Caribou Biosciences (CRBU) Stock Price, News & Analysis

Company Overview

Caribou Biosciences, Inc. is a clinical-stage biopharmaceutical company focused on developing transformative therapies based on its proprietary CRISPR technology. The company’s platform is built around novel CRISPR-Cas enzymes and delivery systems designed to enable precise gene editing in both cell‐based and in vivo applications. Caribou’s core therapeutic areas include oncology, immunology and rare genetic diseases, where its technologies aim to create next-generation cell therapies and targeted gene-editing treatments.

Among Caribou’s leading programs is its allogeneic cell therapy platform, which employs engineered T cells to target blood cancers and solid tumors. The company has also advanced multiple in vivo gene-editing candidates, leveraging lipid nanoparticle and viral delivery technologies to correct disease-causing mutations directly within patients. In addition to therapeutic development, Caribou provides its CRISPR tools and enzyme variants to a broad network of academic and industry collaborators working in human health research, agricultural biotechnology and synthetic biology.

Founded in 2011, Caribou Biosciences traces its origins to the University of California, Berkeley, where Nobel laureate Jennifer Doudna and her colleagues pioneered CRISPR research. Since its inception, the company has grown from an academic spin-out into a publicly traded entity, establishing state-of-the-art research facilities in the San Francisco Bay Area and collaborating with partners worldwide. Caribou’s strategic alliances encompass pharmaceutical collaborations, licensing agreements and joint development projects across North America, Europe and Asia.

Leadership at Caribou includes a seasoned management team with deep expertise in biotechnology, drug development and regulatory affairs. Co-founder and chief scientific officer Jennifer Doudna continues to guide the company’s scientific direction, while the executive team brings experience from leading global biopharma organizations. Together, they oversee a multidisciplinary workforce committed to advancing Caribou’s pipeline of CRISPR-based therapies and expanding the capabilities of gene-editing platforms on a global scale.

Key Stats

• Today's Range: $1.62 to $1.72
• 50-Day Range: $0.75 to $1.75
• 52-Week Range: $0.66 to $3.00
• Volume: 1.16 million shs
• Average Volume: 1.33 million shs
• Market Capitalization: $151.59 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $8.50
• Consensus Rating: Buy

Caribou Biosciences Stock Analysis - MarketRank™

Caribou Biosciences scored higher than 56% of companies evaluated by MarketBeat, and ranked 471st out of 944 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.5 / 5
• Analyst Rating: Buy

Consensus Rating

Caribou Biosciences has received a consensus rating of Buy. The company's average rating score is 3.00, and is based on 4 buy ratings, no hold ratings, and no sell ratings.

Amount of Analyst Coverage

Caribou Biosciences has only been the subject of 1 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Caribou Biosciences are expected to decrease in the coming year, from ($1.64) to ($1.78) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Caribou Biosciences is -1.01, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Caribou Biosciences is -1.01, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Caribou Biosciences has a P/B Ratio of 0.58. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.

Short Interest

• Score: 3.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

7.64% of the float of Caribou Biosciences has been sold short.

Short Interest Ratio / Days to Cover

Caribou Biosciences has a short interest ratio ("days to cover") of 4.6.

Change versus previous month

Short interest in Caribou Biosciences has recently decreased by 43.47%, indicating that investor sentiment is improving significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Caribou Biosciences does not currently pay a dividend.

Dividend Growth

Caribou Biosciences does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

7.64% of the float of Caribou Biosciences has been sold short.

Short Interest Ratio / Days to Cover

Caribou Biosciences has a short interest ratio ("days to cover") of 4.6.

Change versus previous month

Short interest in Caribou Biosciences has recently decreased by 43.47%, indicating that investor sentiment is improving significantly.

News and Social Media

• Score: 2.7 / 5
• News Sentiment: 0.86

News Sentiment

Caribou Biosciences has a news sentiment score of 0.86. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 1.00 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 3 news articles for Caribou Biosciences this week, compared to 5 articles on an average week.

Search Interest

4 people have searched for CRBU on MarketBeat in the last 30 days. This is an increase of 33% compared to the previous 30 days.

MarketBeat Follows

4 people have added Caribou Biosciences to their MarketBeat watchlist in the last 30 days. This is an increase of 100% compared to the previous 30 days.

Company Ownership

• Score: 1.7 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Caribou Biosciences insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 8.28% of the stock of Caribou Biosciences is held by insiders.

Percentage Held by Institutions

77.51% of the stock of Caribou Biosciences is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

CRBU Stock Analysis - Frequently Asked Questions

How have CRBU shares performed this year?

Caribou Biosciences' stock was trading at $1.59 at the beginning of the year. Since then, CRBU shares have increased by 2.5% and is now trading at $1.63.

How were Caribou Biosciences' earnings last quarter?

Caribou Biosciences, Inc. (NASDAQ:CRBU) announced its earnings results on Thursday, May, 8th. The company reported ($0.43) earnings per share for the quarter, hitting analysts' consensus estimates of ($0.43). The business earned $2.35 million during the quarter, compared to analyst estimates of $1.48 million. Caribou Biosciences had a negative trailing twelve-month return on equity of 55.70% and a negative net margin of 1,490.84%.

When did Caribou Biosciences IPO?

Caribou Biosciences (CRBU) raised $202 million in an initial public offering on Friday, July 23rd 2021. The company issued 13,500,000 shares at a price of $14.00-$16.00 per share.

How do I buy shares of Caribou Biosciences?

Shares of CRBU stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Caribou Biosciences own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Caribou Biosciences investors own include Voyager Therapeutics (VYGR), American Water Works (AWK), The RMR Group (RMR), Waste Connections (WCN), AU Optronics (AUOTY), DiamondRock Hospitality (DRH) and iShares Micro-Cap ETF (IWC).

Company Calendar

• Last Earnings: 5/08/2025
• Today: 7/12/2025
• Next Earnings (Estimated): 8/05/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:CRBU
• CIK: 1619856
• Web: cariboubio.com
• Phone: 510-982-6030
• Fax: N/A
• Employees: 100
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Caribou Biosciences: $8.50
• High Price Target: $14.00
• Low Price Target: $3.00
• Potential Upside/Downside: +421.5%
• Consensus Rating: Buy
• Rating Score (0-4): 3.00
• Research Coverage: 4 Analysts

Profitability

• EPS (Trailing Twelve Months): ($1.62)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$149.10 million
• Net Margins: -1,490.84%
• Pretax Margin: -1,490.94%
• Return on Equity: -55.70%
• Return on Assets: -45.35%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 7.63
• Quick Ratio: 7.63

Sales & Book Value

• Annual Sales: $9.99 million
• Price / Sales: 15.17
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $2.79 per share
• Price / Book: 0.58

Miscellaneous

• Outstanding Shares: 93,000,000
• Free Float: 85,304,000
• Market Cap: $151.59 million
• Optionable: Optionable
• Beta: 2.48