| 5/19/2025 | Jane Street Group LLC | 27,849 | $600K | 0.0% | +119.0% | 0.222% | |
| 5/16/2025 | Goldman Sachs Group Inc. | 42,143 | $908K | 0.0% | +203.8% | 0.336% | |
| 5/16/2025 | Checkpoint Capital L.P. | 104,380 | $2.25M | 1.2% | -47.0% | 0.832% | |
| 5/16/2025 | BVF Inc. IL | 924,642 | $19.92M | 0.8% | -15.4% | 7.369% | |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 990,000 | $21.33M | 0.0% | +167.6% | 7.890% | |
| 5/16/2025 | ADAR1 Capital Management LLC | 20,938 | $451K | 0.1% | -16.0% | 0.167% | |
| 5/15/2025 | Vestal Point Capital LP | 504,542 | $10.87M | 0.8% | N/A | 4.021% | |
| 5/15/2025 | OMERS ADMINISTRATION Corp | 19,300 | $416K | 0.0% | +53.2% | 0.154% | |
| 5/13/2025 | American Century Companies Inc. | 10,409 | $224K | 0.0% | N/A | 0.083% | |
| 5/13/2025 | Aberdeen Group plc | 120,879 | $2.60M | 0.0% | N/A | 0.963% | |
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| 5/12/2025 | Vivo Capital LLC | 684,276 | $14.74M | 2.0% | +2.0% | 5.454% | |
| 5/9/2025 | West Michigan Advisors LLC | 13,500 | $291K | 0.1% | N/A | 0.108% | |
| 2/17/2025 | VR Adviser LLC | 765,723 | $20.58M | 1.4% | N/A | 10.861% | |
| 2/17/2025 | Stempoint Capital LP | 47,642 | $1.28M | 0.3% | N/A | 0.676% | |
| 2/17/2025 | Point72 Asia Singapore Pte. Ltd. | 2,085 | $56K | 0.0% | N/A | 0.030% | |
| 2/17/2025 | Point72 Asset Management L.P. | 6,148 | $165K | 0.0% | N/A | 0.087% | |
| 2/17/2025 | OMERS ADMINISTRATION Corp | 12,600 | $339K | 0.0% | N/A | 0.179% | |
| 2/17/2025 | Millennium Management LLC | 35,960 | $967K | 0.0% | +158.4% | 0.510% | |
| 2/17/2025 | BVF Inc. IL | 1,092,796 | $29.37M | 1.0% | +55.4% | 15.501% | |
| 2/17/2025 | Alethea Capital Management LLC | 14,311 | $385K | 0.3% | -82.1% | 0.203% | |
| 2/17/2025 | Acuta Capital Partners LLC | 54,473 | $1.46M | 1.5% | N/A | 0.773% | |
| 2/14/2025 | RA Capital Management L.P. | 1,092,796 | $29.37M | 0.4% | +55.4% | 15.501% | |
| 2/14/2025 | Jane Street Group LLC | 12,714 | $342K | 0.0% | N/A | 0.180% | |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 49,557 | $1.33M | 0.0% | +154.1% | 0.703% | |
| 2/14/2025 | TCG Crossover Management LLC | 1,005,901 | $26.09M | 2.5% | N/A | 14.268% | |
| 2/14/2025 | Northern Trust Corp | 33,957 | $913K | 0.0% | +6.8% | 0.482% | |
| 2/14/2025 | Boothbay Fund Management LLC | 15,601 | $419K | 0.0% | N/A | 0.221% | |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 369,954 | $9.94M | 0.0% | +765.3% | 5.248% | |
| 2/14/2025 | Vivo Capital LLC | 670,600 | $18.03M | 2.0% | N/A | 9.512% | |
| 2/13/2025 | Renaissance Technologies LLC | 95,617 | $2.57M | 0.0% | -2.2% | 1.356% | |
| 2/13/2025 | ADAR1 Capital Management LLC | 24,938 | $670K | 0.1% | N/A | 0.354% | |
| 11/16/2024 | Geode Capital Management LLC | 52,898 | $569K | 0.0% | +22.7% | 0.750% | |
| 11/15/2024 | RA Capital Management L.P. | 703,080 | $7.56M | 0.1% | N/A | 9.973% | |
| 11/15/2024 | Checkpoint Capital L.P. | 182,426 | $1.96M | 1.0% | +25.5% | 2.588% | |
| 8/15/2024 | Alethea Capital Management LLC | 79,908 | $954K | 0.7% | -95.0% | 1.752% | |
| 8/9/2024 | Renaissance Technologies LLC | 95,517 | $1.14M | 0.0% | -96.3% | 2.094% | |
| 5/17/2024 | Alethea Capital Management LLC | 1,598,492 | $1.47M | 1.2% | -1.8% | 35.055% | |
| 5/10/2024 | Tocqueville Asset Management L.P. | 163,000 | $150K | 0.0% | +71.6% | 3.573% | |
| 5/3/2024 | Callan Capital LLC | 95,169 | $88K | 0.0% | -8.0% | 2.087% | |
| 11/14/2023 | Pale Fire Capital SE | 54,356 | $51K | 0.0% | N/A | 0.060% | |
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| 11/9/2023 | Tocqueville Asset Management L.P. | 98,000 | $92K | 0.0% | -13.3% | 0.108% | |
| 10/24/2023 | Raymond James Financial Services Advisors Inc. | 79,119 | $75K | 0.0% | +25.2% | 0.088% | |
| 10/17/2023 | Flagship Harbor Advisors LLC | 30,011 | $28K | 0.0% | N/A | 0.033% | |
| 8/4/2023 | Legacy Wealth Asset Management LLC | 30,000 | $34K | 0.0% | N/A | 0.033% | |
| 8/3/2023 | Mackenzie Financial Corp | 22,566 | $26K | 0.0% | N/A | 0.025% | |
| 7/24/2023 | Vontobel Holding Ltd. | 82,185 | $93K | 0.0% | +55.5% | 0.091% | |
| 7/18/2023 | Stratos Wealth Partners LTD. | 36,489 | $41K | 0.0% | +247.9% | 0.041% | |
| 5/11/2023 | Acadian Asset Management LLC | 941,574 | $1.19M | 0.0% | -25.1% | 1.046% | |
| 5/10/2023 | Tocqueville Asset Management L.P. | 167,000 | $212K | 0.0% | +22.8% | 0.186% | |
| 5/9/2023 | Callan Capital LLC | 323,554 | $411K | 0.0% | +18.3% | 0.359% | |
| 5/5/2023 | Monashee Investment Management LLC | 369,099 | $469K | 0.1% | N/A | 0.410% | |
| 4/28/2023 | Jeppson Wealth Management LLC | 137,060 | $174K | 0.1% | -14.7% | 0.191% | |
| 4/12/2023 | Vontobel Holding Ltd. | 52,841 | $67K | 0.0% | N/A | 0.074% | |
| 2/15/2023 | Nantahala Capital Management LLC | 4,367,464 | $3.30M | 0.2% | -4.2% | 6.098% | |
| 2/13/2023 | Callan Capital LLC | 273,554 | $207K | 0.0% | N/A | 0.382% | |
| 2/9/2023 | Tocqueville Asset Management L.P. | 136,000 | $103K | 0.0% | +30.8% | 0.190% | |
| 1/27/2023 | Jeppson Wealth Management LLC | 160,610 | $121K | 0.1% | -7.8% | 0.224% | |
| 11/14/2022 | Point72 Asset Management L.P. | 3,868,006 | $2.43M | 0.0% | -7.9% | 5.401% | |
| 11/10/2022 | Nantahala Capital Management LLC | 4,559,201 | $2.92M | 0.2% | -5.4% | 6.366% | |
| 11/4/2022 | Prudential Financial Inc. | 54,000 | $34K | 0.0% | N/A | 0.078% | |
| 11/1/2022 | Monashee Investment Management LLC | 369,099 | $232K | 0.1% | N/A | 0.535% | |
| 8/15/2022 | Nantahala Capital Management LLC | 4,819,090 | $2.36M | 0.1% | -2.7% | 6.979% | |
| 8/11/2022 | Knott David M Jr | 635,254 | $310K | 0.1% | +9.7% | 0.920% | |
| 8/3/2022 | Jeppson Wealth Management LLC | 181,075 | $88K | 0.0% | +25.9% | 0.262% | |
| 8/1/2022 | US Bancorp DE | 262,072 | $128K | 0.0% | N/A | 0.380% | |
| 5/12/2022 | Monashee Investment Management LLC | 369,099 | $307K | 0.1% | N/A | 0.535% | |
| 5/12/2022 | Acadian Asset Management LLC | 1,099,299 | $914K | 0.0% | +23.6% | 1.592% | |
| 4/27/2022 | Jeppson Wealth Management LLC | 143,850 | $119K | 0.1% | +30.2% | 0.211% | |
| 2/15/2022 | Stonepine Capital Management LLC | 2,311,530 | $2.94M | 1.3% | +195.3% | 3.466% | |
| 2/15/2022 | Laurion Capital Management LP | 198,635 | $252K | 0.0% | N/A | 0.298% | |
| 2/14/2022 | Point72 Asset Management L.P. | 4,200,000 | $5.33M | 0.0% | N/A | 6.298% | |
| 2/10/2022 | Acadian Asset Management LLC | 889,469 | $1.13M | 0.0% | +51.6% | 1.334% | |
| 2/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 88,097 | $112K | 0.0% | +64.9% | 0.132% | |
| 2/8/2022 | Raymond James Financial Services Advisors Inc. | 75,035 | $95K | 0.0% | -16.0% | 0.113% | |
| 2/7/2022 | West Family Investments Inc. | 368,910 | $469K | 0.1% | N/A | 0.553% | |
| 1/19/2022 | Jeppson Wealth Management LLC | 110,525 | $140K | 0.1% | +83.9% | 0.166% | |
| 11/17/2021 | Jeppson Wealth Management LLC | 60,100 | $134K | 0.1% | +15.4% | 0.121% | |
| 11/17/2021 | Altium Capital Management LP | 1,275,000 | $2.02M | 0.4% | N/A | 2.569% | |
| 11/16/2021 | Squarepoint Ops LLC | 87,419 | $196K | 0.0% | -26.2% | 0.177% | |
| 11/16/2021 | Two Sigma Advisers LP | 468,594 | $1.05M | 0.0% | +1,054.3% | 0.947% | |
| 11/16/2021 | Two Sigma Investments LP | 373,338 | $836K | 0.0% | +571.5% | 0.754% | |
| 11/16/2021 | BVF Inc. IL | 4,776,904 | $10.70M | 0.4% | +9.9% | 9.649% | |
| 11/15/2021 | Marshall Wace LLP | 184,027 | $412K | 0.0% | N/A | 0.372% | |
| 11/12/2021 | Renaissance Technologies LLC | 1,120,261 | $2.51M | 0.0% | +7.1% | 2.263% | |
| 11/12/2021 | Stonepine Capital Management LLC | 782,817 | $1.75M | 0.8% | -35.4% | 1.581% | |
| 11/12/2021 | Connor Clark & Lunn Investment Management Ltd. | 53,431 | $120K | 0.0% | N/A | 0.108% | |
| 11/10/2021 | Goldman Sachs Group Inc. | 109,894 | $246K | 0.0% | -17.2% | 0.222% | |
| 11/9/2021 | BlackRock Inc. | 332,066 | $743K | 0.0% | -10.3% | 0.671% | |
| 11/9/2021 | Monashee Investment Management LLC | 369,099 | $827K | 0.2% | N/A | 0.746% | |
| 10/19/2021 | Kestra Advisory Services LLC | 30,500 | $68K | 0.0% | N/A | 0.062% | |
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| 9/3/2021 | Parametric Portfolio Associates LLC | 34,001 | $69K | 0.0% | N/A | 0.069% | |
| 8/17/2021 | Millennium Management LLC | 580,793 | $1.17M | 0.0% | +810.8% | 1.203% | |
| 8/17/2021 | Bridgeway Capital Management LLC | 118,878 | $240K | 0.0% | -27.5% | 0.246% | |
| 8/17/2021 | BVF Inc. IL | 4,346,904 | $8.78M | 0.3% | +16.2% | 9.002% | |
| 8/16/2021 | Squarepoint Ops LLC | 118,482 | $239K | 0.0% | -36.7% | 0.245% | |
| 8/16/2021 | Opaleye Management Inc. | 73,351 | $148K | 0.0% | N/A | 0.152% | |
| 8/16/2021 | Alethea Capital Management LLC | 1,172,044 | $2.37M | 1.5% | +0.7% | 2.427% | |
| 8/16/2021 | Charles Schwab Investment Management Inc. | 25,006 | $51K | 0.0% | -66.7% | 0.052% | |
| 8/16/2021 | State Street Corp | 73,000 | $147K | 0.0% | -88.9% | 0.151% | |
| 8/16/2021 | Tibra Equities Europe Ltd | 174,900 | $353K | 0.1% | N/A | 0.362% | |
