NASDAQ:ATXI Avenue Therapeutics (ATXI) Stock Price, News & Analysis $0.82 -0.04 (-4.65%) As of 09/12/2025 03:44 PM Eastern Add Compare Share Share Stock Analysis Stock AnalysisChartCompetitorsHeadlinesInsider TradesOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock About Avenue Therapeutics Stock (NASDAQ:ATXI) 30 days 90 days 365 days Advanced Chart View Price History Chart DataSkip Price History Chart Get Avenue Therapeutics alerts:Sign Up Key Stats Today's Range$0.60▼$0.8650-Day Range$0.23▼$0.8952-Week Range$0.17▼$2.93Volume1,896 shsAverage Volume161,471 shsMarket Capitalization$2.61 millionP/E Ratio0.04Dividend YieldN/APrice TargetN/AConsensus RatingN/A Company Overview Avenue Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the development and commercialization of novel therapies for disorders of the central nervous system, with an initial emphasis on acute pain management. The company’s research and development efforts are centered on reformulating established active pharmaceutical ingredients to address unmet needs in hospital and outpatient settings, aiming to improve safety profiles, reduce opioid exposure and support enhanced patient recovery. The company’s lead product candidate is intravenous tramadol, a unique non-solicited opioid analgesic that combines dual mechanisms of action to manage moderate to severe acute pain. Avenue has completed pivotal Phase 3 clinical trials and submitted a New Drug Application to the U.S. Food and Drug Administration, seeking approval to introduce the first IV tramadol formulation in the United States. If approved, the therapy is expected to offer clinicians an alternative to existing intravenous opioids while leveraging a lower potential for respiratory depression and abuse. Avenue Therapeutics is headquartered in the United States and conducts its operations through collaborations with contract research organizations and commercial partners. The company is led by a management team with extensive experience in pharmaceutical development, regulatory strategy and product commercialization, and it continues to explore additional central nervous system pipeline opportunities designed to leverage its formulation expertise and address high-unmet medical needs.AI Generated. May Contain Errors. Read More Avenue Therapeutics Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks24th Percentile Overall ScoreATXI MarketRank™: Avenue Therapeutics scored higher than 24% of companies evaluated by MarketBeat. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's OpinionN/AAnalyst RatingN/A Consensus RatingThere is not enough analysis data for Avenue Therapeutics. Earnings and Valuation1.9 / 5Proj. Earnings GrowthN/A Price to Earnings Ratio vs. the MarketThe P/E ratio of Avenue Therapeutics is 0.04, which means that it is trading at a less expensive P/E ratio than the market average P/E ratio of about 280.89.Price to Earnings Ratio vs. SectorThe P/E ratio of Avenue Therapeutics is 0.04, which means that it is trading at a less expensive P/E ratio than the Medical sector average P/E ratio of about 75.34.Price to Book Value per Share RatioAvenue Therapeutics has a P/B Ratio of 0.43. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.Read more about Avenue Therapeutics' valuation and earnings. Short Interest2.0 / 5Short Interest LevelBearish Percentage of Shares Shorted2.41% of the float of Avenue Therapeutics has been sold short.Short Interest Ratio / Days to CoverAvenue Therapeutics has a short interest ratio ("days to cover") of 5.9.Change versus previous month Dividend0.0 / 5Dividend StrengthN/A Dividend YieldAvenue Therapeutics does not currently pay a dividend.Dividend GrowthAvenue Therapeutics does not have a long track record of dividend growth. Sustainability and ESG4.6 / 5Environmental Score-0.99 Percentage of Shares Shorted2.41% of the float of Avenue Therapeutics has been sold short.Short Interest Ratio / Days to CoverAvenue Therapeutics has a short interest ratio ("days to cover") of 5.9.Change versus previous month News and Social Media0.6 / 5News SentimentN/A MarketBeat Follows1 people have added Avenue Therapeutics to their MarketBeat watchlist in the last 30 days. Company Ownership0.0 / 5Insider TradingN/A Insider Buying vs. Insider SellingIn the past three months, Avenue Therapeutics insiders have not sold or bought any company stock.Percentage Held by InsidersOnly 1.80% of the stock of Avenue Therapeutics is held by insiders.Percentage Held by InstitutionsOnly 17.34% of the stock of Avenue Therapeutics is held by institutions.Read more about Avenue Therapeutics' insider trading history. Receive ATXI Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Avenue Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. ATXI Stock News HeadlinesAvenue Therapeutics Reports Positive Earnings Amid ChallengesAugust 22, 2025 | msn.comUniversity Avenue will be closed for repair due to a sinkhole in MorgantownJuly 20, 2025 | msn.comReagan’s former tech advisor sharing bombshell announcementGeorge Gilder handed President Reagan the first microchip that helped create $6.5 trillion in wealth over the last 40 years. Now he's stepping forward with an even bigger prediction about what's being built in the Arizona desert. He believes 3 little-known companies will explode when a bombshell announcement just days from now. Smart investors are already positioning themselves.September 13 at 2:00 AM | Banyan Hill Publishing (Ad)17-year-old dies from gunshot wound near Colley Avenue, police sayJuly 20, 2025 | msn.comCrash involving a fire engine reported on Tennessee Avenue in Bond HillJuly 20, 2025 | msn.comKatipunan Avenue now passable after billboard collapse forces temporary closureJuly 20, 2025 | msn.com"Dhaba on Devon Avenue" makes it to Writers Theatre in Glencoe, Illinois, after 5 yearsJuly 19, 2025 | msn.comEighteenth Avenue Family Enrichment Center joins program to provide free mealsJuly 19, 2025 | msn.comSee More Headlines ATXI Stock Analysis - Frequently Asked Questions How have ATXI shares performed this year? Avenue Therapeutics' stock was trading at $2.00 at the beginning of the year. Since then, ATXI stock has decreased by 59.0% and is now trading at $0.82. How were Avenue Therapeutics' earnings last quarter? Avenue Therapeutics, Inc. (NASDAQ:ATXI) announced its quarterly earnings data on Friday, August, 9th. The company reported ($6.43) earnings per share (EPS) for the quarter, missing analysts' consensus estimates of ($1.05) by $5.38. When did Avenue Therapeutics' stock split? Shares of Avenue Therapeutics reverse split before market open on Friday, April 26th 2024.The 1-75 reverse split was announced on Friday, April 26th 2024. The number of shares owned by shareholders was adjusted after the market closes on Friday, April 26th 2024. An investor that had 100 shares of stock prior to the reverse split would have 1 shares after the split. When did Avenue Therapeutics IPO? Avenue Therapeutics (ATXI) raised $30 million in an IPO on Tuesday, June 27th 2017. The company issued 5,000,000 shares at $5.00-$7.00 per share. Oppenheimer served as the underwriter for the IPO and National Securities Corp. was co-manager. How do I buy shares of Avenue Therapeutics? Shares of ATXI stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Avenue Therapeutics own? Based on aggregate information from My MarketBeat watchlists, some other companies that Avenue Therapeutics investors own include Meta Platforms (META), NVIDIA (NVDA), CymaBay Therapeutics (CBAY), Broadcom (AVGO), GE Aerospace (GE), CrowdStrike (CRWD) and Novo Nordisk A/S (NVO). Company Calendar Last Earnings8/09/2024Today9/13/2025Next Earnings (Estimated)11/12/2025Fiscal Year End12/31/2025Get Stock AlertsIndustry, Sector and Symbol Stock ExchangeNASDAQ SectorMedical Industry Pharmaceutical preparations Sub-IndustryPharmaceutical Products Current SymbolNASDAQ:ATXI CIK1644963 Webwww.avenuetx.com Phone(781) 652-4500FaxN/AEmployees4Year Founded2015Profitability EPS (Trailing Twelve Months)($0.95) Trailing P/E Ratio0.04 Forward P/E RatioN/A P/E GrowthN/ANet Income-$10.38 million Net MarginsN/A Pretax MarginN/A Return on Equity-471.57% Return on Assets-296.50% Debt Debt-to-Equity RatioN/A Current Ratio2.70 Quick Ratio2.70 Sales & Book Value Annual SalesN/A Price / SalesN/A Cash FlowN/A Price / Cash FlowN/A Book Value$1.92 per share Price / Book0.43Miscellaneous Outstanding Shares3,183,000Free Float2,017,000Market Cap$2.61 million OptionableNot Optionable Beta-0.07 Social Links Options Trading Made Easy - Download NowLearn the basics of options trading and how to use them to boost returns and manage risk with this free report from MarketBeat. Click the link below to get your free copy.Get This Free Report This page (NASDAQ:ATXI) was last updated on 9/13/2025 by MarketBeat.com Staff From Our PartnersWhy Trump’s “Smart Dollar” could rewrite the rulesMUST SEE: Donald Trump's Radical Overhaul of the U.S. Dollar Congress just approved President Trump's lates...Stansberry Research | SponsoredTrump's Law S.1582: $21T Dollar Revolution ComingDo you have money in any of these banks? Chase. Bank of America. Citigroup. Wells Fargo. U.S. Bancorp. I...Brownstone Research | SponsoredRetire Comfortably with These New Monthly Income ETFs?Too many retirees lie awake at night, worried their savings won’t last. 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