This company has been marked as potentially delisted and may not be actively trading. Nightstar Therapeutics (NITE) Competitors Add Compare Share Share Competitors Stock AnalysisCompetitorsTrendsBuy This Stock NITE vs. PRME, IKT, PLX, IZTC, ACHL, CRTX, BLUE, ZIVO, CYTH, and FNCHShould you be buying Nightstar Therapeutics stock or one of its competitors? The main competitors of Nightstar Therapeutics include Prime Medicine (PRME), Inhibikase Therapeutics (IKT), Protalix BioTherapeutics (PLX), Invizyne Technologies (IZTC), Achilles Therapeutics (ACHL), Cortexyme (CRTX), bluebird bio (BLUE), ZIVO Bioscience (ZIVO), Cyclo Therapeutics (CYTH), and Finch Therapeutics Group (FNCH). These companies are all part of the "medical" sector. Nightstar Therapeutics vs. Its Competitors Prime Medicine Inhibikase Therapeutics Protalix BioTherapeutics Invizyne Technologies Achilles Therapeutics Cortexyme bluebird bio ZIVO Bioscience Cyclo Therapeutics Finch Therapeutics Group Prime Medicine (NYSE:PRME) and Nightstar Therapeutics (NASDAQ:NITE) are both small-cap medical companies, but which is the better stock? We will contrast the two businesses based on the strength of their analyst recommendations, valuation, earnings, risk, dividends, institutional ownership, media sentiment and profitability. Which has more volatility & risk, PRME or NITE? Prime Medicine has a beta of 2.33, indicating that its stock price is 133% more volatile than the S&P 500. Comparatively, Nightstar Therapeutics has a beta of 2.84, indicating that its stock price is 184% more volatile than the S&P 500. Do analysts recommend PRME or NITE? Prime Medicine currently has a consensus target price of $10.08, suggesting a potential upside of 219.09%. Given Prime Medicine's stronger consensus rating and higher possible upside, equities research analysts plainly believe Prime Medicine is more favorable than Nightstar Therapeutics.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Prime Medicine 0 Sell rating(s) 3 Hold rating(s) 4 Buy rating(s) 1 Strong Buy rating(s) 2.75Nightstar Therapeutics 0 Sell rating(s) 0 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 0.00 Does the media prefer PRME or NITE? In the previous week, Prime Medicine had 3 more articles in the media than Nightstar Therapeutics. MarketBeat recorded 3 mentions for Prime Medicine and 0 mentions for Nightstar Therapeutics. Prime Medicine's average media sentiment score of 0.97 beat Nightstar Therapeutics' score of 0.00 indicating that Prime Medicine is being referred to more favorably in the media. Company Overall Sentiment Prime Medicine Positive Nightstar Therapeutics Neutral Which has higher valuation and earnings, PRME or NITE? Nightstar Therapeutics has lower revenue, but higher earnings than Prime Medicine. Nightstar Therapeutics is trading at a lower price-to-earnings ratio than Prime Medicine, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioPrime Medicine$3.85M107.88-$198.13M-$1.61-1.96Nightstar TherapeuticsN/AN/A-$36.86M-$1.26-24.97 Do institutionals & insiders have more ownership in PRME or NITE? 70.4% of Prime Medicine shares are held by institutional investors. Comparatively, 32.8% of Nightstar Therapeutics shares are held by institutional investors. 22.9% of Prime Medicine shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term. Is PRME or NITE more profitable? Nightstar Therapeutics' return on equity of -30.89% beat Prime Medicine's return on equity.Company Net Margins Return on Equity Return on Assets Prime MedicineN/A -107.87% -74.97% Nightstar Therapeutics N/A -30.89%-27.65% SummaryPrime Medicine beats Nightstar Therapeutics on 10 of the 15 factors compared between the two stocks. Get Nightstar Therapeutics News Delivered to You Automatically Sign up to receive the latest news and ratings for NITE and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding NITE and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart NITE vs. The Competition Export to ExcelMetricNightstar TherapeuticsBiological Products, Except Diagnostic IndustryMedical SectorNASDAQ ExchangeMarket Cap$1.06B$202.67M$5.50B$9.02BDividend YieldN/AN/A5.38%4.10%P/E Ratio-24.97N/A27.6020.30Price / SalesN/A223.65369.54104.24Price / CashN/A22.4436.6357.47Price / Book5.345.618.055.68Net Income-$36.86M-$96.61M$3.18B$249.13M Nightstar Therapeutics Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)NITENightstar TherapeuticsN/A$31.46+0.5%N/A+19.2%$1.06BN/A-24.9747PRMEPrime Medicine3.5886 of 5 stars$2.73+10.5%$10.08+269.4%-40.8%$358.43M$3.85M-1.33234Gap UpHigh Trading VolumeIKTInhibikase Therapeutics1.405 of 5 stars$1.95flat$6.50+233.3%+64.3%$144.97M$260K-0.736News CoveragePLXProtalix BioTherapeutics2.9534 of 5 stars$1.48flat$15.00+913.5%+45.8%$117.82M$59.76M-11.38200IZTCInvizyne TechnologiesN/A$10.39+6.8%N/AN/A$64.96MN/A0.0029News CoverageACHLAchilles TherapeuticsN/A$1.48flatN/AN/A$60.83MN/A-0.90250CRTXCortexymeN/A$1.65+6.5%N/A+128.3%$49.75MN/A-0.5655BLUEbluebird bio2.1689 of 5 stars$4.97flat$44.60+797.4%N/A$48.67M$103.95M-0.13520News CoverageZIVOZIVO BioscienceN/A$11.99-19.6%N/A+69.8%$45.72M$15.85K-2.4610Gap DownCYTHCyclo TherapeuticsN/A$0.72flat$0.95+31.8%N/A$23.72M$870.73K-0.809FNCHFinch Therapeutics Group0.4106 of 5 stars$13.20flatN/A+921.5%$21.20M$110K-1.50190 Related Companies and Tools Related Companies PRME Alternatives IKT Alternatives PLX Alternatives IZTC Alternatives ACHL Alternatives CRTX Alternatives BLUE Alternatives ZIVO Alternatives CYTH Alternatives FNCH Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:NITE) was last updated on 7/4/2025 by MarketBeat.com Staff From Our PartnersPresidential Bombshell: $150T Resource to Be Released as soon as this Summer?Something extraordinary is happening in Washington. 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