| 5/19/2025 | UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC | 272,857 | $6.00M | 0.0% | -2.2% | 0.259% | |
| 5/16/2025 | Woodline Partners LP | 1,096,809 | $24.13M | 0.2% | +93.4% | 1.043% | |
| 5/16/2025 | Exome Asset Management LLC | 71,438 | $1.57M | 1.3% | -12.3% | 0.068% | |
| 5/16/2025 | Fred Alger Management LLC | 27,635 | $608K | 0.0% | N/A | 0.026% | |
| 5/16/2025 | Goldman Sachs Group Inc. | 366,644 | $8.07M | 0.0% | +5.7% | 0.349% | |
| 5/16/2025 | Jones Financial Companies Lllp | 2,120 | $47K | 0.0% | N/A | 0.002% | |
| 5/16/2025 | Parkman Healthcare Partners LLC | 425,407 | $9.36M | 1.1% | +11.6% | 0.404% | |
| 5/16/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,776 | $963K | 0.0% | +6.0% | 0.042% | |
| 5/16/2025 | Granahan Investment Management LLC | 217,667 | $4.79M | 0.2% | -27.4% | 0.207% | |
| 5/16/2025 | EFG Asset Management North America Corp. | 104,386 | $2.30M | 0.4% | +152.5% | 0.099% | |
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| 5/16/2025 | Eventide Asset Management LLC | 568,310 | $12.50M | 0.2% | N/A | 0.540% | |
| 5/16/2025 | Cormorant Asset Management LP | 4,101,992 | $90.24M | 6.8% | +20.4% | 3.899% | |
| 5/16/2025 | Allostery Investments LP | 3,000 | $66K | 0.1% | N/A | 0.003% | |
| 5/16/2025 | Amundi | 308,633 | $6.79M | 0.0% | -9.7% | 0.293% | |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 390,000 | $8.58M | 0.0% | +62.5% | 0.371% | |
| 5/16/2025 | ADAR1 Capital Management LLC | 20,000 | $440K | 0.1% | N/A | 0.019% | |
| 5/15/2025 | First Light Asset Management LLC | 1,852,290 | $40.75M | 4.6% | +137.3% | 1.761% | |
| 5/15/2025 | MPM Bioimpact LLC | 1,105,444 | $24.32M | 4.2% | +2.4% | 1.051% | |
| 5/15/2025 | Braidwell LP | 2,458,808 | $54.09M | 1.9% | +5.4% | 2.347% | |
| 5/15/2025 | Quarry LP | 1,200 | $26K | 0.0% | -40.0% | 0.001% | |
| 5/15/2025 | DAFNA Capital Management LLC | 183,140 | $4.03M | 1.1% | -2.1% | 0.175% | |
| 5/15/2025 | Driehaus Capital Management LLC | 1,375,742 | $30.27M | 0.3% | -7.9% | 1.313% | |
| 5/15/2025 | Siren L.L.C. | 1,696,444 | $37.32M | 2.2% | +131.0% | 1.619% | |
| 5/14/2025 | MetLife Investment Management LLC | 43,883 | $965K | 0.0% | -1.6% | 0.042% | |
| 5/14/2025 | AlphaQuest LLC | 9,358 | $206K | 0.0% | +324.8% | 0.009% | |
| 5/14/2025 | Candriam S.C.A. | 225,796 | $4.97M | 0.0% | -11.1% | 0.216% | |
| 5/14/2025 | Hsbc Holdings PLC | 9,874 | $219K | 0.0% | -8.2% | 0.009% | |
| 5/14/2025 | Wellington Management Group LLP | 113,303 | $2.49M | 0.0% | -44.2% | 0.108% | |
| 5/13/2025 | Northern Trust Corp | 606,692 | $13.35M | 0.0% | -0.8% | 0.579% | |
| 5/13/2025 | American Century Companies Inc. | 779,766 | $17.16M | 0.0% | +1.2% | 0.744% | |
| 5/13/2025 | Aberdeen Group plc | 313,025 | $6.89M | 0.0% | +75.8% | 0.299% | |
| 5/13/2025 | Caitong International Asset Management Co. Ltd | 3,194 | $70K | 0.1% | +55.6% | 0.003% | |
| 5/12/2025 | Nuveen LLC | 202,580 | $4.46M | 0.0% | N/A | 0.193% | |
| 5/12/2025 | Invesco Ltd. | 48,130 | $1.06M | 0.0% | +10.8% | 0.046% | |
| 5/12/2025 | Swiss National Bank | 82,600 | $1.82M | 0.0% | +12.2% | 0.079% | |
| 5/9/2025 | Deutsche Bank AG | 376,060 | $8.27M | 0.0% | +36.3% | 0.359% | |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 521,261 | $11.47M | 0.0% | -3.0% | 0.498% | |
| 5/9/2025 | Vanguard Group Inc. | 4,294,404 | $94.48M | 0.0% | -3.9% | 4.099% | |
| 5/7/2025 | Zurcher Kantonalbank Zurich Cantonalbank | 7,073 | $156K | 0.0% | -10.4% | 0.007% | |
| 5/7/2025 | TD Asset Management Inc | 33,200 | $730K | 0.0% | N/A | 0.032% | |
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| 5/7/2025 | Skandinaviska Enskilda Banken AB publ | 37,591 | $827K | 0.0% | N/A | 0.036% | |
| 5/6/2025 | Readystate Asset Management LP | 361,233 | $7.95M | 0.3% | +1,591.0% | 0.345% | |
| 5/6/2025 | Universal Beteiligungs und Servicegesellschaft mbH | 89,425 | $1.97M | 0.0% | -0.7% | 0.085% | |
| 5/5/2025 | Jennison Associates LLC | 128,746 | $2.83M | 0.0% | N/A | 0.123% | |
| 5/1/2025 | Arizona State Retirement System | 12,201 | $268K | 0.0% | +12.3% | 0.012% | |
| 4/30/2025 | Alps Advisors Inc. | 67,975 | $1.50M | 0.0% | -11.2% | 0.065% | |
| 4/30/2025 | China Universal Asset Management Co. Ltd. | 18,993 | $418K | 0.0% | -5.4% | 0.018% | |
| 4/29/2025 | Moody Aldrich Partners LLC | 182,095 | $4.01M | 0.8% | -3.1% | 0.174% | |
| 4/15/2025 | SG Americas Securities LLC | 12,883 | $283K | 0.0% | N/A | 0.012% | |
| 4/10/2025 | Contravisory Investment Management Inc. | 10,209 | $225K | 0.0% | N/A | 0.010% | |
| 4/8/2025 | Rhumbline Advisers | 108,837 | $2.39M | 0.0% | +6.3% | 0.104% | |
| 4/7/2025 | GAMMA Investing LLC | 30,954 | $681K | 0.0% | +2,243.2% | 0.030% | |
| 3/24/2025 | Wellington Management Group LLP | 202,893 | $5.42M | 0.0% | -1.2% | 0.213% | |
| 2/28/2025 | Universal Beteiligungs und Servicegesellschaft mbH | 90,031 | $2.40M | 0.0% | N/A | 0.095% | |
| 2/25/2025 | Polar Asset Management Partners Inc. | 64,279 | $1.72M | 0.0% | -59.2% | 0.068% | |
| 2/19/2025 | GF Fund Management CO. LTD. | 1,988 | $53K | 0.0% | N/A | 0.002% | |
| 2/18/2025 | Neo Ivy Capital Management | 9,720 | $259K | 0.1% | N/A | 0.010% | |
| 2/18/2025 | Frazier Life Sciences Management L.P. | 1,271,245 | $33.94M | 1.4% | -55.1% | 1.343% | |
| 2/17/2025 | UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 279,125 | $7.45M | 0.0% | +231.1% | 0.295% | |
| 2/17/2025 | Woodline Partners LP | 567,218 | $15.15M | 0.1% | +7.5% | 0.599% | |
| 2/17/2025 | Soleus Capital Management L.P. | 183,300 | $4.89M | 0.3% | N/A | 0.194% | |
| 2/17/2025 | Squarepoint Ops LLC | 26,358 | $704K | 0.0% | +58.5% | 0.028% | |
| 2/17/2025 | Two Sigma Investments LP | 131,667 | $3.52M | 0.0% | -49.6% | 0.139% | |
| 2/17/2025 | Tang Capital Management LLC | 300,000 | $8.01M | 0.5% | N/A | 0.317% | |
| 2/17/2025 | Stempoint Capital LP | 132,706 | $3.54M | 0.9% | +566.9% | 0.140% | |
| 2/17/2025 | Rafferty Asset Management LLC | 11,906 | $318K | 0.0% | -10.1% | 0.013% | |
| 2/17/2025 | Point72 Asset Management L.P. | 106,562 | $2.85M | 0.0% | N/A | 0.113% | |
| 2/17/2025 | Polar Asset Management Partners Inc. | 64,279 | $1.72M | 0.0% | -59.2% | 0.068% | |
| 2/17/2025 | ProShare Advisors LLC | 24,928 | $666K | 0.0% | +29.4% | 0.026% | |
| 2/17/2025 | MPM Bioimpact LLC | 1,079,316 | $28.82M | 4.1% | +17.7% | 1.140% | |
| 2/17/2025 | Paradigm Biocapital Advisors LP | 4,493,929 | $119.99M | 4.2% | +61.1% | 4.746% | |
| 2/17/2025 | Parkman Healthcare Partners LLC | 381,173 | $10.18M | 1.4% | -42.0% | 0.403% | |
| 2/17/2025 | Nuveen Asset Management LLC | 428,858 | $11.45M | 0.0% | +58.6% | 0.453% | |
| 2/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,313 | $1.10M | 0.0% | +4.0% | 0.044% | |
| 2/17/2025 | J. Goldman & Co LP | 107,278 | $2.86M | 0.1% | +82.9% | 0.113% | |
| 2/17/2025 | Janus Henderson Group PLC | 4,983,940 | $133.04M | 0.1% | +9.3% | 5.263% | |
| 2/17/2025 | Graham Capital Management L.P. | 18,415 | $492K | 0.0% | +15.8% | 0.019% | |
| 2/17/2025 | Granahan Investment Management LLC | 300,013 | $8.01M | 0.3% | -41.4% | 0.317% | |
| 2/17/2025 | Ensign Peak Advisors Inc | 80,509 | $2.15M | 0.0% | N/A | 0.085% | |
| 2/17/2025 | Deutsche Bank AG | 275,837 | $7.37M | 0.0% | +26.6% | 0.291% | |
| 2/17/2025 | D. E. Shaw & Co. Inc. | 686,371 | $18.33M | 0.0% | +50.7% | 0.725% | |
| 2/17/2025 | DAFNA Capital Management LLC | 187,140 | $5.00M | 1.3% | -17.9% | 0.198% | |
| 2/17/2025 | Deerfield Management Company L.P. Series C | 2,078,509 | $55.50M | 1.1% | +16.7% | 2.195% | |
| 2/17/2025 | Driehaus Capital Management LLC | 1,493,791 | $39.88M | 0.3% | -23.5% | 1.578% | |
| 2/17/2025 | Deep Track Capital LP | 710,421 | $18.97M | 0.7% | -35.4% | 0.750% | |
| 2/17/2025 | Crestline Management LP | 13,268 | $354K | 0.0% | -50.8% | 0.014% | |
| 2/17/2025 | Cubist Systematic Strategies LLC | 219,549 | $5.86M | 0.0% | N/A | 0.232% | |
| 2/17/2025 | Braidwell LP | 2,332,196 | $62.27M | 1.8% | +19.1% | 2.463% | |
| 2/17/2025 | Brevan Howard Capital Management LP | 25,346 | $677K | 0.0% | +125.3% | 0.027% | |
| 2/17/2025 | Baker BROS. Advisors LP | 6,155,940 | $164.36M | 1.8% | +5.4% | 6.501% | |
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| 2/17/2025 | Balyasny Asset Management L.P. | 23,364 | $624K | 0.0% | N/A | 0.025% | |
| 2/17/2025 | Bamco Inc. NY | 60,000 | $1.60M | 0.0% | N/A | 0.063% | |
| 2/17/2025 | Bank of America Corp DE | 48,907 | $1.31M | 0.0% | -84.1% | 0.052% | |
| 2/17/2025 | BNP Paribas Financial Markets | 33,082 | $883K | 0.0% | N/A | 0.035% | |
| 2/17/2025 | Ameriprise Financial Inc. | 22,584 | $603K | 0.0% | N/A | 0.024% | |
| 2/17/2025 | Algert Global LLC | 110,259 | $2.94M | 0.1% | +1,073.0% | 0.116% | |
| 2/17/2025 | Ally Bridge Group NY LLC | 83,176 | $2.22M | 1.9% | -55.7% | 0.088% | |
| 2/17/2025 | Acuta Capital Partners LLC | 87,658 | $2.34M | 2.4% | +39.1% | 0.093% | |
| 2/14/2025 | Novo Holdings A S | 5,000,000 | $133.50M | 8.1% | -9.9% | 5.280% | |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 268,509 | $7.17M | 0.0% | -50.8% | 0.284% | |
