| 5/23/2025 | Siren L.L.C. | 2,789,833 | $7.87M | 0.5% | -1.5% | 9.321% | |
| 5/21/2025 | Acadian Asset Management LLC | 12,153 | $34K | 0.0% | -37.6% | 0.041% | |
| 5/16/2025 | Woodline Partners LP | 134,492 | $379K | 0.0% | -73.0% | 0.449% | |
| 5/16/2025 | Goldman Sachs Group Inc. | 24,375 | $69K | 0.0% | -33.9% | 0.081% | |
| 5/16/2025 | Parkman Healthcare Partners LLC | 401,746 | $1.13M | 0.1% | -18.2% | 1.342% | |
| 5/15/2025 | Redmile Group LLC | 2,214,947 | $6.25M | 0.6% | -7.7% | 7.400% | |
| 5/15/2025 | Nantahala Capital Management LLC | 1,042,427 | $2.94M | 0.1% | -0.7% | 3.483% | |
| 5/15/2025 | Siren L.L.C. | 2,789,833 | $7.87M | 0.5% | -1.5% | 9.321% | |
| 5/14/2025 | Walleye Capital LLC | 136,150 | $384K | 0.0% | +274.1% | 0.455% | |
| 5/14/2025 | Jump Financial LLC | 26,351 | $74K | 0.0% | N/A | 0.088% | |
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| 4/15/2025 | SG Americas Securities LLC | 308,289 | $869K | 0.0% | -2.9% | 1.030% | |
| 2/17/2025 | Woodline Partners LP | 498,732 | $3.43M | 0.0% | +22.6% | 1.666% | |
| 2/17/2025 | Two Sigma Advisers LP | 98,800 | $680K | 0.0% | +18.6% | 0.330% | |
| 2/17/2025 | Two Sigma Investments LP | 142,052 | $977K | 0.0% | -16.1% | 0.475% | |
| 2/17/2025 | Redmile Group LLC | 2,399,317 | $16.51M | 1.2% | +26.3% | 8.016% | |
| 2/17/2025 | Point72 Asset Management L.P. | 633,100 | $4.36M | 0.0% | +35.3% | 2.115% | |
| 2/17/2025 | Parkman Healthcare Partners LLC | 491,080 | $3.38M | 0.4% | -1.4% | 1.641% | |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 128,990 | $887K | 0.1% | +50.5% | 0.431% | |
| 2/17/2025 | Millennium Management LLC | 473,552 | $3.26M | 0.0% | -57.3% | 1.582% | |
| 2/17/2025 | Integral Health Asset Management LLC | 200,000 | $1.38M | 0.1% | N/A | 0.668% | |
| 2/17/2025 | Cubist Systematic Strategies LLC | 106,320 | $731K | 0.0% | +129.6% | 0.355% | |
| 2/17/2025 | Cantor Fitzgerald L. P. | 539,726 | $3.71M | 0.1% | +61.5% | 1.803% | |
| 2/17/2025 | Bank of America Corp DE | 499,066 | $3.43M | 0.0% | +48,165.6% | 1.667% | |
| 2/17/2025 | Ameriprise Financial Inc. | 16,360 | $113K | 0.0% | N/A | 0.055% | |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 123,200 | $848K | 0.0% | -25.8% | 0.412% | |
| 2/14/2025 | Nantahala Capital Management LLC | 1,049,676 | $7.22M | 0.3% | +424.8% | 3.507% | |
| 2/14/2025 | Boothbay Fund Management LLC | 351,527 | $2.42M | 0.1% | +105.4% | 1.174% | |
| 2/14/2025 | Virtus ETF Advisers LLC | 10,772 | $74K | 0.0% | +130.5% | 0.036% | |
| 2/14/2025 | Hsbc Holdings PLC | 172,834 | $1.19M | 0.0% | -2.8% | 0.577% | |
| 2/13/2025 | Marshall Wace LLP | 488,889 | $3.36M | 0.0% | +190.3% | 1.633% | |
| 2/13/2025 | Walleye Capital LLC | 36,397 | $250K | 0.0% | N/A | 0.122% | |
| 2/13/2025 | Barclays PLC | 6,126 | $42K | 0.0% | +83.8% | 0.020% | |
| 2/13/2025 | ADAR1 Capital Management LLC | 18,000 | $124K | 0.0% | -55.3% | 0.060% | |
| 2/12/2025 | Trexquant Investment LP | 63,663 | $438K | 0.0% | N/A | 0.213% | |
| 2/12/2025 | JPMorgan Chase & Co. | 3,793 | $26K | 0.0% | N/A | 0.013% | |
| 2/11/2025 | Commonwealth of Pennsylvania Public School Empls Retrmt SYS | 19,467 | $134K | 0.0% | N/A | 0.065% | |
| 1/24/2025 | China Universal Asset Management Co. Ltd. | 9,963 | $69K | 0.0% | N/A | 0.033% | |
| 1/23/2025 | Custom Index Systems LLC | 11,861 | $82K | 0.0% | -17.7% | 0.040% | |
| 1/17/2025 | SG Americas Securities LLC | 317,628 | $2.19M | 0.0% | -7.4% | 1.061% | |
| 1/13/2025 | FNY Investment Advisers LLC | 17,515 | $120K | 0.1% | N/A | 0.059% | |
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| 1/3/2025 | GAMMA Investing LLC | 6,092 | $42K | 0.0% | +609.2% | 0.020% | |
| 11/19/2024 | Barclays PLC | 3,333 | $61K | 0.0% | -40.2% | 0.011% | |
| 11/15/2024 | Barclays PLC | 3,333 | $61K | 0.0% | -40.2% | 0.011% | |
| 11/15/2024 | Y Intercept Hong Kong Ltd | 21,078 | $383K | 0.0% | +22.9% | 0.070% | |
| 11/15/2024 | Redmile Group LLC | 1,899,317 | $34.53M | 2.0% | -5.7% | 6.346% | |
| 11/15/2024 | Point72 Asset Management L.P. | 467,800 | $8.51M | 0.0% | +219.3% | 1.563% | |
| 11/15/2024 | Parkman Healthcare Partners LLC | 497,870 | $9.05M | 1.2% | +71.8% | 1.664% | |
| 11/15/2024 | Ikarian Capital LLC | 587,343 | $10.68M | 1.4% | +15.9% | 1.962% | |
| 11/15/2024 | Janus Henderson Group PLC | 1,087,228 | $19.80M | 0.0% | +32.8% | 3.633% | |
| 11/14/2024 | Eventide Asset Management LLC | 640,000 | $11.64M | 0.2% | N/A | 2.138% | |
| 11/14/2024 | Verition Fund Management LLC | 11,390 | $207K | 0.0% | N/A | 0.038% | |
| 11/13/2024 | The Manufacturers Life Insurance Company | 17,490 | $318K | 0.0% | N/A | 0.058% | |
| 10/23/2024 | Values First Advisors Inc. | 3,091 | $56K | 0.0% | N/A | 0.010% | |
| 9/16/2024 | Cubist Systematic Strategies LLC | 9,438 | $179K | 0.0% | -74.0% | 0.032% | |
| 8/19/2024 | Point72 Asset Management L.P. | 146,500 | $2.78M | 0.0% | +1,686.6% | 0.490% | |
| 8/16/2024 | Quarry LP | 6,000 | $114K | 0.0% | N/A | 0.020% | |
| 8/15/2024 | Millennium Management LLC | 782,941 | $14.88M | 0.0% | +91.2% | 2.616% | |
| 8/14/2024 | Cubist Systematic Strategies LLC | 9,438 | $179K | 0.0% | -74.0% | 0.032% | |
| 8/14/2024 | Marshall Wace LLP | 149,397 | $2.84M | 0.0% | +7.3% | 0.499% | |
| 8/14/2024 | Lombard Odier Asset Management USA Corp | 2,405,998 | $45.71M | 3.4% | +0.7% | 8.039% | |
| 8/13/2024 | M28 Capital Management LP | 185,100 | $3.52M | 4.6% | -38.2% | 0.618% | |
| 8/9/2024 | Renaissance Technologies LLC | 39,100 | $743K | 0.0% | -62.4% | 0.131% | |
| 8/9/2024 | Rathbones Group PLC | 18,421 | $350K | 0.0% | -7.5% | 0.062% | |
| 8/8/2024 | First Turn Management LLC | 537,338 | $10.21M | 1.7% | N/A | 1.795% | |
| 8/8/2024 | Nicholas Investment Partners LP | 150,480 | $2.86M | 0.3% | N/A | 0.503% | |
| 8/6/2024 | Custom Index Systems LLC | 14,836 | $282K | 0.2% | N/A | 0.050% | |
| 7/26/2024 | Legato Capital Management LLC | 19,800 | $376K | 0.1% | N/A | 0.066% | |
| 7/12/2024 | SG Americas Securities LLC | 343,196 | $6.52M | 0.0% | +4,802.8% | 1.147% | |
| 5/30/2024 | Lynx1 Capital Management LP | 526,642 | $11.38M | 2.9% | +123.4% | 1.760% | |
| 5/17/2024 | Artal Group S.A. | 2,779,619 | $60.04M | 1.5% | -7.3% | 9.287% | |
| 5/16/2024 | Janus Henderson Group PLC | 625,864 | $13.58M | 0.0% | N/A | 2.091% | |
| 5/16/2024 | Redmile Group LLC | 2,027,669 | $43.80M | 1.6% | N/A | 6.775% | |
| 5/15/2024 | Lazard Asset Management LLC | 1,415 | $29K | 0.0% | -37.7% | 0.005% | |
| 5/15/2024 | M28 Capital Management LP | 299,400 | $6.47M | 4.8% | -17.7% | 1.000% | |
| 5/7/2024 | SG Americas Securities LLC | 7,000 | $151K | 0.0% | +10.5% | 0.023% | |
| 4/22/2024 | Vivo Capital LLC | 1,105,454 | $23.88M | 1.9% | +116.7% | 3.694% | |
| 2/15/2024 | Parkman Healthcare Partners LLC | 232,942 | $4.05M | 0.6% | +20.8% | 0.778% | |
| 2/15/2024 | Cantor Fitzgerald L. P. | 146,777 | $2.55M | 0.5% | -12.7% | 0.490% | |
| 2/7/2024 | Vivo Capital LLC | 510,204 | $8.86M | 0.7% | N/A | 1.705% | |
| 1/12/2024 | SG Americas Securities LLC | 6,333 | $110K | 0.0% | N/A | 0.021% | |
| 11/14/2023 | Lynx1 Capital Management LP | 235,787 | $2.32M | 1.5% | N/A | 0.788% | |
| 8/15/2023 | Cantor Fitzgerald L. P. | 293,893 | $1.62M | 0.0% | +1.6% | 0.982% | |
| 8/14/2023 | Lombard Odier Asset Management Europe Ltd | 3,415,360 | $18.78M | 0.9% | +3.7% | 11.411% | |
| 8/14/2023 | Lombard Odier Asset Management USA Corp | 4,120,416 | $18.67M | 0.4% | +4.1% | 13.767% | |
| 8/11/2023 | M28 Capital Management LP | 363,800 | $2.00M | 2.6% | +149.3% | 1.216% | |
| 8/11/2023 | Artal Group S.A. | 1,700,000 | $9.35M | 0.3% | +236.6% | 5.680% | |
| 2/14/2023 | Lombard Odier Asset Management Europe Ltd | 3,218,200 | $49.08M | 2.0% | 0.0% | 8.967% | |
| 2/10/2023 | M28 Capital Management LP | 145,900 | $2.23M | 2.1% | N/A | 0.407% | |
| 2/2/2023 | SG Americas Securities LLC | 87,987 | $1.34M | 0.0% | -11.1% | 0.245% | |
| 11/15/2022 | TCG Crossover Management LLC | 2,104,875 | $21.12M | 6.3% | N/A | 5.865% | |
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| 11/15/2022 | Parkman Healthcare Partners LLC | 127,458 | $1.28M | 0.4% | +385.6% | 0.355% | |
| 11/15/2022 | BVF Inc. IL | 1,508,416 | $14.89M | 0.6% | +126.3% | 4.203% | |
| 11/15/2022 | Cantor Fitzgerald L. P. | 209,886 | $2.11M | 0.0% | -0.7% | 0.585% | |
| 11/14/2022 | Point72 Asset Management L.P. | 550,875 | $5.53M | 0.0% | +120.4% | 1.535% | |
| 11/14/2022 | UBS Oconnor LLC | 79,636 | $786K | 0.0% | +176.4% | 0.222% | |
| 10/31/2022 | SG Americas Securities LLC | 98,953 | $977K | 0.0% | -2.5% | 0.276% | |
| 5/23/2022 | Cantor Fitzgerald L. P. | 173,725 | $3.30M | 0.2% | -31.7% | 0.580% | |
| 5/16/2022 | Lombard Odier Asset Management Europe Ltd | 1,561,551 | $29.67M | 1.1% | N/A | 5.218% | |
| 5/16/2022 | Frazier Life Sciences Management L.P. | 881,173 | $16.74M | 1.4% | N/A | 2.944% | |
| 2/18/2022 | Lombard Odier Asset Management USA Corp | 3,472,521 | $82.96M | 3.2% | +480.6% | 11.603% | |
