3.09

19.1% of Inventiva shares are held by institutional investors. 3.8% of Zentalis Pharmaceuticals shares are held by company insiders. Comparatively, 32.0% of Inventiva shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Zentalis Pharmaceuticals has higher earnings, but lower revenue than Inventiva.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zentalis PharmaceuticalsN/AN/A-$137.06M-$1.95N/A
Inventiva$4.48M159.85-$400.67MN/AN/A

Zentalis Pharmaceuticals has a beta of 1.85, indicating that its stock price is 85% more volatile than the broader market. Comparatively, Inventiva has a beta of 0.71, indicating that its stock price is 29% less volatile than the broader market.

Inventiva's return on equity of 0.00% beat Zentalis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Zentalis PharmaceuticalsN/A -70.18% -51.46%
Inventiva N/A N/A N/A

Summary

Inventiva beats Zentalis Pharmaceuticals on 10 of the 13 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding ZNTL and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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ZNTL vs. The Competition

MetricZentalis PharmaceuticalsPharmaceuticals IndustryHealthcare SectorNASDAQ Exchange
Market Cap$220.75M$12.60B$7.31B$13.29B
Dividend YieldN/A2.63%2.52%12.57%
P/E Ratio-1.47792.28274.0825.69
Price / SalesN/A862.22638.2178.99
Price / CashN/A88.6477.8052.76
Price / Book0.9610.5910.476.32
Net Income-$137.06M$2.81B$3.49B$359.73M
7 Day Performance-6.82%-0.11%-0.67%0.17%
1 Month Performance-23.67%-1.34%-3.17%-3.27%
1 Year Performance88.82%2.86%15.14%5.58%

Zentalis Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
ZNTL
Zentalis Pharmaceuticals
3.7345 of 5 stars
$2.87
-6.8%
$6.75
+135.2%
+91.3%$220.75MN/AN/A106
HELP
Cybin
4.6234 of 5 stars
$13.61
+4.9%
$48.60
+257.1%
N/A$980.68MN/AN/A100
SGP
Spyglass Pharma
2.5068 of 5 stars
$28.66
+4.1%
$44.00
+53.5%
N/A$920.09MN/AN/A65
ARDX
Ardelyx
2.6701 of 5 stars
$3.52
-1.7%
$13.90
+294.9%
-43.4%$892.09M$407.32MN/A489
TBPH
Theravance Biopharma
3.0802 of 5 stars
$17.03
+0.1%
$19.40
+13.9%
+21.0%$883.14M$107.46M16.8690

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This page (NASDAQ:ZNTL) was last updated on 9/24/2026 by MarketBeat.com Staff.
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