Karyopharm Therapeutics (KPTI) Short Interest Ratio & Short Volume $4.39 -0.04 (-0.79%) As of 10:50 AM Eastern This is a fair market value price provided by Polygon.io. Learn more. Add Compare Share Share Short Interest Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Karyopharm Therapeutics Short Interest DataKaryopharm Therapeutics (KPTI) has a short interest of 2.09 million shares, representing 26.26% of the float (the number of shares available for trading by the public). This marks a 5.56% increase in short interest from the previous month. The short interest ratio (days to cover) is 15.9, indicating that it would take 15.9 days of the average trading volume of 81,637 shares to cover all short positions.Current Short Interest2,090,000 sharesPrevious Short Interest1,980,000 sharesChange Vs. Previous Month+5.56%Dollar Volume Sold Short$11.37 millionShort Interest Ratio15.9 Days to CoverLast Record DateMay 15, 2025Outstanding Shares8,640,000 sharesFloat Size7,960,000 sharesShort Percent of Float26.26%Today's Trading Volume11,182 sharesAverage Trading Volume81,637 sharesToday's Volume Vs. Average14% Short Selling Karyopharm Therapeutics? Sign up to receive the latest short interest report for Karyopharm Therapeutics and its competitors with MarketBeat's FREE newsletter. Email Address Skip Charts & View Short Interest HistoryShort Interest ChartDays to Cover ChartShort Percent of Float ChartKPTI Short Interest Over TimeKPTI Days to Cover Over TimeKPTI Percentage of Float Shorted Over Time Karyopharm Therapeutics Short Interest History Export to ExcelReport DateTotal Shares Sold ShortDollar Volume Sold ShortChange from Previous ReportPercentage of Float ShortedDays to CoverPrice on Report Date 5/15/20252,090,000 shares $11.37 million +5.6%26.3%15.9 $5.44 4/30/20251,980,000 shares $13.37 million +8.2%25.1%15.5 $6.75 4/15/20251,830,000 shares $7.80 million +39.7%23.1%15 $4.26 3/31/20251,310,000 shares $4.90 million +22.4%16.7%11.4 $3.74 3/15/20251,070,000 shares $7.22 million +0.9%13.6%11.3 $6.75 2/28/20251,060,000 shares $8.43 million -23.7%13.5%11.5 $7.95 2/15/20251,390,000 shares $12.86 million -93.1%17.9%19.2 $9.25 1/31/202520,140,000 shares $12.53 million +1.7%N/A22.3 $0.62 1/15/202519,800,000 shares $12.59 million +1.8%N/A20.2 $0.64 12/31/202419,460,000 shares $13.16 million -1.7%N/A21 $0.68 Get the Latest News and Ratings for KPTI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 12/15/202419,790,000 shares $13.85 million +4.6%N/A21.1 $0.70 11/30/202418,920,000 shares $15.99 million -0.1%N/A23.2 $0.85 11/15/202418,930,000 shares $15.41 million +7.0%N/A25.3 $0.81 10/31/202417,690,000 shares $17.51 million +0.5%N/A23.7 $0.99 10/15/202417,610,000 shares $14.74 million -5.3%N/A27.2 $0.84 9/30/202418,600,000 shares $15.44 million +3.7%N/A24.6 $0.83 9/15/202417,930,000 shares $13.70 million -3.2%N/A18.3 $0.76 8/31/202418,520,000 shares $14.08 million +1.4%N/A18.2 $0.76 8/15/202418,260,000 shares $15.23 million -0.6%N/A15.3 $0.83 7/31/202418,370,000 shares $18.16 million -2.8%N/A13.5 $0.99 7/15/202418,890,000 shares $18.29 million -12.7%N/A13.6 $0.97 6/30/202421,640,000 shares $18.77 million +1.2%N/A15.1 $0.87 6/15/202421,380,000 shares $20.45 million +6.1%N/A17.7 $0.96 5/31/202420,150,000 shares $19.53 million +14.8%N/A16.8 $0.97 5/15/202417,560,000 shares $19.84 million +2.3%N/A13.6 $1.13 4/30/202417,170,000 shares $17.69 million -27.1%N/A12.1 $1.03 4/15/202423,560,000 shares $27.21 million +2.7%N/A13.5 $1.16 3/31/202422,950,000 shares $34.65 million -0.8%N/A13.3 $1.51 3/15/202423,130,000 shares $34.93 million -1.3%N/A13.1 $1.51 2/29/202423,440,000 shares $27.19 million +0.0%N/A12.5 $1.16 2/15/202423,430,000 shares $30.46 million +24.0%N/A13.3 $1.30 1/31/202418,900,000 shares $14.18 million +1.2%N/A12 $0.75 1/15/202418,680,000 shares $13.90 million +4.1%N/A15.8 $0.74 12/31/202317,950,000 shares $15.53 million +1.2%N/A15.6 $0.87 12/15/202317,740,000 shares $13.75 million -4.3%N/A14.4 $0.77 11/30/202318,530,000 shares $14.27 million -1.9%N/A16.4 $0.77 11/15/202318,890,000 shares $13.71 million +5.5%N/A16.3 $0.73 10/31/202317,910,000 shares $15.58 million +1.8%N/A13.9 $0.87 10/15/202317,590,000 shares $20.93 million +5.7%N/A12.1 $1.19 9/30/202316,640,000 shares $22.30 million +10.6%N/A7.7 $1.34The DOJ Just Paved the Way for Account Seizures (Ad)Washington is running out of money…And guess where they'll look next? When governments go broke, they take from the people. It's happened before, and it's happening again. The Department of Justice just admitted that cash isn't legally YOUR property.Get your free guide now by clicking here >> 9/15/202315,040,000 shares $18.20 million +2.2%N/A6.5 $1.21 8/31/202314,710,000 shares $18.83 million +1.4%N/A5.2 $1.28 8/15/202314,510,000 shares $25.54 million -3.3%N/A4.9 $1.76 7/31/202315,000,000 shares $27 million +8.3%N/A4.8 $1.80 7/15/202313,850,000 shares $21.61 million +10.4%N/A4.2 $1.56 6/30/202312,550,000 shares $22.46 million -24.0%N/A4.3 $1.79 6/15/202316,520,000 shares $34.20 million +0.3%N/A5.7 $2.07 5/31/202316,470,000 shares $37.22 million -3.8%N/A6.3 $2.26 5/15/202317,120,000 shares $42.46 million -4.7%N/A6.6 $2.48 4/30/202317,960,000 shares $64.30 million +1.1%N/A6.9 $3.58 4/15/202317,760,000 shares $76.72 million -7.0%N/A7.6 $4.32 3/31/202319,090,000 shares $74.26 million +14.1%N/A7.3 $3.89 3/15/202316,730,000 shares $58.22 million -8.7%N/A6.1 $3.48 2/28/202318,330,000 shares $55.36 million -14.1%N/A6.6 $3.02 2/15/202321,330,000 shares $78.07 million -7.8%N/A7.9 $3.66 1/31/202323,140,000 shares $76.36 million +6.8%N/A8.8 $3.30 1/15/202321,670,000 shares $71.51 million +3.6%N/A8.1 $3.30 12/30/202220,910,000 shares $71.09 million +27.3%N/A9 $3.40 12/15/202216,430,000 shares $53.07 million +20.6%23.0%7.8 $3.23 11/30/202213,620,000 shares $72.05 million -0.2%19.1%7.7 $5.29 11/15/202213,640,000 shares $76.79 million +0.9%19.1%7.6 $5.63 10/31/202213,520,000 shares $64.36 million -1.2%18.6%7.5 $4.76 10/15/202213,690,000 shares $65.58 million +1.9%19.1%7.5 $4.79 9/30/202213,440,000 shares $73.38 million -5.8%18.8%7.3 $5.46 9/15/202214,260,000 shares $73.72 million -5.5%19.9%7.5 $5.17 8/31/202215,090,000 shares $76.36 million -11.4%21.1%7.1 $5.06 8/15/202217,030,000 shares $93.15 million -5.2%23.8%7.8 $5.47 7/31/202217,970,000 shares $76.37 million -0.6%25.2%7.5 $4.25 7/15/202218,080,000 shares $85.16 million +10.7%26.2%7.5 $4.71 6/30/202216,340,000 shares $73.69 million +6.5%23.7%6.6 $4.51 6/15/202215,350,000 shares $69.84 million +6.1%28.8%6.2 $4.55 5/31/202214,470,000 shares $90.87 million -0.7%21.0%5.6 $6.28 5/15/202214,570,000 shares $77.80 million +4.4%21.1%4.6 $5.34 4/30/202213,950,000 shares $85.10 million +3.7%20.2%3.7 $6.10 4/15/202213,450,000 shares $104.91 million -2.9%19.5%3.6 $7.80 3/31/202213,850,000 shares $102.07 million +21.1%20.3%3.7 $7.37 3/15/202211,440,000 shares $71.16 million -8.4%16.7%3.2 $6.22 2/28/202212,490,000 shares $129.02 million +13.3%18.3%3.5 $10.33 2/15/202211,020,000 shares $129.04 million -3.4%16.7%3.5 $11.71 1/31/202211,410,000 shares $101.55 million -2.6%17.4%4.9 $8.90 1/15/202211,710,000 shares $94.15 million -3.4%17.8%5 $8.04 12/31/202112,120,000 shares $77.93 million -10.1%18.4%5.6 $6.43 12/15/202113,480,000 shares $84.25 million +6.1%20.5%6.5 $6.25 11/30/202112,710,000 shares $88.33 million -1.8%19.3%7.1 $6.95 11/15/202112,940,000 shares $105.07 million -1.4%19.7%7.5 $8.12 10/29/202113,120,000 shares $71.64 million -1.7%20.0%7.3 $5.46 10/15/202113,340,000 shares $74.57 million -7.6%20.3%8.8 $5.59 9/30/202114,440,000 shares $84.04 million +9.5%22.0%9.8 $5.82 9/15/202113,190,000 shares $74.92 million -5.3%20.1%8.8 $5.68 8/31/202113,930,000 shares $80.79 million -0.8%21.2%9.3 $5.80The DOJ Just Paved the Way for Account Seizures (Ad)Washington is running out of money…And guess where they'll look next? When governments go broke, they take from the people. It's happened before, and it's happening again. The Department of Justice just admitted that cash isn't legally YOUR property.Get your free guide now by clicking here >> 8/13/202114,040,000 shares $68.52 million -6.7%21.4%9.2 $4.88 7/30/202115,050,000 shares $125.37 million +0.1%22.9%10.1 $8.33 7/15/202115,040,000 shares $138.22 million -0.1%23.0%10.3 $9.19 6/30/202115,050,000 shares $155.32 million +4.2%23.0%9.5 $10.32 6/15/202114,440,000 shares $144.54 million +5.3%22.1%8.4 $10.01 5/28/202113,720,000 shares $127.32 million -7.7%21.0%7.9 $9.28 5/14/202114,860,000 shares $138.35 million -0.1%N/A7.8 $9.31 4/30/202114,870,000 shares $142.16 million -6.5%N/A6.9 $9.56 4/15/202115,900,000 shares $162.18 million +2.7%N/A6.4 $10.20 3/31/202115,480,000 shares $154.10 million -0.7%N/A6.1 $9.96 3/15/202115,590,000 shares $191.91 million -7.0%N/A5.4 $12.31 2/26/202116,760,000 shares $244.03 million +6.5%N/A5.7 $14.56 2/12/202115,740,000 shares $241.61 million +10.9%N/A5.6 $15.35 1/29/202114,190,000 shares $212.85 million -10.5%N/A5.5 $15.00 1/15/202115,860,000 shares $242.98 million +2.8%N/A7 $15.32 12/31/202015,430,000 shares $236.08 million +4.9%N/A7.8 $15.30 12/15/202014,710,000 shares $229.03 million -1.9%N/A8.5 $15.57 11/30/202015,000,000 shares $227.10 million -3.4%N/A10.9 $15.14 11/15/202015,520,000 shares $238.39 million -1.3%N/A12.7 $15.36 10/30/202015,730,000 shares $245.39 million +1.8%N/A13 $15.60 10/15/202015,450,000 shares $245.66 million +3.2%N/A12.2 $15.90 9/30/202014,970,000 shares $218.56 million +4.0%N/A10.8 $14.60 9/15/202014,400,000 shares $228.96 million +0.8%N/A9.5 $15.90 8/31/202014,280,000 shares $217.20 million -7.8%N/A8.4 $15.21 8/14/202015,490,000 shares $227.39 million -0.5%N/A8.4 $14.68 7/31/202015,570,000 shares $249.90 million -6.7%N/A8.2 $16.05 7/15/202016,690,000 shares $322.28 million +7.1%N/A9 $19.31 6/30/202015,580,000 shares $295.09 million +7.6%N/A8.9 $18.94 6/15/202014,480,000 shares $253.69 million +4.5%N/A8.5 $17.52 KPTI Short Interest - Frequently Asked Questions What is Karyopharm Therapeutics' current short interest? Short interest is the volume of Karyopharm Therapeutics shares that have been sold short but have not yet been covered or closed out. As of May 15th, investors have sold 2,090,000 shares of KPTI short. 26.26% of Karyopharm Therapeutics' shares are currently sold short. Learn More on Karyopharm Therapeutics' current short interest. What is a good short interest ratio for Karyopharm Therapeutics? The short interest ratio, also known as the "days to cover ratio", is calculated by dividing the number of shares of a stock sold short divided by its average trading volume. A short interest ratio ranging between 1 and 4 generally indicates strong positive sentiment about a stock and a lack of short sellers. A short interest ratio of 10 or greater indicates strong pessimism about a stock. KPTI shares currently have a short interest ratio of 16.0. Learn More on Karyopharm Therapeutics's short interest ratio. What is a good short interest percentage for Karyopharm Therapeutics? Companies that have a short interest as a percentage of float below 10% indicates positive investor sentiment and few short sellers. Stocks with a short interest percentage above 10% is considered high, suggesting some investors are pessimistic about the stock. Companies with a short interest percentage of 20% or more indicates widespread negative sentiment. 26.26% of Karyopharm Therapeutics' floating shares are currently sold short. Is Karyopharm Therapeutics' short interest increasing or decreasing? Karyopharm Therapeutics saw a increase in short interest during the month of May. As of May 15th, there was short interest totaling 2,090,000 shares, an increase of 5.6% from the previous total of 1,980,000 shares. Changes in short volume can be used to identify positive and negative investor sentiment. Investors that short sell a stock are betting that its price will decline in the future. An increase in short sale volume suggests bearish (negative) sentiment among investors. A decrease on short sale volume suggests bullish (positive) sentiment. What is Karyopharm Therapeutics' float size? Karyopharm Therapeutics currently has issued a total of 8,640,000 shares. Some of Karyopharm Therapeutics' outstanding shares are available for trading, while others are subject to various restrictions. The public float, also referred to as floating shares or "the float", are shares that publicly owned, unrestricted and available to trade on the open market. Karyopharm Therapeutics currently has a public float of 7,960,000 shares. How does Karyopharm Therapeutics' short interest compare to its competitors? 26.26% of Karyopharm Therapeutics' shares are currently sold short. Here is how the short interest of companies in the industry of "pharmaceutical products" compare to Karyopharm Therapeutics: Eupraxia Pharmaceuticals Inc. (0.59%), Larimar Therapeutics, Inc. (15.96%), FitLife Brands, Inc. (0.18%), Alector, Inc. (7.10%), Black Diamond Therapeutics, Inc. (15.67%), Enanta Pharmaceuticals, Inc. (14.35%), Compugen Ltd. (1.91%), Greenwich LifeSciences, Inc. (16.86%), Protara Therapeutics, Inc. (12.46%), Protalix BioTherapeutics, Inc. (1.23%), Which stocks are the most shorted right now? As of the most recent reporting period, the following stocks had the largest short interest positions: Invesco QQQ ($29.20 billion), Strategy Incorporated ($10.88 billion), iShares 20+ Year Treasury Bond ETF ($10.04 billion), Capital One Financial Co. ($5.51 billion), Charter Communications, Inc. ($5.00 billion), Super Micro Computer, Inc. ($4.43 billion), Apollo Global Management, Inc. ($4.02 billion), Hims & Hers Health, Inc. ($3.65 billion), VanEck Semiconductor ETF ($3.27 billion), and Coinbase Global, Inc. ($3.10 billion). View all of the most shorted stocks. What does it mean to sell short Karyopharm Therapeutics stock? Short selling KPTI is an investing strategy that aims to generate trading profit from Karyopharm Therapeutics as its price is falling. KPTI shares are trading down $0.04 today. To short a stock, an investor borrows shares, sells them and buys the shares back on the public market later to return it to the lender. Short sellers are betting that a stock will decline in price. If the stock does drop after selling, the short seller buys it back at a lower price and returns it to the lender. The difference between the sell price and the buy price is the trader's profit. How does a short squeeze work against Karyopharm Therapeutics? A short squeeze for Karyopharm Therapeutics occurs when it has a large amount of short interest and its stock increases in price. This forces short sellers to cover their short interest positions by buying actual shares of KPTI, which in turn drives the price of the stock up even further. How often is Karyopharm Therapeutics' short interest reported? Short interest is typically published by a stock exchange once per month. However, NASDAQ publishes a report for U.S. stocks, including KPTI, twice per month. The most recent reporting period available is May, 15 2025. More Short Interest Resources from MarketBeat Related Companies EPRX Short Interest LRMR Short Interest FTLF Short Interest ALEC Short Interest BDTX Short Interest ENTA Short Interest CGEN Short Interest GLSI Short Interest TARA Short Interest PLX Short Interest Short Interest Tools Stocks to Short Largest Short Interest Positions Short Interest Increases Short Interest Decreases Short Interest Reporting Dates This page (NASDAQ:KPTI) was last updated on 6/11/2025 by MarketBeat.com Staff From Our PartnersTrump wipes out trillions overnight…Is there anybody more powerful than Donald Trump right now? In a single tariff announcement, he wiped out n...Porter & Company | SponsoredElon’s NEXT Big IPO?Cancel your internet TODAY!? 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