| 9/15/2020 | Two Sigma Advisers LP | 36,880 | $100K | 0.0% | +27.7% | 0.132% | |
| 8/14/2020 | BVF Inc. IL | 1,742,112 | $4.74M | 0.3% | -19.2% | 6.214% | |
| 8/5/2020 | Russell Investments Group Ltd. | 39,171 | $0.11M | 0.0% | +29.6% | 0.140% | |
| 5/15/2020 | Squarepoint Ops LLC | 24,436 | $52K | 0.0% | N/A | 0.087% | |
| 5/15/2020 | Morgan Stanley | 32,920 | $69K | 0.0% | -14.8% | 0.118% | |
| 5/15/2020 | Two Sigma Investments LP | 99,258 | $0.21M | 0.0% | -8.6% | 0.355% | |
| 5/15/2020 | Two Sigma Advisers LP | 28,880 | $61K | 0.0% | +74.2% | 0.103% | |
| 5/13/2020 | Connor Clark & Lunn Investment Management Ltd. | 85,604 | $0.18M | 0.0% | +4.7% | 0.306% | |
| 5/6/2020 | Russell Investments Group Ltd. | 30,220 | $63K | 0.0% | N/A | 0.108% | |
| 4/23/2020 | Hikari Power Ltd | 60,959 | $0.13M | 0.0% | -23.8% | 0.218% | |
|
| 3/2/2020 | Connor Clark & Lunn Investment Management Ltd. | 81,800 | $0.45M | 0.0% | +9.5% | 0.278% | |
| 2/20/2020 | Geode Capital Management LLC | 137,555 | $0.75M | 0.0% | +6.3% | 0.468% | |
| 2/18/2020 | EcoR1 Capital LLC | 737,612 | $4.01M | 0.4% | N/A | 2.508% | |
| 2/14/2020 | BVF Inc. IL | 1,627,568 | $8.85M | 0.7% | -46.6% | 5.535% | |
| 2/14/2020 | Bank of America Corp DE | 22,811 | $0.12M | 0.0% | -51.9% | 0.078% | |
| 2/14/2020 | Jacobs Levy Equity Management Inc. | 75,996 | $0.41M | 0.0% | +76.7% | 0.258% | |
| 2/14/2020 | Goldman Sachs Group Inc. | 107,176 | $0.58M | 0.0% | +79.0% | 0.364% | |
| 2/13/2020 | Oxford Asset Management LLP | 159,773 | $0.87M | 0.0% | +29.2% | 0.543% | |
| 2/13/2020 | Renaissance Technologies LLC | 906,200 | $4.93M | 0.0% | +6.4% | 3.082% | |
| 2/12/2020 | Connor Clark & Lunn Investment Management Ltd. | 81,800 | $0.45M | 0.0% | +9.5% | 0.278% | |
| 2/11/2020 | TD Asset Management Inc. | 13,583 | $74K | 0.0% | -68.8% | 0.046% | |
| 2/6/2020 | Acadian Asset Management LLC | 79,233 | $0.43M | 0.0% | N/A | 0.269% | |
| 2/4/2020 | Hikari Power Ltd | 80,000 | $0.44M | 0.0% | -38.5% | 0.272% | |
| 11/27/2019 | Millennium Management LLC | 952,197 | $2.87M | 0.0% | +1,174.1% | 3.238% | |
| 11/27/2019 | Orbimed Advisors LLC | 6,767,584 | $20.37M | 0.4% | +3.1% | 23.011% | |
| 8/17/2019 | Orbimed Advisors LLC | 6,565,685 | $24.56M | 0.4% | +10.0% | 22.340% | |
| 8/16/2019 | Cowen Inc. | 576,231 | $2.16M | 0.2% | -1.3% | 1.961% | |
| 8/15/2019 | Price T Rowe Associates Inc. MD | 1,762,248 | $6.59M | 0.0% | -10.4% | 5.996% | |
| 8/14/2019 | Morgan Stanley | 32,631 | $0.12M | 0.0% | -43.1% | 0.111% | |
| 8/14/2019 | Paloma Partners Management Co | 39,787 | $0.15M | 0.0% | N/A | 0.135% | |
| 8/14/2019 | Cowen Inc. | 576,231 | $2.16M | 0.2% | -1.3% | 1.961% | |
| 8/14/2019 | Vanguard Group Inc. | 487,636 | $1.82M | 0.0% | +6.1% | 1.659% | |
| 8/13/2019 | Jacobs Levy Equity Management Inc. | 59,718 | $0.22M | 0.0% | N/A | 0.203% | |
| 8/13/2019 | BlackRock Inc. | 332,934 | $1.24M | 0.0% | -63.9% | 1.133% | |
| 8/13/2019 | Parametric Portfolio Associates LLC | 13,359 | $50K | 0.0% | N/A | 0.045% | |
| 8/13/2019 | Northern Trust Corp | 141,717 | $0.53M | 0.0% | -6.0% | 0.482% | |
| 8/12/2019 | Renaissance Technologies LLC | 833,098 | $3.12M | 0.0% | +6.6% | 2.835% | |
| 8/12/2019 | Fosun International Ltd | 184,116 | $0.62M | 0.0% | +7.7% | 0.626% | |
| 8/7/2019 | Connor Clark & Lunn Investment Management Ltd. | 64,325 | $0.24M | 0.0% | +9.1% | 0.219% | |
| 8/7/2019 | JPMorgan Chase & Co. | 66,687 | $0.23M | 0.0% | -60.1% | 0.227% | |
| 6/20/2019 | Sphera Funds Management LTD. | 83,607 | $0.34M | 0.0% | -74.0% | 0.285% | |
| 6/16/2019 | FMR LLC | 845,556 | $3.40M | 0.0% | -18.8% | 2.883% | |
| 5/10/2019 | Fosun International Ltd | 170,974 | $0.67M | 0.0% | +7.5% | 0.583% | |
| 5/8/2019 | Connor Clark & Lunn Investment Management Ltd. | 58,951 | $0.24M | 0.0% | +18.3% | 0.201% | |
| 4/15/2019 | Raymond James Trust N.A. | 13,158 | $53K | 0.0% | N/A | 0.045% | |
| 4/1/2019 | Deutsche Bank AG | 207,782 | $0.76M | 0.0% | +304.0% | 0.708% | |
| 2/26/2019 | FMR LLC | 1,041,256 | $3.82M | 0.0% | -48.4% | 3.556% | |
| 2/15/2019 | Millennium Management LLC | 60,248 | $0.22M | 0.0% | +61.2% | 0.206% | |
| 2/14/2019 | Paloma Partners Management Co | 15,900 | $58K | 0.0% | N/A | 0.054% | |
| 2/14/2019 | Squarepoint Ops LLC | 73,454 | $0.27M | 0.0% | +44.5% | 0.251% | |
| 2/14/2019 | Bank of America Corp DE | 80,281 | $0.29M | 0.0% | +32.0% | 0.274% | |
| 2/14/2019 | Two Sigma Investments LP | 68,700 | $0.25M | 0.0% | N/A | 0.235% | |
| 2/14/2019 | Telemetry Investments L.L.C. | 135,123 | $0.50M | 0.3% | N/A | 0.461% | |
| 2/14/2019 | Puissance Capital Management LP | 284,869 | $1.05M | 1.2% | N/A | 0.973% | |
| 2/13/2019 | Geode Capital Management LLC | 152,361 | $0.56M | 0.0% | +19.0% | 0.520% | |
| 2/13/2019 | Dimensional Fund Advisors LP | 336,327 | $1.23M | 0.0% | +29.0% | 1.149% | |
| 2/8/2019 | BlackRock Inc. | 946,378 | $3.47M | 0.0% | -21.6% | 3.232% | |
| 2/7/2019 | Prudential Financial Inc. | 21,545 | $79K | 0.0% | +15.0% | 0.074% | |
| 1/31/2019 | Rhumbline Advisers | 18,203 | $67K | 0.0% | +44.1% | 0.062% | |
| 1/31/2019 | Fosun International Ltd | 158,982 | $0.52M | 0.0% | N/A | 0.543% | |
| 1/29/2019 | Hikari Power Ltd | 130,000 | $0.48M | 0.1% | +305.1% | 0.444% | |
| 1/1/2019 | TIAA CREF Investment Management LLC | 22,645 | $0.19M | 0.0% | -18.9% | 0.077% | |
| 12/13/2018 | Vanguard Group Inc | 677,974 | $5.82M | 0.0% | +2.0% | 2.315% | |
| 11/23/2018 | Vanguard Group Inc. | 677,974 | $5.82M | 0.0% | +2.0% | 2.315% | |
| 11/14/2018 | EcoR1 Capital LLC | 351,401 | $3.02M | 0.3% | -22.0% | 1.200% | |
| 11/14/2018 | Sphera Funds Management LTD. | 321,430 | $2.76M | 0.3% | -4.3% | 1.098% | |
| 11/13/2018 | Renaissance Technologies LLC | 396,900 | $3.41M | 0.0% | +22.2% | 1.356% | |
| 11/13/2018 | Citadel Advisors LLC | 21,264 | $0.18M | 0.0% | N/A | 0.073% | |
| 11/13/2018 | Bridgeway Capital Management Inc. | 104,600 | $0.90M | 0.0% | +23.1% | 0.357% | |
| 11/13/2018 | Dimensional Fund Advisors LP | 260,701 | $2.24M | 0.0% | +66.6% | 0.890% | |
| 11/13/2018 | Credit Suisse AG | 22,593 | $0.19M | 0.0% | N/A | 0.077% | |
| 11/9/2018 | Trexquant Investment LP | 12,483 | $0.11M | 0.0% | N/A | 0.043% | |
| 11/9/2018 | FMR LLC | 2,018,812 | $17.32M | 0.0% | -18.5% | 6.895% | |
| 11/9/2018 | BlackRock Inc. | 1,206,520 | $10.35M | 0.0% | +7.8% | 4.121% | |
| 10/31/2018 | Hikari Power Ltd | 32,090 | $0.28M | 0.0% | N/A | 0.110% | |
| 10/30/2018 | Acadian Asset Management LLC | 34,229 | $0.29M | 0.0% | +59.2% | 0.117% | |
| 9/18/2018 | Northern Trust Corp | 149,846 | $1.65M | 0.0% | +69.2% | 0.513% | |
| 8/17/2018 | Cowen Inc. | 534,397 | $5.87M | 0.2% | N/A | 1.830% | |
| 8/15/2018 | Millennium Management LLC | 345,574 | $3.79M | 0.0% | -42.9% | 1.183% | |
| 8/13/2018 | Renaissance Technologies LLC | 324,900 | $3.57M | 0.0% | -23.9% | 1.113% | |
| 8/13/2018 | International Biotechnology Trust PLC | 81,341 | $0.89M | 0.3% | N/A | 0.279% | |
| 8/10/2018 | FMR LLC | 2,478,297 | $27.21M | 0.0% | -2.9% | 8.487% | |
| 8/10/2018 | Dimensional Fund Advisors LP | 156,471 | $1.72M | 0.0% | +16.4% | 0.536% | |
| 8/9/2018 | BlackRock Inc. | 1,119,507 | $12.29M | 0.0% | +51.9% | 3.834% | |
| 8/8/2018 | Schwab Charles Investment Management Inc. | 25,900 | $0.29M | 0.0% | +48.0% | 0.089% | |
| 8/6/2018 | Bank of New York Mellon Corp | 37,099 | $0.41M | 0.0% | +35.8% | 0.127% | |
| 8/6/2018 | Rhumbline Advisers | 13,433 | $0.15M | 0.0% | N/A | 0.046% | |
| 7/24/2018 | Acadian Asset Management LLC | 21,494 | $0.24M | 0.0% | +129.3% | 0.074% | |
| 5/17/2018 | Adams Street Partners LLC | 3,275,616 | $33.99M | 6.5% | +21.9% | 11.222% | |
| 5/16/2018 | Millennium Management LLC | 605,303 | $6.98M | 0.0% | +925.6% | 2.074% | |
| 5/15/2018 | Rock Springs Capital Management LP | 575,000 | $6.63M | 0.3% | +36.1% | 1.970% | |
| 5/11/2018 | Dimensional Fund Advisors LP | 134,436 | $1.55M | 0.0% | +112.9% | 0.638% | |
| 5/10/2018 | JPMorgan Chase & Co. | 218,197 | $2.52M | 0.0% | -11.1% | 1.036% | |
| 5/10/2018 | Spark Investment Management LLC | 10,800 | $0.12M | 0.0% | -62.1% | 0.051% | |
| 5/10/2018 | Sphera Funds Management LTD. | 321,430 | $3.71M | 0.6% | +45.2% | 1.526% | |
| 5/9/2018 | BlackRock Inc. | 737,118 | $8.50M | 0.0% | +10.1% | 3.498% | |
| 5/7/2018 | BVF Inc. IL | 1,954,254 | $22.53M | 2.3% | +325.4% | 9.275% | |
| 2/15/2018 | Millennium Management LLC | 59,017 | $0.61M | 0.0% | +180.8% | 0.280% | |
| 2/14/2018 | Goldman Sachs Group Inc. | 24,395 | $0.25M | 0.0% | N/A | 0.116% | |
| 2/14/2018 | Deutsche Bank AG | 19,058 | $0.20M | 0.0% | +118.1% | 0.091% | |
