PolyPid (PYPD) Stock Price, News & Analysis

Company Overview

PolyPid Ltd is a clinical‐stage biotechnology company focused on polymer‐based drug delivery technologies designed to enhance the performance of therapeutic agents at mucosal surfaces. Leveraging its proprietary Mucoadhesive & Mucus‐Penetrating (MMP) platform, PolyPid develops long‐acting formulations for ocular, oral and pulmonary indications. Its lead candidates include OncoTears and OralTear, therapies targeting dry eye and dry mouth conditions, respectively, as well as Paclical, a polymer‐formulated paclitaxel designed to improve tolerability and antitumor activity in oncology patients.

Founded in 2003 and headquartered in Jerusalem, Israel, PolyPid has assembled an international patent portfolio covering key markets in North America, Europe and Asia. OncoTears has received marketing authorization in select countries of the former CIS, and the company is advancing regulatory filings for its lead assets in the United States and European Union. Research and clinical operations are conducted in Israel, with strategic collaborations established to support commercialization efforts and late‐stage clinical trials in multiple geographies.

Under the leadership of co-founder and Chief Executive Officer Yoel Hakim, PolyPid’s management team brings together expertise in polymer chemistry, pharmacology and regulatory affairs. As a Nasdaq‐listed entity, the company remains focused on driving its clinical programs toward pivotal studies, while exploring new therapeutic applications of its mucus‐penetrating delivery platform to address unmet medical needs across a range of mucosal diseases.

Key Stats

• Today's Range: $3.44 to $3.51
• 50-Day Range: $3.21 to $3.80
• 52-Week Range: $2.30 to $3.93
• Volume: 26,236 shs
• Average Volume: 56,772 shs
• Market Capitalization: $55.16 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $12.40
• Consensus Rating: Buy

PolyPid Stock Analysis - MarketRank™

PolyPid scored higher than 68% of companies evaluated by MarketBeat, and ranked 346th out of 958 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 4.4 / 5
• Analyst Rating: Buy

Consensus Rating

PolyPid has received a consensus rating of Buy. The company's average rating score is 3.17, and is based on 5 buy ratings, no hold ratings, and no sell ratings.

Upside Potential

PolyPid has a consensus price target of $12.40, representing about 257.3% upside from its current price of $3.47.

Amount of Analyst Coverage

PolyPid has only been the subject of 4 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: N/A

Price to Earnings Ratio vs. the Market

The P/E ratio of PolyPid is -0.91, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of PolyPid is -0.91, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

PolyPid has a P/B Ratio of 4.63. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.

Short Interest

• Score: 5.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

0.62% of the float of PolyPid has been sold short.

Short Interest Ratio / Days to Cover

PolyPid has a short interest ratio ("days to cover") of 0.1, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in PolyPid has recently decreased by 26.60%, indicating that investor sentiment is improving significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

PolyPid does not currently pay a dividend.

Dividend Growth

PolyPid does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

0.62% of the float of PolyPid has been sold short.

Short Interest Ratio / Days to Cover

PolyPid has a short interest ratio ("days to cover") of 0.1, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in PolyPid has recently decreased by 26.60%, indicating that investor sentiment is improving significantly.

News and Social Media

• Score: 2.5 / 5
• News Sentiment: 1.45

News Sentiment

PolyPid has a news sentiment score of 1.45. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.93 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 2 news articles for PolyPid this week, compared to 2 articles on an average week.

MarketBeat Follows

Only 1 people have added PolyPid to their MarketBeat watchlist in the last 30 days. This is a decrease of -50% compared to the previous 30 days.

Company Ownership

• Score: 1.7 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, PolyPid insiders have not sold or bought any company stock.

Percentage Held by Insiders

24.70% of the stock of PolyPid is held by insiders. A high percentage of insider ownership can be a sign of company health.

Percentage Held by Institutions

Only 26.47% of the stock of PolyPid is held by institutions.

PYPD Stock Analysis - Frequently Asked Questions

How have PYPD shares performed this year?

PolyPid's stock was trading at $3.04 at the beginning of 2025. Since then, PYPD stock has increased by 14.1% and is now trading at $3.47.

How were PolyPid's earnings last quarter?

PolyPid Ltd. (NASDAQ:PYPD) announced its quarterly earnings data on Wednesday, August, 13th. The company reported ($0.78) EPS for the quarter, missing analysts' consensus estimates of ($0.53) by $0.25.
Read the conference call transcript.

When did PolyPid's stock split?

PolyPid shares reverse split before market open on Thursday, September 21st 2023.The 1-30 reverse split was announced on Wednesday, September 20th 2023. The number of shares owned by shareholders was adjusted after the market closes on Wednesday, September 20th 2023. An investor that had 100 shares of stock prior to the reverse split would have 3 shares after the split.

When did PolyPid IPO?

PolyPid (PYPD) raised $50 million in an initial public offering (IPO) on Friday, June 26th 2020. The company issued 3,100,000 shares at $15.00-$17.00 per share. Barclays and BMO Capital Markets acted as the underwriters for the IPO and Raymond James, National Securities Corporation, Oddo BHF and A.G.P. were co-managers.

Who are PolyPid's major shareholders?

PolyPid's top institutional shareholders include AIGH Capital Management LLC (11.72%), Rosalind Advisors Inc. (6.13%) and Lumbard & Kellner LLC (0.24%).

How do I buy shares of PolyPid?

Shares of PYPD stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of PolyPid own?

Based on aggregate information from My MarketBeat watchlists, some other companies that PolyPid investors own include Advanced Micro Devices (AMD), NVIDIA (NVDA), Tesla (TSLA), Teladoc Health (TDOC), CrowdStrike (CRWD), PayPal (PYPL) and Roku (ROKU).

Company Calendar

• Last Earnings: 8/13/2025
• Today: 9/12/2025
• Next Earnings (Estimated): 11/12/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - DRUGS
• Sub-Industry: Medical Equipment
• Current Symbol: NASDAQ:PYPD
• CIK: 1611842
• Web: www.polypid.com
• Phone: 972-74-719-5700
• Fax: N/A
• Employees: 80
• Year Founded: N/A

Price Target and Rating

• Average Price Target for PolyPid: $12.40
• High Price Target: $14.00
• Low Price Target: $9.00
• Potential Upside/Downside: +257.3%
• Consensus Rating: Buy
• Rating Score (0-4): 3.17
• Research Coverage: 6 Analysts

Profitability

• EPS (Trailing Twelve Months): ($3.83)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$29.02 million
• Net Margins: N/A
• Pretax Margin: N/A
• Return on Equity: -453.95%
• Return on Assets: -138.92%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 2.28
• Quick Ratio: 2.28

Sales & Book Value

• Annual Sales: N/A
• Price / Sales: N/A
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $0.75 per share
• Price / Book: 4.63

Miscellaneous

• Outstanding Shares: 15,900,000
• Free Float: 11,970,000
• Market Cap: $55.17 million
• Optionable: No Data
• Beta: 1.48