CalciMedica (CALC) Stock Price, News & Analysis

Company Overview

CalciMedica, Inc. (NASDAQ:CALC) is a clinical-stage biopharmaceutical company focused on developing therapies that modulate calcium-mediated inflammatory pathways. Headquartered in Northbrook, Illinois, the company applies proprietary ion channel technology to address severe inflammatory disorders driven by dysregulated immune responses.

The company’s lead product candidate, Auxora™, is a selective inhibitor of calcium release-activated calcium (CRAC) channels. Auxora is being evaluated in clinical trials for the treatment of acute pancreatitis associated with systemic inflammatory response syndrome (SIRS) and acute respiratory distress syndrome (ARDS) in patients with severe pulmonary conditions, including COVID-19 pneumonia. Early-phase data suggest that CRAC channel inhibition can reduce inflammatory cytokine release and support organ function in critically ill patients.

CalciMedica pursues a development strategy that combines rigorous clinical evaluation with strategic collaborations to expedite potential regulatory approvals and commercialization. Operating primarily in the United States, the company works closely with academic centers and healthcare organizations to advance its pipeline. By targeting calcium signaling in innate immune cells, CalciMedica aims to fill unmet medical needs in acute inflammatory diseases and improve outcomes for high-risk patient populations.

Key Stats

• Today's Range: $2.96 to $3.23
• 50-Day Range: $2.18 to $4.20
• 52-Week Range: $1.42 to $5.65
• Volume: 86,705 shs
• Average Volume: 68,731 shs
• Market Capitalization: $43.73 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $16.00
• Consensus Rating: Buy

CalciMedica Stock Analysis - MarketRank™

CalciMedica scored higher than 55% of companies evaluated by MarketBeat, and ranked 470th out of 946 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.5 / 5
• Analyst Rating: Buy

Consensus Rating

CalciMedica has received a consensus rating of Buy. The company's average rating score is 3.00, and is based on 1 buy rating, no hold ratings, and no sell ratings.

Upside Potential

CalciMedica has a consensus price target of $16.00, representing about 411.2% upside from its current price of $3.13.

Amount of Analyst Coverage

CalciMedica has received no research coverage in the past 90 days.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for CalciMedica are expected to decrease in the coming year, from ($2.21) to ($2.24) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of CalciMedica is -1.96, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of CalciMedica is -1.96, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

CalciMedica has a P/B Ratio of 2.93. P/B Ratios below 3 indicates that a company is reasonably valued with respect to its assets and liabilities.

Short Interest

• Score: 3.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

1.06% of the float of CalciMedica has been sold short.

Short Interest Ratio / Days to Cover

CalciMedica has a short interest ratio ("days to cover") of 0.9, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in CalciMedica has recently increased by 77.53%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

CalciMedica does not currently pay a dividend.

Dividend Growth

CalciMedica does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

1.06% of the float of CalciMedica has been sold short.

Short Interest Ratio / Days to Cover

CalciMedica has a short interest ratio ("days to cover") of 0.9, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in CalciMedica has recently increased by 77.53%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 2.9 / 5
• News Sentiment: 1.30

News Sentiment

CalciMedica has a news sentiment score of 1.30. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.71 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 2 news articles for CalciMedica this week, compared to 1 article on an average week.

Company Ownership

• Score: 3.3 / 5
• Insider Trading: Acquiring Shares

Insider Buying vs. Insider Selling

In the past three months, CalciMedica insiders have bought 5,837.18% more of their company's stock than they have sold. Specifically, they have bought $216,707.00 in company stock and sold $3,650.00 in company stock.

Percentage Held by Insiders

41.55% of the stock of CalciMedica is held by insiders. A high percentage of insider ownership can be a sign of company health.

CALC Stock Analysis - Frequently Asked Questions

How have CALC shares performed this year?

CalciMedica's stock was trading at $3.54 at the beginning of 2025. Since then, CALC stock has decreased by 11.6% and is now trading at $3.13.

How were CalciMedica's earnings last quarter?

CalciMedica Inc. (NASDAQ:CALC) issued its earnings results on Tuesday, August, 12th. The company reported ($0.40) EPS for the quarter, hitting the consensus estimate of ($0.40).

Who are CalciMedica's major shareholders?

CalciMedica's top institutional shareholders include Envestnet Asset Management Inc. (0.67%), Wealthedge Investment Advisors LLC (0.63%), Stonepine Capital Management LLC (0.61%) and 180 Wealth Advisors LLC (0.36%). Insiders that own company stock include Sanderling Venture Partners Vi, Robert N Wilson, Eric W Roberts, Sudarshan Hebbar, Kenneth A Stauderman, A Rachel Leheny and Stephen Bardin.
View institutional ownership trends.

How do I buy shares of CalciMedica?

Shares of CALC stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of CalciMedica own?

Based on aggregate information from My MarketBeat watchlists, some other companies that CalciMedica investors own include Zomedica (ZOM), Jumia Technologies (JMIA), Nano Dimension (NNDM), AST SpaceMobile (ASTS), NIO (NIO), Bakkt (BKKT) and Castor Maritime (CTRM).

Company Calendar

• Last Earnings: 8/12/2025
• Today: 9/23/2025
• Next Earnings (Estimated): 11/12/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:CALC
• CIK: 1534133
• Web: www.graybug.vision
• Phone: 858-952-5500
• Fax: N/A
• Employees: 30
• Year Founded: N/A

Price Target and Rating

• Average Price Target for CalciMedica: $16.00
• High Price Target: $16.00
• Low Price Target: $16.00
• Potential Upside/Downside: +411.2%
• Consensus Rating: Buy
• Rating Score (0-4): 3.00
• Research Coverage: 1 Analysts

Profitability

• EPS (Trailing Twelve Months): ($1.60)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$13.70 million
• Net Margins: N/A
• Pretax Margin: N/A
• Return on Equity: -206.51%
• Return on Assets: -103.81%

Debt

• Debt-to-Equity Ratio: 1.39
• Current Ratio: 5.45
• Quick Ratio: 5.45

Sales & Book Value

• Annual Sales: N/A
• Price / Sales: N/A
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $1.07 per share
• Price / Book: 2.93

Miscellaneous

• Outstanding Shares: 13,970,000
• Free Float: 8,167,000
• Market Cap: $43.73 million
• Optionable: No Data
• Beta: 1.32