HC Wainwright Predicts Septerna's Q3 Earnings (NASDAQ:SEPN)

Key Points

• HC Wainwright raised its Q3 2026 EPS forecast for Septerna to a loss of $0.31 per share from its previous estimate of $0.66, while maintaining a “Buy” rating and $60 price target.
• Septerna’s latest quarterly results beat expectations, with a loss of $0.29 per share versus the projected $0.43 loss and revenue of $26.75 million compared with the $19.22 million consensus estimate.
• Analyst sentiment is broadly positive: Septerna has a “Moderate Buy” consensus rating and an average price target of $51.33, although the stock has fallen 6.3% and insiders have recently sold shares.

Septerna, Inc. (NASDAQ:SEPN - Free Report) - Equities researchers at HC Wainwright lifted their Q3 2026 EPS estimates for Septerna in a research note issued to investors on Wednesday, August 12th. HC Wainwright analyst R. Selvaraju now forecasts that the company will post earnings per share of ($0.31) for the quarter, up from their previous estimate of ($0.66). HC Wainwright currently has a "Buy" rating and a $60.00 target price on the stock. The consensus estimate for Septerna's current full-year earnings is ($1.54) per share. HC Wainwright also issued estimates for Septerna's Q4 2026 earnings at ($0.35) EPS, FY2026 earnings at ($1.15) EPS, Q1 2027 earnings at ($0.33) EPS, Q2 2027 earnings at ($0.27) EPS, Q3 2027 earnings at ($0.37) EPS, Q4 2027 earnings at ($0.44) EPS and FY2027 earnings at ($1.41) EPS.

A number of other equities analysts have also commented on the company. Raymond James Financial reaffirmed a "strong-buy" rating and issued a $49.00 price objective on shares of Septerna in a research note on Tuesday. Wells Fargo & Company lifted their price objective on shares of Septerna from $48.00 to $50.00 and gave the company an "overweight" rating in a report on Wednesday. JonesTrading upped their price target on Septerna from $43.00 to $62.00 and gave the stock a "buy" rating in a report on Thursday. Guggenheim boosted their price target on shares of Septerna from $45.00 to $51.00 and gave the stock a "buy" rating in a report on Tuesday. Finally, Weiss Ratings restated a "sell (d-)" rating on shares of Septerna in a research note on Friday, July 17th. One analyst has rated the stock with a Strong Buy rating, eight have assigned a Buy rating, one has assigned a Hold rating and one has given a Sell rating to the company's stock. Based on data from MarketBeat.com, Septerna presently has a consensus rating of "Moderate Buy" and a consensus price target of $51.33.

Septerna Stock Down 6.3%

Shares of SEPN opened at $45.14 on Friday. The business has a 50-day simple moving average of $35.57 and a two-hundred day simple moving average of $29.54. Septerna has a 12-month low of $10.74 and a 12-month high of $51.10. The stock has a market cap of $2.11 billion, a PE ratio of -83.59 and a beta of 2.29.

Septerna (NASDAQ:SEPN - Get Free Report) last posted its quarterly earnings results on Monday, August 10th. The company reported ($0.29) earnings per share (EPS) for the quarter, topping the consensus estimate of ($0.43) by $0.14. The business had revenue of $26.75 million for the quarter, compared to analyst estimates of $19.22 million. Septerna had a negative net margin of 24.51% and a negative return on equity of 9.59%.

Institutional Trading of Septerna

Several institutional investors and hedge funds have recently added to or reduced their stakes in SEPN. Group One Trading LLC grew its holdings in shares of Septerna by 111.8% in the fourth quarter. Group One Trading LLC now owns 944 shares of the company's stock valued at $26,000 after purchasing an additional 8,955 shares in the last quarter. Global Retirement Partners LLC purchased a new stake in shares of Septerna in the fourth quarter valued at approximately $35,000. Russell Investments Group Ltd. purchased a new position in shares of Septerna during the third quarter valued at $36,000. Caitong International Asset Management Co. Ltd bought a new stake in Septerna during the fourth quarter valued at about $53,000. Finally, Mirae Asset Global Investments Co. Ltd. purchased a new stake in shares of Septerna during the fourth quarter valued at about $61,000.

Insiders Place Their Bets

In related news, SVP Daniel D. Long sold 15,000 shares of the business's stock in a transaction dated Monday, June 22nd. The shares were sold at an average price of $35.51, for a total transaction of $532,650.00. Following the transaction, the senior vice president owned 96,412 shares in the company, valued at $3,423,590.12. The trade was a 13.46% decrease in their ownership of the stock. The sale was disclosed in a filing with the Securities & Exchange Commission, which is available through this hyperlink. Also, COO Elizabeth Bhatt sold 25,000 shares of the company's stock in a transaction dated Tuesday, August 11th. The stock was sold at an average price of $44.00, for a total transaction of $1,100,000.00. Following the completion of the sale, the chief operating officer directly owned 174,209 shares in the company, valued at $7,665,196. This represents a 12.55% decrease in their ownership of the stock. The SEC filing for this sale provides additional information. In the last ninety days, insiders sold 72,828 shares of company stock worth $2,684,314. 5.80% of the stock is currently owned by corporate insiders.

Septerna News Summary

Here are the key news stories impacting Septerna this week:

• Positive Sentiment: Analyst sentiment strengthened: JonesTrading raised its price target from $43 to $62 and assigned a “buy” rating, while HC Wainwright lifted its target from $40 to $60 and maintained a “buy” rating. JonesTrading Septerna price target HC Wainwright Septerna price target
• Positive Sentiment: Wells Fargo raised its price target from $48 to $50 and reiterated an “overweight” rating. The consensus view remains “Moderate Buy,” with an average target of approximately $51.33. Wells Fargo Septerna price target
• Positive Sentiment: Septerna’s latest quarterly results exceeded expectations. The company reported a loss of $0.29 per share versus the expected $0.43 loss, while revenue of $26.75 million surpassed the $19.22 million consensus estimate. Septerna earnings report
• Neutral Sentiment: The stock has rallied sharply, trading near its 12-month high. With a market capitalization of about $2.1 billion and continuing expected losses, investors may be reassessing valuation following the earnings-driven advance.
• Negative Sentiment: COO Elizabeth Bhatt sold 25,000 shares at an average price of $44 for approximately $1.1 million, reducing her ownership by 12.55%. She still holds 174,209 shares, but the insider sale may be weighing on sentiment and prompting profit-taking after the recent rise. Septerna insider sale filing

About Septerna

We are a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by our proprietary Native Complex Platform™. Our industrial-scale platform aims to unlock the full potential of GPCR therapies and has led to the discovery and development of our deep pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. GPCRs are the largest and most diverse family of cell membrane receptors and regulate physiological processes in nearly every organ system of the human body.

This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to contact@marketbeat.com.

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