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Karyopharm Therapeutics (KPTI) Institutional Ownership

Karyopharm Therapeutics logo
$3.93 +0.12 (+3.15%)
Closing price 08/1/2025 04:00 PM Eastern
Extended Trading
$3.94 +0.01 (+0.25%)
As of 08/1/2025 04:10 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.
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Institutional Ownership Changes (13F Filings) for Karyopharm Therapeutics (NASDAQ:KPTI)

Current
Institutional Ownership
Percentage
66.44%
Number of
Institutional Buyers
(last 12 months)
22
Total
Institutional Inflows
(last 12 months)
$78.97M
Number of
Institutional Sellers
(last 12 months)
22
Total
Institutional Outflows
(last 12 months)
$161.60M
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KPTI Institutional Buying and Selling by Quarter

Karyopharm Therapeutics Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
6/27/2025Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.989%
5/19/2025Jane Street Group LLC11,420$43K0.0%-98.5%0.132%
5/16/2025Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.997%
5/16/2025Adage Capital Partners GP L.L.C.421,322$1.58M0.0%-93.3%4.916%
5/15/2025Birchview Capital LP27,985$105K0.1%-93.3%0.327%
5/15/2025Palo Alto Investors LP324,032$1.21M0.2%-93.4%3.781%
5/14/2025T. Rowe Price Investment Management Inc.139,646$523K0.0%N/A1.629%
5/13/2025Altium Capital Management LLC49,333$185K0.4%-93.3%0.576%
5/5/2025C WorldWide Group Holding A S100,000$374K0.0%-93.3%1.167%
4/29/2025Bank of New York Mellon Corp11,086$41K0.0%-93.3%0.129%
2/17/2025Velan Capital Investment Management LP40,000$27K0.0%N/A0.032%
2/17/2025Two Sigma Advisers LP76,600$52K0.0%+145.5%0.061%
2/17/2025Two Sigma Investments LP137,786$93K0.0%+60.3%0.109%
2/17/2025Shay Capital LLC172,153$116K0.0%N/A0.136%
2/17/2025Millennium Management LLC1,154,414$781K0.0%-8.0%0.915%
2/17/2025Focus Partners Wealth45,818$31K0.0%N/A0.036%
2/17/2025D. E. Shaw & Co. Inc.229,685$155K0.0%-78.1%0.182%
2/17/2025Cubist Systematic Strategies LLC328,807$222K0.0%-33.7%0.261%
2/17/2025Bank of America Corp DE161,708$109K0.0%-29.4%0.128%
2/17/2025BNP Paribas Financial Markets1,313,893$889K0.0%-33.7%1.041%
2/14/2025Jane Street Group LLC748,306$506K0.0%+265.5%0.593%
2/14/2025Northern Trust Corp283,729$192K0.0%+23.5%0.225%
2/14/2025Birchview Capital LP419,832$284K0.2%-10.6%0.333%
2/14/2025Opti Capital Management LP125,000$85K0.0%N/A0.099%
2/14/2025Adage Capital Partners GP L.L.C.6,319,842$4.27M0.0%+46.3%5.008%
2/14/2025Price T Rowe Associates Inc. MD64,300$44K0.0%-52.3%0.051%
2/14/2025Silverarc Capital Management LLC595,990$403K0.1%+6.7%0.472%
2/14/2025Eversept Partners LP2,088,757$1.41M0.1%-62.4%1.655%
2/14/2025TD Waterhouse Canada Inc.48,049$32K0.0%N/A0.038%
2/13/2025Marshall Wace LLP2,401,413$1.63M0.0%+15.3%1.903%
2/13/2025Renaissance Technologies LLC1,202,590$813K0.0%-3.1%0.953%
2/12/2025Geode Capital Management LLC1,392,314$942K0.0%+2.7%1.103%
11/19/2024Barclays PLC95,767$79K0.0%-89.0%0.076%
11/16/2024Geode Capital Management LLC1,355,392$1.13M0.0%+3.3%1.082%
11/15/2024Barclays PLC95,767$79K0.0%-89.0%0.076%
11/15/2024Jane Street Group LLC204,750$170K0.0%-86.8%0.163%
11/15/2024State Street Corp409,510$340K0.0%-9.8%0.327%
11/15/2024Point72 Asia Singapore Pte. Ltd.82,446$68K0.0%-50.1%0.066%
11/13/2024BNP Paribas Financial Markets1,982,354$1.65M0.0%-12.8%1.582%
11/13/2024FMR LLC369,723$307K0.0%+26.1%0.295%
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11/5/2024 GSA Capital Partners LLP1,775,700$1.47M0.1%+80.6%1.424%
10/10/2024 Exchange Traded Concepts LLC218,791$182K0.0%+34.9%0.176%
9/16/2024Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
9/16/2024Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.456%
9/16/2024Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/15/2024AQR Capital Management LLC748,020$649K0.0%+494.5%0.600%
8/15/2024Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/14/2024Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.457%
8/14/2024Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
8/14/2024Marshall Wace LLP2,580,863$2.25M0.0%-0.6%2.071%
8/12/2024XTX Topco Ltd140,576$122K0.0%-42.1%0.113%
8/9/2024Renaissance Technologies LLC756,227$656K0.0%-16.6%0.607%
8/6/2024Acadian Asset Management LLC194,168$167K0.0%N/A0.156%
8/6/2024Los Angeles Capital Management LLC354,020$307K0.0%-8.6%0.284%
7/26/2024Bank of New York Mellon Corp166,315$144K0.0%-65.9%0.133%
5/17/2024Ikarian Capital LLC409,355$618K0.1%+2.3%0.348%
5/10/2024Vanguard Group Inc.8,338,401$12.59M0.0%-4.3%7.160%
5/3/2024 GSA Capital Partners LLP1,299,151$1.96M0.2%-44.4%1.115%
4/24/2024 Simplicity Wealth LLC44,011$66K0.0%N/A0.038%
2/15/2024Birchview Capital LP469,832$406K0.3%-17.8%0.410%
2/12/2024Monashee Investment Management LLC132,435$115K0.0%N/A0.116%
2/8/2024Panagora Asset Management Inc.227,445$197K0.0%N/A0.199%
2/7/2024BNP Paribas Financial Markets1,769,184$1.53M0.0%+6.5%1.545%
2/6/2024Los Angeles Capital Management LLC391,540$339K0.0%N/A0.342%
1/29/2024Simplicity Solutions LLC37,938$33K0.0%N/A0.033%
1/25/2024 Bleakley Financial Group LLC37,938$33K0.0%N/A0.033%
1/12/2024SG Americas Securities LLC73,430$64K0.0%+295.0%0.064%
1/5/2024 Exchange Traded Concepts LLC115,864$100K0.0%+34.0%0.101%
11/15/2023Tejara Capital Ltd1,077,388$1.44M0.8%-5.8%0.941%
11/15/2023 GSA Capital Partners LLP568,298$762K0.1%N/A0.496%
11/14/2023Avidity Partners Management LP8,298,570$11.12M0.4%-0.9%7.246%
11/13/2023Silverarc Capital Management LLC561,955$753K0.2%+8.3%0.491%
11/13/2023Tejara Capital Ltd1,077,388$1.44M1.1%-5.8%0.941%
11/8/2023Wade G W & Inc.45,140$60K0.0%N/A0.039%
11/7/2023Quantbot Technologies LP21,699$29K0.0%-60.1%0.019%
11/7/2023Barclays PLC1,152,298$1.54M0.0%+4.2%1.008%
10/18/2023 Exchange Traded Concepts LLC86,484$116K0.0%+30.2%0.076%
8/15/2023Silverarc Capital Management LLC518,985$929K0.3%-66.3%0.454%
8/14/2023Prelude Capital Management LLC15,933$29K0.0%-62.4%0.014%
8/14/2023Graham Capital Management L.P.62,414$112K0.0%N/A0.055%
8/11/2023Rubric Capital Management LP919,196$1.65M0.1%-79.3%0.804%
8/11/2023Tejara Capital Ltd1,143,991$2.05M1.0%+128.1%1.000%
8/11/2023 Platinum Investment Management Ltd.500,000$895K0.0%N/A0.437%
8/11/2023ExodusPoint Capital Management LP2,382,451$4.27M0.0%N/A2.083%
8/9/2023BNP Paribas Arbitrage SNC461,096$825K0.0%+24.8%0.403%
8/8/2023AlphaCentric Advisors LLC810,000$1.45M0.8%+237.5%0.708%
8/8/2023Candriam S.C.A.1,435,694$2.57M0.0%-6.5%1.255%
8/7/2023Principal Financial Group Inc.32,838$59K0.0%-32.8%0.029%
8/7/2023Acadian Asset Management LLC98,946$177K0.0%N/A0.087%
8/4/2023American International Group Inc.54,514$98K0.0%+45.1%0.048%
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7/26/2023Simplicity Solutions LLC15,966$29K0.0%N/A0.014%
7/20/2023 Exchange Traded Concepts LLC66,422$119K0.0%N/A0.058%
7/19/2023 Kennedy Investment Group35,000$63K0.0%+75.0%0.031%
7/10/2023SG Americas Securities LLC14,868$27K0.0%-58.5%0.013%
6/1/2023Prelude Capital Management LLC42,427$165K0.0%-27.5%0.037%
6/1/2023 Kennedy Investment Group20,000$78K0.0%N/A0.018%
5/16/2023Altium Capital Management LP505,781$1.97M1.1%N/A0.444%
5/15/2023Affinity Asset Advisors LLC460,979$1.79M0.6%-30.3%0.404%
5/15/2023Rubric Capital Management LP4,441,056$17.28M0.4%-46.5%3.895%
5/12/2023AlphaCentric Advisors LLC240,000$934K0.6%N/A0.211%
(Data available from 1/1/2016 forward)

KPTI Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of KPTI shares?

During the previous two years, 61 institutional investors and hedge funds held shares of Karyopharm Therapeutics. The most heavily invested institutionals were Vanguard Group Inc. ($12.59M), Avidity Partners Management LP ($11.12M), ExodusPoint Capital Management LP ($4.27M), Candriam S.C.A. ($2.57M), Rubric Capital Management LP ($1.65M), Marshall Wace LLP ($1.63M), and Adage Capital Partners GP L.L.C. ($1.58M).Learn more on Karyopharm Therapeutics' institutional investors.

What percentage of Karyopharm Therapeutics' stock is owned by institutional investors?

66.44% of Karyopharm Therapeutics' stock is owned by institutional investors. Learn more on KPTI's institutional investor holdings.

Which institutional investors have been buying Karyopharm Therapeutics' stock?

Of the 40 institutional investors that purchased Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: ExodusPoint Capital Management LP ($2.38M), Adage Capital Partners GP L.L.C. ($2M), GSA Capital Partners LLP ($1.36M), Cubist Systematic Strategies LLC ($1.14M), Tejara Capital Ltd ($642.43K), AQR Capital Management LLC ($622.19K), and AlphaCentric Advisors LLC ($570K).

How much institutional buying is happening at Karyopharm Therapeutics?

Institutional investors have bought a total of 6,985,260 shares in the last 24 months. This purchase volume represents approximately $78.97M in transactions.

Which of Karyopharm Therapeutics' major shareholders have been selling company stock?

Of the 22 institutional investors that sold Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Adage Capital Partners GP L.L.C. ($5.90M), Palo Alto Investors LP ($4.58M), Eversept Partners LP ($3.46M), Goldman Sachs Group Inc. ($2.50M), Jane Street Group LLC ($2.08M), Barclays PLC ($1.56M), and C WorldWide Group Holding A S ($1.40M).

How much institutional selling is happening at Karyopharm Therapeutics?

Institutional investors have sold a total of 25,417,193 shares in the last 24 months. This volume of shares sold represents approximately $161.60M in transactions.


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This page (NASDAQ:KPTI) was last updated on 8/3/2025 by MarketBeat.com Staff
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