AC Immune (ACIU) Stock Price, News & Analysis

Company Overview

AC Immune AG is a clinical-stage biopharmaceutical company headquartered in Lausanne, Switzerland, with a subsidiary in Boston, Massachusetts. The company specializes in the discovery and development of therapeutics and diagnostics for neurodegenerative diseases, with a primary focus on Alzheimer’s disease, Parkinson’s disease and other protein misfolding disorders. AC Immune leverages proprietary platform technologies to identify and optimize candidates that target pathological protein aggregates.

Since its founding in 2003, AC Immune has advanced multiple programs into clinical development. Its SupraAntigen™ platform is designed to generate active vaccines that elicit a targeted immune response against disease-associated proteins, while its Morphomer™ platform discovers small molecules that bind misfolded proteins and inhibit their toxic aggregation. Among the company’s leading assets are anti-tau vaccine candidates in mid-stage clinical trials and small-molecule inhibitors aimed at disrupting toxic oligomer formation.

AC Immune maintains collaborations and strategic partnerships with major pharmaceutical firms to accelerate development and expand global reach. Notable alliances include research agreements with Janssen Pharmaceuticals and UCB to co-develop immunotherapies for Alzheimer’s and Parkinson’s diseases, as well as partnerships with Eli Lilly and Genentech focused on diagnostic imaging agents. These collaborations strengthen AC Immune’s ability to advance its pipeline while accessing broader regulatory and commercialization expertise.

Under the leadership of CEO Dr. Andrea Pfeifer, who co-founded the company and has guided its growth since inception, AC Immune continues to invest in innovative approaches to neurodegeneration. The company’s integrated research and development model, combining both therapeutic and diagnostic strategies, aims to deliver precision solutions that address unmet medical needs in aging populations across North America, Europe and Asia.

Key Stats

• Today's Range: $2.52 to $2.64
• 50-Day Range: $2.12 to $2.66
• 52-Week Range: $2.03 to $4.00
• Volume: 380,455 shs
• Average Volume: 206,040 shs
• Market Capitalization: $266.64 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $7.50
• Consensus Rating: Hold

AC Immune Stock Analysis - MarketRank™

AC Immune scored higher than 53% of companies evaluated by MarketBeat, and ranked 444th out of 911 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.8 / 5
• Analyst Rating: Hold

Consensus Rating

AC Immune has received a consensus rating of Hold. The company's average rating score is 2.40, and is based on no strong buy ratings, 3 buy ratings, 1 hold rating, and 1 sell rating.

Upside Potential

AC Immune has a consensus price target of $7.50, representing about 186.3% upside from its current price of $2.62.

Amount of Analyst Coverage

AC Immune has only been the subject of 3 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for AC Immune are expected to grow in the coming year, from ($0.60) to $0.17 per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of AC Immune is -4.85, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of AC Immune is -4.85, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

AC Immune has a P/B Ratio of 5.95. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.

Short Interest

• Score: 1.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

3.66% of the float of AC Immune has been sold short.

Short Interest Ratio / Days to Cover

AC Immune has a short interest ratio ("days to cover") of 18.18, which indicates bearish sentiment.

Change versus previous month

Short interest in AC Immune has recently increased by 4.58%, indicating that investor sentiment is decreasing.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

AC Immune does not currently pay a dividend.

Dividend Growth

AC Immune does not have a long track record of dividend growth.

News and Social Media

• Score: 3.2 / 5
• News Sentiment: 1.19

News Sentiment

AC Immune has a news sentiment score of 1.19. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.67 average news sentiment score of Healthcare companies.

News Coverage This Week

MarketBeat has tracked 9 news articles for AC Immune this week, compared to 3 articles on an average week.

Search Interest

Only 1 people have searched for ACIU on MarketBeat in the last 30 days. This is a decrease of -83% compared to the previous 30 days.

Company Ownership

• Score: 1.5 / 5
• Insider Trading: Selling Shares

Insider Buying vs. Insider Selling

In the past three months, AC Immune insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $27,900.00 in company stock.

Percentage Held by Insiders

4.60% of the stock of AC Immune is held by insiders.

Percentage Held by Institutions

51.36% of the stock of AC Immune is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

Company Calendar

• Last Earnings: 8/06/2026
• Today: 8/12/2026
• Fiscal Year End: 12/31/2026

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Healthcare
• Industry: Biotechnology
• Sub-Industry: Biotechnology
• Current Symbol: NASDAQ:ACIU
• CIK: 1651625
• Web: www.acimmune.com
• Phone: (121) 345-9121
• Fax: 41-21-345-9120
• Employees: 140
• Year Founded: 2003

Price Target and Rating

• Average Price Target for AC Immune: $7.50
• High Price Target: $8.00
• Low Price Target: $7.00
• Potential Upside/Downside: +186.3%
• Consensus Rating: Hold
• Rating Score (0-4): 2.40
• Research Coverage: 5 Analysts

Profitability

• EPS (Trailing Twelve Months): ($0.54)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$85.03 million
• Net Margins: -245.32%
• Pretax Margin: -1,796.18%
• Return on Equity: -100.17%
• Return on Assets: -28.36%

Debt

• Debt-to-Equity Ratio: 0.11
• Current Ratio: 0.93
• Quick Ratio: 1.02

Sales & Book Value

• Annual Sales: $4.31 million
• Price / Sales: 61.86
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $0.44 per share
• Price / Book: 5.95

Miscellaneous

• Outstanding Shares: 101,770,000
• Free Float: 97,092,000
• Market Cap: $266.64 million
• Optionable: Optionable
• Beta: 1.59