What is Sema4's operating income?

Sema4's total operating income in 2025 was -$13.08 million, based on the following breakdown: Total Gross Profit: $298.17 million Total Operating Expenses: $311.25 million

Sema4 (SMFRW) Financials

$0.0002 0.00 (0.00%)

As of 07/22/2026

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Annual Income Statements for Sema4

This table shows Sema4's income and expenses over time, based on annual financial data. All values are USD millions unless otherwise specified.

Metric	2019	2020	2021	2022	2023	2024	2025
Period end date	12/31/2019	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025
Net Income / (Loss) Attributable to Common Shareholders	-33	-241	-245	-549	-176	-52	-21
Consolidated Net Income / (Loss)	-30	-241	-245	-549	-176	-52	-21
Net Income / (Loss) Continuing Operations	-30	-241	-245	-549	-176	-52	-21
Total Pre-Tax Income	-30	-241	-245	-598	-177	-53	-21
Total Operating Income	-30	-242	-446	-668	-181	-23	-13
Total Gross Profit	83	4.03	-17	-27	90	194	298
Total Revenue	196	179	212	235	203	305	428
Operating Revenue	196	179	212	235	203	305	428
Total Cost of Revenue	113	175	229	261	113	111	129
Operating Cost of Revenue	113	175	229	261	113	111	129
Total Operating Expenses	113	246	430	641	271	218	311
Selling, General & Admin Expense	29	101	206	216	139	105	151
Marketing Expense	39	63	113	122	61	67	88
Research & Development Expense	35	73	105	86	58	46	72
Other Operating Expenses / (Income)	9.45	9.40	5.66	6.31	1.96	0.00	0.00
Impairment Charge	-	0.00	0.00	210	10	0.00	0.00
Total Other Income / (Expense), net	0.71	0.65	201	70	3.90	-29	-8.06
Interest & Investment Income	0.99	0.51	0.08	-	1.11	-3.03	-2.54
Other Income / (Expense), net	0.50	2.62	204	70	2.79	-26	-5.52
Income Tax Expense	0.00	0.00	0.00	-49	-0.93	-0.34	-0.12
Basic Earnings per Share	($264,056.00)	($47,036.00)	($2.27)	($53.63)	($7.23)	($1.94)	($0.73)
Weighted Average Basic Shares Outstanding	124.00	5.13K	108.08M	10.24M	24.31M	26.89M	28.64M
Diluted Earnings per Share	($264,056.00)	($47,036.00)	($2.27)	($53.63)	($7.23)	($1.94)	($0.73)
Weighted Average Diluted Shares Outstanding	124.00	5.13K	108.08M	10.24M	24.31M	26.89M	28.64M
Weighted Average Basic & Diluted Shares Outstanding	-	-	244.96M	798.25M	26.05M	28.07M	29.29M

This table shows Sema4's income and expenses over time, based on quarterly financial data. All values are USD millions unless otherwise specified.

Metric	Q4 2023	Q1 2024	Q2 2024	Q3 2024	Q4 2024	Q1 2025	Q2 2025	Q3 2025	Q4 2025	Q1 2026	Q2 2026
Period end date	12/31/2023	3/31/2024	6/30/2024	9/30/2024	12/31/2024	3/31/2025	6/30/2025	9/30/2025	12/31/2025	3/31/2026	6/30/2026
Net Income / (Loss) Attributable to Common Shareholders	-26	-20	-29	-8.31	5.44	-6.53	11	-7.64	-18	-63	-18
Consolidated Net Income / (Loss)	-26	-20	-29	-8.31	5.44	-6.53	11	-7.64	-18	-63	-18
Net Income / (Loss) Continuing Operations	-26	-20	-29	-8.31	5.44	-6.53	11	-7.64	-18	-63	-18
Total Pre-Tax Income	-26	-20	-29	-8.36	5.41	-6.08	11	-7.39	-18	-62	-18
Total Operating Income	-26	-14	-11	-7.78	8.81	-4.55	8.96	-3.25	-14	-57	-17
Total Gross Profit	31	37	43	48	66	58	71	85	84	68	78
Total Revenue	57	62	71	77	96	87	103	117	121	102	114
Operating Revenue	57	62	71	77	96	87	103	117	121	102	114
Total Cost of Revenue	27	25	28	29	29	29	32	32	37	34	36
Operating Cost of Revenue	27	25	28	29	29	29	32	32	37	34	36
Total Operating Expenses	56	51	54	56	57	63	62	88	99	126	96
Selling, General & Admin Expense	27	23	26	27	27	50	47	44	47	75	76
Research & Development Expense	12	12	11	12	12	13	15	20	25	20	20
Impairment Charge	-	-	-	-	-	0.00	0.00	-	-	31	0.00
Total Other Income / (Expense), net	-1.71	-6.66	-19	-0.58	-3.39	-1.53	1.60	-4.14	-4.00	-4.95	-0.80
Interest Expense	-	-	-	-	-	0.00	0.00	-	-	6.57	0.00
Interest & Investment Income	-	-0.60	-0.89	-0.84	-	-0.64	-0.82	-0.56	-0.52	-0.72	-1.19
Other Income / (Expense), net	-0.73	-6.06	-18	0.26	-2.69	-0.89	2.42	-3.58	-3.48	2.33	0.38
Income Tax Expense	-0.41	-0.08	-0.19	-0.05	-0.02	0.45	-0.25	0.25	-0.56	0.90	-0.52
Basic Earnings per Share	($1.06)	($0.78)	($1.10)	($0.31)	$0.20	($0.23)	$0.38	($0.27)	($0.61)	($2.16)	($0.60)
Weighted Average Basic Shares Outstanding	24.31M	26.06M	26.62M	27.10M	26.89M	28.15M	28.58M	28.80M	28.64M	29.34M	29.71M
Diluted Earnings per Share	($1.06)	($0.78)	($1.10)	($0.31)	$0.20	($0.23)	$0.36	($0.27)	($0.59)	($2.16)	($0.60)
Weighted Average Diluted Shares Outstanding	24.31M	26.06M	26.62M	27.10M	26.89M	28.15M	29.75M	28.80M	28.64M	29.34M	29.71M
Weighted Average Basic & Diluted Shares Outstanding	26.05M	26.14M	26.94M	27.47M	28.07M	28.53M	28.73M	28.90M	29.29M	29.69M	29.82M

This table details how cash moves in and out of Sema4's business through operations, investing, and financing, using annual figures. All values are USD millions unless otherwise specified.

Metric	2019	2020	2021	2022	2023	2024	2025
Period end date	12/31/2019	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025
Net Change in Cash & Equivalents	114	3.95	283	-263	-38	-14	20
Net Cash From Operating Activities	-19	-93	-190	-319	-180	-28	33
Net Cash From Continuing Operating Activities	-19	-93	-192	-319	-180	-28	33
Net Income / (Loss) Continuing Operations	-30	-241	-245	-549	-176	-52	-21
Consolidated Net Income / (Loss)	-30	-241	-245	-549	-176	-52	-21
Depreciation Expense	6.41	12	22	59	34	22	25
Non-Cash Adjustments To Reconcile Net Income	6.73	123	25	183	3.71	23	42
Changes in Operating Assets and Liabilities, net	-2.16	14	6.65	-13	-41	-21	-12
Net Cash From Investing Activities	-15	-32	-21	-141	-44	-30	-62
Net Cash From Continuing Investing Activities	-15	-32	-21	-141	-44	-30	-62
Purchase of Property, Plant & Equipment	-15	-32	-21	-14	-5.71	-5.49	-19
Acquisitions	-	0.00	0.00	-127	-12	0.00	-33
Purchase of Investments	-	-	-	0.00	-48	-66	-56
Sale of Property, Plant & Equipment	-	-	-	0.00	4.03	0.00	0.00
Sale and/or Maturity of Investments	-	-	-	0.00	18	42	46
Net Cash From Financing Activities	148	129	494	197	186	44	48
Net Cash From Continuing Financing Activities	148	129	498	197	186	44	48
Repayment of Debt	-1.71	-0.19	-10	0.00	-2.00	-0.50	-1.21
Issuance of Debt	0.00	16	0.00	0.00	49	0.00	0.00
Issuance of Common Equity	0.00	0.00	793	198	143	47	50
Other Financing Activities, net	31	-4.01	-2.46	-0.34	-3.31	-2.33	-0.43
Cash Interest Paid	0.31	1.75	2.75	1.93	3.04	6.68	6.41
Cash Income Taxes Paid	0.00	0.00	0.35	1.24	1.47	1.17	1.28

This table details how cash moves in and out of Sema4's business through operations, investing, and financing, using quarterly figures. All values are USD millions unless otherwise specified.

Metric	Q4 2023	Q1 2024	Q2 2024	Q3 2024	Q4 2024	Q1 2025	Q2 2025	Q3 2025	Q4 2025	Q1 2026	Q2 2026
Period end date	12/31/2023	3/31/2024	6/30/2024	9/30/2024	12/31/2024	3/31/2025	6/30/2025	9/30/2025	12/31/2025	3/31/2026	6/30/2026
Net Change in Cash & Equivalents	12	-16	-28	1.82	27	14	-26	22	9.03	-11	-34
Net Cash From Operating Activities	-30	-16	-4.51	-4.40	-3.18	10	10	16	-3.09	-32	-29
Net Cash From Continuing Operating Activities	-30	-16	-4.51	-4.40	-3.45	10	10	16	-3.09	-32	-29
Net Income / (Loss) Continuing Operations	-26	-20	-29	-8.31	5.44	-6.53	11	-7.64	-18	-63	-18
Consolidated Net Income / (Loss)	-26	-20	-29	-8.31	5.44	-6.53	11	-7.64	-18	-63	-18
Depreciation Expense	6.09	5.25	5.22	5.93	5.56	5.68	6.19	6.47	6.88	6.81	6.71
Non-Cash Adjustments To Reconcile Net Income	-2.74	5.46	22	2.89	-7.99	6.48	9.37	19	7.10	45	4.08
Changes in Operating Assets and Liabilities, net	-7.44	-6.88	-2.85	-4.90	-6.45	4.56	-16	-1.63	0.60	-21	-22
Net Cash From Investing Activities	-4.86	0.84	-23	-7.76	-0.52	-9.41	-36	-4.69	-11	-17	-5.63
Net Cash From Continuing Investing Activities	-4.86	0.84	-23	-7.76	-0.52	-9.41	-36	-4.69	-11	-17	-5.63
Purchase of Property, Plant & Equipment	-2.38	-0.44	-1.35	-0.65	-3.05	-6.13	-2.37	-6.17	-4.35	-6.45	-10
Purchase of Investments	-3.74	-5.17	-24	-23	-14	-17	-14	-5.77	-19	-20	-8.89
Sale and/or Maturity of Investments	1.10	6.45	2.87	16	16	14	13	7.25	12	9.38	13
Net Cash From Financing Activities	47	-0.44	-0.39	14	31	14	0.35	11	23	39	1.01
Net Cash From Continuing Financing Activities	47	-0.44	-0.39	14	31	14	0.35	11	23	39	1.01
Issuance of Common Equity	-	0.00	-	15	32	14	1.13	12	23	97	-95
Other Financing Activities, net	-1.45	-0.44	-0.39	-0.42	-1.08	0.12	-0.49	-0.73	0.66	-0.44	-0.49
Cash Interest Paid	1.93	2.02	2.01	2.04	0.61	1.60	1.61	1.63	1.58	1.75	2.07
Cash Income Taxes Paid	0.29	0.30	0.26	0.35	0.26	0.21	0.71	0.12	0.24	0.75	1.47

This table presents Sema4's assets and liabilities at the end of each period, using annual balance sheet data. All values are USD millions unless otherwise specified.

Metric	2020	2021	2022	2023	2024	2025
Period end date	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025
Total Assets	252	554	491	419	419	524
Total Current Assets	174	484	213	182	198	268
Cash & Equivalents	108	401	124	100	85	105
Short-Term Investments	-	-	0.00	30	56	66
Accounts Receivable	32	27	43	33	38	74
Inventories, net	25	33	14	8.78	11	14
Prepaid Expenses	4.56	19	32	11	8.50	8.69
Plant, Property, & Equipment, net	63	63	52	32	33	46
Total Noncurrent Assets	14	7.83	227	204	189	210
Goodwill	-	-	-	-	0.00	14
Intangible Assets	-	0.00	187	173	159	168
Other Noncurrent Operating Assets	14	7.83	40	31	30	28
Total Liabilities & Shareholders' Equity	252	554	491	419	419	524
Total Liabilities	247	166	237	191	174	216
Total Current Liabilities	73	101	144	59	55	109
Accounts Payable	28	47	85	37	31	58
Other Current Liabilities	30	34	59	21	24	51
Total Noncurrent Liabilities	174	65	93	132	119	107
Long-Term Debt	19	11	6.25	53	52	48
Capital Lease Obligations	21	0.00	60	63	61	56
Noncurrent Deferred & Payable Income Tax Liabilities	-	0.00	2.66	1.56	0.97	0.76
Other Noncurrent Operating Liabilities	2.07	54	24	15	5.52	1.64
Commitments & Contingencies	0.00	0.00	0.00	0.00	0.00	0.00
Total Equity & Noncontrolling Interests	-330	388	254	228	245	308
Total Preferred & Common Equity	-330	388	254	228	245	308
Preferred Stock	0.00	0.00	0.00	0.00	0.00	0.00
Total Common Equity	-330	388	254	228	245	308
Common Stock	0.00	964	1,378	1,528	1,597	1,681
Retained Earnings	-330	-575	-1,124	-1,300	-1,352	-1,373
Accumulated Other Comprehensive Income / (Loss)	-	-	0.00	0.43	0.83	0.94

This table presents Sema4's assets and liabilities at the end of each period, using quarterly balance sheet data. All values are USD millions unless otherwise specified.

Metric	Q1 2023	Q2 2023	Q3 2023	Q1 2024	Q2 2024	Q3 2024	Q1 2025	Q2 2025	Q3 2025	Q1 2026	Q2 2026
Period end date	3/31/2023	6/30/2023	9/30/2023	3/31/2024	6/30/2024	9/30/2024	3/31/2025	6/30/2025	9/30/2025	3/31/2026	6/30/2026
Total Assets	545	476	417	395	389	409	446	464	494	506	481
Total Current Assets	272	213	172	163	162	186	226	205	238	271	246
Cash & Equivalents	202	157	87	84	56	58	100	74	96	94	60
Short-Term Investments	-	-	27	29	51	59	59	60	59	77	72
Accounts Receivable	34	34	32	29	26	38	46	48	61	77	84
Inventories, net	12	12	9.35	12	10	11	13	12	11	12	18
Prepaid Expenses	12	11	16	9.97	19	20	8.01	10	11	11	12
Plant, Property, & Equipment, net	50	43	36	31	31	31	36	40	42	50	54
Total Noncurrent Assets	223	220	210	200	196	191	184	219	214	186	181
Goodwill	-	-	-	-	-	-	-	13	13	1.64	1.64
Intangible Assets	183	180	176	169	166	162	155	177	173	145	141
Other Noncurrent Operating Assets	40	40	34	31	30	29	29	29	29	39	38
Total Liabilities & Shareholders' Equity	545	476	417	395	389	409	446	464	494	506	481
Total Liabilities	217	180	163	187	195	204	189	187	202	252	237
Total Current Liabilities	119	84	68	51	68	77	70	71	88	88	75
Accounts Payable	74	55	39	32	52	56	42	49	50	47	42
Other Current Liabilities	45	30	29	18	16	21	28	22	37	41	33
Total Noncurrent Liabilities	98	96	95	137	127	127	119	115	114	165	163
Long-Term Debt	6.25	6.25	6.05	52	52	52	52	52	52	97	97
Capital Lease Obligations	64	64	64	62	61	60	60	60	57	66	65
Noncurrent Deferred & Payable Income Tax Liabilities	2.51	2.25	2.06	1.42	1.17	1.05	1.15	0.75	1.03	1.40	0.87
Other Noncurrent Operating Liabilities	25	24	23	21	13	14	6.62	3.28	4.26	0.07	0.07
Commitments & Contingencies	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Total Equity & Noncontrolling Interests	328	296	254	207	194	205	257	277	292	254	244
Total Preferred & Common Equity	328	296	254	207	194	205	257	277	292	254	244
Preferred Stock	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Total Common Equity	328	296	254	207	194	205	257	277	292	254	244
Common Stock	1,514	1,528	1,529	1,527	1,543	1,561	1,616	1,625	1,647	1,690	1,698
Retained Earnings	-1,185	-1,232	-1,274	-1,320	-1,350	-1,358	-1,359	-1,348	-1,356	-1,437	-1,455
Accumulated Other Comprehensive Income / (Loss)	-	-	-	0.29	0.46	0.92	0.91	0.81	1.00	0.68	0.34

This table displays calculated financial ratios and metrics derived from Sema4's official financial filings.

Metric	2019	2020	2021	2022	2023	2024	2025
Period end date	12/31/2019	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025
Growth Metrics	-	-	-	-	-	-	-
Revenue Growth	0.00%	-8.59%	18.33%	10.60%	-13.69%	50.79%	39.97%
EBITDA Growth	0.00%	-868.59%	3.02%	-143.73%	73.01%	80.97%	123.97%
EBIT Growth	0.00%	-700.33%	-1.36%	-146.20%	70.04%	72.29%	62.50%
NOPAT Growth	0.00%	-695.69%	-84.36%	-49.65%	72.95%	87.15%	43.67%
Net Income Growth	0.00%	-712.48%	-1.68%	-123.72%	67.98%	70.25%	59.80%
EPS Growth	0.00%	82.19%	100.00%	-123.72%	86.52%	73.17%	62.37%
Operating Cash Flow Growth	0.00%	-397.27%	-104.49%	-67.59%	43.56%	84.18%	216.78%
Free Cash Flow Firm Growth	0.00%	0.00%	-240.96%	-79.05%	78.36%	86.34%	-69.90%
Invested Capital Growth	0.00%	0.00%	97.58%	13,472.10%	8.91%	1.59%	11.17%
Revenue Q/Q Growth	0.00%	0.00%	0.00%	1.54%	-1.90%	14.30%	6.30%
EBITDA Q/Q Growth	0.00%	0.00%	0.00%	-81.56%	63.68%	52.69%	-77.25%
EBIT Q/Q Growth	0.00%	0.00%	0.00%	-82.20%	61.23%	38.70%	-456.01%
NOPAT Q/Q Growth	0.00%	0.00%	0.00%	-45.60%	62.36%	59.74%	-210.57%
Net Income Q/Q Growth	0.00%	0.00%	0.00%	-95.78%	61.69%	37.38%	-1,109.17%
EPS Q/Q Growth	0.00%	0.00%	0.00%	-95.78%	59.36%	37.01%	-1,142.86%
Operating Cash Flow Q/Q Growth	0.00%	0.00%	-21.46%	-4.13%	16.19%	48.35%	0.28%
Free Cash Flow Firm Q/Q Growth	0.00%	0.00%	0.00%	0.00%	-39.87%	36.43%	10.24%
Invested Capital Q/Q Growth	0.00%	0.00%	0.00%	-55.74%	1.71%	8.21%	-1.95%
Profitability Metrics	-	-	-	-	-	-	-
Gross Margin	42.20%	2.25%	-7.82%	-11.40%	44.43%	63.64%	69.74%
EBITDA Margin	-11.98%	-126.94%	-104.04%	-229.26%	-71.70%	-9.05%	1.55%
Operating Margin	-15.50%	-134.95%	-210.25%	-284.48%	-89.15%	-7.60%	-3.06%
EBIT Margin	-15.25%	-133.49%	-114.34%	-254.53%	-88.35%	-16.24%	-4.35%
Profit (Net Income) Margin	-15.14%	-134.58%	-115.64%	-233.91%	-86.77%	-17.12%	-4.92%
Tax Burden Percent	100.00%	100.00%	100.00%	91.80%	99.48%	99.35%	99.45%
Interest Burden Percent	99.31%	100.82%	101.14%	100.11%	98.72%	106.11%	113.65%
Effective Tax Rate	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Return on Invested Capital (ROIC)	0.00%	0.00%	0.00%	-480.40%	-61.74%	-7.55%	-4.00%
ROIC Less NNEP Spread (ROIC-NNEP)	0.00%	0.00%	0.00%	-443.90%	74.98%	160.55%	20.88%
Return on Net Nonoperating Assets (RNNOA)	0.00%	0.00%	0.00%	309.33%	-11.24%	-14.55%	-3.60%
Return on Equity (ROE)	0.00%	-5,500.00%	-125.04%	-171.07%	-72.97%	-22.10%	-7.60%
Cash Return on Invested Capital (CROIC)	0.00%	0.00%	0.00%	-339.15%	-70.26%	-9.13%	-14.58%
Operating Return on Assets (OROA)	0.00%	-95.12%	-60.23%	-114.32%	-39.35%	-11.84%	-3.94%
Return on Assets (ROA)	0.00%	-95.91%	-60.91%	-105.06%	-38.64%	-12.48%	-4.46%
Return on Common Equity (ROCE)	0.00%	413,692.00%	-18.49%	-171.07%	-72.97%	-22.10%	-7.60%
Return on Equity Simple (ROE_SIMPLE)	0.00%	73.12%	-63.23%	-216.39%	-77.09%	-21.32%	0.00%
Net Operating Profit after Tax (NOPAT)	-21	-169	-312	-467	-126	-16	-9.15
NOPAT Margin	-10.85%	-94.46%	-147.18%	-199.13%	-62.41%	-5.32%	-2.14%
Net Nonoperating Expense Percent (NNEP)	0.00%	-221.79%	29.45%	-36.50%	-136.72%	-168.10%	-24.88%
Return On Investment Capital (ROIC_SIMPLE)	-	-	-	-	-36.79%	-4.54%	-2.22%
Cost of Revenue to Revenue	57.80%	97.75%	107.82%	111.40%	55.57%	36.36%	30.26%
SG&A Expenses to Revenue	15.03%	56.18%	97.07%	92.11%	66.03%	33.10%	35.28%
R&D to Revenue	17.80%	40.54%	49.56%	36.73%	28.76%	14.97%	16.85%
Operating Expenses to Revenue	57.70%	137.19%	202.43%	273.08%	133.59%	71.24%	72.80%
Earnings before Interest and Taxes (EBIT)	-30	-239	-243	-597	-179	-50	-19
Earnings before Interest, Taxes, Depreciation and Amortization (EBITDA)	-24	-228	-221	-538	-145	-28	6.63
Valuation Ratios	-	-	-	-	-	-	-
Price to Book Value (P/BV)	0.00	0.00	2.77	0.40	0.31	8.61	12.20
Price to Tangible Book Value (P/TBV)	0.00	0.00	2.77	1.52	1.29	24.37	29.79
Price to Revenue (P/Rev)	1.96	3.41	5.07	0.43	0.35	6.91	8.79
Price to Earnings (P/E)	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Dividend Yield	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Earnings Yield	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Enterprise Value to Invested Capital (EV/IC)	0.00	0.00	0.00	0.23	0.27	9.60	15.31
Enterprise Value to Revenue (EV/Rev)	0.00	4.91	3.24	0.19	0.28	6.82	8.64
Enterprise Value to EBITDA (EV/EBITDA)	0.00	0.00	0.00	0.00	0.00	0.00	557.24
Enterprise Value to EBIT (EV/EBIT)	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Enterprise Value to NOPAT (EV/NOPAT)	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Enterprise Value to Operating Cash Flow (EV/OCF)	0.00	0.00	0.00	0.00	0.00	0.00	110.95
Enterprise Value to Free Cash Flow (EV/FCFF)	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Leverage & Solvency	-	-	-	-	-	-	-
Debt to Equity	0.00	9.86	0.03	0.26	0.51	0.46	0.34
Long-Term Debt to Equity	0.00	9.06	0.03	0.26	0.51	0.46	0.34
Financial Leverage	0.00	-14.79	-1.16	-0.70	-0.15	-0.09	-0.17
Leverage Ratio	0.00	57.35	2.05	1.63	1.89	1.77	1.70
Compound Leverage Factor	0.00	57.82	2.08	1.63	1.86	1.88	1.94
Debt to Total Capital	0.00%	90.79%	2.76%	20.71%	33.65%	31.51%	25.27%
Short-Term Debt to Total Capital	0.00%	7.36%	0.00%	0.00%	0.00%	0.00%	0.00%
Long-Term Debt to Total Capital	0.00%	83.43%	2.76%	20.71%	33.65%	31.51%	25.27%
Preferred Equity to Total Capital	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Noncontrolling Interests to Total Capital	0.00%	701.97%	0.00%	0.00%	0.00%	0.00%	0.00%
Common Equity to Total Capital	0.00%	-692.76%	97.24%	79.29%	66.35%	68.49%	74.73%
Debt to EBITDA	0.00	-0.19	-0.05	-0.12	-0.80	-4.08	15.73
Net Debt to EBITDA	0.00	0.29	1.76	0.11	0.10	1.03	-10.12
Long-Term Debt to EBITDA	0.00	-0.17	-0.05	-0.12	-0.80	-4.08	15.73
Debt to NOPAT	0.00	-0.26	-0.04	-0.14	-0.91	-6.94	-11.39
Net Debt to NOPAT	0.00	0.38	1.25	0.12	0.11	1.74	7.33
Long-Term Debt to NOPAT	0.00	-0.23	-0.04	-0.14	-0.91	-6.94	-11.39
Altman Z-Score	0.00	-2.30	2.20	-6.32	-4.70	3.51	7.86
Noncontrolling Interest Sharing Ratio	0.00%	7,621.67%	85.21%	0.00%	0.00%	0.00%	0.00%
Liquidity Ratios	-	-	-	-	-	-	-
Current Ratio	0.00	2.37	4.77	1.47	3.10	3.61	2.46
Quick Ratio	0.00	1.91	4.22	1.16	2.77	3.26	2.26
Cash Flow Metrics	-	-	-	-	-	-	-
Free Cash Flow to Firm (FCFF)	0.00	-109	-371	-665	-144	-20	-33
Operating Cash Flow to CapEx	-121.17%	-291.26%	-916.16%	-2,228.42%	-10,742.22%	-518.96%	175.00%
Free Cash Flow to Firm to Interest Expense	0.00	-44.02	-130.98	-998.28	0.00	0.00	0.00
Operating Cash Flow to Interest Expense	-23.92	-37.64	-67.17	-479.21	0.00	0.00	0.00
Operating Cash Flow Less CapEx to Interest Expense	-43.66	-50.57	-74.50	-500.72	0.00	0.00	0.00
Efficiency Ratios	-	-	-	-	-	-	-
Asset Turnover	0.00	0.71	0.53	0.45	0.45	0.73	0.91
Accounts Receivable Turnover	0.00	5.55	7.21	6.71	5.32	8.67	7.63
Inventory Turnover	0.00	7.02	7.83	11.10	10.03	11.43	10.52
Fixed Asset Turnover	0.00	2.84	3.37	4.11	4.82	9.35	10.88
Accounts Payable Turnover	0.00	6.22	6.06	3.96	1.84	3.29	2.92
Days Sales Outstanding (DSO)	0.00	65.81	50.65	54.36	68.61	42.09	47.81
Days Inventory Outstanding (DIO)	0.00	51.98	46.60	32.89	36.39	31.93	34.71
Days Payable Outstanding (DPO)	0.00	58.64	60.21	92.28	198.35	110.93	125.03
Cash Conversion Cycle (CCC)	0.00	59.15	37.05	-5.03	-93.35	-36.91	-42.52
Capital & Investment Metrics	-	-	-	-	-	-	-
Invested Capital	0.00	-60	-1.47	196	213	217	241
Invested Capital Turnover	0.00	-5.93	-6.85	2.41	0.99	1.42	1.87
Increase / (Decrease) in Invested Capital	0.00	-60	59	198	17	3.40	24
Enterprise Value (EV)	0.00	881	686	44	57	2,083	3,692
Market Capitalization	385	611	1,076	102	71	2,111	3,759
Book Value per Share	$0.00	($5.96)	$1.61	$0.66	$8.81	$8.93	$10.66
Tangible Book Value per Share	$0.00	($5.96)	$1.61	$0.17	$2.14	$3.15	$4.37
Total Capital	0.00	48	399	320	344	358	412
Total Debt	0.00	43	11	66	116	113	104
Total Long-Term Debt	0.00	40	11	66	116	113	104
Net Debt	0.00	-65	-390	-58	-15	-28	-67
Capital Expenditures (CapEx)	15	32	21	14	1.68	5.49	19
Debt-free, Cash-free Net Working Capital (DFCFNWC)	0.00	-3.96	-18	-56	-6.63	1.97	-12
Debt-free Net Working Capital (DFNWC)	0.00	104	382	68	124	143	159
Net Working Capital (NWC)	0.00	101	382	68	124	143	159
Net Nonoperating Expense (NNE)	8.41	72	-67	82	49	36	12
Net Nonoperating Obligations (NNO)	0.00	-65	-390	-58	-15	-28	-67
Total Depreciation and Amortization (D&A)	6.41	12	22	59	34	22	25
Debt-free, Cash-free Net Working Capital to Revenue	0.00%	-2.21%	-8.63%	-23.69%	-3.27%	0.64%	-2.78%
Debt-free Net Working Capital to Revenue	0.00%	58.09%	180.15%	29.11%	60.98%	46.87%	37.28%
Net Working Capital to Revenue	0.00%	56.14%	180.15%	29.11%	60.98%	46.87%	37.28%
Earnings Adjustments	-	-	-	-	-	-	-
Adjusted Basic Earnings per Share	$0.00	$0.00	$0.00	($53.79)	($7.23)	($1.94)	($0.73)
Adjusted Weighted Average Basic Shares Outstanding	0.00	0.00	0.00	10.24M	24.31M	26.89M	28.64M
Adjusted Diluted Earnings per Share	$0.00	$0.00	$0.00	($53.79)	($7.23)	($1.94)	($0.73)
Adjusted Weighted Average Diluted Shares Outstanding	0.00	0.00	0.00	10.24M	24.31M	26.89M	28.64M
Adjusted Basic & Diluted Earnings per Share	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00
Adjusted Weighted Average Basic & Diluted Shares Outstanding	0.00	0.00	0.00	24.19M	26.05M	28.07M	29.29M
Normalized Net Operating Profit after Tax (NOPAT)	-21	-169	-312	-320	-119	-16	-9.15
Normalized NOPAT Margin	-10.85%	-94.46%	-147.18%	-136.46%	-58.81%	-5.32%	-2.14%
Pre Tax Income Margin	-15.14%	-134.58%	-115.64%	-254.81%	-87.23%	-17.23%	-4.94%
Debt Service Ratios	-	-	-	-	-	-	-
EBIT to Interest Expense	-38.20	-96.76	-85.59	-896.95	0.00	0.00	0.00
NOPAT to Interest Expense	-27.19	-68.47	-110.16	-701.74	0.00	0.00	0.00
EBIT Less CapEx to Interest Expense	-57.94	-109.68	-92.92	-918.45	0.00	0.00	0.00
NOPAT Less CapEx to Interest Expense	-46.93	-81.39	-117.49	-723.24	0.00	0.00	0.00
Payout Ratios	-	-	-	-	-	-	-
Dividend Payout Ratio	0.00%	0.00%	-21.09%	0.00%	0.00%	0.00%	0.00%
Augmented Payout Ratio	0.00%	0.00%	-21.09%	0.00%	0.00%	0.00%	0.00%

This table displays calculated financial ratios and metrics derived from Sema4's official financial filings.

Metric	Q4 2023	Q1 2024	Q2 2024	Q3 2024	Q4 2024	Q1 2025	Q2 2025	Q3 2025	Q4 2025	Q1 2026	Q2 2026
Period end date	12/31/2023	3/31/2024	6/30/2024	9/30/2024	12/31/2024	3/31/2025	6/30/2025	9/30/2025	12/31/2025	3/31/2026	6/30/2026
DEI Shares Outstanding	-	-	-	-	-	-	-	-	-	29,288,739.00	29,688,027.00
DEI Adjusted Shares Outstanding	-	-	-	-	-	-	-	-	-	29,288,739.00	29,688,027.00
DEI Earnings Per Adjusted Shares Outstanding	-	-	-	-	-	-	-	-	-	-2.16	-0.60
Growth Metrics	-	-	-	-	-	-	-	-	-	-	-
Revenue Growth	-6.41%	44.70%	44.77%	44.22%	66.57%	39.56%	45.63%	51.86%	26.50%	17.38%	11.44%
EBITDA Growth	92.62%	72.41%	38.26%	95.44%	157.54%	101.63%	175.57%	77.82%	-192.79%	-20,577.97%	-158.96%
EBIT Growth	91.46%	67.72%	40.68%	82.73%	123.17%	72.41%	139.97%	9.18%	-389.76%	-913.18%	-250.03%
NOPAT Growth	92.11%	77.37%	79.51%	81.89%	149.28%	66.68%	223.81%	58.21%	-212.66%	-1,162.82%	-233.26%
Net Income Growth	91.65%	66.82%	37.56%	80.34%	121.10%	67.74%	137.05%	8.14%	-424.86%	-869.77%	-264.12%
EPS Growth	96.49%	74.34%	40.22%	81.10%	118.87%	70.51%	132.73%	12.90%	-395.00%	-839.13%	-266.67%
Operating Cash Flow Growth	53.82%	70.46%	91.58%	89.34%	89.34%	162.04%	331.30%	458.75%	2.92%	-418.29%	-378.13%
Free Cash Flow Firm Growth	91.67%	76.63%	-98.95%	-98.02%	115.38%	86.57%	-2,436.08%	-1,290.00%	-727.84%	-1,600.55%	28.85%
Invested Capital Growth	8.91%	13.04%	-4.45%	-4.51%	1.59%	0.64%	26.85%	22.68%	11.17%	17.41%	7.68%
Revenue Q/Q Growth	7.72%	8.72%	12.96%	9.02%	24.41%	-8.91%	17.88%	13.68%	3.64%	-15.48%	11.92%
EBITDA Q/Q Growth	41.78%	24.26%	-60.62%	93.17%	835.35%	-97.98%	7,345.34%	-102.00%	-2,976.42%	-346.28%	78.57%
EBIT Q/Q Growth	39.38%	21.75%	-44.34%	73.60%	181.32%	-189.04%	309.11%	-159.98%	-159.45%	-211.33%	69.04%
NOPAT Q/Q Growth	40.32%	46.73%	22.55%	26.46%	262.41%	-136.02%	387.81%	-124.82%	-337.87%	-303.73%	69.63%
Net Income Q/Q Growth	39.05%	21.47%	-44.14%	71.51%	165.42%	-220.06%	265.55%	-170.64%	-131.38%	-258.41%	71.98%
EPS Q/Q Growth	35.37%	26.42%	-41.03%	71.82%	164.52%	-215.00%	256.52%	-175.00%	-118.52%	-266.10%	72.22%
Operating Cash Flow Q/Q Growth	27.58%	45.03%	72.55%	2.44%	27.58%	419.89%	2.34%	51.31%	-119.60%	-948.80%	10.57%
Free Cash Flow Firm Q/Q Growth	-117.45%	5.04%	105.67%	110.31%	35.74%	-182.90%	-887.12%	-7.13%	28.38%	-124.54%	58.70%
Invested Capital Q/Q Growth	1.71%	-2.28%	-4.07%	0.15%	8.21%	-3.20%	20.92%	-3.14%	-1.95%	2.23%	10.90%
Profitability Metrics	-	-	-	-	-	-	-	-	-	-	-
Gross Margin	53.56%	59.93%	60.91%	62.22%	69.22%	67.13%	69.04%	72.40%	69.65%	66.71%	68.37%
EBITDA Margin	-35.32%	-23.19%	-32.97%	-2.06%	12.20%	0.27%	17.11%	-0.30%	-8.95%	-47.26%	-9.05%
Operating Margin	-44.66%	-21.88%	-15.00%	-10.12%	9.21%	-5.22%	8.73%	-2.78%	-11.77%	-56.20%	-15.25%
EBIT Margin	-45.94%	-31.60%	-40.37%	-9.78%	6.39%	-6.25%	11.08%	-5.85%	-14.64%	-53.92%	-14.92%
Profit (Net Income) Margin	-44.89%	-32.42%	-41.37%	-10.81%	5.69%	-7.49%	10.53%	-6.54%	-14.60%	-61.92%	-15.50%
Tax Burden Percent	98.43%	99.60%	99.35%	99.44%	100.44%	107.35%	102.33%	103.34%	96.91%	101.44%	97.16%
Interest Burden Percent	99.27%	103.03%	103.14%	111.22%	88.58%	111.76%	92.82%	108.23%	102.94%	113.21%	106.94%
Effective Tax Rate	0.00%	0.00%	0.00%	0.00%	-0.44%	0.00%	-2.33%	0.00%	0.00%	0.00%	0.00%
Return on Invested Capital (ROIC)	-30.93%	-17.29%	-12.49%	-9.23%	13.13%	-5.77%	14.25%	-3.51%	-15.38%	-76.31%	-18.40%
ROIC Less NNEP Spread (ROIC-NNEP)	-9.25%	-2.30%	41.55%	2.61%	29.02%	8.76%	-4.87%	17.75%	0.77%	7.53%	-205.92%
Return on Net Nonoperating Assets (RNNOA)	1.39%	0.61%	-6.83%	-0.28%	-2.63%	-0.87%	0.18%	-1.80%	-0.13%	-0.81%	-2.33%
Return on Equity (ROE)	-29.54%	-16.67%	-19.32%	-9.50%	10.50%	-6.64%	14.43%	-5.31%	-15.51%	-77.12%	-20.73%
Cash Return on Invested Capital (CROIC)	-70.26%	-59.91%	-27.19%	-15.06%	-9.13%	-5.35%	-21.48%	-16.66%	-14.58%	-36.25%	-31.93%
Operating Return on Assets (OROA)	-20.46%	-14.92%	-22.73%	-6.33%	4.66%	-4.90%	9.41%	-5.21%	-13.27%	-50.11%	-14.34%
Return on Assets (ROA)	-19.99%	-15.31%	-23.29%	-7.00%	4.14%	-5.88%	8.94%	-5.83%	-13.24%	-57.54%	-14.90%
Return on Common Equity (ROCE)	-29.54%	-16.67%	-19.32%	-9.50%	10.50%	-6.64%	14.43%	-5.31%	-15.51%	-77.12%	-20.73%
Return on Equity Simple (ROE_SIMPLE)	0.00%	-65.16%	-60.54%	-40.83%	0.00%	-14.99%	0.00%	0.00%	0.00%	0.00%	0.00%
Net Operating Profit after Tax (NOPAT)	-18	-9.56	-7.41	-5.45	8.85	-3.19	9.17	-2.28	-9.96	-40	-12
NOPAT Margin	-31.26%	-15.32%	-10.50%	-7.08%	9.25%	-3.66%	8.93%	-1.95%	-8.24%	-39.34%	-10.68%
Net Nonoperating Expense Percent (NNEP)	-21.67%	-14.99%	-54.04%	-11.84%	-15.89%	-14.52%	19.12%	-21.27%	-16.14%	-83.84%	187.52%
Return On Investment Capital (ROIC_SIMPLE)	-5.22%	-	-	-	2.47%	-0.86%	2.36%	-0.57%	-2.42%	-9.64%	-3.01%
Cost of Revenue to Revenue	46.44%	40.07%	39.09%	37.78%	30.78%	32.87%	30.96%	27.60%	30.35%	33.29%	31.63%
SG&A Expenses to Revenue	46.37%	35.96%	35.70%	34.01%	28.60%	36.89%	26.70%	38.07%	38.71%	72.95%	66.44%
R&D to Revenue	21.33%	18.53%	15.46%	15.17%	12.12%	14.44%	14.68%	16.99%	20.28%	19.37%	17.18%
Operating Expenses to Revenue	98.22%	81.82%	75.92%	72.34%	60.02%	72.35%	60.32%	75.19%	81.41%	122.91%	83.62%
Earnings before Interest and Taxes (EBIT)	-26	-20	-28	-7.52	6.11	-5.44	11	-6.83	-18	-55	-17
Earnings before Interest, Taxes, Depreciation and Amortization (EBITDA)	-20	-14	-23	-1.59	12	0.24	18	-0.35	-11	-48	-10
Valuation Ratios	-	-	-	-	-	-	-	-	-	-	-
Price to Book Value (P/BV)	0.31	1.14	3.52	5.59	8.61	9.66	9.50	10.59	12.20	7.40	8.35
Price to Tangible Book Value (P/TBV)	1.29	6.20	24.04	26.96	24.37	24.30	30.10	28.96	29.79	17.49	20.13
Price to Revenue (P/Rev)	0.35	1.07	2.80	4.28	6.91	7.53	7.27	7.70	8.79	4.25	4.49
Price to Earnings (P/E)	0.00	0.00	0.00	0.00	0.00	0.00	1,873.33	1,485.82	0.00	0.00	0.00
Dividend Yield	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Earnings Yield	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.05%	0.07%	0.00%	0.00%	0.00%
Enterprise Value to Invested Capital (EV/IC)	0.27	1.14	3.44	5.68	9.60	11.61	10.28	12.40	15.31	7.60	7.56
Enterprise Value to Revenue (EV/Rev)	0.28	1.07	2.83	4.26	6.82	7.39	7.21	7.58	8.64	4.23	4.55
Enterprise Value to EBITDA (EV/EBITDA)	0.00	0.00	0.00	0.00	0.00	0.00	93.61	104.67	557.24	0.00	0.00
Enterprise Value to EBIT (EV/EBIT)	0.00	0.00	0.00	0.00	0.00	0.00	575.79	583.58	0.00	0.00	0.00
Enterprise Value to NOPAT (EV/NOPAT)	0.00	0.00	0.00	0.00	0.00	0.00	524.75	368.24	0.00	0.00	0.00
Enterprise Value to Operating Cash Flow (EV/OCF)	0.00	0.00	0.00	0.00	0.00	0.00	200.45	91.86	110.95	0.00	0.00
Enterprise Value to Free Cash Flow (EV/FCFF)	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Leverage & Solvency	-	-	-	-	-	-	-	-	-	-	-
Debt to Equity	0.51	0.55	0.58	0.55	0.46	0.43	0.40	0.37	0.34	0.64	0.66
Long-Term Debt to Equity	0.51	0.55	0.58	0.55	0.46	0.43	0.40	0.37	0.34	0.64	0.66
Financial Leverage	-0.15	-0.27	-0.16	-0.11	-0.09	-0.10	-0.04	-0.10	-0.17	-0.11	0.01
Leverage Ratio	1.89	1.75	1.77	1.80	1.77	1.81	1.81	1.82	1.70	1.86	1.81
Compound Leverage Factor	1.87	1.81	1.82	2.00	1.57	2.02	1.68	1.97	1.75	2.11	1.94
Debt to Total Capital	33.65%	35.55%	36.79%	35.47%	31.51%	30.26%	28.65%	27.12%	25.27%	39.09%	39.83%
Short-Term Debt to Total Capital	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Long-Term Debt to Total Capital	33.65%	35.55%	36.79%	35.47%	31.51%	30.26%	28.65%	27.12%	25.27%	39.09%	39.83%
Preferred Equity to Total Capital	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Noncontrolling Interests to Total Capital	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Common Equity to Total Capital	66.35%	64.45%	63.21%	64.53%	68.49%	69.74%	71.35%	72.88%	74.73%	60.91%	60.17%
Debt to EBITDA	-0.80	-1.08	-1.23	-1.92	-4.08	-8.64	3.99	3.73	15.73	-3.89	-2.31
Net Debt to EBITDA	0.10	-0.01	-0.07	0.07	1.03	3.67	-0.83	-1.59	-10.12	0.18	-0.42
Long-Term Debt to EBITDA	-0.80	-1.08	-1.23	-1.92	-4.08	-8.64	3.99	3.73	15.73	-3.89	-2.31
Debt to NOPAT	-0.91	-1.22	-1.74	-2.78	-6.94	-11.32	22.37	13.13	-11.39	-3.53	-2.50
Net Debt to NOPAT	0.11	-0.02	-0.09	0.10	1.74	4.81	-4.67	-5.60	7.33	0.17	-0.45
Long-Term Debt to NOPAT	-0.91	-1.22	-1.74	-2.78	-6.94	-11.32	22.37	13.13	-11.39	-3.53	-2.50
Altman Z-Score	-3.49	-3.19	-2.08	-0.38	3.95	4.75	5.60	6.50	7.86	1.45	2.18
Noncontrolling Interest Sharing Ratio	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Liquidity Ratios	-	-	-	-	-	-	-	-	-	-	-
Current Ratio	3.10	3.22	2.38	2.41	3.61	3.25	2.87	2.71	2.46	3.09	3.30
Quick Ratio	2.77	2.80	1.95	2.00	3.26	2.95	2.56	2.47	2.26	2.83	2.90
Cash Flow Metrics	-	-	-	-	-	-	-	-	-	-	-
Free Cash Flow to Firm (FCFF)	-35	-34	1.91	4.01	5.45	-4.51	-45	-48	-34	-77	-32
Operating Cash Flow to CapEx	-1,339.52%	-3,704.97%	-333.21%	-680.34%	-104.36%	166.13%	439.85%	255.46%	-71.08%	-502.22%	-286.54%
Free Cash Flow to Firm to Interest Expense	0.00	-56.33	0.00	0.00	0.00	0.00	0.00	0.00	0.00	-11.69	0.00
Operating Cash Flow to Interest Expense	0.00	-27.49	0.00	0.00	0.00	0.00	0.00	0.00	0.00	-4.94	0.00
Operating Cash Flow Less CapEx to Interest Expense	0.00	-28.23	0.00	0.00	0.00	0.00	0.00	0.00	0.00	-5.92	0.00
Efficiency Ratios	-	-	-	-	-	-	-	-	-	-	-
Asset Turnover	0.45	0.47	0.56	0.65	0.73	0.79	0.85	0.89	0.91	0.93	0.96
Accounts Receivable Turnover	5.32	7.10	8.11	7.54	8.67	8.81	9.76	8.09	7.63	7.20	6.90
Inventory Turnover	10.03	9.16	9.82	10.76	11.43	9.45	10.69	11.44	10.52	10.82	9.36
Fixed Asset Turnover	4.82	5.49	6.53	7.95	9.35	9.76	10.14	10.89	10.88	10.23	9.62
Accounts Payable Turnover	1.84	2.06	2.01	2.27	3.29	3.09	2.35	2.29	2.92	3.05	3.05
Days Sales Outstanding (DSO)	68.61	51.39	45.01	48.41	42.09	41.41	37.38	45.11	47.81	50.67	52.87
Days Inventory Outstanding (DIO)	36.39	39.85	37.18	33.91	31.93	38.63	34.16	31.90	34.71	33.72	39.01
Days Payable Outstanding (DPO)	198.35	177.42	181.56	160.60	110.93	118.19	155.32	159.58	125.03	119.74	119.75
Cash Conversion Cycle (CCC)	-93.35	-86.17	-99.37	-78.28	-36.91	-38.15	-83.78	-82.57	-42.52	-35.35	-27.88
Capital & Investment Metrics	-	-	-	-	-	-	-	-	-	-	-
Invested Capital	213	209	200	200	217	210	254	246	241	247	273
Invested Capital Turnover	0.99	1.13	1.19	1.30	1.42	1.58	1.60	1.80	1.87	1.94	1.72
Increase / (Decrease) in Invested Capital	17	24	-9.31	-9.46	3.40	1.33	54	45	24	37	19
Enterprise Value (EV)	57	238	689	1,139	2,083	2,438	2,611	3,049	3,692	1,873	2,067
Market Capitalization	71	236	683	1,143	2,111	2,486	2,634	3,095	3,759	1,881	2,038
Book Value per Share	$8.81	$7.95	$7.42	$7.59	$8.93	$9.17	$9.71	$10.17	$10.66	$8.68	$8.23
Tangible Book Value per Share	$2.14	$1.46	$1.09	$1.57	$3.15	$3.65	$3.07	$3.72	$4.37	$3.67	$3.41
Total Capital	344	322	307	317	358	369	388	401	412	417	406
Total Debt	116	114	113	112	113	112	111	109	104	163	162
Total Long-Term Debt	116	114	113	112	113	112	111	109	104	163	162
Net Debt	-15	1.41	6.10	-4.06	-28	-47	-23	-46	-67	-7.62	29
Capital Expenditures (CapEx)	2.23	0.44	1.35	0.65	3.05	6.13	2.37	6.17	4.35	6.45	10
Debt-free, Cash-free Net Working Capital (DFCFNWC)	-6.63	-0.22	-13	-7.79	1.97	-2.89	-1.13	-5.12	-12	12	39
Debt-free Net Working Capital (DFNWC)	124	113	94	109	143	156	133	150	159	183	172
Net Working Capital (NWC)	124	113	94	109	143	156	133	150	159	183	172
Net Nonoperating Expense (NNE)	7.82	11	22	2.87	3.41	3.34	-1.64	5.36	7.70	23	5.52
Net Nonoperating Obligations (NNO)	-15	1.41	6.10	-4.06	-28	-47	-23	-46	-67	-7.62	29
Total Depreciation and Amortization (D&A)	6.09	5.25	5.22	5.93	5.56	5.68	6.19	6.47	6.88	6.81	6.71
Debt-free, Cash-free Net Working Capital to Revenue	-3.27%	-0.10%	-5.32%	-2.92%	0.64%	-0.87%	-0.31%	-1.27%	-2.78%	2.78%	8.62%
Debt-free Net Working Capital to Revenue	60.98%	50.80%	38.54%	40.66%	46.87%	47.34%	36.83%	37.29%	37.28%	41.34%	37.79%
Net Working Capital to Revenue	60.98%	50.80%	38.54%	40.66%	46.87%	47.34%	36.83%	37.29%	37.28%	41.34%	37.79%
Earnings Adjustments	-	-	-	-	-	-	-	-	-	-	-
Adjusted Basic Earnings per Share	($1.06)	($0.78)	($1.10)	($0.31)	$0.20	($0.23)	$0.38	($0.27)	($0.61)	($2.16)	($0.60)
Adjusted Weighted Average Basic Shares Outstanding	24.31M	26.06M	26.62M	27.10M	26.89M	28.15M	28.58M	28.80M	28.64M	29.34M	29.71M
Adjusted Diluted Earnings per Share	($1.06)	($0.78)	($1.10)	($0.31)	$0.20	($0.23)	$0.36	($0.27)	($0.59)	($2.16)	($0.60)
Adjusted Weighted Average Diluted Shares Outstanding	24.31M	26.06M	26.62M	27.10M	26.89M	28.15M	29.75M	28.80M	28.64M	29.34M	29.71M
Adjusted Basic & Diluted Earnings per Share	($1.06)	$0.00	$0.00	$0.00	$0.20	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00
Adjusted Weighted Average Basic & Diluted Shares Outstanding	26.05M	26.14M	26.94M	27.47M	28.07M	28.53M	28.73M	28.90M	29.29M	29.69M	29.82M
Normalized Net Operating Profit after Tax (NOPAT)	-18	-9.56	-7.41	-5.45	6.16	-3.19	6.27	-2.28	-9.96	-18	-12
Normalized NOPAT Margin	-31.26%	-15.32%	-10.50%	-7.08%	6.45%	-3.66%	6.11%	-1.95%	-8.24%	-17.92%	-10.68%
Pre Tax Income Margin	-45.60%	-32.55%	-41.64%	-10.87%	5.66%	-6.98%	10.29%	-6.33%	-15.07%	-61.04%	-15.95%
Debt Service Ratios	-	-	-	-	-	-	-	-	-	-	-
EBIT to Interest Expense	0.00	-33.04	0.00	0.00	0.00	0.00	0.00	0.00	0.00	-8.40	0.00
NOPAT to Interest Expense	0.00	-16.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	-6.13	0.00
EBIT Less CapEx to Interest Expense	0.00	-33.78	0.00	0.00	0.00	0.00	0.00	0.00	0.00	-9.38	0.00
NOPAT Less CapEx to Interest Expense	0.00	-16.76	0.00	0.00	0.00	0.00	0.00	0.00	0.00	-7.11	0.00
Payout Ratios	-	-	-	-	-	-	-	-	-	-	-
Dividend Payout Ratio	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
Augmented Payout Ratio	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Financials Breakdown Chart

Key Financial Trends

GeneDx Holdings Corp. (NASDAQ: WGS) showed a dramatic turnaround in 2025 and into Q1 2026, but the latest quarter also shows the business is still not consistently profitable and remains heavily dependent on cash and financing.

Revenue growth has been strong over the last year. In Q1 2026, GeneDx reported $102.3 million in revenue, up from $120.99 million in Q4 2025 and $87.1 million in Q1 2025. That was a major improvement versus 2024, when quarterly revenue generally ranged from about $62 million to $96 million. The company is clearly operating at a much larger scale than it was a year or two ago.

Profitability, however, remains inconsistent. Q1 2026 produced a net loss of $63.3 million, compared with a loss of $17.7 million in Q4 2025 and a profit of $10.8 million in Q2 2025. Operating income was also deeply negative in Q1 2026 at -$57.5 million, hurt by $31.3 million in impairment charges and still-heavy SG&A and R&D spending. By contrast, Q2 2025 was the standout quarter, when GeneDx posted operating income of $9.0 million and net income of $10.8 million.

Cash flow remains a key mixed signal. In Q1 2026, operating cash flow was -$32.4 million, which is a deterioration from the positive $15.8 million in Q3 2025 and $10.4 million in Q2 2025. That suggests the latest loss was not just accounting noise; the business was burning cash from operations. On the other hand, financing inflows helped cushion the blow, as GeneDx raised $97.5 million from common equity issuance in the quarter.

The balance sheet is much stronger than it was two years ago. As of Q1 2026, GeneDx held $93.9 million in cash and equivalents plus $76.8 million in short-term investments, for a total liquid position of roughly $170.7 million. Total assets were $506.3 million, and shareholders’ equity was $254.1 million. That gives the company more flexibility than in 2023, when it was much more strained financially.

Debt is still significant, though there has been some reduction over time. In Q1 2026, GeneDx reported $96.7 million in long-term debt and $66.3 million in capital lease obligations, compared with a much larger debt load in parts of 2025. So while leverage has improved, the company is not debt-free and still carries meaningful fixed obligations.

Over the last several years, the big-picture trend is clear:

Revenue has grown sharply from 2023 to 2026, indicating strong commercial momentum.
The company’s liquidity position is substantially better than it was in 2023, with a large cash and investment balance.
GeneDx reached profitability in parts of 2025, including Q2 2025, showing the model can produce earnings under the right conditions.
Gross profit has generally improved as revenue has scaled, but margins remain inconsistent quarter to quarter.
The company continues to rely on equity issuance and financing to support operations and reduce balance sheet pressure.
Intangible assets remain a large part of the balance sheet, which adds some accounting risk if performance weakens.
Q1 2026 operating income swung sharply back into the red because of impairment charges and higher operating expenses.
Operating cash flow turned negative again in Q1 2026, signaling renewed cash burn from the core business.
Debt and lease obligations remain meaningful, so the company still faces financing and interest-related pressure.
Share count has risen over time, which can dilute existing shareholders.

Bottom line: GeneDx looks much healthier than it did in 2023, with much stronger revenue and liquidity. But Q1 2026 shows the turnaround is not fully complete. Investors should watch whether management can keep revenue growing while controlling impairment charges, operating costs, and cash burn.

08/17/26 06:39 PM ETAI Generated. May Contain Errors.

Sema4 Financials - Frequently Asked Questions

According to the most recent income statement we have on file, Sema4's fiscal year ends in December. Their fiscal year 2025 ended on December 31, 2025.

Sema4's net income appears to be on a downward trend, with a most recent value of -$21.02 million in 2025, falling from -$29.70 million in 2019. The previous period was -$52.29 million in 2024.

Sema4's total operating income in 2025 was -$13.08 million, based on the following breakdown:

Total Gross Profit: $298.17 million
Total Operating Expenses: $311.25 million

Over the last 6 years, Sema4's total revenue changed from $196.17 million in 2019 to $427.54 million in 2025, a change of 117.9%.

Sema4's total liabilities were at $215.53 million at the end of 2025, a 23.8% increase from 2024, and a 12.8% decrease since 2020.

In the past 5 years, Sema4's cash and equivalents has ranged from $85.21 million in 2024 to $400.57 million in 2021, and is currently $105.00 million as of their latest financial filing in 2025.

Over the last 6 years, Sema4's book value per share changed from 0.00 in 2019 to 10.66 in 2025, a change of 1,066.2%.

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Financial statements for NASDAQ:SMFRW last updated on 8/3/2026 by MarketBeat.com Staff. New filings and market data are monitored continuously.

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Sema4 (SMFRW) Financials

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Sema4 (SMFRW) Financials

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How has Sema4's net income changed over the last 6 years?

What is Sema4's operating income?

How has Sema4's revenue changed over the last 6 years?

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